Using Nourished Fasting for Metabolic Health and Longevity with Dr. William Hsu

In this episode, Dr. Jockers and Dr. William Hsu dive into how nourished fasting can reduce insulin resistance, activate autophagy, and slow aging. They discuss how the fasting mimicking diet triggers cellular repair while still providing nourishment.

 

Learn how nutrient-sensing pathways like mTOR and IGF-1 influence metabolic health and why modern eating habits may accelerate aging. Dr. Hsu explains how short-term fasting can promote healing by tapping into the body’s natural survival mechanisms.

 

Discover how to apply nourished fasting in your life with the ProLon protocol and why a few cycles a year can significantly improve your healthspan.

 

In This Episode:

• 00:00 Introduction to the Fast Mimicking Diet

• 02:49 Interview with Dr. William Hsu: Metabolic Health and Fasting

• 04:48 The Science Behind Fasting and Cellular Healing

• 06:49 The Evolutionary Perspective on Fasting

• 09:22 Understanding Nutrient Sensing Pathways

• 14:33 The Nobel Prize-Winning Research on Autophagy

• 17:44 The Concept of Fasting Mimicking Diet

• 21:25 Exploring the Benefits of Fasting Mimicking Diet

• 22:01 The Science Behind Fasting and Systemic Health

• 23:22 The Role of Lifestyle Medicine

• 24:16 Understanding Digestive Health and Stomach Acid

• 26:10 Hormetic Stress and Health Benefits

• 27:16 Clinical Research on Fasting Mimicking Diet

• 31:32 Practical Application of Fasting Mimicking Diet

• 32:43 Personalized Programs for Health Conditions

• 35:22 The Future of Lifestyle Medicine

• 40:54 Final Thoughts and Call to Action

 

 

Still cooking with seed oils? That could be fueling inflammation. I’ve switched to Paleovalley’s 100% grass-fed beef tallow—it’s rich in CLA, packed with flavor, and stable at high heat. It’s one of the cleanest, most nutrient-dense fats you can cook with. Head to paleovalley.com/jockers and use code JOCKERS for 15% off your order.

Heartburn doesn’t mean you have too much stomach acid—it usually means you don’t have enough. That’s why I recommend Just Thrive’s Digestive Bitters. They help ignite stomach acid, enzymes, and bile so you can finally break down food the way you’re supposed to. Go to justthrivehealth.com and use code JOCKERS to save 20%.

 

 

 

"Autophagy is your body’s self-cleaning cycle—and most people never turn it on."

~ Dr. Jockers

 

 

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