QC: Endometriosis Across Borders: How Geography Shapes Disease Expression

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Dr. Abhishek Mangeshikar explores how endometriosis severity varies globally, highlighting the interplay between genetics, environmental factors, and healthcare access. While genetic components exist in endometriosis development, expression is influenced by epigenetics including diet, stress, and environmental conditions that determine disease progression patterns.

• Endometriosis has a genetic component, but gene expression depends on epigenetic factors
• Environmental factors, diet, hormones, and physiological stress influence disease expression
• Healthcare access significantly impacts observed disease severity across regions
• Lower-income countries typically see more advanced disease due to delayed diagnosis
• Early intervention in higher-income countries often prevents progression of certain disease types
• More diverse, multicultural studies are needed to understand global endometriosis patterns

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Episode Transcript

Speaker 1 (00:00):
Life moves fast and so should the answers to your
biggest questions.
Welcome to EndoBattery's QuickConnect, your direct line to
expert insights Short, powerfuland right to the point.
You send in the questions, Ibring in the experts and in just
five minutes you get theknowledge you need.
No long episodes, no extra timeneeded, and just remember

(00:20):
expert opinions shared here arefor general information and not
for personalized medical advice.
Always consult your providerfor your case-specific guidance.
Got a question?
Send it in and let's quicklyget you the answers.
I'm your host, alana, and it'stime to connect.
Today I'm joined by my expertguest, dr Abhishek Mangeshkar, a

(00:48):
leading endometriosisspecialist and minimally
invasive gynecologic surgeonfrom Mumbai, india.
He's the founder and directorof the Indian Center for
Endometriosis and has extensiveexpertise in treating deep
infiltrating endometriosisthrough advanced laparoscopic
techniques, with training inneuropelviology and thousands of
complex surgeries performed.
Dr Mings is passionate about apatient-first, multidisciplinary

(01:09):
approach to care.
I'm thrilled to have him joinme today to share his expertise.
Let's dive in.
In your opinion, do you feellike you see, endometriosis and
its severity vary based onculture, geographical location
or the different foods anddifferent cultures?

Speaker 2 (01:26):
We do know that endometriosis has definitely got
a genetic component to it, sothere is a gene passed down.
But whether that gene expressesitself has a lot to do with
epigenetics and probablyenvironmental dietary hormonal
you know stress, and I don'tmean just mental stress.

(01:48):
It could be physiological,inflammatory stress that causes
whether the disease grows, howit expresses itself and how
aggressively it can grow andspread.
That determines these certainphenotypes of disease.
The short answer is we don'tknow yet.
There should be a lot morestudies going on about this, but

(02:09):
it's very difficult to get awidespread diaspora,
multicultural, multidiversepopulation to study.

Speaker 1 (02:18):
Yeah, and I would imagine that part of that comes
down to access to care too,because I know in different
parts of the world care is notreally accessible for a lot of
people, so I think it's probablyhard to really get a good study
based off of.
What we currently have is likecare is not accessible for a lot

(02:38):
of people in a first worldcountry, let alone a third world
country.

Speaker 2 (02:42):
Actually I think you kind of nailed it or you hit the
nail on the head, because whenyou would see more advanced
disease from the lower economypopulations compared to the US
or Europe or Australia, wherethey would get early primary
care, so you know they wouldhave the cysts dealt with
earlier and the people diseasewhich is more complex and very

(03:04):
few people can treat that kindof gets left behind and
sheltered through, whereas inthe other populations like India
, the Middle East, africa, asia,they would not have such early
access to care or there would bedelays in diagnosis and
treatment.
So you would see more advanceddisease in those cases,
especially when it had to dowith cysts in the ovaries,

(03:25):
affecting the tubes or evenuterine disease.
That's being allowed toprogress because of the inertia
of the medical systems in thosecountries.

Speaker 1 (03:34):
That's a wrap for this Quick Connect.
I hope today's insights helpedyou move forward with more
clarity and confidence.
Do you have more questions?
Keep them coming, send them inand I'll bring you the expert
answers.
You can send them in by usingthe link in the top of the
description of this podcastepisode or by emailing contact
at endobatterycom or visitingthe endobatterycom contact page.

(03:59):
Until next time, keep feelingempowered through knowledge.