The Science of Protein Cycling, Autophagy and Fat Loss with Vanessa Spina

In this episode, Dr. Jockers and Vanessa Spina break down new human research showing why high protein doesn't block autophagy when calories are low. You'll learn how this changes everything we've believed about protein timing, fasting, and cellular repair. The conversation also reveals why prioritizing protein can accelerate fat loss without sacrificing muscle.

 

You'll hear how protein impacts appetite, hormones, and metabolic flexibility—and why many people overeat simply because they're under-consuming essential amino acids. Vanessa explains the protein leverage effect and how it naturally reduces cravings, stabilizes blood sugar, and makes eating "effortlessly" satisfying. These insights can help you rethink how you build your daily meals.

 

You'll discover why certain fasting styles can increase visceral fat loss, support hormonal balance, and boost performance. Expect a mix of science, real-world application, and surprising findings you may not have heard before.

 

 

In This Episode: 

00:00 Introduction and Exciting New Study

00:21 Welcome and Guest Introduction

00:30 Deep Dive into the New Study

01:52 Vanessa Spina's Expertise and Background

05:47 Interview with Vanessa Spina Begins

06:15 Discussion on Protein Absorption Study

14:04 Personal Experiences with Protein and Fasting

16:55 Debunking Protein Myths

18:10 Nutrition Principles and Protein Prioritization

22:23 Ketones, Satiety, and Inflammation

27:07 Balancing Hormones and Stress

31:17 Understanding Autophagy and Protein Intake

32:35 The Importance of Human Trials in Research

35:11 Study on High Protein Fasting Mimicking Diet

38:38 Results and Implications of the Study

42:18 Personal Experiences with Protein-Sparing Modified Fasting

45:32 Practical Tips for Implementing Protein-Sparing Modified Fasting

57:54 Comparing Different Fasting Approaches

01:01:13 Conclusion and Final Thoughts

 

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I just wanna take a moment to interrupt this podcast to tell you about one of my favorite podcasts I listen to. It's called The Dr. Josh Axe Show, hosted by my good friend Dr. Josh Axe. Every week he shares how to balance your hormones, restore your gut, boost your energy, and slow aging without relying on harsh medications or quick fixes. He shares both ancient biblical practices and the latest breakthroughs in nutrition, herbal remedies, and lifestyle medicine. If you're ready to take control of your health, renew your energy, and transform your mind, body, and spirit, tune into The Dr. Josh Axe Show every Monday and Thursday wherever you get your podcasts.

 

 

"Most people don't overeat because they lack willpower — they lack protein." 

 

 

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