Foundation Fighting Blindness

Foundation Fighting Blindness

The Foundation Fighting Blindness is the driving force in the global development of treatments and cures for blinding diseases. To learn more, go to FightingBlindness.org.

Episodes

Eye on the Cure Podcast | Episode 90: Dr. Christina Ohnsman

August 8, 2025 • 27 mins
August 8, 2025. Dr. Christina Ohnsman talks to host Ben Shaberman about Tern Therapeutics, a start-up company she co-founded to develop gene therapies for Batten disease and potentially other conditions. Dr. Ohnsman reviews early results for a Batten disease (CLN2) retinal gene therapy clinical trial. She also reflects on her previous work as a pediatric ophthalmologist and roles with Spark Therapeutics and Regenxbio.
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Wet AMD Treatment Susvimo Preserves Vision for Five Years in Phase 3 Clinical Trial

August 6, 2025 • 3 mins
Susvimo is an FDA-approved treatment that continuously delivers drug through a tiny, implanted capsule
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Eye on the Cure Podcast | Episode 89: Dr. Christine Curcio

July 25, 2025 • 37 mins
July 25, 2025. Dr. Christine Curcio, one of the world's foremost experts in age-related macular degeneration (AMD) pathogenesis and the associated risk of advanced vision loss, talks to host Ben Shaberman about her epical career and recent Proctor Medal lecture with Dr. Cynthia Owsley at the 2025 meeting of the Association for Eye and Vision Research (ARVO). Her work has led to a highly effective test for predicting who is at great...
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Ocugen Launches Phase 2/3 Clinical Trial for Stargardt Disease Gene-Modifier Therapy

July 21, 2025 • 1 min
The therapy delivers copies of the RORA gene to address multiple disease pathways.
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Nanoscope Begins Rolling BLA Submission to FDA for Seeking Approval for its Optogenetic Therapy

July 14, 2025 • 2 mins
The company plans to complete BLA submission in early 2026.
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Eye on the Cure Podcast | Episode 88: Richard Small

July 11, 2025 • 25 mins
July 11, 2025. Richard Small, CEO of Neurotech, talks to host Ben Shaberman about ENCELTO™, the first and only FDA-approved treatment for adults with idiopathic Macular Telangiectasia Type 2 (MacTel). The therapy is a tiny, implantable capsule, the size of a rice grain, that delivers neurotrophic factors to preserve the patient's retinal cells and vision. The approach was previously developed to treat retinitis pigmentosa and age-r...
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Atsena Gets FDA Nod to Expand XLRS Gene Therapy Clinical Trial to Include Pivotal Phase 3 Cohort

July 9, 2025 • 4 mins
The expanded Phase 1/2/3 shortens time to potential FDA approval.
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Eye on the Cure Podcast | Episode 87: Dr. Philip Beales

June 13, 2025 • 18 mins
June 13, 2025. Dr. Philip Beales, a co-founder of Axovia Therapeutics, talks to host Ben Shaberman about Bardet Biedl syndrome, ciliopathies, and his company's emerging gene therapy for Bardet Biedl syndrome type 1 (BBS1) which is moving toward a clinical trial.
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Eye on the Cure Podcast | Episode 86: Lenore von Krusenstiern, MD, PhD

May 23, 2025 • 31 mins
May 23, 2025. Lenore von Krusenstiern, MD, PhD, at BlueRock Therapeutics talks to host Ben Shaberman about the company's clinical trial for a photoreceptor replacement therapy for people with inherited retinal conditions such as retinitis pigmentosa and cone-rod dystrophy. The approach, which uses induced pluripotent stem cells to develop photoreceptor precursors, comes out of the lab of stem cell pioneer David Gamm, MD, PhD, Unive...
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J&J’s XLRP Gene Therapy Didn’t Meet Primary Endpoint in Phase 3 Clinical Trial

May 15, 2025 • 2 mins
Despite missing the primary endpoint, the treatment improved vision for some patients.
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ARVO 2025 Highlight: PYC Reports Encouraging Phase 1/2 Clinical Trial Results for its RNA Therapy Targeting RP (PRPF31 Mutations)

May 13, 2025 • 4 mins
The company is planning a Phase 2/3 clinical trial for therapy in late 2025.
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ARVO 2025 Highlight: Atsena’s XLRS Gene Therapy Provides Vision and Structural Improvements in Phase 1/2 Clinical Trial

May 12, 2025 • 4 mins
Part B of the trial will enroll nine adult patients as well as three pediatric patients.
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ARVO 2025 Highlight: Beacon Reports Encouraging Results for Second Eyes Dosed in Clinical Trial for XLRP Gene Therapy

May 9, 2025 • 3 mins
The company is currently enrolling patients in its Phase 2/3 VISTA Clinical Trial.
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Eye on the Cure Podcast | Episode 85: Cindy Elden

May 9, 2025 • 28 mins
Cindy Elden, who co-founded the Usher III Initiative with her late father, talks to host Ben Shaberman about her journey with Usher syndrome type 3 (USH3), the decades-long work and persistence of her non-profit, and the clinical trial it launched for an USH3 small molecule therapy.
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Eye on the Cure Podcast | Episode 84: Contact Congress

April 1, 2025 • 35 mins
April 3, 2025. In this episode of Eye on the Cure, Jen Bernstein at Horizon Government Affairs, and Sharon King of Taylor’s Tale, talk to host Ben Shaberman about how to schedule and conduct a visit with your House Member in your local district to advocate for important issues. With federal eye research funding at great risk and a Congressional district work period coming in mid-April, now is an ideal time to schedule a visit with ...
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Eye on the Cure Podcast | Episode 83: Michel Michaelides

March 19, 2025 • 33 mins
March 21, 2025. Professor Michel Michaelides, a world-renowned clinical researcher for inherited retinal diseases at Moorfields Eye Hospital and University College London, talks to host Ben Shaberman about the extraordinary vision improvements for young blind children receiving gene therapy for Leber congenital amaurosis 4 (LCA4). Professor also talks about emerging therapies in clinical trials for X-linked retinitis pigmentosa and...
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Luxa Reports Vision Improvements in Clinical Trial of its RPE Stem Cell Therapy for Dry AMD

March 10, 2025 • 4 mins
Patients with worse vision at trial enrollment had greatest vision improvements.
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Neurotech’s Encapsulated Cell Technology Receives FDA Approval for Treatment of MacTel

March 6, 2025 • 2 mins
The technology was previously funded by the Foundation for the treatment of retinitis pigmentosa and dry age-related macular degeneration.
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Eye on the Cure Podcast | Episode 82: Dr. Aaron Nagiel

March 4, 2025 • 32 mins
March 7, 2025. Aaron Nagiel, MD, PhD, a retina surgeon at Children’s Hospital Los Angeles, talks to host Ben Shaberman about how gene therapy is administered to the retina, what the surgery and recovery is like for patients, and the vision improvements for young patients receiving LUXTURNA, the first FDA-approved gene therapy for the eye or an inherited condition. Dr. Nagiel also discusses other retinal gene therapies in clinical ...
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Adverum Advancing Wet AMD Gene Therapy into Phase 3 Clinical Trials

February 27, 2025 • 3 mins
In earlier clinical trials, the emerging gene therapy greatly reduced the treatment burden associated with injections of approved anti-VEGF therapies.
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