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May 23, 2024 • 16 mins

Are your food choices influencing your mood? Uncover the startling connections between your diet and your mental well-being as we scrutinize a pivotal study from BMC Psychiatry. Delve into the realm of low-grade chronic inflammation and its potential role in depression, with a special focus on healthcare professionals. We dissect the use of the innovative Empirical Dietary Inflammatory Index (EDII) and how it could revolutionize your approach to combatting depressive symptoms through diet.

Join the conversation with us, Dr Journal Club, as we navigate the latest in research and evidence-based medicine, integrating thinkers at the forefront of clinical practice. Your input is vital to our discussions, so link up with us on social platforms and share your thoughts on this complex topic. Whether you're seeking to refine your clinical practice or simply curious about the impact of diet on mental health, this episode promises insights that could very well reshape your daily habits.

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Episode Transcript

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Introducer (00:02):
Welcome to the Dr Journal Club podcast, the show
that goes under the hood ofevidence-based integrative
medicine.
We review recent researcharticles, interview
evidence-based medicine thoughtleaders and discuss the
challenges and opportunities ofintegrating evidence-based and
integrative medicine.
Continue your learning afterthe show at www.

(00:23):
drjournalclub.
com.

Dr. Joshua Goldenberg (00:31):
Please bear in mind that this is for
educational and entertainmentpurposes only, Talk to your
doctor before making any medicaldecisions, changes etc.
Everything we're talking aboutthat's to teach you guys stuff
and have fun.
We are not your doctors.
Also, we would love to answeryour specific questions on
drjournalclub.
com.
You can post questions andcomments for specific videos,

(00:55):
but go ahead and email usdirectly at josh at
drjournalclub.
com.
That's josh at drjournalclub.
com.
Send us your listener questionsand we will discuss it on our
pod.
Hello everybody, this is DrJoshua Goldenberg for the Dr
Journal Club podcast.
Today it is just me lonely herein the studio.

(01:19):
You might have noticed, thepast couple of weeks we've
released super speedies.
We haven't had our normal backand forth with Adam, we've just
had a lot of technical issues.
It's almost like the universedidn't want us to record.
Every time we'd meet There'd besome new problem.
Anyway, it has just been somany of these so far that I just

(01:41):
felt like I should go ahead andtry to record the article that
we had planned to talk aboutbefore all these issues, so you
would hear something from usduring this time.
So I'm going to talk about astudy that came out just a
little bit ago Pro-InflammatoryDiet and Depressive Symptoms in
the Healthcare Setting.

(02:02):
And this is a study that cameout in BMC Psychiatry and we
will link to it in the shownotes.
I just feel so sad doing thiswithout Adam.
It just feels so weird.
It's like speaking out into theether.
I miss you, buddy.
All right, so hopefully nextweek we'll all be together, but
let's do this.

(02:22):
So essentially, it's a cutelittle study that tries to look
at the association between dietand depression.
So let me kind of walk youthrough this here.
So there is the way they setthis up.
Is there's this sort ofbackground, rationale or
methodology that might connectdepression with diet?
So, for example, they kind oftalk about all the issues that

(02:44):
there is with depression ingeneral.
But oh, you know, meds aren'tperfect and they're limited and
so much of the effect seems tobe placebo and we need, you know
, more interventions fordepression.
Fair enough.
And they also argue that thereis growing rationale or growing
evidence that inflammation,low-grade chronic inflammation

(03:05):
in particular, may lead to arole in the development of
depression.
And they argue sort ofdifferent potential mechanisms
such as pro-inflammatorycytokines, dnf-alpha, all the
things right.
So they're basically saying,look, we have some evidence
connecting depression and diet.
It's probably through theinflammatory cascades, and so it

(03:28):
makes sense to study it further.
Okay, and they have someclinical evidence that they
point to in the background,suggesting that pro-inflammatory
dietary patterns are associatedwith an increased risk of
depression.
Right, and then they say, okay,and then on the flip side, you
know, regularly eatinganti-inflammatory foods can

(03:51):
reduce the risk of depressionand reduce this inflammation, et
cetera, et cetera.
So they're setting up thisargument and there was a
previous instrument, the DietaryInflamm dietary inflammatory
index, that had been previouslyvalidated in other studies.
That basically shows, you know,the amount of inflammatory

(04:12):
foods that one is eating andthat had been used in correlated
with depression levels inpeople.
But the problem is what?
What is the issue here?
What is the issue that theauthors are trying to solve or
the researchers are trying tosolve?
They're trying to say, look,that was awesome that the
authors are trying to solve.
Or the researchers are tryingto solve.
They're trying to say, look,that was awesome, but that
instrument is very difficult touse in practice, it's very
cumbersome, it'll take forever,et cetera, et cetera.
And other researchers haddeveloped a sort of more quick

(04:37):
and dirty version called theEmpirical Dietary Inflammatory
Index and it has been validated.
But what they, what theseauthors want to say is okay,
what if we use this instrumentand try to look for association
with depression as well, and theutility there would be that
this is an instrument, in myopinion anyway, that is very

(04:57):
easily used in clinics.
So if we do see an associationhere, it might be something that
providers out there might beinterested in using, or even
non-providers kind of assesstheir own diets, if you will.
And this Empirical DietaryInflammatory Index, this EDII,
is really based on the weeklyconsumption of 16 foods that are

(05:22):
either pro or anti-inflammatoryfood groups, and that's sort of
the main thing that it asksabout.
And then, based on that scorethat you get, then you say, okay
, is this associated withincreased risk of depression?
And so that was what they triedto do.
So they used my favorite REDCapsoftware.
I believe that this was done ata medical school I think a

(05:47):
doctor of osteopathy school, Ibelieve.
But basically they went and gotall of their cohort to fill out
this survey that they ranthrough REDCap, which is the
same software we use for surveys.
In fact, right before thisrecording, I was crazily
updating our RED-CAP survey fora study we're doing on teaching

(06:08):
evidence synthesis withneurotrauma, all sorts of fun
stuff We'll talk more about thatlater.
And so basically they wentahead and they got all these
patients, these participants,and they had them do this score
and then they gave them thePHQ-9, which essentially

(06:31):
measures their depression.
So that's what we're looking athere.
Look, the thing is we don't dothis for money.
This is pro bono and, quitehonestly, the mothership kind of
ekes it out every month or so,right?
So we do this because we careabout this, we think it's
important, we think thatintegrating evidence-based
medicine and integrativemedicine is essential and there

(06:52):
just aren't other resources outthere.
The moment we find somethingthat does it better, we'll
probably drop it.
We're busy folks, but right nowthis is what's out there,
unfortunately, that's it.
And so we're going to keep onfighting that good fight.
And if you believe in that, ifyou believe in intellectual
honesty in the profession andintegrative medicine and being
an integrative provider andbringing that into the

(07:13):
integrative space, please helpus, and you can help us by
becoming a member on Dr JournalClub.
If you're in need of continuingeducation credits, take our
NANSEAC approved courses.
We have ethics courses,pharmacy courses, general
courses.
Interact with us on socialmedia, listen to the podcast,
rate our podcast, tell yourfriends.
These are all ways that you cansort of help support the cause.

(07:39):
So so we talked about the, thethis, this instrument.
Looking at 16 foods, eight werepro-inflammatory, eight
anti-inflammatory.
So let's just just forcuriosity, let's go through this
.
So the pro-inflammatory foodsin this instrument are red meat,
processed meats, organ meats,non-oily fish, so like white

(08:00):
fish, eggs, sugar-sweetenedbeverages like soda, tomatoes
and refined grains.
So these would all count aspro-inflammatory, meaning not
good.
And the anti-inflammatory foodsthat are asked about in your
weekly intake over in thisinstrument are leafy green
vegetables, dark yellowvegetables like carrots,

(08:22):
pumpkins, et cetera, fruit juice, oily fish, like salmon and
sardines.
Coffee my dad will be happy tohear about the sardines, I will
be happy to hear about thesalmon Coffee, tea, wine and
other beer or alcoholicbeverages.
So again, this is interestingly.
You know, not all of thesewould be immediately intuitive,
but this is sort of based offthe Mediterranean diet.
So if you think about it thatway, the idea of having some

(08:44):
alcohol and coffee asanti-inflammatory makes sense.
And we do have evidence, ofcourse, that these are
anti-inflammatory, they're chockfull of antioxidants, et cetera
.
Ok, so you get this.
You basically get this scoreand you get a score of, you know
, pro-inflammatory foods, basedon your frequency of eating them
, will give you a score of likezero, one or two.
And then you get negativepoints for your

(09:04):
anti-inflammatory foods.
They sort of cancel it out andat the end of the day you try to
see you know what's your netscore at the end of that.
And then they're looking for anassociation between that and
the PHQ-9.
So what is the PHQ-9?
That, if you're a clinician,you're probably very familiar
with that, very commonly usedinstrument to measure depression
.

(09:24):
Where 0 to 4 is there'sbasically no depression, 5 to 9,
mild depression, 10 to 14,moderate, 15 and above we're
talking about moderate to severeand then 20 and above severe
depression.
So what did they find?
They have results from 631participants.
So this is a decent, prettymore than decent.
This is a very large samplesize.

(09:44):
They also looked at if theyneeded to transform the data for
covariates of gender, previouspsychiatric diagnoses, physical
exercise frequency and also Ithought this was interesting
spiritual exercise frequency aswell, and they built their model
off of that and what they foundwas that overall, there is an

(10:08):
association between the higherscore, meaning the net
pro-inflammatory index there isassociated with higher
depression scores, andspecifically there were several
specific components that wereassociated.
So eating fewer leafy greenswas correlated with more
depression.

(10:28):
Okay, that was interesting.
Consuming more bread or pastawas associated with more
depression.
Sugar, sweetened beverages moreof those met more depression or
associated with more depression.
Processed meats as well, andthis is sort of interesting
overall.
So we're talking about anassociation here.
Now.

(10:48):
So we know people that are moredepressed now are scoring
higher on this pro-inflammatorydiet.
The question we always have toask with these sorts of studies
is you know, association doesn'tequal causation here, right?
Like, is it possible thatdepressed people eat differently
, right?
And you know, if you're feelingkind of low, you go and eat a

(11:11):
bunch of bread, for example, ormaybe you're not craving the
salad so much, right?
So it's possible that, eventhough the assumption is that
the diet is driving the moodhere, it could be that the mood
is driving the diet.
So it's called reversecausation bias.
So that's a concern, of course,that you need to consider with
a study like this.

(11:32):
And it's one of the limitationsof this sort of study and they
kind of go through this in thediscussion.
They recognize that that'spossible and they say that
indeed, some studies havesuggested that depression can
lead to altered food choices.
No duh, but the research beingresearch, we had to apparently
study that, et cetera, et cetera, et cetera.
So these are sort of the notesthat they look at.

(11:57):
However, they do note thatthere are other studies that
found that pro-inflammatorydiets at baseline increase the
risk for depression symptomsover a five-year period,
especially among women, and sobasically what they're saying is
, yes, this could be reversecausation bias.
But if you look at similarstudies where they looked

(12:18):
prospectively at this, theystarted with, you know, a good
diet and then, or a poor diet,and looked at what developed
over time with depression, notcoexisting depression.
They seem to suggest that thereis an association there.
And then, of course, previouslythey had given all sorts of
rationale about how that couldbe possible, the different

(12:39):
mechanisms through inflammationand inflammatory cytokines that
we talked about earlier, and soI think that's the main take
home here.
It's a cute little paper.
I mean, I think it's relevantbecause two things.
One, it's a very large survey,so over 600 participants, and I
think, even though themethodology is not ironclad,

(12:59):
meaning possibility for reversecausation bias, it fits within a
narrative, et cetera, and Ithink the more clinically
relevant aspect, at least for mewhen selecting this article to
talk about, was the fact thatthis is using an instrument that
we could all use in clinic.
It's just sort of asking aboutweekly intake of these 18 foods,

(13:22):
you know, eightpro-inflammatory, eight
anti-inflammatory and I feltlike that was interesting in a
way to kind of maybe integrateinto clinical practice, if you
wish.
I did run that by Adam and hewas like eh, we have enough
surveys and questionnaires forour patients to fill out.
I don't know that I want togive them another one, so fair
enough.
So if you have any questionsabout this, please go ahead and

(13:42):
reach out to us at josh atdrjournalclubcom.
Josh at drjournalclubcom.
If you have any recommendationsfor articles, please send them.
We got through our backlog and,honestly, it took me a while to
even find this one, and I'm notsuper jazzed about this one
anyway.
So it must have been like aslow month in the research world
.
So if you have a researcharticle that you think would be

(14:04):
of interest to our community, goahead and send it to us Until
next time.
This is Dr Joshua Goldenbergsigning off for Dr Journal Club.
If you enjoy this podcast,chances are that one of your
colleagues and friends probablywould as well.
Please do us a favor and letthem know about the podcast and,

(14:25):
if you have a little bit ofextra time, even just a few
seconds, if you could rate usand review us on Apple Podcast
or any other distributor, itwould be greatly appreciated.
It would mean a lot to us andhelp get the word out to other
people that would really enjoyour content.
Thank you, hey y'all.
This is Josh.
You know we talked about somereally interesting stuff today.
I think one of the things we'regoing to do that's relevant.
There is a course we have on DrJournal Club called the EBM

(14:48):
Boot Camp.
That's really meant forclinicians to sort of help them
understand how to criticallyevaluate the literature, et
cetera, et cetera Some of thethings that we've been talking
about today.
Go ahead and check out the shownotes link.
We're going to link to itdirectly.
I think it might be of interest.
Don't forget to follow us onsocial and interact with us on
social media at Dr Journal ClubDr Journal Club on Twitter.

(15:10):
We're on Facebook, we're onLinkedIn, etc.
Etc.
So please reach out to us.
We always love to talk to ourfans and our listeners.
If you have any specificquestions you'd like to ask us
about research, evidence, beinga clinician, etc.
Don't hesitate to ask.
And then, of course, if youhave any topics that you'd like
us to cover on the pod, pleaselet us know as well.

Introducer (15:32):
Thank you for listening to the Doctor Journal
Club podcast, the show that goesunder the hood of
evidence-based integrativemedicine.
We review recent researcharticles, interview
evidence-based medicine thoughtleaders and discuss the
challenges and opportunities ofintegrating evidence-based and
integrative medicine.
Be sure to visit www.
drrjournalclub.
com to learn more.
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