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May 6, 2025 3 secs

File name: Atrial Fibrillation Pathophysiology Pdf

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Abstract—Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, is an important contributor to population morbidity and mortality. An arrhythmia that is particularly common in the elderly, AF is growing in prevalence with the aging of the population. Sep 1,  · Atrial fibrillation (AF), a prevalent cardiac arrhythmia, carries significant clinical implications, impacting the risk of stroke, heart failure, and other cardiovascular complications. The pathophysiology of AF centers around 4 general types of disturbances that promote ectopic firing and reentrant mechanisms, and include the following: (1) ion channel dysfunction, (2) Ca2+-handling abnormalities, (3) structural remodeling, and (4) autonomic neural dysregulation. • Atrial fibrillation (AF) is the most common supraventricular arrhythmia affecting up to 1% of the general population: its prevalence reaches up to ∼10% in the elderly. • AF insurgence depends on intertwined genetic and epigenetic causes. • The risk of AF is significantly lower in non-White races and ethnicities (including. The pathophysiology of AF centers around 4 general types of disturbances that promote ectopic firing and reentrant mechanisms, and include the following: (1) ion channel dysfunction, (2) Ca2+-handling abnormalities, (3) structural remodeling, and (4) autonomic neural dysregulation. Abstract—Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, is an important contributor to population morbidity and mortality. An arrhythmia that is particularly common in the elderly, AF is growing in prevalence with the aging of the population.
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