February 2, 2024 • 65 mins
Embark on an illuminating journey through the tangled web of diabetes with me, Dr. Dwain Woode, as your seasoned endocrinology navigator. Our discussion promises to give you a deeper understanding of how insulin functions as the maestro of your metabolism, orchestrating the energy conversion of every morsel we consume. We're not just talking about diabetes; we're exploring its reverberations across numerous health conditions, emphasizing the critical need for preemptive action and smarter lifestyle choices. Prepare to be enlightened on the staggering prediabetes statistics and the beacon of hope that certain medications can be, possibly leading to a life less dependent on medical intervention.
As your confidant, I pull back the curtain on my metabolic dance with insulin and glucose following an intense 72-hour fast. Witness firsthand how our dietary decisions affect our health, and arm yourself with actionable strategies to manage blood sugar levels. We'll navigate the delicate balance between insulin and glucagon and how medication can harmonize or disrupt this intricate duet. Let's journey together towards a horizon where insulin sensitivity is improved and the reliance on medication is minimized, paving the way for a healthier, more vibrant life.
Concluding our expedition, we'll dissect the complexities of diabetes medications, both their life-altering benefits and the potential side effects. From the latest on GLP-1 receptor agonists to the kidney-protective qualities of SGLT2 inhibitors, I'll guide you through these pharmaceutical landscapes. You'll even get a glimpse into my own diabetes management playbook, integrating fasting and cutting-edge technology. The episode crescendos with an empowering call to action: partner with your healthcare providers, dust off your willpower for fasting challenges, and become an agent of health awareness in your own community. Join us, and let's not just manage diabetes but chase the dream of remission together.
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Transcript
Episode Transcript
Available transcripts are automatically generated. Complete accuracy is not guaranteed.
Speaker 1 (00:00):
If you've been following the news in any
respect, you know that diabetesis a huge problem.
You know that we havepandemic-sized issues with
diabetes.
Diabetes is a leading cause ofheart disease.
It's a leading cause ofblindness and amputations and
renal dialysis.
(00:20):
It is a major cause and a majorsource of morbidity and
mortality and it is a majorsource of cost.
How do we put diabetes andremission?
How do we reverse diabetes?
How do we get off of some ofthis medication?
Tonight we're going to talkabout some medications that you
(00:41):
may want to talk to your doctorabout.
Starting.
That's right.
Y'all We've been talking aboutgetting off medication.
We've been talking aboutgetting rid of things, we've
been talking about reducing, butmaybe there are some
medications that we can use tohelp us bridge the gap as we
move in that direction, andthat's what we're going to be
talking about tonight.
(01:01):
If you're new to me, I'm DrDwayne Wood, that's Wood with an
E the E stands forendocrinology.
Here on the channel, I educate,I empower and I encourage you
to take charge of your health,your life, avoid complications
and go to the next level.
We're creating the life we'vealways wanted and in this year
2024, our new theme is New Year.
(01:22):
New Year, we are specificallytalking about adults with type
(01:46):
two diabetes, but, as I've saidsince I started, the things that
we talk about for diabetics arethe same things that we want to
promote for all the otherpeople that suffer with other
illnesses and other conditions.
We're talking about high bloodpressure, high cholesterol,
polycystic ovarian syndrome,coronary artery disease,
(02:06):
non-alcoholic fatty liverdisease.
We're talking about metabolicsyndrome.
All of those can improve withthe things that we're going to
talk about and the things thatwe are teaching.
So make sure you tune in as weget down this road.
Well, why don't we hop over?
Why don't we go ahead and let'sdo a little background work?
(02:27):
Because we got to get there.
We got to get there y'all.
Diabetes 430 to 460 millionpeople around the world who are
suffering with diabetes.
You know the numbers.
We're talking about half abillion, almost half a billion,
and they're telling me that asthe diabetes levels have gone up
(02:48):
, we see a correspondingincrease in obesity right,
that's weight.
So very allied with diabetes isthis idea of insulin resistance
and increasing weight.
In the United States, there are88 million people a little over
88 million actually who arepre-diabetic.
(03:10):
These are people that areheading in the direction of
diabetes and we've not been ableto curtail, we've not been able
to stop it.
It just keeps getting biggerand bigger and bigger and bigger
.
And perhaps one of the reasonsthat it's getting bigger is
because we're having the wrongconversation, maybe we're having
(03:32):
the incorrect idea of howthings work, and so we're going
to spend a little time doingsome background and we're going
to come talk about thesemedications here in a minute.
So when we think about diabetes,when we think about food, the
idea that we have is that we eatfood, it gets digested and it
goes to create energy.
(03:53):
So everybody says, hey, I'mfeeling weak, I must be hungry,
or I didn't eat today.
Or somebody feels faint and wesay, oh, did you eat?
That's the first question wehad.
Did you eat anything today?
You know how we do, right.
And so we have this idea thatfood digestion goes to energy.
(04:16):
And, in fact, even when we talkabout the different types of
food right, proteins, fats,carbs we get them digested and
we say, hey, this is what myfood is going to do, is going to
provide energy for me, and thatis really a surface
understanding of how things work.
In fact, when we talk aboutfood.
(04:37):
Anytime we're eating, the foodthat we eat turns a switch.
So the food that you put inyour mouth, when it goes into
the body, when it gets digested,a switch gets turned and the
guy that controls the switch isa hormone called insulin, and
insulin comes out from thepancreas.
Insulin is the hormone that hasbeen, has been, the culprit in
(05:05):
diabetes, right?
So everybody's heard of insulinresistance.
You know, you've got cousins,brothers, sisters, coworkers,
somebody you know who's probablyon, probably on some insulin.
But insulin has a very uniquefunction in the body.
Not only does it help to bringblood sugar down when we eat,
(05:28):
not only does it help toregulate blood sugar, because
that's why we give it, that'swhy we give people who are
diabetic insulin but insulinalso is the guy in the body that
makes the determination of whathappens to the food.
Does it go for energy or doesit go to storage?
(05:53):
All right, does it go to energy, does it go to storage?
And insulin makes the decisionabout that based on what's in
the food.
You could think of it kind oflike oh yeah, so I traveled
recently.
I traveled recently and we got,you know, the precheck, the
(06:16):
yeah, when you travel and someof you may have gotten a free
precheck or clear or whatever itis they have now.
And so you show up and if youhave the if you don't have a
precheck, you go to one line.
And when I look over that line,that's that long line that
(06:36):
comes down and wraps around andround and round and goes down
the hall, around the corner,down the stairs, right.
So that's the line, that's theline in the airport.
But if you have the precheck,they take you into a different
line and sometimes they take youalong the track of the same
line and you get up front.
So the precheck allows you togo to one line.
(07:02):
If you have it, you go to oneline, if you don't have it, you
go somewhere else.
So that's what insulin does.
When insulin looks at the foodthat you eat, it makes a
determination of what happens tothe food Either it's going
storage or it's going somewhereelse.
And the thing that insulin islooking for is insulin is
(07:23):
looking for glucose.
Hmm, come on, come on, come on,let's say it, let's say it.
So when glucose comes into thebody, your insulin.
When sugar comes into the body,sugar, you know people say, oh,
maybe I'm eating some differenttypes.
So let's, let's go through them.
So, glucose, lactose, which hastwo types of sugars in it, that
(07:47):
gets broken down into glucose,right?
Fructose all the differentnames of glucose and sugar that
we've talked about.
High fructose, corn syrup,molasses, brown sugar, molasses,
brown sugar, refined sugar,right, all the the oses, right?
Molotos, dextrose, all of those.
(08:08):
When they come in the body, thenthey signal the body to produce
insulin and when insulin comesout, insulin says, hey, that's
stuff that we're seeing rightnow, I'm going to store it.
That's insulin's job.
When it sees sugar, it storesit.
That's the signal.
So anytime you're eating foodthat is high in carbs, then that
(08:36):
signal says hey, this is goingto storage, got it so far right,
so let's go in storage.
So let's hop back over here.
So we're making that decisionAre we going to storage or are
we making energy from this stuff?
And as we store it, then it getsput in different places.
(08:58):
Now, the liver is only so big,it can only hold so much.
So when it becomes stored inthe liver, the liver gets full.
Then the body has to take itand put it somewhere else, and
the somewhere else is over thedifferent places in your body.
(09:19):
So it puts some of it in yourmuscles.
It puts some of it in your fatcells, and I've commented before
here on this show and I had alady know for that said this to
her and she's like no, dr Wood,that's not true.
I said to her and I'm gonna sayit to you do you know that right
now you have the same amount offat cells in your body that you
(09:40):
were born with?
And she said no, no, no, no,that's not true.
There has to be more.
And I said no, it's not more.
What happened is we just putmore stuff in it.
Right, we put more stuff in thefat cells, we put stuff in the
pancreas.
Sometimes we put thoseglycerides, triglycerides, those
(10:05):
fat cells.
Yeah, they're floating aroundthe blood, they get into the
bloodstream and they go into thevessels.
Now I want you to notice, asI'm describing where this is
going.
You can begin seeing thedisease process that comes as a
result of that, because if I goto the liver and I pack the
liver, then I have fatty liver.
(10:28):
If I go to the muscles and Ipack the muscles, I've got
muscle aches, muscle pains.
If I put it in the fat cellsright now, I have obesity, you
see.
So insulin is the guy that says,hey, I see it, let's go ahead
(10:49):
and we're gonna put it intostorage.
Make sense, all right, now whathappens in diabetes?
And so the model that we'veused with diabetes before is
this lock and key model.
We said, hey, blood sugar comesin, the insulin sees the blood
sugar, and the insulin is whatdecides if it goes into the cell
.
And that, basically, is true,but we sometimes leave off the
(11:15):
part about the storage.
And because the insulin isunable to get blood sugar into
the cell, then the body makesmore and more and more and more,
and that's our definition,that's our description of
insulin resistance.
But what if?
(11:38):
What if?
What if?
Along with that idea, there'salso this other idea, and I want
you to hear me.
Suppose we think of your cellkind of like a suitcase, right,
and you're putting stuff in thesuitcase, and the reason that we
(11:59):
can't get more stuff in thesuitcase is because the suitcase
is already packed, so we keeptrying to put stuff once again.
I traveled recently right,we're not to California my son,
my wife, my mother-in-law and I,and we were traveling, I packed
my suitcase and somebody elsein our house said to me hey, I
(12:23):
got this stuff that can't fit inmy suitcase.
Can you put it in your suitcase?
And so I went and opened up mysuitcase and I think I got some
stuff in there, but my suitcasewas so packed I literally had to
sit on it y'all to zip it backup.
Now imagine if I tried to putmore things in that suitcase.
Now I want to put it in.
The suitcase is designed for itto go in there, but I can't get
(12:47):
any more in because thesuitcase is already full.
And so, in order for us to makea decision, what we did is we
traveled, because we weretraveling up to Nashville to
catch the airplane up there.
So we took an extra bag with usand we got up there and once we
(13:09):
got to the parking lot, westood in the parking lot with
the car with the suitcase open,and then we made a decision
about what we could take.
So either we need to get morebags, so bigger cells, or we had
to decide that, hey, we're nottaking some of this stuff with
us, right?
(13:30):
Or we had to put this stuff inand maybe get an elephant to sit
on the suitcase so that we canzip it up.
More insulin.
So what's the plan?
What's the plan?
What's the idea?
How about, instead of givingmore insulin, we decrease the
(14:02):
insulin's ability to make thedecision to store stuff and to
allow it to use the energy thatwe're putting in?
What does that look like?
What does that look like?
One of the very first tools thatwe talked about was fasting.
So we're going to bring theinsulin level down.
(14:24):
How do we bring the insulinlevel down?
By not one-to-one putting stuffin that forces insulin to rise.
Now you're looking at me andyou're saying well, that makes
sense.
Right?
That's the whole idea ofwatching your diet, low-carb
diet, so on and so forth.
Yes, that's true, but I want totake it a step further, because
(14:45):
I want you to understand whythat works, why that is
important.
Because you say, well, yeah, ifI lower my blood sugar, I don't
need insulin.
Well, I'm not just talkingabout the insulin that we give
from outside.
We're not just talking aboutinsulin, the medication.
I'm talking about the insulinin your body.
How do I lower the insulin inyour body?
(15:09):
We've already talked about somemedications that we probably
should try to get off.
That was last week.
If you haven't watched that, goahead and watch that Right,
because those are secretagogues.
Those are things that forceyour body to make insulin.
We talked about getting off ofinsulin itself.
Let me put a point right hereand just make sure that
everybody knows we're talkingabout type 2 diabetics, type 1,
(15:30):
they are insulin requiring.
That is vital for their success, for their survival.
We're not talking about type 2.
We're talking about type 1.
We're talking about type 2diabetics and specifically here,
we're talking about adults.
Now there's a whole otherconversation for children,
because we're starting to seeguys.
I think my youngest type 2patient when I and she's grown
(15:52):
up now was 6 years old with type2 diabetes.
Yeah, so we're starting to seetype 2 in younger and younger
and younger folks.
So it's not restricted now tothe adult population.
(16:12):
We're starting to see our kidsthere, and so there's this whole
conversation that we shouldhave and we're probably going to
have on a different show aboutwhat that means, because
everybody is saying, oh, it'sgenetic.
Well, wait a minute, howquickly did genetics change?
How quickly did our geneticschange?
Because if you go back 50 years, 60 years, 70 years from
(16:35):
previously, we didn't have thisproblem and are we to believe
that our genetics changed overthe course of 70 years, that
drastically.
Anyway, that's a whole otherconversation, right?
Okay?
So what we want to do is we wantto lower the things that we put
(16:58):
in that cause insulin to rise,because when we do that, the
body is able to use the insulinthat it's making more
efficiently, and that is calleddecreasing insulin resistance.
Let me go through that again.
So if I'm putting stuff in thebody that are low enough in the
(17:26):
signal to the body that hey, yougot to produce more insulin,
right, because remember, highersugar, higher glucose, more
insulin comes out, more insulincomes out, more storage weight,
and as the weight goes up, ofcourse the whole idea of insulin
resistance goes up, and so theblood sugar is rise and rise and
rise.
So if I put something in wherethe body doesn't have to produce
(17:49):
as much insulin, then my body'sresponse to the insulin that it
makes is improved.
That, by definition, isdecreasing insulin resistance.
So we talked about fasting as away to do that.
Okay, so let's move on.
(18:10):
Let's move on.
So the fed state, the fastingstate.
So glucose comes in, we digestit, insulin comes out and
insulin is the thing thatconverts it to energy or stores
it, depending on what we haveNow.
Here's a, here's a, and let mesee, maybe let me pop back over
and I want to go back to my, goback to my, my discussion from
(18:36):
yesterday.
Okay, my sister's going to killme because she's going to say
you're telling this people, Imade your blood sugar go up.
She didn't do it, I made thedecision Right.
So look at, right there.
So so here I am Right.
So this is Sunday, let's see.
Let's go back to Friday.
So Friday, so this is where Ibroke my fast.
(18:57):
Right, it was a 72 hour fast.
So right, here, about 645.
Okay, and blood sugars, I mean,that's what?
Okay, so, yeah, so about one.
So we started out down here at79, up, up, up, up, up, up, up,
up, right, so we're going 80s,90s, 120s, 130s, 100s.
(19:24):
Now I want you to notice thisis no medication, right, so the
body is doing its thing.
The body is doing its thing.
Right, here we rose because mysister came, she cooked, I ate.
We got up to 194, y'all, okay,and then we dropped back down
and then, on the way to theairport, we decided we're going
to stop off.
If you didn't know, if you, ifyou didn't hear that story, go
(19:46):
watch the show from last night,right, go, go.
Go watch the show from lastnight and you'll see what
happened.
And look at that 246.
So what do you think happenedto insulin at that point?
Right, insulin spiked up.
So what I'm saying is, if wedon't put things in that forces
(20:09):
the body to make insulin, thebody is well able to manage on
its own Right.
And then look at today, right,so this is today.
Look at that.
And I dare say to you that theresult that you're seeing right
(20:29):
here, these results for today,are a consequence, or I
shouldn't say a consequence.
They are the benefit of thefast that I did three days ago,
right?
So my body is still in that, inthat adjusted phase, and we'll
see what, what my, what my othernumbers are here in just a
little while.
Okay, all right.
(20:52):
So let's put things in, let'sput the less things in.
So that's the whole idea of therefined carbs and so forth.
Okay, all right.
So so let's get to what I wantto talk about tonight.
So, everybody got that so far.
So put less things in, put lessthings in.
The other thing that we can dois we can get rid of, we can
(21:13):
decrease the blood sugar inanother way.
That's the whole idea ofexercise.
So we are trying to do thingswithout the use of insulin.
So first of all, we got rid ofinsulin itself.
We discussed that last week.
We got rid of the secretagoguesthose are the things that force
our body to make insulin.
Now we're putting less refinedcarbs in and actually the reason
(21:38):
that I brought that slide upwas a minute ago is the spike
that you see in blood sugars isdirectly related to how intense
the body sees the sugar.
So the more refined the sugarthat you eat, the bigger the
spike in insulin.
The more refined the sugar, themore refined the carbs, the
(22:01):
bigger the spike that you willsee.
So that if we're not putting inthose highly refined things in
the body, then we get betterinsulin response and then the
insulin because the blood sugarsmay not spike that high, we
don't get as big a spike in ourinsulin level.
If we don't get a big a spikein our insulin level, then the
(22:24):
push to store is lower and someof that gets pushed over to
energy.
So we're decreasing our carbs,we're watching our diet and
we're fasting.
So those are ways that we'regoing to use to bring our
glucose down.
If we bring our glucose down,we bring our insulin down.
(22:45):
If we bring our insulin down,we improve our insulin
resistance and we improve theside effects of insulin.
So that's the basis of the restof the conversation that we're
going to have as we move forward.
So once again, just an exampleas blood sugars go down blood
(23:06):
sugars that graph that you seeon top as blood sugars go down,
the insulin corresponds to that.
Because insulin cannot y'all.
Insulin cannot stay high if youhave low blood sugar.
This is the body's normalresponse.
So I was talking to someonetoday in the office, a patient.
(23:27):
She was saying hey, my bloodsugars dropped and I felt kind
of fuzzy headed, light headed.
One of the reasons that happensis because we still have
medication on board that'spushing our blood sugar down.
If we didn't have medication onboard when your blood sugar
dropped, the body wouldessentially turn your insulin
(23:49):
off and you would not feel that.
But because the medication isstill there, the medication is
still driving the blood sugardown and because we're used to
being higher in our blood sugar,we feel that a lot more.
Okay, all right.
So glucose level right.
So here's another interestingside that's going to be a
(24:12):
benefit for us later on.
So as blood sugars go down, sodoes the insulin.
But as insulin goes down, thecounter hormone to insulin goes
up.
That's called glucagon.
So insulin says, hey, store it.
When insulin goes down,glucagon comes out and glucagon
says, hey, now I've got to usethat stuff, I've got to use the
(24:35):
blood sugar.
That's why.
That's why, for those of youwho take insulin, you get
prescribed that glucagon pen,because the glucagon pen, when
your blood sugar goes down, yougive some glucagon and glucagon
goes into the body and it findssugar, it breaks down the
glycogen that's stored in theliver and it pumps it into the
blood, so that your blood sugarscome up.
(24:58):
And of course, we have all thetoxicities, right.
So the triglycerides that areformed when insulin is trying to
store things.
That's where all of thosedifferent things go, right.
So lipotoxins, yes, the toxiclevels of the lipids.
The beta cell becomesdysfunctional because now we're
putting fat there.
And then other components.
(25:20):
So the other parts of the body,the liver, right so fatty liver
and so on, all right.
So.
And then, of course, all thedisease processes, and we've
talked at length about those.
So what I want to do is I wantto say hey, how do we decrease
the sugar?
And we've talked about severalways, but this brings us to the
medication.
(25:40):
This brings us to themedication.
Now, as I've said and you'veheard me talk about it here on
the show that our goal isreversing diabetes.
Now notice, I use the wordreverse, right, because you
usually hear me say remission,putting in diabetes and
(26:02):
remission.
The words are being usedinterchangeably, and the reason
I like the remission version ofthat word better is because it
gives the impression rightly sothat your diabetes is controlled
(26:24):
.
You may not be, you're not onany medication.
That's what remission meansthat you have good blood sugars,
you're not on any medicationand there's actually a timeline
how long you have to be off ofmedication with good blood sugar
for you to be considered to bein remission.
The reason I like that idea isbecause when we talk about
(26:47):
reversing diabetes, people getthe or they think that, oh, my
diabetes is gone and so now Ican do whatever I want and the
blood sugars are going to staygood.
And that's not the case.
But we're going to use those.
You hear me use those wordsinterchangeably, but I want you
to understand if you hear me usethe word remission, it's
(27:09):
because I want people tounderstand that this is a
lifestyle that they've got toadopt.
Okay, all right, so, yes, solet's talk about the medication,
right?
So one of the ways, one of theways of decreasing sugar in the
(27:30):
body is with the use of somemedications, and these are
called SGLT2 inhibitors.
Sglt2 inhibitors, and the SGLT2inhibitor class is a class that
the question is can we use somemedication to help us bridge
(27:51):
the gap as we move in thedirection of remission, reversal
, improve blood sugar control?
And so the first group ofmedications I want to talk about
are these medications that arecalled SGLT2 inhibitors.
Sglt2 inhibitors, and thesemedications work by basically
(28:16):
taking sugar and they put thesugar into the, they put the
sugar into the urine.
Okay, and let me pull that slideup here really quickly.
So for type two diabetics, whathappens is that, and let's see
if you can see I hope you cansee my pointer.
(28:39):
It doesn't look like you can,but anyway, you see the big part
to the left there, that this isbasically a part of the kidney,
and you don't have to look atall the wires and all the, all
the arrows, but right there atthe top, at the left side is
where your blood goes into thekidney and then the kidney
(29:02):
filters it out, and all the wayat the other end, to the right
side of that graph, down at thebottom, the blue line or the
blue arrow is where your urineis coming out.
Okay, that's where the urine iscoming out.
And so for people who arediabetic, for people who are
diabetic, there is a defect intheir kidney.
(29:23):
There's a defect in theirkidney, and so when, when the
body filters the blood, one ofthe things that happens is that
sugar comes out of the blood andit's being filtered through the
kidney and the body.
Because of this defect that'sin the kidney, the body brings
(29:45):
the sugar back into the blood.
Now it's supposed to go out,it's supposed to go into the
urine, but because of thisdefect, the body pulls it back
in, and so you end up havinghigher blood sugars than you
should.
You got that so far.
(30:06):
So, because of this defect, thesugar that should be not coming
back into the body ends upcoming back into the body and it
doesn't get put into the urine.
And this medication what itdoes is it stops that process or
(30:27):
it fixes that process and itallows sugar that's in the body
that now gets put into the urineto go into the urine, and it
stays out there.
Now notice that this processdoes not use any insulin.
(30:51):
We just talked about decreasingthe problem with the insulin.
So we just took some sugar outof the body, we put it in the
urine.
It's gone.
So the amount of insulin thatyou've got to take from outside
that is, insulin shots or thesecretogogs that you have which
(31:16):
are forcing the body to makeinsulin, or your bodies seeing
the sugar that's high anddeciding to make more insulin,
decreases.
And that's the point.
That's the goal of what we'redoing as we head to remission
(31:37):
because we got to get rid of thesugar somehow.
Now you're saying you say wait aminute, so we're going to get
on medication to get inremission.
And the answer is yes, becausethe idea in this model is not
that we're on the medication andthat's it Right.
(32:00):
In the old model we say hey,your blood sugar is a high, this
is going to be a chronic thing,this is going to be a forever
thing.
So you just take this medicineand you keep taking as much as
you need to get those bloodsugars down.
Now what we're saying is hey,let's figure out how to get rid
of some of the sugar so that wecan deal with the defect, and
the defect is an insulin issue.
(32:20):
When we deal with the defect,we have all the benefits of
decreased insulin Better insulinsensitivity Right.
So now the insulin becomessensitive, it works.
Whatever your body makes works.
We stop shuttling energy intothose storage places liver, fat
cells, pancreas Right.
(32:42):
So all of those diseaseprocesses improve and we have
the improvement that we have.
That comes from the fastingthat we're doing.
So the goal decrease the sugar,get the insulin down.
Now, ultimately, we're going totalk about okay, now, that if
(33:04):
you're on this medication thatwe did, now we're off the
insulin, now we're off thesecretogogs now we're off the
DPP4s and if you don't remember,go back and watch that show
from last week we're off ofthose.
We're doing the fasting, andhere's another way to bring the
blood sugars down.
Okay, so that's one of them.
All, right, so let's hop overand let's talk about another
(33:28):
class of medication and thisclass of medication, like I said
, you've heard, you've seen andthis is what everybody's talking
about that's helping peoplelose weight.
Okay, Well, actually, before Ido that, let me talk to you
about what some of the names ofthese medications are, and these
(33:48):
are.
And there are two others thatare not as prominent in the
market.
They actually were taken offthe market.
I think one of them is still onthe market, but Jardians and
Farsica, those are the names,those are the brand names.
I'm not going to tell you thescientific name, because you
probably have heard it, buteverybody knows these, okay, so
(34:09):
let's go ahead and say them.
So Jardians and Farsica are thetwo that we were talking about,
right?
So these medications, all theydo is they take sugar.
I shouldn't say all they dowhen it comes to blood sugar.
What they do is they take sugar, they put it in the urine.
They correct a defect that's inthe kidney of patients who have
(34:31):
diabetes, where their bodynormally resorbs, brings sugar
back into the body that shouldbe put in the urine.
So it basically fixes that andit gets rid of the sugar.
If the sugar is lower, insulingoes down.
That's the key.
Now you hear me say that overand over.
Sugar goes down, insulin goesdown.
(34:51):
That is the key.
Okay, all right, and Teresa,thank you for hopping on.
I see your question there, oryour comment there.
I'm going to go ahead and start, and we'll come back to that in
just a little bit.
Okay, does that make sense?
(35:12):
So far for everybody?
Yes, yes, yes, okay, if itmakes sense, put yes in the
comments and, as I'm talking,guys, go ahead and drop those in
the comments, because we'regoing to come back, we're going
to deal with some of those herein just a little bit, okay, all
right, so let's then look atanother group of medications.
(35:32):
As I said, these are the onesthat everybody's been talking
about that are helping to loseweight, and I want you to look
at this graph, look at all thedifferent things that you see
that these medications do.
The ones, though, that I wantyou to kind of pay attention to
are the ones you'll see up thereat the top the brain, okay, and
(35:56):
then you'll see the pancreas mymouse is not working, so I'm
going to have to describe, okayand the skeletal muscle Okay, so
they do a couple of things thatare going to help us.
Number one these medicationsare secretogogs.
Okay, let me go ahead and saythat they are secretogogs, and
(36:20):
so they work similar to theDPP-4s that I just told you we
need to get off, right.
These are the ones that makethe body produce insulin.
However, the benefit that weget from them is that they also
help to suppress the appetite.
They suppress the appetite.
(36:41):
They send the signal to thebrain that we're full.
They help the muscles to useinsulin more effectively.
Right, so several things.
The benefits may outweigh theinsulin that we're getting,
because if we're decreasing ourfood intake, decreasing the
(37:02):
things that we're putting in thesugar, right, those cravings
are going down.
If the cravings are going down,the blood sugars are going down
.
If the blood sugars are goingdown, the insulin level is going
down.
And, ultimately, our goal isgoing to be right.
During the process of being onthese medications, during the
process of fasting, right, we'regoing to be learning some ways
(37:26):
to manage our blood sugar,manage our food, manage our
cravings, so that, when thesemedications go away, we can
process that on our own.
Okay, now notice what I'm saying.
We're going to be on thebridges to where we need to go,
so we're not saying, hey, you'regoing to be on this and this is
(37:47):
it.
We're saying how do we?
Because we've got a strategy,y'all right, we've got a
strategy on how we're going todo this, and the strategy
includes hey, how do we get offof this medication and these
medications?
As I said, they are one of theones that help with our weight,
(38:11):
right?
So everybody's all excitedabout that.
So it's great, you know, youget that tummy, you get rid of
that fat.
Now, the guy that's on the left,that abdomen that you see, that
(38:33):
abdomen comes as a directresult of insulin resistance.
Insulin resistance this is agood place.
Let me, let me do this.
I'm going to hop over, let mecome back here so you can see me
full screen, because I want tomake this point.
If, if you are, if you stand upand I'm going to stand up if
(39:05):
you look down and you see yourtummy, then you've got insulin
resistance.
People say how do I know if I'minsulin resistant?
That's how you know, becausethe storage of energy, one of
(39:29):
the places it goes, is rightthere, that omentum.
And that's what that?
That within inside the omentum,that's that fat pad that covers
the abdomen.
On the inside you can't see it.
You can't, well, you can't seeit from the inside, but you see
it on the outside and if youlook down and you can see your
(39:51):
stomach, that is a sign ofinsulin resistance.
So you don't have to wonder,you don't have to guess yes, it
is.
And insulin resistance, as wejust talked about, is a.
That's what everybody says.
Diabetes is right, insulinresistance.
(40:12):
But insulin resistance is morethan just diabetes.
That's why I say to those ofyou who are out there, if you
don't have diabetes, don't tunethis out, because this is for
you as well, because how do youget rid of the omentum, the
omentum, how do you get rid ofthat stuff right there?
The exact same way as we'retalking about the diabetics, the
(40:35):
same way that we're going toput diabetes and remission is
the same way that we get rid ofthat.
And here, in a minute, I'mgoing to show you, I'm going to
show you my weight, as we dowith all of our numbers.
We're going to see that here injust a second.
Okay, all right.
So so when we talk about, whenwe talk about diabetes, the goal
(40:57):
, the goal, one of the primarygoals, is how do we get the
insulin down?
And we get the insulin down bygetting the sugar down.
How do we get the sugar down?
One, by fasting.
Two, by getting rid of sugar,and how do we make it through
(41:18):
the fast and how do we deal withthose cravings?
Maybe the GLPs are a way ofdoing that, okay, and those
medications are ozympic andeverybody's probably heard of
ozympic.
There is also biata, bi-durionvictosa rebellisis is the only
(41:44):
oral form of that of that classright now.
And then manjaro has a GLP init, but it also has another
component, right?
So it's a combination of things, All right.
So that's the question, that'sthe explanation.
(42:09):
We're going to come back and I'mgoing to tell you what my
opinion.
So this, I'm just giving youdata right now.
Right, I'm just giving you aradio.
I'm going to tell you myopinion of those, what I think,
right, when I answer thequestion should I start taking
some of these medications?
Should I start taking one ofthose medications?
All right, so let's do this,let's hop over and let's take a
(42:33):
look at some numbers, right?
So we've already shown you whatthe DEXCOM has shown.
I think, yeah, so that's myDEXCOM right now, what it's
saying.
My blood sugar is, and, ofcourse, that's the Libre.
So let me go ahead and let'spop over and I want to do the
blood sugar here.
All right, let's see what thatshows.
(42:53):
And I do people say, hey, whenyou're not doing the 72 hour
fast.
What do you do?
Well, my normal plan is to dolike a five to six hour eating
window, so I don't eat anything.
Once I stop eating at night, Idon't eat anything until I eat
in the office with my team or mywife.
(43:17):
So I'm going maybe 14, 16 hourswhen I'm not fasting, but of
course, as you know, my fast Ido that and you see that I do
(43:38):
that.
That's been a 72 hour fast.
Let's go ahead and put thisblood on this meter and let's
see what that shows.
Right now, and for you, ourgoal has been for you to work
your way up.
Look at that 1.1.
So that's actually pretty good,all right.
(43:59):
So if you remember, when wetalk about nutritional ketosis
nutritional ketosis what we'retalking about?
Having ketones of 0.5 to 1.5.
And when we talk abouttherapeutic ketosis, we're
talking about having ketoneshigher than that.
So now my blood sugar is 115and my ketones are 1.1.
(44:24):
And let's pull over now and goto our app, because the app is
going to suck it in and then Iget to show you the graph of
what has been going on over thelast couple of days with that.
So let's go ahead and it shouldbe pulling in here just a sec.
If not, I'm going to hit thebutton to have it scan and it
(44:52):
says yes, boom, got it, allright.
So there we are, and let's takea look at our graph, because I
want you to see here All right.
So, right there.
That was before I broke thefast, so that was Friday evening
(45:14):
, and so look at that my ketonesare high, my glucose is low.
Now let me pause here, becauseif you've not been with us,
you're like well, what does thatmean and what does that have to
do with our diabetes?
Well, when your body doesn'thave sugar, it switches to burn
(45:37):
another source of energy, andthe other source of energy is
ketones, and you can measure theketones in your body and you
can tell when the body isactually using something other
than sugar to burn energy, andthat's what this is an
indication of.
And then you notice that when Istop fasting, so my blood sugar
(46:00):
went up and then my ketonesdropped.
So down here, my ketones arelike 0.6.
0.7.
And, of course, 1.1.
, but my blood sugar is.
What did we just say was 111.
Okay, awesome, all right, sothat's where those numbers are.
(46:23):
Let's hop over and let me grabsome of these questions, some of
these comments.
All right, let's see what itmeans.
So Lashas and I'm assuming Ipredicted that correctly she
said thank you, that's what's awelcome, I'm assuming.
And then she says my insulinwas at 8, 2 years ago and I got
it down by lifestyle changes.
(46:45):
Yes, definitely, definitely.
I love that.
Go ahead and, if you don't mind, just drop in the comments what
it was that you did.
What did you do?
What did lifestyle changesexplain a little bit more of
that to us.
Teresa says which one would yousuggest that have very little
(47:05):
side effects?
Very good question.
And so let me give a littlebackground for those people who
don't know much about the GLP-1s.
The GLP-1s work.
One of the things they do isthey slow food as it moves
through the body, as it movesthrough the stomach.
So some people feel that asqueasiness, some people feel it
as nausea.
There are actually some peoplethat actually can throw up from
(47:27):
it, and that happens because thepancreas becomes inflamed for
some people.
The other thing that can happenis they throw up.
So that's the big side effect,right?
So the GI symptoms that peoplehave Now for most of the
(47:50):
medications, most of those GLPs,and I'm assuming that's the one
you're talking about.
Actually you didn't say,because let me talk about both
then.
So for the GLPs, the big sideeffect, of course, is the
slowing of the food as it movesthrough your stomach.
Because you feel fuller, peoplefeel as queasiness.
You adjust the dose if you needto.
Some people come off of it.
(48:12):
Now, one of the things thathappened to me years ago was
when these guys first came onthe market, I tried taking them
and I couldn't because theyslowed my GI tract so much that
I started getting constipation.
So when they first came out, Icouldn't take them.
I tried, I'll tell you,multiple times.
I tried and tried and tried.
I went to my doctor and he saiddon't you want to try it?
(48:34):
I said sure, and this is me asthe endocrinologist y'all, but I
couldn't take them.
And so for years and years andyears they didn't work for me.
And then we talk about theSGLT2s, as the other group the
Jardians and the Farsica, thosebecause they're putting sugar in
(48:55):
the urine, people who are proneto yeast infections can have a
yeast infection.
It has also to do with how bigthe blood sugars are, as we're
dumping sugar.
The higher your blood sugarsare, the more possibility it is
that you may have a urinarytract infection, and some people
(49:17):
can have a severe urinary tractinfection called Furnace
gangrene.
So that's one of the sideeffects there.
All right, as then Teresa said,I heard that some cause thyroid
or kidney issues, right.
So the SGLT2s, the issues thatyou're hearing there, are the
(49:38):
urinary tract infection and thesevere infection in the general
area.
They actually have been nowapproved, many of them for
kidney protection, right?
So when they first came out,people saw, hey, wait a minute,
we're putting sugar in the urine.
Now, when I trained, when I wascoming through medical school,
(50:00):
it was bad to have sugar in theurine, right.
If you found somebody who hadsugar in their urine, they were
called diabetic, right.
But now, because of themechanism of action, right, we
actually use that fact.
We didn't understand that backthen.
We used the fact that it putsugar in the urine to treat the
blood sugars.
The other thing about thyroid,so we're talking about now going
(50:23):
back to fictosa and ozimpic andmungero and the rebalysis and
the GLPs.
So there have been cases ofmedullary thyroid cancer in
rodents, right.
So when they tested them, theserodents had medullary thyroid
cancer and so someone who has ahistory in their family or have
(50:45):
a personal history of medullarythyroid cancer, we don't put
them on it.
But we've never seen that inhumans, right?
But because the studies whenthey did them, they showed that
it actually has to show up onthe, on the marketing and on the
box.
So let's see.
Teresa says yes, okay, so ifyou know somebody I think that
(51:07):
was the answer yes, and oh, itdoes make sense.
It makes sense, thank you,because I see Jeff says yes,
makes sense as well.
And receive, receive, I'm goingto give you some music.
Hey, take a real close look.
Okay, I got to find my handclap again.
(51:29):
For some reason it went away.
But anyway, receive, thanks forstopping by.
I said which class of thesemedications do you recommend?
I'm on ozimpic but have someside effects, okay, so receive,
I'm going to hold that questionfor a minute because I'm going
to come back and give you mythoughts in just a sec, right?
And then Jeff says which doesmetformin fit in all of these
(51:53):
meds?
So metformin is not one ofthese medications, right, it is
not one of the ones that wetalked about in terms of getting
off, right, stopping, right, wedid that show last week, and
it's not one of the ones thatwe're talking about getting on
right now.
Right, starting, it is one wehave not discussed yet, and I've
(52:15):
deliberately not discussed ityet.
And well, actually there are acouple of other medications that
we've not discussed yet aboutwhat we're going to do with them
.
I suppose I well, you'veprobably heard me say this in
one of my other shows, anyway.
So so metformin has been one ofthose medications that's been
around forever and of themedications that, when they
(52:42):
initially were studying diabetesin terms of complications and
improvement and so forth, it wasone of the medications that
showed the slowing of theprogression from pre diabetes to
diabetes.
It's also a medication thatwe've used to treat metabolic
syndrome, obesity, and on and onand on.
(53:03):
So, if I, if I, if I put my hey, my doctor hat on, I'm like
this is actually a goodmedication for us to use, okay,
because it does what we want itto do.
I want to hasten to say, though, that, as we're talking about
remission, we're not justtalking about remission getting
(53:24):
off of one medication or anothermedication or we're talking
about getting off of allmedication.
So so, just like I'm saying toyou, hey, consider these
medications should we get onthem and we should get off of
those?
Metformin is one of thosethat's in the between.
So if people are on metforminright now and that's the only
(53:46):
thing they're on, then our goalis to get them off the metformin
.
But if they're not on metforminand I need to treat their
diabetes right now to get thembetter as we move towards
progression, revision sorry,towards remission, then it is a
(54:07):
tool that I use.
So what I do in my office, whatI try to do in my office, is if
someone comes in and they areon insulin they're on a
secretogoc my goal is to try tominimize those and get them on
an SGLT2 and get them on a DPB4.
(54:28):
That's what I do Now.
Before everybody was talkingabout the weight loss that you
get with ozympic and menjaro andall those, we were in the
office when people's patientscame in.
We were putting them on a GLPbecause I knew if I got them on
(54:49):
a GLP I didn't have to use asmuch insulin.
I would put them on an SGLT2because I knew if I got them on
an SGLT2, we wouldn't need asmuch insulin.
Do I think those are goodmedications?
Yes, I think they are.
I use them almost every day, Ishouldn't say almost every day.
I use them every day for mypatients, I use them for myself.
(55:20):
We're going to come back andwe're going to talk about that
story and another show, but oneof the things that I want to
show you is, along with bloodsugar, as you guys know, you've
been watching me and you knowthat I've been also tracking my
(55:42):
weight.
This is where we are today.
This has been our trend overthe last month.
Remember, I came on close tothe beginning of the month and
said, hey, look at this, I havegone below my weight, I've
(56:06):
reached my goal.
That was, I think, over heresomewhere, 199.
Right there, that was back onthe 15th of January.
I want you to notice something15th, 16th, and so we went to
197.
We went down to 197.
We got down to 194 right herey'all and then 197, 200, 201,
(56:28):
198, 195, 197, 199, 198.
Now let me make a statement here.
Let me show you the month view.
I want you to notice the graph.
The graph is not linear.
It doesn't just go in onedirection.
(56:50):
It goes up, it goes down.
You need those fluctuationsthere.
I want to point out to youbecause some of you are out
there and you're frustrated inyour weight journey.
I want to point out to you thatthe daily fluctuations that you
see is not where your concernshould be.
(57:12):
What you want to see is, whenyou look over the course of time
, that the trend is what youwant, because if I look on this
right here, I'm like man.
I was up 200, down 195.
Look at me, I'm 198.
(57:33):
Even if I look at this, I'mlike man.
Look at those fluctuations.
I'm going up and down, and upand down.
When I look over the course oftime, y'all I want you to see
that, right there, that was 240pounds.
That's March of last year.
This is now 240, down to 198.
(58:04):
Given that, if I look backfurther, I want you to see this
guy.
That was 260 pounds.
That was January of 2022.
I don't have recorded on thisdevice, but at one point that
(58:25):
number was up at 285 pounds.
That must have been I don'tknow 2000, 10 to 15-ish.
(58:45):
As we are on this journey it isa journey there are going to be
stops and starts.
Our goal is not necessarilythat tomorrow we get where we're
going, because we're not goingto get where we're going.
Let me say that to you.
You're not getting where you'regoing tomorrow.
It is a journey, but we wantthat journey to continue,
(59:06):
heading us or taking us in theright direction.
One of the things I love aboutthis space and you've heard me
say it before, I'll say it againI come on this show and I talk
with you and I teach the thingsI do because you're part of my
therapy group.
I know, I know I'm part of whohelps me to be who I need to be.
(59:33):
As I talk about new year, newyou, everybody thinks that
they're by themselves.
Everybody thinks, oh, it's justme.
I'm telling you some of thethings that I talk to you about.
I struggle with all the time,but I want to be able to say
(59:59):
that I'm moving forward in myjourney and this year, y'all
together in this group, yeah,yeah, we're heading.
We're heading in the direction.
Let me see, jeff said, for yourthought of the day, my Freestyle
Libre 3 provides so muchinformation for me.
(01:00:19):
Let's see, for your thought ofthe day, my Freestyle Libre 3.
Where do you, jeff?
I think I missed the first partof that.
Oh, you want me to use that asa thought of the day?
Okay, I like that.
Thank you, awesome, awesome,all right.
So, if you've not already doneso, everybody, if you've not
(01:00:40):
already done so and you're here,so maybe you have already done
so, but if not, I would like toask you for three things.
Okay, I'd like to ask you forthree things.
What we've been doing is we'vebeen talking about the fasting,
talking about, okay, what do wedo with the fasting?
(01:01:01):
And if you're out there,whether you're diabetic or not,
my challenge to you is to workyour way up so that you can fast
for 24 hours.
So that's what we planned to doin January.
That was the plan.
Work our way up so we can fastfor a 24-hour period.
(01:01:21):
In the month of February, we'regoing to do another challenge,
dealing with that 24 hours.
Okay, so for right now, right,fasting 24 hours.
Work your way up wherever youare.
I want you to expand that sothat you can be able to do that.
And meaning that you're alsotalking to your healthcare
(01:01:44):
provider.
If you're on medication thatyou are having healthcare
provider, help you adjust that.
If you're one of my patients,one of my clients, one of the
people who talks to me, that'swhat we do, right?
So how do we back off of someof these medications?
We've talked now aboutmedications you should stop try
to get off of.
We've talked now aboutmedications.
(01:02:06):
You should probably talk aboutstarting and you've heard the
benefits of those.
The fasting helps in thatentire process.
So, first of all, what I'masking you to do is work your
way up so you can fast for a24-hour period.
Number two I want you to committo being on this journey with
(01:02:27):
us.
Being on this journey with me.
That means showing up as welearn this stuff together.
That you are here, that youshare your information, that you
share the successes that you'vehad, you share some of these
disappointments that you've had.
That you ask the questionsBecause, as you do that, the
(01:02:48):
other people that are herelistening, the people who are
even going to be watching thison the replay they benefit
because now they know it's notjust them.
Now they know somebody else outthere is having the same issue.
Somebody else out there isseeing the same thing.
Somebody else out there ishaving success because maybe
they're not seeing success.
(01:03:11):
To show up in the community,engage in the community.
And then the third thing thatI'm asking you to do is to bring
somebody with you.
You can bring somebody with youon the show, send them a link,
let them know what's going on,help them sign up, help them
subscribe, tell your doctor,tell your pastor, tell your
(01:03:34):
cousin, tell your mom and themabout what we're doing here,
because the 460 million peoplearound the world that have
diabetes, the millions of peoplethat are struggling with
prediabetes and obesity andmetabolic syndrome and high
(01:03:56):
blood pressure and highcholesterol and polycystic over
in syndrome, and on and on andon, they all benefit from this
information.
So you can be the person whohelps to spread that, to help
improve their lives.
Good night, we'll see you atthe next show.
This is Dr Dwayne Wood, that'sWood with an E.
The E stands for endocrinology.
(01:04:18):
Here on the channel, I educate,I empower and I encourage you
to take charge of your health,take charge of your life, avoid
complications and go to the nextlevel, creating the life you
always wanted.
And for this year, y'all, newYear, new Year.
If you've been following the news in any
respect, you know that diabetesis a huge problem.
You know that we havepandemic-sized issues with
diabetes.
Diabetes is a leading cause ofheart disease.
It's a leading cause ofblindness and amputations and
renal dialysis.
(00:20):
It is a major cause and a majorsource of morbidity and
mortality and it is a majorsource of cost.
How do we put diabetes andremission?
How do we reverse diabetes?
How do we get off of some ofthis medication?
Tonight we're going to talkabout some medications that you
(00:41):
may want to talk to your doctorabout.
Starting.
That's right.
Y'all We've been talking aboutgetting off medication.
We've been talking aboutgetting rid of things, we've
been talking about reducing, butmaybe there are some
medications that we can use tohelp us bridge the gap as we
move in that direction, andthat's what we're going to be
talking about tonight.
(01:01):
If you're new to me, I'm DrDwayne Wood, that's Wood with an
E the E stands forendocrinology.
Here on the channel, I educate,I empower and I encourage you
to take charge of your health,your life, avoid complications
and go to the next level.
We're creating the life we'vealways wanted and in this year
2024, our new theme is New Year.
(01:22):
New Year, we are specificallytalking about adults with type
(01:46):
two diabetes, but, as I've saidsince I started, the things that
we talk about for diabetics arethe same things that we want to
promote for all the otherpeople that suffer with other
illnesses and other conditions.
We're talking about high bloodpressure, high cholesterol,
polycystic ovarian syndrome,coronary artery disease,
(02:06):
non-alcoholic fatty liverdisease.
We're talking about metabolicsyndrome.
All of those can improve withthe things that we're going to
talk about and the things thatwe are teaching.
So make sure you tune in as weget down this road.
Well, why don't we hop over?
Why don't we go ahead and let'sdo a little background work?
(02:27):
Because we got to get there.
We got to get there y'all.
Diabetes 430 to 460 millionpeople around the world who are
suffering with diabetes.
You know the numbers.
We're talking about half abillion, almost half a billion,
and they're telling me that asthe diabetes levels have gone up
(02:48):
, we see a correspondingincrease in obesity right,
that's weight.
So very allied with diabetes isthis idea of insulin resistance
and increasing weight.
In the United States, there are88 million people a little over
88 million actually who arepre-diabetic.
(03:10):
These are people that areheading in the direction of
diabetes and we've not been ableto curtail, we've not been able
to stop it.
It just keeps getting biggerand bigger and bigger and bigger
.
And perhaps one of the reasonsthat it's getting bigger is
because we're having the wrongconversation, maybe we're having
(03:32):
the incorrect idea of howthings work, and so we're going
to spend a little time doingsome background and we're going
to come talk about thesemedications here in a minute.
So when we think about diabetes,when we think about food, the
idea that we have is that we eatfood, it gets digested and it
goes to create energy.
(03:53):
So everybody says, hey, I'mfeeling weak, I must be hungry,
or I didn't eat today.
Or somebody feels faint and wesay, oh, did you eat?
That's the first question wehad.
Did you eat anything today?
You know how we do, right.
And so we have this idea thatfood digestion goes to energy.
(04:16):
And, in fact, even when we talkabout the different types of
food right, proteins, fats,carbs we get them digested and
we say, hey, this is what myfood is going to do, is going to
provide energy for me, and thatis really a surface
understanding of how things work.
In fact, when we talk aboutfood.
(04:37):
Anytime we're eating, the foodthat we eat turns a switch.
So the food that you put inyour mouth, when it goes into
the body, when it gets digested,a switch gets turned and the
guy that controls the switch isa hormone called insulin, and
insulin comes out from thepancreas.
Insulin is the hormone that hasbeen, has been, the culprit in
(05:05):
diabetes, right?
So everybody's heard of insulinresistance.
You know, you've got cousins,brothers, sisters, coworkers,
somebody you know who's probablyon, probably on some insulin.
But insulin has a very uniquefunction in the body.
Not only does it help to bringblood sugar down when we eat,
(05:28):
not only does it help toregulate blood sugar, because
that's why we give it, that'swhy we give people who are
diabetic insulin but insulinalso is the guy in the body that
makes the determination of whathappens to the food.
Does it go for energy or doesit go to storage?
(05:53):
All right, does it go to energy, does it go to storage?
And insulin makes the decisionabout that based on what's in
the food.
You could think of it kind oflike oh yeah, so I traveled
recently.
I traveled recently and we got,you know, the precheck, the
(06:16):
yeah, when you travel and someof you may have gotten a free
precheck or clear or whatever itis they have now.
And so you show up and if youhave the if you don't have a
precheck, you go to one line.
And when I look over that line,that's that long line that
(06:36):
comes down and wraps around andround and round and goes down
the hall, around the corner,down the stairs, right.
So that's the line, that's theline in the airport.
But if you have the precheck,they take you into a different
line and sometimes they take youalong the track of the same
line and you get up front.
So the precheck allows you togo to one line.
(07:02):
If you have it, you go to oneline, if you don't have it, you
go somewhere else.
So that's what insulin does.
When insulin looks at the foodthat you eat, it makes a
determination of what happens tothe food Either it's going
storage or it's going somewhereelse.
And the thing that insulin islooking for is insulin is
(07:23):
looking for glucose.
Hmm, come on, come on, come on,let's say it, let's say it.
So when glucose comes into thebody, your insulin.
When sugar comes into the body,sugar, you know people say, oh,
maybe I'm eating some differenttypes.
So let's, let's go through them.
So, glucose, lactose, which hastwo types of sugars in it, that
(07:47):
gets broken down into glucose,right?
Fructose all the differentnames of glucose and sugar that
we've talked about.
High fructose, corn syrup,molasses, brown sugar, molasses,
brown sugar, refined sugar,right, all the the oses, right?
Molotos, dextrose, all of those.
(08:08):
When they come in the body, thenthey signal the body to produce
insulin and when insulin comesout, insulin says, hey, that's
stuff that we're seeing rightnow, I'm going to store it.
That's insulin's job.
When it sees sugar, it storesit.
That's the signal.
So anytime you're eating foodthat is high in carbs, then that
(08:36):
signal says hey, this is goingto storage, got it so far right,
so let's go in storage.
So let's hop back over here.
So we're making that decisionAre we going to storage or are
we making energy from this stuff?
And as we store it, then it getsput in different places.
(08:58):
Now, the liver is only so big,it can only hold so much.
So when it becomes stored inthe liver, the liver gets full.
Then the body has to take itand put it somewhere else, and
the somewhere else is over thedifferent places in your body.
(09:19):
So it puts some of it in yourmuscles.
It puts some of it in your fatcells, and I've commented before
here on this show and I had alady know for that said this to
her and she's like no, dr Wood,that's not true.
I said to her and I'm gonna sayit to you do you know that right
now you have the same amount offat cells in your body that you
(09:40):
were born with?
And she said no, no, no, no,that's not true.
There has to be more.
And I said no, it's not more.
What happened is we just putmore stuff in it.
Right, we put more stuff in thefat cells, we put stuff in the
pancreas.
Sometimes we put thoseglycerides, triglycerides, those
(10:05):
fat cells.
Yeah, they're floating aroundthe blood, they get into the
bloodstream and they go into thevessels.
Now I want you to notice, asI'm describing where this is
going.
You can begin seeing thedisease process that comes as a
result of that, because if I goto the liver and I pack the
liver, then I have fatty liver.
(10:28):
If I go to the muscles and Ipack the muscles, I've got
muscle aches, muscle pains.
If I put it in the fat cellsright now, I have obesity, you
see.
So insulin is the guy that says,hey, I see it, let's go ahead
(10:49):
and we're gonna put it intostorage.
Make sense, all right, now whathappens in diabetes?
And so the model that we'veused with diabetes before is
this lock and key model.
We said, hey, blood sugar comesin, the insulin sees the blood
sugar, and the insulin is whatdecides if it goes into the cell
.
And that, basically, is true,but we sometimes leave off the
(11:15):
part about the storage.
And because the insulin isunable to get blood sugar into
the cell, then the body makesmore and more and more and more,
and that's our definition,that's our description of
insulin resistance.
But what if?
(11:38):
What if?
What if?
Along with that idea, there'salso this other idea, and I want
you to hear me.
Suppose we think of your cellkind of like a suitcase, right,
and you're putting stuff in thesuitcase, and the reason that we
(11:59):
can't get more stuff in thesuitcase is because the suitcase
is already packed, so we keeptrying to put stuff once again.
I traveled recently right,we're not to California my son,
my wife, my mother-in-law and I,and we were traveling, I packed
my suitcase and somebody elsein our house said to me hey, I
(12:23):
got this stuff that can't fit inmy suitcase.
Can you put it in your suitcase?
And so I went and opened up mysuitcase and I think I got some
stuff in there, but my suitcasewas so packed I literally had to
sit on it y'all to zip it backup.
Now imagine if I tried to putmore things in that suitcase.
Now I want to put it in.
The suitcase is designed for itto go in there, but I can't get
(12:47):
any more in because thesuitcase is already full.
And so, in order for us to makea decision, what we did is we
traveled, because we weretraveling up to Nashville to
catch the airplane up there.
So we took an extra bag with usand we got up there and once we
(13:09):
got to the parking lot, westood in the parking lot with
the car with the suitcase open,and then we made a decision
about what we could take.
So either we need to get morebags, so bigger cells, or we had
to decide that, hey, we're nottaking some of this stuff with
us, right?
(13:30):
Or we had to put this stuff inand maybe get an elephant to sit
on the suitcase so that we canzip it up.
More insulin.
So what's the plan?
What's the plan?
What's the idea?
How about, instead of givingmore insulin, we decrease the
(14:02):
insulin's ability to make thedecision to store stuff and to
allow it to use the energy thatwe're putting in?
What does that look like?
What does that look like?
One of the very first tools thatwe talked about was fasting.
So we're going to bring theinsulin level down.
(14:24):
How do we bring the insulinlevel down?
By not one-to-one putting stuffin that forces insulin to rise.
Now you're looking at me andyou're saying well, that makes
sense.
Right?
That's the whole idea ofwatching your diet, low-carb
diet, so on and so forth.
Yes, that's true, but I want totake it a step further, because
(14:45):
I want you to understand whythat works, why that is
important.
Because you say, well, yeah, ifI lower my blood sugar, I don't
need insulin.
Well, I'm not just talkingabout the insulin that we give
from outside.
We're not just talking aboutinsulin, the medication.
I'm talking about the insulinin your body.
How do I lower the insulin inyour body?
(15:09):
We've already talked about somemedications that we probably
should try to get off.
That was last week.
If you haven't watched that, goahead and watch that Right,
because those are secretagogues.
Those are things that forceyour body to make insulin.
We talked about getting off ofinsulin itself.
Let me put a point right hereand just make sure that
everybody knows we're talkingabout type 2 diabetics, type 1,
(15:30):
they are insulin requiring.
That is vital for their success, for their survival.
We're not talking about type 2.
We're talking about type 1.
We're talking about type 2diabetics and specifically here,
we're talking about adults.
Now there's a whole otherconversation for children,
because we're starting to seeguys.
I think my youngest type 2patient when I and she's grown
(15:52):
up now was 6 years old with type2 diabetes.
Yeah, so we're starting to seetype 2 in younger and younger
and younger folks.
So it's not restricted now tothe adult population.
(16:12):
We're starting to see our kidsthere, and so there's this whole
conversation that we shouldhave and we're probably going to
have on a different show aboutwhat that means, because
everybody is saying, oh, it'sgenetic.
Well, wait a minute, howquickly did genetics change?
How quickly did our geneticschange?
Because if you go back 50 years, 60 years, 70 years from
(16:35):
previously, we didn't have thisproblem and are we to believe
that our genetics changed overthe course of 70 years, that
drastically.
Anyway, that's a whole otherconversation, right?
Okay?
So what we want to do is we wantto lower the things that we put
(16:58):
in that cause insulin to rise,because when we do that, the
body is able to use the insulinthat it's making more
efficiently, and that is calleddecreasing insulin resistance.
Let me go through that again.
So if I'm putting stuff in thebody that are low enough in the
(17:26):
signal to the body that hey, yougot to produce more insulin,
right, because remember, highersugar, higher glucose, more
insulin comes out, more insulincomes out, more storage weight,
and as the weight goes up, ofcourse the whole idea of insulin
resistance goes up, and so theblood sugar is rise and rise and
rise.
So if I put something in wherethe body doesn't have to produce
(17:49):
as much insulin, then my body'sresponse to the insulin that it
makes is improved.
That, by definition, isdecreasing insulin resistance.
So we talked about fasting as away to do that.
Okay, so let's move on.
(18:10):
Let's move on.
So the fed state, the fastingstate.
So glucose comes in, we digestit, insulin comes out and
insulin is the thing thatconverts it to energy or stores
it, depending on what we haveNow.
Here's a, here's a, and let mesee, maybe let me pop back over
and I want to go back to my, goback to my, my discussion from
(18:36):
yesterday.
Okay, my sister's going to killme because she's going to say
you're telling this people, Imade your blood sugar go up.
She didn't do it, I made thedecision Right.
So look at, right there.
So so here I am Right.
So this is Sunday, let's see.
Let's go back to Friday.
So Friday, so this is where Ibroke my fast.
(18:57):
Right, it was a 72 hour fast.
So right, here, about 645.
Okay, and blood sugars, I mean,that's what?
Okay, so, yeah, so about one.
So we started out down here at79, up, up, up, up, up, up, up,
up, right, so we're going 80s,90s, 120s, 130s, 100s.
(19:24):
Now I want you to notice thisis no medication, right, so the
body is doing its thing.
The body is doing its thing.
Right, here we rose because mysister came, she cooked, I ate.
We got up to 194, y'all, okay,and then we dropped back down
and then, on the way to theairport, we decided we're going
to stop off.
If you didn't know, if you, ifyou didn't hear that story, go
(19:46):
watch the show from last night,right, go, go.
Go watch the show from lastnight and you'll see what
happened.
And look at that 246.
So what do you think happenedto insulin at that point?
Right, insulin spiked up.
So what I'm saying is, if wedon't put things in that forces
(20:09):
the body to make insulin, thebody is well able to manage on
its own Right.
And then look at today, right,so this is today.
Look at that.
And I dare say to you that theresult that you're seeing right
(20:29):
here, these results for today,are a consequence, or I
shouldn't say a consequence.
They are the benefit of thefast that I did three days ago,
right?
So my body is still in that, inthat adjusted phase, and we'll
see what, what my, what my othernumbers are here in just a
little while.
Okay, all right.
(20:52):
So let's put things in, let'sput the less things in.
So that's the whole idea of therefined carbs and so forth.
Okay, all right.
So so let's get to what I wantto talk about tonight.
So, everybody got that so far.
So put less things in, put lessthings in.
The other thing that we can dois we can get rid of, we can
(21:13):
decrease the blood sugar inanother way.
That's the whole idea ofexercise.
So we are trying to do thingswithout the use of insulin.
So first of all, we got rid ofinsulin itself.
We discussed that last week.
We got rid of the secretagoguesthose are the things that force
our body to make insulin.
Now we're putting less refinedcarbs in and actually the reason
(21:38):
that I brought that slide upwas a minute ago is the spike
that you see in blood sugars isdirectly related to how intense
the body sees the sugar.
So the more refined the sugarthat you eat, the bigger the
spike in insulin.
The more refined the sugar, themore refined the carbs, the
(22:01):
bigger the spike that you willsee.
So that if we're not putting inthose highly refined things in
the body, then we get betterinsulin response and then the
insulin because the blood sugarsmay not spike that high, we
don't get as big a spike in ourinsulin level.
If we don't get a big a spikein our insulin level, then the
(22:24):
push to store is lower and someof that gets pushed over to
energy.
So we're decreasing our carbs,we're watching our diet and
we're fasting.
So those are ways that we'regoing to use to bring our
glucose down.
If we bring our glucose down,we bring our insulin down.
(22:45):
If we bring our insulin down,we improve our insulin
resistance and we improve theside effects of insulin.
So that's the basis of the restof the conversation that we're
going to have as we move forward.
So once again, just an exampleas blood sugars go down blood
(23:06):
sugars that graph that you seeon top as blood sugars go down,
the insulin corresponds to that.
Because insulin cannot y'all.
Insulin cannot stay high if youhave low blood sugar.
This is the body's normalresponse.
So I was talking to someonetoday in the office, a patient.
(23:27):
She was saying hey, my bloodsugars dropped and I felt kind
of fuzzy headed, light headed.
One of the reasons that happensis because we still have
medication on board that'spushing our blood sugar down.
If we didn't have medication onboard when your blood sugar
dropped, the body wouldessentially turn your insulin
(23:49):
off and you would not feel that.
But because the medication isstill there, the medication is
still driving the blood sugardown and because we're used to
being higher in our blood sugar,we feel that a lot more.
Okay, all right.
So glucose level right.
So here's another interestingside that's going to be a
(24:12):
benefit for us later on.
So as blood sugars go down, sodoes the insulin.
But as insulin goes down, thecounter hormone to insulin goes
up.
That's called glucagon.
So insulin says, hey, store it.
When insulin goes down,glucagon comes out and glucagon
says, hey, now I've got to usethat stuff, I've got to use the
(24:35):
blood sugar.
That's why.
That's why, for those of youwho take insulin, you get
prescribed that glucagon pen,because the glucagon pen, when
your blood sugar goes down, yougive some glucagon and glucagon
goes into the body and it findssugar, it breaks down the
glycogen that's stored in theliver and it pumps it into the
blood, so that your blood sugarscome up.
(24:58):
And of course, we have all thetoxicities, right.
So the triglycerides that areformed when insulin is trying to
store things.
That's where all of thosedifferent things go, right.
So lipotoxins, yes, the toxiclevels of the lipids.
The beta cell becomesdysfunctional because now we're
putting fat there.
And then other components.
(25:20):
So the other parts of the body,the liver, right so fatty liver
and so on, all right.
So.
And then, of course, all thedisease processes, and we've
talked at length about those.
So what I want to do is I wantto say hey, how do we decrease
the sugar?
And we've talked about severalways, but this brings us to the
medication.
(25:40):
This brings us to themedication.
Now, as I've said and you'veheard me talk about it here on
the show that our goal isreversing diabetes.
Now notice, I use the wordreverse, right, because you
usually hear me say remission,putting in diabetes and
(26:02):
remission.
The words are being usedinterchangeably, and the reason
I like the remission version ofthat word better is because it
gives the impression rightly sothat your diabetes is controlled
(26:24):
.
You may not be, you're not onany medication.
That's what remission meansthat you have good blood sugars,
you're not on any medicationand there's actually a timeline
how long you have to be off ofmedication with good blood sugar
for you to be considered to bein remission.
The reason I like that idea isbecause when we talk about
(26:47):
reversing diabetes, people getthe or they think that, oh, my
diabetes is gone and so now Ican do whatever I want and the
blood sugars are going to staygood.
And that's not the case.
But we're going to use those.
You hear me use those wordsinterchangeably, but I want you
to understand if you hear me usethe word remission, it's
(27:09):
because I want people tounderstand that this is a
lifestyle that they've got toadopt.
Okay, all right, so, yes, solet's talk about the medication,
right?
So one of the ways, one of theways of decreasing sugar in the
(27:30):
body is with the use of somemedications, and these are
called SGLT2 inhibitors.
Sglt2 inhibitors, and the SGLT2inhibitor class is a class that
the question is can we use somemedication to help us bridge
(27:51):
the gap as we move in thedirection of remission, reversal
, improve blood sugar control?
And so the first group ofmedications I want to talk about
are these medications that arecalled SGLT2 inhibitors.
Sglt2 inhibitors, and thesemedications work by basically
(28:16):
taking sugar and they put thesugar into the, they put the
sugar into the urine.
Okay, and let me pull that slideup here really quickly.
So for type two diabetics, whathappens is that, and let's see
if you can see I hope you cansee my pointer.
(28:39):
It doesn't look like you can,but anyway, you see the big part
to the left there, that this isbasically a part of the kidney,
and you don't have to look atall the wires and all the, all
the arrows, but right there atthe top, at the left side is
where your blood goes into thekidney and then the kidney
(29:02):
filters it out, and all the wayat the other end, to the right
side of that graph, down at thebottom, the blue line or the
blue arrow is where your urineis coming out.
Okay, that's where the urine iscoming out.
And so for people who arediabetic, for people who are
diabetic, there is a defect intheir kidney.
(29:23):
There's a defect in theirkidney, and so when, when the
body filters the blood, one ofthe things that happens is that
sugar comes out of the blood andit's being filtered through the
kidney and the body.
Because of this defect that'sin the kidney, the body brings
(29:45):
the sugar back into the blood.
Now it's supposed to go out,it's supposed to go into the
urine, but because of thisdefect, the body pulls it back
in, and so you end up havinghigher blood sugars than you
should.
You got that so far.
(30:06):
So, because of this defect, thesugar that should be not coming
back into the body ends upcoming back into the body and it
doesn't get put into the urine.
And this medication what itdoes is it stops that process or
(30:27):
it fixes that process and itallows sugar that's in the body
that now gets put into the urineto go into the urine, and it
stays out there.
Now notice that this processdoes not use any insulin.
(30:51):
We just talked about decreasingthe problem with the insulin.
So we just took some sugar outof the body, we put it in the
urine.
It's gone.
So the amount of insulin thatyou've got to take from outside
that is, insulin shots or thesecretogogs that you have which
(31:16):
are forcing the body to makeinsulin, or your bodies seeing
the sugar that's high anddeciding to make more insulin,
decreases.
And that's the point.
That's the goal of what we'redoing as we head to remission
(31:37):
because we got to get rid of thesugar somehow.
Now you're saying you say wait aminute, so we're going to get
on medication to get inremission.
And the answer is yes, becausethe idea in this model is not
that we're on the medication andthat's it Right.
(32:00):
In the old model we say hey,your blood sugar is a high, this
is going to be a chronic thing,this is going to be a forever
thing.
So you just take this medicineand you keep taking as much as
you need to get those bloodsugars down.
Now what we're saying is hey,let's figure out how to get rid
of some of the sugar so that wecan deal with the defect, and
the defect is an insulin issue.
(32:20):
When we deal with the defect,we have all the benefits of
decreased insulin Better insulinsensitivity Right.
So now the insulin becomessensitive, it works.
Whatever your body makes works.
We stop shuttling energy intothose storage places liver, fat
cells, pancreas Right.
(32:42):
So all of those diseaseprocesses improve and we have
the improvement that we have.
That comes from the fastingthat we're doing.
So the goal decrease the sugar,get the insulin down.
Now, ultimately, we're going totalk about okay, now, that if
(33:04):
you're on this medication thatwe did, now we're off the
insulin, now we're off thesecretogogs now we're off the
DPP4s and if you don't remember,go back and watch that show
from last week we're off ofthose.
We're doing the fasting, andhere's another way to bring the
blood sugars down.
Okay, so that's one of them.
All, right, so let's hop overand let's talk about another
(33:28):
class of medication and thisclass of medication, like I said
, you've heard, you've seen andthis is what everybody's talking
about that's helping peoplelose weight.
Okay, Well, actually, before Ido that, let me talk to you
about what some of the names ofthese medications are, and these
(33:48):
are.
And there are two others thatare not as prominent in the
market.
They actually were taken offthe market.
I think one of them is still onthe market, but Jardians and
Farsica, those are the names,those are the brand names.
I'm not going to tell you thescientific name, because you
probably have heard it, buteverybody knows these, okay, so
(34:09):
let's go ahead and say them.
So Jardians and Farsica are thetwo that we were talking about,
right?
So these medications, all theydo is they take sugar.
I shouldn't say all they dowhen it comes to blood sugar.
What they do is they take sugar, they put it in the urine.
They correct a defect that's inthe kidney of patients who have
(34:31):
diabetes, where their bodynormally resorbs, brings sugar
back into the body that shouldbe put in the urine.
So it basically fixes that andit gets rid of the sugar.
If the sugar is lower, insulingoes down.
That's the key.
Now you hear me say that overand over.
Sugar goes down, insulin goesdown.
(34:51):
That is the key.
Okay, all right, and Teresa,thank you for hopping on.
I see your question there, oryour comment there.
I'm going to go ahead and start, and we'll come back to that in
just a little bit.
Okay, does that make sense?
(35:12):
So far for everybody?
Yes, yes, yes, okay, if itmakes sense, put yes in the
comments and, as I'm talking,guys, go ahead and drop those in
the comments, because we'regoing to come back, we're going
to deal with some of those herein just a little bit, okay, all
right, so let's then look atanother group of medications.
(35:32):
As I said, these are the onesthat everybody's been talking
about that are helping to loseweight, and I want you to look
at this graph, look at all thedifferent things that you see
that these medications do.
The ones, though, that I wantyou to kind of pay attention to
are the ones you'll see up thereat the top the brain, okay, and
(35:56):
then you'll see the pancreas mymouse is not working, so I'm
going to have to describe, okayand the skeletal muscle Okay, so
they do a couple of things thatare going to help us.
Number one these medicationsare secretogogs.
Okay, let me go ahead and saythat they are secretogogs, and
(36:20):
so they work similar to theDPP-4s that I just told you we
need to get off, right.
These are the ones that makethe body produce insulin.
However, the benefit that weget from them is that they also
help to suppress the appetite.
They suppress the appetite.
(36:41):
They send the signal to thebrain that we're full.
They help the muscles to useinsulin more effectively.
Right, so several things.
The benefits may outweigh theinsulin that we're getting,
because if we're decreasing ourfood intake, decreasing the
(37:02):
things that we're putting in thesugar, right, those cravings
are going down.
If the cravings are going down,the blood sugars are going down
.
If the blood sugars are goingdown, the insulin level is going
down.
And, ultimately, our goal isgoing to be right.
During the process of being onthese medications, during the
process of fasting, right, we'regoing to be learning some ways
(37:26):
to manage our blood sugar,manage our food, manage our
cravings, so that, when thesemedications go away, we can
process that on our own.
Okay, now notice what I'm saying.
We're going to be on thebridges to where we need to go,
so we're not saying, hey, you'regoing to be on this and this is
(37:47):
it.
We're saying how do we?
Because we've got a strategy,y'all right, we've got a
strategy on how we're going todo this, and the strategy
includes hey, how do we get offof this medication and these
medications?
As I said, they are one of theones that help with our weight,
(38:11):
right?
So everybody's all excitedabout that.
So it's great, you know, youget that tummy, you get rid of
that fat.
Now, the guy that's on the left,that abdomen that you see, that
(38:33):
abdomen comes as a directresult of insulin resistance.
Insulin resistance this is agood place.
Let me, let me do this.
I'm going to hop over, let mecome back here so you can see me
full screen, because I want tomake this point.
If, if you are, if you stand upand I'm going to stand up if
(39:05):
you look down and you see yourtummy, then you've got insulin
resistance.
People say how do I know if I'minsulin resistant?
That's how you know, becausethe storage of energy, one of
(39:29):
the places it goes, is rightthere, that omentum.
And that's what that?
That within inside the omentum,that's that fat pad that covers
the abdomen.
On the inside you can't see it.
You can't, well, you can't seeit from the inside, but you see
it on the outside and if youlook down and you can see your
(39:51):
stomach, that is a sign ofinsulin resistance.
So you don't have to wonder,you don't have to guess yes, it
is.
And insulin resistance, as wejust talked about, is a.
That's what everybody says.
Diabetes is right, insulinresistance.
(40:12):
But insulin resistance is morethan just diabetes.
That's why I say to those ofyou who are out there, if you
don't have diabetes, don't tunethis out, because this is for
you as well, because how do youget rid of the omentum, the
omentum, how do you get rid ofthat stuff right there?
The exact same way as we'retalking about the diabetics, the
(40:35):
same way that we're going toput diabetes and remission is
the same way that we get rid ofthat.
And here, in a minute, I'mgoing to show you, I'm going to
show you my weight, as we dowith all of our numbers.
We're going to see that here injust a second.
Okay, all right.
So so when we talk about, whenwe talk about diabetes, the goal
(40:57):
, the goal, one of the primarygoals, is how do we get the
insulin down?
And we get the insulin down bygetting the sugar down.
How do we get the sugar down?
One, by fasting.
Two, by getting rid of sugar,and how do we make it through
(41:18):
the fast and how do we deal withthose cravings?
Maybe the GLPs are a way ofdoing that, okay, and those
medications are ozympic andeverybody's probably heard of
ozympic.
There is also biata, bi-durionvictosa rebellisis is the only
(41:44):
oral form of that of that classright now.
And then manjaro has a GLP init, but it also has another
component, right?
So it's a combination of things, All right.
So that's the question, that'sthe explanation.
(42:09):
We're going to come back and I'mgoing to tell you what my
opinion.
So this, I'm just giving youdata right now.
Right, I'm just giving you aradio.
I'm going to tell you myopinion of those, what I think,
right, when I answer thequestion should I start taking
some of these medications?
Should I start taking one ofthose medications?
All right, so let's do this,let's hop over and let's take a
(42:33):
look at some numbers, right?
So we've already shown you whatthe DEXCOM has shown.
I think, yeah, so that's myDEXCOM right now, what it's
saying.
My blood sugar is, and, ofcourse, that's the Libre.
So let me go ahead and let'spop over and I want to do the
blood sugar here.
All right, let's see what thatshows.
(42:53):
And I do people say, hey, whenyou're not doing the 72 hour
fast.
What do you do?
Well, my normal plan is to dolike a five to six hour eating
window, so I don't eat anything.
Once I stop eating at night, Idon't eat anything until I eat
in the office with my team or mywife.
(43:17):
So I'm going maybe 14, 16 hourswhen I'm not fasting, but of
course, as you know, my fast Ido that and you see that I do
(43:38):
that.
That's been a 72 hour fast.
Let's go ahead and put thisblood on this meter and let's
see what that shows.
Right now, and for you, ourgoal has been for you to work
your way up.
Look at that 1.1.
So that's actually pretty good,all right.
(43:59):
So if you remember, when wetalk about nutritional ketosis
nutritional ketosis what we'retalking about?
Having ketones of 0.5 to 1.5.
And when we talk abouttherapeutic ketosis, we're
talking about having ketoneshigher than that.
So now my blood sugar is 115and my ketones are 1.1.
(44:24):
And let's pull over now and goto our app, because the app is
going to suck it in and then Iget to show you the graph of
what has been going on over thelast couple of days with that.
So let's go ahead and it shouldbe pulling in here just a sec.
If not, I'm going to hit thebutton to have it scan and it
(44:52):
says yes, boom, got it, allright.
So there we are, and let's takea look at our graph, because I
want you to see here All right.
So, right there.
That was before I broke thefast, so that was Friday evening
(45:14):
, and so look at that my ketonesare high, my glucose is low.
Now let me pause here, becauseif you've not been with us,
you're like well, what does thatmean and what does that have to
do with our diabetes?
Well, when your body doesn'thave sugar, it switches to burn
(45:37):
another source of energy, andthe other source of energy is
ketones, and you can measure theketones in your body and you
can tell when the body isactually using something other
than sugar to burn energy, andthat's what this is an
indication of.
And then you notice that when Istop fasting, so my blood sugar
(46:00):
went up and then my ketonesdropped.
So down here, my ketones arelike 0.6.
0.7.
And, of course, 1.1.
, but my blood sugar is.
What did we just say was 111.
Okay, awesome, all right, sothat's where those numbers are.
(46:23):
Let's hop over and let me grabsome of these questions, some of
these comments.
All right, let's see what itmeans.
So Lashas and I'm assuming Ipredicted that correctly she
said thank you, that's what's awelcome, I'm assuming.
And then she says my insulinwas at 8, 2 years ago and I got
it down by lifestyle changes.
(46:45):
Yes, definitely, definitely.
I love that.
Go ahead and, if you don't mind, just drop in the comments what
it was that you did.
What did you do?
What did lifestyle changesexplain a little bit more of
that to us.
Teresa says which one would yousuggest that have very little
(47:05):
side effects?
Very good question.
And so let me give a littlebackground for those people who
don't know much about the GLP-1s.
The GLP-1s work.
One of the things they do isthey slow food as it moves
through the body, as it movesthrough the stomach.
So some people feel that asqueasiness, some people feel it
as nausea.
There are actually some peoplethat actually can throw up from
(47:27):
it, and that happens because thepancreas becomes inflamed for
some people.
The other thing that can happenis they throw up.
So that's the big side effect,right?
So the GI symptoms that peoplehave Now for most of the
(47:50):
medications, most of those GLPs,and I'm assuming that's the one
you're talking about.
Actually you didn't say,because let me talk about both
then.
So for the GLPs, the big sideeffect, of course, is the
slowing of the food as it movesthrough your stomach.
Because you feel fuller, peoplefeel as queasiness.
You adjust the dose if you needto.
Some people come off of it.
(48:12):
Now, one of the things thathappened to me years ago was
when these guys first came onthe market, I tried taking them
and I couldn't because theyslowed my GI tract so much that
I started getting constipation.
So when they first came out, Icouldn't take them.
I tried, I'll tell you,multiple times.
I tried and tried and tried.
I went to my doctor and he saiddon't you want to try it?
(48:34):
I said sure, and this is me asthe endocrinologist y'all, but I
couldn't take them.
And so for years and years andyears they didn't work for me.
And then we talk about theSGLT2s, as the other group the
Jardians and the Farsica, thosebecause they're putting sugar in
(48:55):
the urine, people who are proneto yeast infections can have a
yeast infection.
It has also to do with how bigthe blood sugars are, as we're
dumping sugar.
The higher your blood sugarsare, the more possibility it is
that you may have a urinarytract infection, and some people
(49:17):
can have a severe urinary tractinfection called Furnace
gangrene.
So that's one of the sideeffects there.
All right, as then Teresa said,I heard that some cause thyroid
or kidney issues, right.
So the SGLT2s, the issues thatyou're hearing there, are the
(49:38):
urinary tract infection and thesevere infection in the general
area.
They actually have been nowapproved, many of them for
kidney protection, right?
So when they first came out,people saw, hey, wait a minute,
we're putting sugar in the urine.
Now, when I trained, when I wascoming through medical school,
(50:00):
it was bad to have sugar in theurine, right.
If you found somebody who hadsugar in their urine, they were
called diabetic, right.
But now, because of themechanism of action, right, we
actually use that fact.
We didn't understand that backthen.
We used the fact that it putsugar in the urine to treat the
blood sugars.
The other thing about thyroid,so we're talking about now going
(50:23):
back to fictosa and ozimpic andmungero and the rebalysis and
the GLPs.
So there have been cases ofmedullary thyroid cancer in
rodents, right.
So when they tested them, theserodents had medullary thyroid
cancer and so someone who has ahistory in their family or have
(50:45):
a personal history of medullarythyroid cancer, we don't put
them on it.
But we've never seen that inhumans, right?
But because the studies whenthey did them, they showed that
it actually has to show up onthe, on the marketing and on the
box.
So let's see.
Teresa says yes, okay, so ifyou know somebody I think that
(51:07):
was the answer yes, and oh, itdoes make sense.
It makes sense, thank you,because I see Jeff says yes,
makes sense as well.
And receive, receive, I'm goingto give you some music.
Hey, take a real close look.
Okay, I got to find my handclap again.
(51:29):
For some reason it went away.
But anyway, receive, thanks forstopping by.
I said which class of thesemedications do you recommend?
I'm on ozimpic but have someside effects, okay, so receive,
I'm going to hold that questionfor a minute because I'm going
to come back and give you mythoughts in just a sec, right?
And then Jeff says which doesmetformin fit in all of these
(51:53):
meds?
So metformin is not one ofthese medications, right, it is
not one of the ones that wetalked about in terms of getting
off, right, stopping, right, wedid that show last week, and
it's not one of the ones thatwe're talking about getting on
right now.
Right, starting, it is one wehave not discussed yet, and I've
(52:15):
deliberately not discussed ityet.
And well, actually there are acouple of other medications that
we've not discussed yet aboutwhat we're going to do with them
.
I suppose I well, you'veprobably heard me say this in
one of my other shows, anyway.
So so metformin has been one ofthose medications that's been
around forever and of themedications that, when they
(52:42):
initially were studying diabetesin terms of complications and
improvement and so forth, it wasone of the medications that
showed the slowing of theprogression from pre diabetes to
diabetes.
It's also a medication thatwe've used to treat metabolic
syndrome, obesity, and on and onand on.
(53:03):
So, if I, if I, if I put my hey, my doctor hat on, I'm like
this is actually a goodmedication for us to use, okay,
because it does what we want itto do.
I want to hasten to say, though, that, as we're talking about
remission, we're not justtalking about remission getting
(53:24):
off of one medication or anothermedication or we're talking
about getting off of allmedication.
So so, just like I'm saying toyou, hey, consider these
medications should we get onthem and we should get off of
those?
Metformin is one of thosethat's in the between.
So if people are on metforminright now and that's the only
(53:46):
thing they're on, then our goalis to get them off the metformin
.
But if they're not on metforminand I need to treat their
diabetes right now to get thembetter as we move towards
progression, revision sorry,towards remission, then it is a
(54:07):
tool that I use.
So what I do in my office, whatI try to do in my office, is if
someone comes in and they areon insulin they're on a
secretogoc my goal is to try tominimize those and get them on
an SGLT2 and get them on a DPB4.
(54:28):
That's what I do Now.
Before everybody was talkingabout the weight loss that you
get with ozympic and menjaro andall those, we were in the
office when people's patientscame in.
We were putting them on a GLPbecause I knew if I got them on
(54:49):
a GLP I didn't have to use asmuch insulin.
I would put them on an SGLT2because I knew if I got them on
an SGLT2, we wouldn't need asmuch insulin.
Do I think those are goodmedications?
Yes, I think they are.
I use them almost every day, Ishouldn't say almost every day.
I use them every day for mypatients, I use them for myself.
(55:20):
We're going to come back andwe're going to talk about that
story and another show, but oneof the things that I want to
show you is, along with bloodsugar, as you guys know, you've
been watching me and you knowthat I've been also tracking my
(55:42):
weight.
This is where we are today.
This has been our trend overthe last month.
Remember, I came on close tothe beginning of the month and
said, hey, look at this, I havegone below my weight, I've
(56:06):
reached my goal.
That was, I think, over heresomewhere, 199.
Right there, that was back onthe 15th of January.
I want you to notice something15th, 16th, and so we went to
197.
We went down to 197.
We got down to 194 right herey'all and then 197, 200, 201,
(56:28):
198, 195, 197, 199, 198.
Now let me make a statement here.
Let me show you the month view.
I want you to notice the graph.
The graph is not linear.
It doesn't just go in onedirection.
(56:50):
It goes up, it goes down.
You need those fluctuationsthere.
I want to point out to youbecause some of you are out
there and you're frustrated inyour weight journey.
I want to point out to you thatthe daily fluctuations that you
see is not where your concernshould be.
(57:12):
What you want to see is, whenyou look over the course of time
, that the trend is what youwant, because if I look on this
right here, I'm like man.
I was up 200, down 195.
Look at me, I'm 198.
(57:33):
Even if I look at this, I'mlike man.
Look at those fluctuations.
I'm going up and down, and upand down.
When I look over the course oftime, y'all I want you to see
that, right there, that was 240pounds.
That's March of last year.
This is now 240, down to 198.
(58:04):
Given that, if I look backfurther, I want you to see this
guy.
That was 260 pounds.
That was January of 2022.
I don't have recorded on thisdevice, but at one point that
(58:25):
number was up at 285 pounds.
That must have been I don'tknow 2000, 10 to 15-ish.
(58:45):
As we are on this journey it isa journey there are going to be
stops and starts.
Our goal is not necessarilythat tomorrow we get where we're
going, because we're not goingto get where we're going.
Let me say that to you.
You're not getting where you'regoing tomorrow.
It is a journey, but we wantthat journey to continue,
(59:06):
heading us or taking us in theright direction.
One of the things I love aboutthis space and you've heard me
say it before, I'll say it againI come on this show and I talk
with you and I teach the thingsI do because you're part of my
therapy group.
I know, I know I'm part of whohelps me to be who I need to be.
(59:33):
As I talk about new year, newyou, everybody thinks that
they're by themselves.
Everybody thinks, oh, it's justme.
I'm telling you some of thethings that I talk to you about.
I struggle with all the time,but I want to be able to say
(59:59):
that I'm moving forward in myjourney and this year, y'all
together in this group, yeah,yeah, we're heading.
We're heading in the direction.
Let me see, jeff said, for yourthought of the day, my Freestyle
Libre 3 provides so muchinformation for me.
(01:00:19):
Let's see, for your thought ofthe day, my Freestyle Libre 3.
Where do you, jeff?
I think I missed the first partof that.
Oh, you want me to use that asa thought of the day?
Okay, I like that.
Thank you, awesome, awesome,all right.
So, if you've not already doneso, everybody, if you've not
(01:00:40):
already done so and you're here,so maybe you have already done
so, but if not, I would like toask you for three things.
Okay, I'd like to ask you forthree things.
What we've been doing is we'vebeen talking about the fasting,
talking about, okay, what do wedo with the fasting?
(01:01:01):
And if you're out there,whether you're diabetic or not,
my challenge to you is to workyour way up so that you can fast
for 24 hours.
So that's what we planned to doin January.
That was the plan.
Work our way up so we can fastfor a 24-hour period.
(01:01:21):
In the month of February, we'regoing to do another challenge,
dealing with that 24 hours.
Okay, so for right now, right,fasting 24 hours.
Work your way up wherever youare.
I want you to expand that sothat you can be able to do that.
And meaning that you're alsotalking to your healthcare
(01:01:44):
provider.
If you're on medication thatyou are having healthcare
provider, help you adjust that.
If you're one of my patients,one of my clients, one of the
people who talks to me, that'swhat we do, right?
So how do we back off of someof these medications?
We've talked now aboutmedications you should stop try
to get off of.
We've talked now aboutmedications.
(01:02:06):
You should probably talk aboutstarting and you've heard the
benefits of those.
The fasting helps in thatentire process.
So, first of all, what I'masking you to do is work your
way up so you can fast for a24-hour period.
Number two I want you to committo being on this journey with
(01:02:27):
us.
Being on this journey with me.
That means showing up as welearn this stuff together.
That you are here, that youshare your information, that you
share the successes that you'vehad, you share some of these
disappointments that you've had.
That you ask the questionsBecause, as you do that, the
(01:02:48):
other people that are herelistening, the people who are
even going to be watching thison the replay they benefit
because now they know it's notjust them.
Now they know somebody else outthere is having the same issue.
Somebody else out there isseeing the same thing.
Somebody else out there ishaving success because maybe
they're not seeing success.
(01:03:11):
To show up in the community,engage in the community.
And then the third thing thatI'm asking you to do is to bring
somebody with you.
You can bring somebody with youon the show, send them a link,
let them know what's going on,help them sign up, help them
subscribe, tell your doctor,tell your pastor, tell your
(01:03:34):
cousin, tell your mom and themabout what we're doing here,
because the 460 million peoplearound the world that have
diabetes, the millions of peoplethat are struggling with
prediabetes and obesity andmetabolic syndrome and high
(01:03:56):
blood pressure and highcholesterol and polycystic over
in syndrome, and on and on andon, they all benefit from this
information.
So you can be the person whohelps to spread that, to help
improve their lives.
Good night, we'll see you atthe next show.
This is Dr Dwayne Wood, that'sWood with an E.
The E stands for endocrinology.
(01:04:18):
Here on the channel, I educate,I empower and I encourage you
to take charge of your health,take charge of your life, avoid
complications and go to the nextlevel, creating the life you
always wanted.
And for this year, y'all, newYear, new Year.
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