Thank you Ardelyx for your support of this FAQ Video Module.
For years, the primary treatment options for irritable bowel syndrome with constipation (IBS-C) have been limited to secretagogues, offering varying doses and tolerability. However, a new mechanism of action (MOA) is now available, revolutionizing treatment choices for healthcare providers and patients alike. In this discussion, Kim Orleck, PA-C, from Atlanta Gastroenterology Associates, explores the triple-action MOA of this novel IBS-C therapy and how it enhances clinical decision-making.
This innovative therapy works by targeting the sodium-hydrogen exchanger isoform 3 (NHE3) on the apical surfaces of the small intestine and colon. By inhibiting NHE3, three key physiological effects occur. First, dietary sodium absorption is reduced, leading to increased luminal water content, which accelerates intestinal transit and softens stool consistency. Second, intestinal permeability is decreased, which helps to reduce abdominal pain. Lastly, visceral hypersensitivity is lowered, further alleviating the pain associated with IBS-C. These combined actions address multiple aspects of IBS-C pathophysiology, providing a minimally absorbed yet highly effective approach to symptom management.
With this exciting advancement, healthcare providers now have a novel treatment option that expands beyond traditional secretagogues, offering a new level of relief for patients struggling with IBS-C. To learn more, visit the GHAPP website for additional insights and expert perspectives on IBS-C management.
Popular Podcasts
Stuff You Should Know
If you've ever wanted to know about champagne, satanism, the Stonewall Uprising, chaos theory, LSD, El Nino, true crime and Rosa Parks, then look no further. Josh and Chuck have you covered.
Medal of Honor: Stories of Courage
Rewarded for bravery that goes above and beyond the call of duty, the Medal of Honor is the United States’ top military decoration. The stories we tell are about the heroes who have distinguished themselves by acts of heroism and courage that have saved lives. From Judith Resnik, the second woman in space, to Daniel Daly, one of only 19 people to have received the Medal of Honor twice, these are stories about those who have done the improbable and unexpected, who have sacrificed something in the name of something much bigger than themselves. Every Wednesday on Medal of Honor, uncover what their experiences tell us about the nature of sacrifice, why people put their lives in danger for others, and what happens after you’ve become a hero. Special thanks to series creator Dan McGinn, to the Congressional Medal of Honor Society and Adam Plumpton. Medal of Honor begins on May 28. Subscribe to Pushkin+ to hear ad-free episodes one week early. Find Pushkin+ on the Medal of Honor show page in Apple or at Pushkin.fm. Subscribe on Apple: apple.co/pushkin Subscribe on Pushkin: pushkin.fm/plus
Dateline NBC
Current and classic episodes, featuring compelling true-crime mysteries, powerful documentaries and in-depth investigations. Follow now to get the latest episodes of Dateline NBC completely free, or subscribe to Dateline Premium for ad-free listening and exclusive bonus content: DatelinePremium.com