The source provides a comprehensive overview of the paradigm shift occurring in Alzheimer's disease (AD) therapeutics, detailing the move from modest symptomatic relief to the first disease-modifying therapies (DMTs). It explains that while traditional treatments like cholinesterase inhibitors temporarily managed symptoms, recent FDA approvals of anti-amyloid antibodies, such as lecanemab and donanemab, prove that targeting underlying pathology can slow cognitive decline, despite introducing safety risks like ARIA. The text further highlights the diversifying drug pipeline beyond amyloid to include anti-tau agents, neuroinflammation modulators, and repurposed drugs like semaglutide. This progress is underscored by a revolution in diagnostics, where non-invasive blood-based biomarkers like p-tau217 now enable earlier and more accurate patient identification, supporting a future model of integrated, personalized AD care that combines pharmacotherapy with lifestyle interventions like those validated by the U.S. POINTER trial.
Popular Podcasts
Stuff You Should Know
If you've ever wanted to know about champagne, satanism, the Stonewall Uprising, chaos theory, LSD, El Nino, true crime and Rosa Parks, then look no further. Josh and Chuck have you covered.
Las Culturistas with Matt Rogers and Bowen Yang
Ding dong! Join your culture consultants, Matt Rogers and Bowen Yang, on an unforgettable journey into the beating heart of CULTURE. Alongside sizzling special guests, they GET INTO the hottest pop-culture moments of the day and the formative cultural experiences that turned them into Culturistas. Produced by the Big Money Players Network and iHeartRadio.
Crime Junkie
Does hearing about a true crime case always leave you scouring the internet for the truth behind the story? Dive into your next mystery with Crime Junkie. Every Monday, join your host Ashley Flowers as she unravels all the details of infamous and underreported true crime cases with her best friend Brit Prawat. From cold cases to missing persons and heroes in our community who seek justice, Crime Junkie is your destination for theories and stories you won’t hear anywhere else. Whether you're a seasoned true crime enthusiast or new to the genre, you'll find yourself on the edge of your seat awaiting a new episode every Monday. If you can never get enough true crime... Congratulations, you’ve found your people. Follow to join a community of Crime Junkies! Crime Junkie is presented by audiochuck Media Company.