Foundation Fighting Blindness

Foundation Fighting Blindness

The Foundation Fighting Blindness is the driving force in the global development of treatments and cures for blinding diseases. To learn more, go to FightingBlindness.org.

Episodes

Eye on the Cure Podcast | Episode 97: Lindsey Rambo

December 19, 2025 • 39 mins
Lindsey Rambo, a special education teaching assistant, mom, and wife, talks to host Ben Shaberman about her journey with Leber congenital amaurosis 5 (LCA5), participation in Opus Genetics' LCA5 gene therapy clinical trial, and her appearance on Good Morning America to tell her story about meaningful vision improvements. 
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Beacon Therapeutics Launches Clinical Trial for Bilateral Administration of XLRP Gene Therapy

December 18, 2025 • 2 mins
The company has also fully enrolled the Phase 2/3 VISTA clinical trial for its XLRP gene therapy.
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Eye on the Cure Podcast | Episode 96: Dr. Deniz Dalkara

December 5, 2025 • 43 mins
Dr. Deniz Dalkara, a research director at INSERM in France, talks to hose Ben Shaberman about her emerging gene-agnostic, gene therapy designed to restore cone-mediated vision in people with advanced retinitis pigmentosa. Known as SPVN20 and clinically developed by SparingVision, the treatment recently moved into a clinical trial in Europe. Dr. Dakara also discusses her earlier work in retinal gene and optogenetic therapy developme...
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Belite Bio to Seek FDA Approval for its Stargardt Disease Drug

December 2, 2025 • 3 mins
Tinlarebant slowed disease progression by 36 percent in the Dragon Phase 3 clinical trial.
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Opus Genetics Launches Gene Therapy Clinical Trial for Best Disease

November 14, 2025 • 2 mins
The Foundation funded preclinical studies for the approach and launched Opus.
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Eye on the Cure Podcast | Episode 95: Greta Streimikyte

November 14, 2025 • 20 mins
Greta Streimikyte, a blind para-athletic running champion from Ireland, talks to host Ben Shaberman about growing up with substantial vision loss from retinopathy of prematurity and her competitive running career. Greta has won gold in the women's 1500 meters at the 2018 and 2021 European Para Athletic Championships and is a three-time Paralympian.
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Eye on the Cure Podcast | Episode 94: Dr. Victoria Claire

October 31, 2025 • 53 mins
October 31, 2025. Dr. Victoria Claire has commissioned more than 200 sculptures, received an honorary doctorate, and is pursuing a PhD. She talks with host Ben Shaberman about her journey with retinitis pigmentosa, and how blindness has provided her with new and profound insights into herself and perceiving the world. Visitors to her current exhibition, "The Sense of Sculpture" (Oct. 18 - Nov. 1) at The Art House in Wakefield, Engl...
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SparingVision Launches Clinical Trial for Therapy to Re-Activate Dormant Cones in Advanced RP

October 28, 2025 • 4 mins
The approach may provide better visual acuity than current optogenetic therapies in clinical trials.
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Eye on the Cure Podcast | Episode 93: Sam Seavey

October 17, 2025 • 41 mins
October 17, 2025. Sam Seavey, founder and host of the acclaimed The Blind Life YouTube channel, talks with host Ben Shaberman about his journey with Stargardt disease, some of the latest assistive technologies, and how the 900+ videos on The Blind Life can be informative and helpful for people with low vision.
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Sepul Bio’s LCA10 RNA Therapy Moves into Phase 3 Clinical Trial

October 2, 2025 • 3 mins
The emerging therapy improved vision for some participants in an earlier clinical trial.
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Opus Reports Vision Improvements for Three Pediatric Patients in Phase 1/2 Clinical Trial for LCA5 Gene Therapy

September 30, 2025 • 4 mins
Durable vision improvements were also observed out to 18 months for previously dosed adult patients in the trial.
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Eye on the Cure Podcast | Episode 92: Lance Baldo, MD

September 26, 2025 • 30 mins
Lance Baldo, MD, CEO at Beacon Therapeutics, talks to host Ben Shaberman about his company's fully enrolled Phase 3 VISTA clinical trial for laru-zova, a gene therapy for X-linked retinitis pigmentosa (RPGR mutations) that's showed promising results in earlier trials. They also discuss Beacon's forthcoming clinical trial for its dry age-related macular degeneration gene therapy.
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Agnes Gund – Renowned Philanthropist, Social Justice Champion, and Art Patron – Passes Away

September 22, 2025 • 2 mins
The documentary “Aggie: An Incredible Story of Art and Justice” chronicles her story.
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Nacuity’s Antioxidative Therapy NACA Performs Encouragingly in Phase 1/2 Clinical Trial

September 12, 2025 • 3 mins
NACA is a gene-agnostic, oral medication designed to preserve vision in people with retinitis pigmentosa and Usher syndrome.
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Eye on the Cure Podcast | Episode 91: Dr. George Magrath

September 5, 2025 • 22 mins
September 5, 2025. Dr. George Magrath, CEO of Opus Genetics, talks with host Ben Shaberman about the company's evolution and progress in clinically developing gene therapies for several inherited retinal diseases including those caused by mutations in the genes: LCA5, BEST1, RHO, RDH12, MERTK, NMNAT1, and CNGB1.
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Opus Genetics Receives FDA Clearance to Launch Clinical Trial for Best1 Gene Therapy

August 22, 2025 • 2 mins
The Foundation funded earlier, proof-of-concept studies for the Best1 gene therapy and later launched Opus to develop several IRD gene therapies.
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jCyte Launches New Phase 2 Clinical Trial for its Cell-Based RP Therapy

August 20, 2025 • 3 mins
The trial is evaluating a cell dose that is 50 percent higher than the highest dose used in a previous Phase 2b trial.
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Eye on the Cure Podcast | Episode 90: Dr. Christina Ohnsman

August 8, 2025 • 27 mins
August 8, 2025. Dr. Christina Ohnsman talks to host Ben Shaberman about Tern Therapeutics, a start-up company she co-founded to develop gene therapies for Batten disease and potentially other conditions. Dr. Ohnsman reviews early results for a Batten disease (CLN2) retinal gene therapy clinical trial. She also reflects on her previous work as a pediatric ophthalmologist and roles with Spark Therapeutics and Regenxbio.
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Wet AMD Treatment Susvimo Preserves Vision for Five Years in Phase 3 Clinical Trial

August 6, 2025 • 3 mins
Susvimo is an FDA-approved treatment that continuously delivers drug through a tiny, implanted capsule
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Eye on the Cure Podcast | Episode 89: Dr. Christine Curcio

July 25, 2025 • 37 mins
July 25, 2025. Dr. Christine Curcio, one of the world's foremost experts in age-related macular degeneration (AMD) pathogenesis and the associated risk of advanced vision loss, talks to host Ben Shaberman about her epical career and recent Proctor Medal lecture with Dr. Cynthia Owsley at the 2025 meeting of the Association for Eye and Vision Research (ARVO). Her work has led to a highly effective test for predicting who is at great...
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