In this episode, Matt Tack and Dr. Alfred Alessi explore the potential of stem cells in treating neurological disorders. They discuss current debates, FDA-approved therapies, and the future of stem cell treatment. Ethical, regulatory, and insurance considerations are examined, along with the importance of evaluating stem cell product quality. They emphasize balancing optimism with informed research and discuss integrating stem cells with lifestyle choices. The episode concludes with insights on promoting ethical care and listener engagement.
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(00:00):
Stem cells and what's the future of thismedicine, or is it just hype?
Intermittal therapies using stem cells arebeing explored for stroke recovery, Parkinson's
disease, and Alzheimer's.
Honestly, this is groundbreaking because it'sit's allowed for more avenues in personalized
medicine.
The the applications for this are usually indisease modeling, drug discovery, and and
(00:21):
there's a lot of promise for using these forcell therapy as well, potentially reducing,
like, immune rejection risks.
Welcome to Health Decoded, your number onesource for real health information with your
host, doctor Alessi and Matt Tack.
Welcome back to another episode of HealthDecoded.
(00:43):
I am your host, doctor Alfred Alessi.
And the co host, Matt Tac.
Matt Tac, my guy.
Well, welcome back.
Today, we're gonna explore some cutting edgehealth and wellness topics, specifically diving
into the world of stem cell therapy.
We really wanna separate what's fact, what'sfiction, and kind of explore the potential, for
(01:05):
stem cells in functional medicine.
Yeah.
And we also wanna highlight some growinginterest and debates surrounding stem cell
treatments.
Are they the magical bullet for radical healingtransformation or setting the stage for an
in-depth discussion?
We're excited to talk about it.
I'm excited to talk about it.
This is something that we've been trying topilot for a while and really just kind of, I
(01:30):
wanna say, like, organically came upon arelationship with, with a clinic who offers
this and that we have, you know, partneredwith.
And it just it feels like it was kinda meantto, elaborate and kinda come into this
fruition.
So, how you doing, man?
First off, how are you?
I'm doing fantastic.
(01:52):
Had a little bit of an issue last night.
You know what?
It it it's funny.
You try to optimize your sleep, and sometimesyou have, sleep interruptions.
You know?
So I'm figuring that out right now.
I've had a few sleep interruptions.
So Yeah.
But overall, doing good, man.
How about yourself?
I'm doing good.
Are you tracking your sleep in with anything?
Or
I need to get back to that.
(02:12):
So I was using the Whoop Band.
Yeah.
But I am gonna go over to the Oura.
It's just something that I think I can sleepwith.
I usually don't sleep with, like, variousthings, like, on my end.
Yeah.
But I feel like, data in general, gets it I Ithink the Oura is probably some of the best
(02:32):
value in terms of data feedback, that you canget, with it being on your with it being on
your ring, but not imposing you.
You know?
Your wrist tend to, like if you wear somethingon your wrist at night Yeah.
I feel like it it poses you a little bit more.
So, I'm gonna try out the Oura ring.
Yeah.
How about yourself?
I mean, yeah, I'm wearing the Garmin, and it'sit's nice because it's a seven day, eight day
(02:55):
life on the battery, so I do wear it to sleep.
I don't it doesn't bother me too much.
I can definitely feel it, but, I have I likethe tracking because I've noticed that if I can
get a cold shower or do, like, a cold plunge,like, later in the day, my deep sleep is, like
it's almost, like, 1.5 x.
Like, I'm getting another hour of deep sleep atnight.
(03:16):
It's awesome.
So I've definitely seen that correlation aswell as, like, the nights where I get home late
and I don't have dinner till, like, 8PM.
You know, those nights where we're at theclinic late or something, that's affecting my
deep sleep so that I'm getting less deep sleepand less REM.
And more than likely because my body's, youknow, still kind of metabolically processing
that that meal.
I've I've switched from, like, a meal to just,like, doing a big smoothie instead so it at at
(03:40):
least digest a little quicker.
But, again, man, it's like data.
Like, knowing, like, wow.
Those things are affecting my sleep.
That's why I'm waking up the next day feelinglike a little, weird.
But last night, I played I played lacrosseuntil, like, 08:30 at night.
So my you know, everything's burnt, like, realhot.
But then I came home and I did a real, like,real cold shower before bed, and I got amazing
(04:01):
deep sleep last night.
So, you know, little hacks that you canimplement to obviously kind of make sure you're
not disrupting that sleep pattern.
Yeah.
That was something we had something going onlast night, and I told you, like, I wanted to
go hit the gym and workout.
But then I kept getting later and later.
And I'm like, if I accelerate my heart rate,like, at Yeah.
08:30 at night, it's not something I wanna dofor my sleep.
(04:24):
So I, like, chose not to work out last night.
But, those are things that I think about interms of, like, how late do you typically work
out because we're usually those, you know,midday guys, lunch hour, get in there, get out.
So, you know, that that's something I thinkabout as well.
It's just like, how do you how do you kindamodify your heart rate to prepare for sleep?
(04:44):
That's a good word.
That's right.
Yeah.
Accelerating it either early or midday, butnot, like, later than 4PM or 5PM.
You know?
That's good.
Obviously, if that's the only time you have toexercise, then you'd make it work.
But Yeah.
Make it work.
Taking a day off every now and then when workguys who are there five, six days a week is not
gonna kill you.
You know?
It's not gonna That's right.
It's not gonna derail your results.
(05:05):
But That's Cool, man.
Well, that's good, brother.
Well, sorry you didn't get the best sleep, butlet's, let's let's provide value here, man.
That's the goal with this podcast.
So we wanna thank you guys for tuning in.
As always, we really wanna just separate whatis what is real and what's, you know, maybe
some fluff information.
And so everything we talk about, we do a littlebit of research into.
We get some studies around kind of theinformation.
(05:27):
That way, you know, we're on top of it.
And these you know, we're not going back twentyyears for these studies either.
We're we're we're sticking, like, you know,very recent within the last five years.
Right?
Stuff that's relevant and stuff that has somemerit to it.
So, you know, today, we're gonna talk aboutstem cell therapy and what does regenerative
medicine look like and kind of the emergingworld of this because it is relatively on the
(05:49):
forefront.
And, you know, like anything, the FDA has theirhands in it, and they control a lot of it.
And so there's, like, what is FDA approved, andthen there's, like, what is available, and then
there's, like, what is out there.
Right?
And so, you know, there's if if you go, you canfind, right, you can find whatever you need if
you go certain places.
So we're gonna kinda get into that.
(06:10):
But first off, we wanna obviously give a littlebackground, like, what are stem cells for for
people, listeners who may not even know whatthis is.
And so stem cells are amazing because they areunique cells with the ability to self renew,
and they can differentiate into whatever theyneed to be.
So, basically, the term is undifferentiated.
So then as soon as they get into the body oryour body technically has them within the bone
(06:34):
marrow, it's gonna use them where needed.
Right?
You injure your your soft tissue muscle tendon,it's gonna become tendon.
You have, a disorder with the the vasculature,it's gonna become artery tissue.
Right?
And so this dual capacity allows them to play acrucial role in the body's repair and
maintenance systems.
They can develop into many different cell typesin the body, especially during early life and
(06:56):
growth.
So at young ages, the body is producing massamounts of stem cells to build you and to
create that new tissue.
And so there's really four types that thatyou're gonna hear about or or see or that are
available, I should say.
And so let's just touch on those real quick.
So kind of the most popular is, like, embryonicstem cells.
Now these are derived from early stage embryos,specifically the inner cell mass of a
(07:21):
blastocyst, which is typically around five dayspost fertilization.
And so these are pluripotent, meaning that theycan differentiate into all cell types of the
adult body.
This characteristic makes them invaluable fordevelopmental studies and potential therapeutic
applications.
So due to this versatility, ESCs areextensively used in research to understand
(07:44):
early human development, and they're beingexplored as regenerative medicine.
The next type is adult stem cells or what wewould call somatic or tissue specific stem
cells.
So these are located in various tissuesthroughout the body, such as bone marrow
primarily, as well as the brain and the liver.
So they remain in a what's called a quiescentstate until they are activated during some type
(08:10):
of disease or tissue injury or inflammation.
So unlike embryonic stem cells, adult stemcells are are typically multipotent, meaning
they can differentiate, but only into a limitedtype of cell.
So, for example, like a hematopoietic stem cellin the marrow can become various blood cells,
but it's not gonna become a neural cell or a ora muscle cell.
(08:34):
Right?
And so applications for these are currentlyused in treatments like bone marrow transplants
for leukemia patients.
Research is ongoing to expand the therapeuticpotential for these as well for other things.
The next type is what we call inducedpluripotent stem cells.
So these are actually generated byreprogramming the adult somatic cells, such as
(08:57):
skin fibroblast to then an embryonic stem cellstate, through the induction of specific genes.
So these are a little bit more modified.
Right?
And so these exhibit that pluripotency, whichis similar to the embryonic, allowing them to
differentiate into any cell type.
And, honestly, this is groundbreaking becauseit's it's allowed for more avenues in
(09:18):
personalized medicine.
And, you know, the the applications for thisare usually in disease modeling, drug
discovery, and and there's a lot of promisefor, using these for cell therapy as well,
potentially reducing, like, immune rejectionrisks.
Right?
When you put something into the body, is thebody gonna accept it or reject it?
That's always something to consider.
(09:39):
And then the final form is the mesenchymal stemcells, and these are found in various tissues
including bone marrow, adipose tissue, andumbilical cord tissue.
And these are multipotent as well, so they candifferentiate into bone, cartilage, muscle, and
fat cells, and they actually do have animmunomodulatory and anti inflammatory
(10:01):
property.
So it's very important.
These are mostly the type of stem cells that wekind of work with within our kind of
boundaries, and would focus on.
And so they're widely studied for theregenerative capabilities as well, specifically
in things like orthopedic injuries, autoimmunedisease, cardiovascular conditions, and they're
(10:21):
currently being used in clinical applicationsas regenerative medicine for treating
osteoarthritis, degenerative disc or jointdisease, and tissue healing.
And so these have, you know, vast, applicationsfor longevity as well.
And so, you know, within personalized medicine,which we talk about a lot, which is where we
can just kind of do you know, explore theboundaries of what our body can do, these have
(10:45):
a great, tremendous, use.
So, you know, understanding the distinctcharacteristics and potentials of each type is
fundamental for how we advance this thisregenerative medicine, you know, field.
And so developing different therapeuticstrategies.
And then, you know, the research is ongoing tocontinue to unlock these capabilities aiming to
(11:06):
translate these findings into effectiveclinical applications, down the line.
So that's, you know, that's just the differenttypes of stem cells that are out there and,
that you can see obviously being researched,but then also now being applied to different
treatments.
Yeah.
And there's many different applications of stemcell therapy, and I'm just gonna dive into a
(11:27):
few here.
So the FDA has approved, stem cell treatments,and these are the ones.
So the most widely used and FDA approved stemcell therapies is hematopoietic.
So stem cell transplantation, it's also knownas HSCT, primarily used to treat blood
disorders such as leukemia, lymphoma, andcertain immune system deficiencies.
(11:50):
This therapy involves transplanting healthyhematopoietic stem cells from the bone marrow
or peripheral blood to replace damaged ordiseased cells.
Emerging applications in regenerative medicine,research in stem cells is rapidly expanding as
Alfred doctor Alfred said, showing promise in avariety of chronic and degenerative conditions.
(12:15):
As mentioned before, the number one beingcardiovascular disease.
Studies suggest that stem cells could helpgenerate heart tissue after myocardial
infarction, which is a heart attack.
Early trials indicate that mesenchymal stemcells, also known as SMCs, may improve heart
function and reduce scar tissue.
That was from the Journal of American Collegeof Cardiology in 2020.
(12:39):
So stem cells and what's the future of thismedicine, or is it just hype?
So neurological disorders.
Experimental therapies using stem cells arebeing explored for stroke recovery, Parkinson's
disease, and Alzheimer's, which preliminaryresults showing improved cognitive and motor
functions in animal models.
(12:59):
So this was coming from Frontiers inNeuroscience in 2021.
So there's a lot of research that is behindthis.
And where you wanna focus the use of stem cellsfor tissue and joint healing.
So that's that's where we're going into theregenerative side, and we really wanna dive
into this.
So one of the most exciting frontiers in stemcell therapy is it's in orthopedic and
(13:21):
musculoskeletal conditions.
This is where we see the biggest impact for ourpatients at Alessi Functional Health.
So research shows that mesenchymal stells, alsoknown as MSCs, derived from bone marrow or the
umbilical cord tissue can regenerate damagedcartilage, tendons, and ligaments offering a
naturally minimally invasive alternative tosurgery.
(13:44):
So it's reducing the inflammation.
So joint pain and osteoporosis.
A study published in stem cells translationmedicine in 2019 found that MSC injection
significantly improved pain and function inknee osteoporosis patients with long lasting
effects.
So another thing is tendon injuries.
(14:06):
A lot of tendon injuries, sports relatedinjuries that could date back to high school
days, college days, whatever it might be, butMSCs have shown to promise an accelerated
healing conditions like a rotator cuff andAchilles injury, and that was from the American
Journal of Sports and Medicine in 2020.
So longevity and antiaging.
(14:26):
Stem cells are also being studied for theirrole in promoting tissue repair, reducing
inflammation, and improving overallcardiovascular health.
Key components of longevity and healthy aging.
So MSCs have been found to secrete bioactivemolecules that promote tissue regeneration and
modulate the immune system.
(14:49):
So here in conclusion, understanding thedistinct characteristics and potentials of
these stem cells is fundamental for advancingregenerative medicine and developing novel
therapeutic strategies.
The exciting applications of stem cells andjoint tissue healing combined with their
potential to enhance longevity offer a glimpseinto the future of personalized natural health
(15:12):
care.
So ongoing research continues to unlock theircapabilities, but aiming to translate these
findings into effective clinical applicationsfor the pain free future.
Yeah.
That's right, man.
And like you said, like, old injuries thatcould be that's what we see all the time.
Somebody had something that was from a longtime ago.
Hey.
I got in a car accident ten years ago, and theyhad a cervical sprain or a lumbar sprain plus
(15:37):
some degenerative disc, and now it's snowballedinto severely degenerative spinal condition.
These have applications for restoring thattissue ten years later.
It's amazing.
And so it's like the body's always healing.
The body's always turning over new tissue.
And if you can add to that, right, you can putsome gasoline on the fire.
You're gonna speed that up, obviously.
(15:58):
And so, you know, there's, you know, there'ssignificant advancements being made in this
field, and that's kind of, you know, the nextlittle little piece we wanna talk about here.
And, you know, some of this applies to whatwe're we're doing and some of this doesn't, but
either way, there's some really cool studiesbeing done specifically, like, one is is and I
wanted to highlight this.
A phase one trial showed the safety of stemcells in treating vision loss from a condition
(16:22):
called retinitis pigmentosa, basically wherethe the the retina starts to get kind of worn
and degenerative over time.
And so people are losing their vision or thevision's becoming less effective.
This can restore that.
So it's pretty amazing what they're doing, andthis was from the journal stem cells,
translational medicine in 2021.
Another really cool one was, Australianscientists conducting a world first trial
(16:47):
aiming to restore movement in paralyzedpatients by implement implanting their own stem
cells into injury sites within the spinal cord.
And so this came from the Lancet of neurologyjust couple years ago in 2023, and it suggests
that patients had regained partial motorfunction, improved quality of life from these,
stem cells.
And so the cool thing, man, is, like, what ison the horizon and really kinda like what the
(17:11):
market and and patient outcomes can are arecoming from this.
And so the global stem cell market is projectedto grow from 18,900,000,000.0 in 2024 to
54,700,000,000.0 in 2033, which is a growthrate of about 12.6%.
And this is according to Grand View Research in2024.
(17:31):
And this growth is driven by, obviously,increased investment into regenerative
medicine, but also the rising prevalence ofchronic disease.
Right?
And then the advancement in in the need fordifferent technologies.
So the patient success rates that that we canexpect preliminary data from clinics, like DVC
(17:53):
STEM suggest that approximately eighty sevenpoint five percent of patients have report
sustained improvements within three months oftherapy.
And that's amazing, I mean, especially with themesenchymal based therapies.
And this led to significant pain reduction andfunctional improvement in seventy eight percent
of osteoarthritis patients.
That is a huge number and very exciting for us.
(18:14):
Right?
And we already get amazing outcomes with ourpatients, but the limited few that we maybe are
are are hitting kind of a wall with, this willbe able to then obviously take them to the next
level.
And so these findings really highlight thattransformative potential that stem cell therapy
has in regenerative medicine and the promisingfuture for patient outcomes as well.
(18:35):
And so we we discussed in a previous episodehow the incorporation of stem cell therapy
along with our natural and alternative healingmodalities is really gonna amplify the results
that we can achieve with our patients, helpingthem to avoid things like spinal surgery and
recurrent steroid injections and ultimatelywhat's called pain management, which is
managing someone's pain and symptoms for a longtime.
(18:58):
Right?
And we do the opposite in our clinic.
We want to get people back to health andultimately live in that pain free future.
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(20:27):
I think these are some of the crucial things totalk about, and then this going coincides with
our interpretation of what the legality comesfrom.
So we wanna always consider the ethicalconsiderations, for our patients and then also
the regulatory landscape.
Whether it might be it might be one of thosescenarios where, they're wrong.
(20:48):
Right?
The FDA seems it seems to be wrong a lot oftimes.
But we wanna make sure we're in a regulatorylandscape that coincides, with how we're
treating our patients.
Right?
So, of course, with anything of this nature,there's an ethical debate all the time.
And the use of stem cells ensuring therapiesare done in the right way, that is not harmful
(21:11):
or unethical.
So let's dive a little bit into the embryonicstem cells, such as the controversy over
destroying embryos for research purposes andthe legal restrictions in many countries right
now.
So there's a lot of unregulated clinics outthere.
Right?
So you definitely need a deep dive and do yourown research.
(21:34):
And there's a fine line between offeringcutting edge therapies and preying on desperate
people.
So too many of our clinics too many of theclinics out there make big promises without
delivering those results.
What frustrates me is when these places chargetens of thousand dollars for treatments that
have zero clinical backing.
So LSE Functional Health, our priority is topractice with integrity always, only offering
(21:58):
treatments backed by solid science.
That's why we have Health Dakota, and we bringyou what is science backed.
Right?
If we can't stand behind it 100%, we won'toffer it.
Simple as that.
So clinics in The US and abroad offerunapproved therapies for 10 to $15,000 often
with no scientific backing.
(22:19):
Talked about a few where they're diluting someof their stem cell production.
We wanna make sure they're hyper focused andthey're gonna get to that pain free future.
That's why people are taking stem cells forthat regenerative therapy.
So the AFDA issued a warning in 2021 againstunproven stem cell treatments.
And, only 29% of the stem cells advertisedonline had supporting clinical evidence, and
(22:44):
that was according to JAMA in the 2021, whichis why we partner with a company that provides
the highest biologically available stem cellsthat have been researched for purity and
delivered at a cost that is feasible for ourpatients.
So that is one thing to note.
Right now, where we're in the realm of researchwith stem cells, these aren't covered by
(23:08):
insurance.
Right?
Insurance typically is going to be morereactive care than it is proactive care.
So this is really taking you taking your bodyand your health very seriously when you're when
you're willing to explore these opportunitiesof what's step cells might, do for you.
So patient safety is paramount, and we alwaysstress the importance of informed consent that
(23:29):
our patients know that they're what they arereceiving and verify their credentials as well
as published outcomes.
Yeah.
That's huge, man.
And, you know, this is a statement I'm about tosay that maybe gets our show banned.
But but it's like, insurance wants people tostay in a moderately sick condition because
that's how they can profit off of them.
And what I tell every single patient who asksthese insurance questions, like, why is
(23:53):
insurance not cover alternative?
That kind of stuff.
I'm like, your number one insurance isultimately, like, knowing what your body is
doing and and and making those proactivechoices.
Right?
Eating healthy, exercising, moving, gettingadequate sleep.
That is your insurance.
Right?
That is your insurance against chronic disease.
Right?
You don't need a company, a multimillionbillion dollar company who's, you know, taking
(24:16):
money from people all the time to tell you, youknow, how to stay healthy.
Right?
And they don't ultimately do that anyway.
So your number one insurance is be your ownadvocate.
And then, obviously, emergencies happen andstuff like that.
So having backup is cool, but I think I'm gonnachallenge listeners to think a little bit
differently about what health insurance is.
(24:37):
Right?
It shouldn't be, oh, if my health insurancecovers it, I can do it.
You you you shouldn't think that way becauseyou're gonna limit yourself to a box of, like,
now I only do things when somebody tells mewhat I can do, and I'm not thinking
proactively.
I'm thinking reactively like you said, versus,okay, the health insurance is there as a backup
if I get into a major accident or somethingcatastrophic happens.
(25:00):
But I am being proactive about my health,eating healthy, moving, and doing all the
things to focus on longevity that then I needthe insurance less.
Right?
And full transparency here, I don't use healthinsurance.
I don't have it.
My health insurance is the way that I operate,and I have I focus on maintaining some
supplemental income for the back end of that ifsomething were to happen.
(25:20):
Right?
But that's just a state of of where I'm atright now.
I'm not telling people to do that.
I'm not advocating that.
I'm just saying that that's it take a differentapproach to how we think about things and
ultimately be your own health insurance first.
Right?
And so, you know, to to kinda, like, summarizeon this, man, like, the the the the clinic that
we partnered with and that we're gonna beproviding these stem cells from, they are, I
(25:44):
mean, hands down, probably some of the bestpeople we've ever met.
They're just, like, all they care about is,like, okay.
What is the patient outcome?
Right?
What is what is gonna benefit the person, notus?
And and so we're able to get, like, a a reallygood kind of financial, cost breakdown for our
patients, something that can be affordable andultimately get them the outcomes that they
don't have to feel like they're, you know,going crazy out of pocket and that thing.
(26:08):
And also the the stem cells that they use, Imean, I was just going through the research and
and all the the literature that they providedfor us.
Hands down, the best that you can get in thiscountry, you know, and probably in the world if
if anything because they're using stem cellsthat are not altered.
A lot of these these companies like you hadjust mentioned are going to dilute and expand
(26:30):
the cells.
So when they expand the cell, the cellenlarges, it makes it look like there's more,
but there's actually less.
They're just expanded versus they useunexpanded, and so the cells are in their
natural state.
They're gonna be more effective, and they'regonna go to the place that need to be and
actually get the job done.
So, you know, that's important to us.
It's like we don't want to skim, but we wedon't wanna use a watered down product.
(26:55):
Right?
So making sure we're delivering the highestpotentially valuable, product that we can for
our patients because that's all we care about.
So, you know, in summary, really, to what wetalked about, stem cell therapy holds
significant promise, but requires some cautiousoptimism as well.
Right?
Making sure you're you're doing the rightresearch behind what kind of product you're
(27:17):
putting into your body and using a a providerthat cares about you, not just their their
wallet.
And so making sure we're consulting qualifiedhealth care professionals before we consider
this.
What are the options?
Is this right for me?
All of that.
And so, you know, may making sure we're stayinginformed.
Yeah.
We always wanna stay informed, stay up to datewith the latest research.
(27:38):
That's why listening to this podcast is gonnahelp, when you wanna stay informed about the
latest trends and activities of what it meansfor your health.
So stem cell therapy, you know, holdsincredible potential, but it's not a magic
bullet.
It's up to you.
Right?
You have to use, the stem cells, actively.
(27:58):
Where stem cells gonna are gonna get the mostproduction is when you're exercising, when
you're doing the maintenance in terms of yourstructural imbalances and a lot realigning
those.
Right?
Then your body's kinetically fueling that.
Your cardiovascular system's able to pumpfreely, and you'll be able to tune with your
central nervous system.
So those are important things.
And as always, we seek out ethical providerswho prioritize patient safety and evidence
(28:22):
based care.
As always, if you're enjoying this podcast,please like, subscribe, and share the show with
anyone who's considering alternative treatmentsand wants to stay ahead of the curve and help
the health of science.
Great word, man.
And as always, head over to Alessifxhealth.com.
(28:42):
Sign up for our newsletter.
This is gonna keep you informed on everythingthat we're doing, the latest and greatest in
natural health care and regenerative medicine.
You can also explore more of our resources onthat page as well, and send any questions you
have to ask at alesi f x health dot com.
We would love to answer them and highlightthose on a future episode for you to keep you
(29:03):
informed and keep you knowledgeable on thissubject.
As always, stay curious, stay empowered, andremember that your health is in your hands.
Thank you for tuning in to Health Decoded,where we break down the truth about all things
health and empower you to take charge of yourwell-being.
If you found value in today's episode, pleasesubscribe, leave a review, and share it with
(29:28):
someone who needs to hear this.
For more resources and personalized support,visit us at Alessifunctionalhealth.com and sign
up for our newsletter.
To hear your questions answered live on theshow, send them to ask@Alessifxhealth.com.
That's ask@alessifxhealth.com.
(29:49):
Until next time.
Stay curious, stay empowered, and remember,your health is in your hands.
Stem cells and what's the future of thismedicine, or is it just hype?
Intermittal therapies using stem cells arebeing explored for stroke recovery, Parkinson's
disease, and Alzheimer's.
Honestly, this is groundbreaking because it'sit's allowed for more avenues in personalized
medicine.
The the applications for this are usually indisease modeling, drug discovery, and and
(00:21):
there's a lot of promise for using these forcell therapy as well, potentially reducing,
like, immune rejection risks.
Welcome to Health Decoded, your number onesource for real health information with your
host, doctor Alessi and Matt Tack.
Welcome back to another episode of HealthDecoded.
(00:43):
I am your host, doctor Alfred Alessi.
And the co host, Matt Tac.
Matt Tac, my guy.
Well, welcome back.
Today, we're gonna explore some cutting edgehealth and wellness topics, specifically diving
into the world of stem cell therapy.
We really wanna separate what's fact, what'sfiction, and kind of explore the potential, for
(01:05):
stem cells in functional medicine.
Yeah.
And we also wanna highlight some growinginterest and debates surrounding stem cell
treatments.
Are they the magical bullet for radical healingtransformation or setting the stage for an
in-depth discussion?
We're excited to talk about it.
I'm excited to talk about it.
This is something that we've been trying topilot for a while and really just kind of, I
(01:30):
wanna say, like, organically came upon arelationship with, with a clinic who offers
this and that we have, you know, partneredwith.
And it just it feels like it was kinda meantto, elaborate and kinda come into this
fruition.
So, how you doing, man?
First off, how are you?
I'm doing fantastic.
(01:52):
Had a little bit of an issue last night.
You know what?
It it it's funny.
You try to optimize your sleep, and sometimesyou have, sleep interruptions.
You know?
So I'm figuring that out right now.
I've had a few sleep interruptions.
So Yeah.
But overall, doing good, man.
How about yourself?
I'm doing good.
Are you tracking your sleep in with anything?
Or
I need to get back to that.
(02:12):
So I was using the Whoop Band.
Yeah.
But I am gonna go over to the Oura.
It's just something that I think I can sleepwith.
I usually don't sleep with, like, variousthings, like, on my end.
Yeah.
But I feel like, data in general, gets it I Ithink the Oura is probably some of the best
(02:32):
value in terms of data feedback, that you canget, with it being on your with it being on
your ring, but not imposing you.
You know?
Your wrist tend to, like if you wear somethingon your wrist at night Yeah.
I feel like it it poses you a little bit more.
So, I'm gonna try out the Oura ring.
Yeah.
How about yourself?
I mean, yeah, I'm wearing the Garmin, and it'sit's nice because it's a seven day, eight day
(02:55):
life on the battery, so I do wear it to sleep.
I don't it doesn't bother me too much.
I can definitely feel it, but, I have I likethe tracking because I've noticed that if I can
get a cold shower or do, like, a cold plunge,like, later in the day, my deep sleep is, like
it's almost, like, 1.5 x.
Like, I'm getting another hour of deep sleep atnight.
(03:16):
It's awesome.
So I've definitely seen that correlation aswell as, like, the nights where I get home late
and I don't have dinner till, like, 8PM.
You know, those nights where we're at theclinic late or something, that's affecting my
deep sleep so that I'm getting less deep sleepand less REM.
And more than likely because my body's, youknow, still kind of metabolically processing
that that meal.
I've I've switched from, like, a meal to just,like, doing a big smoothie instead so it at at
(03:40):
least digest a little quicker.
But, again, man, it's like data.
Like, knowing, like, wow.
Those things are affecting my sleep.
That's why I'm waking up the next day feelinglike a little, weird.
But last night, I played I played lacrosseuntil, like, 08:30 at night.
So my you know, everything's burnt, like, realhot.
But then I came home and I did a real, like,real cold shower before bed, and I got amazing
(04:01):
deep sleep last night.
So, you know, little hacks that you canimplement to obviously kind of make sure you're
not disrupting that sleep pattern.
Yeah.
That was something we had something going onlast night, and I told you, like, I wanted to
go hit the gym and workout.
But then I kept getting later and later.
And I'm like, if I accelerate my heart rate,like, at Yeah.
08:30 at night, it's not something I wanna dofor my sleep.
(04:24):
So I, like, chose not to work out last night.
But, those are things that I think about interms of, like, how late do you typically work
out because we're usually those, you know,midday guys, lunch hour, get in there, get out.
So, you know, that that's something I thinkabout as well.
It's just like, how do you how do you kindamodify your heart rate to prepare for sleep?
(04:44):
That's a good word.
That's right.
Yeah.
Accelerating it either early or midday, butnot, like, later than 4PM or 5PM.
You know?
That's good.
Obviously, if that's the only time you have toexercise, then you'd make it work.
But Yeah.
Make it work.
Taking a day off every now and then when workguys who are there five, six days a week is not
gonna kill you.
You know?
It's not gonna That's right.
It's not gonna derail your results.
(05:05):
But That's Cool, man.
Well, that's good, brother.
Well, sorry you didn't get the best sleep, butlet's, let's let's provide value here, man.
That's the goal with this podcast.
So we wanna thank you guys for tuning in.
As always, we really wanna just separate whatis what is real and what's, you know, maybe
some fluff information.
And so everything we talk about, we do a littlebit of research into.
We get some studies around kind of theinformation.
(05:27):
That way, you know, we're on top of it.
And these you know, we're not going back twentyyears for these studies either.
We're we're we're sticking, like, you know,very recent within the last five years.
Right?
Stuff that's relevant and stuff that has somemerit to it.
So, you know, today, we're gonna talk aboutstem cell therapy and what does regenerative
medicine look like and kind of the emergingworld of this because it is relatively on the
(05:49):
forefront.
And, you know, like anything, the FDA has theirhands in it, and they control a lot of it.
And so there's, like, what is FDA approved, andthen there's, like, what is available, and then
there's, like, what is out there.
Right?
And so, you know, there's if if you go, you canfind, right, you can find whatever you need if
you go certain places.
So we're gonna kinda get into that.
(06:10):
But first off, we wanna obviously give a littlebackground, like, what are stem cells for for
people, listeners who may not even know whatthis is.
And so stem cells are amazing because they areunique cells with the ability to self renew,
and they can differentiate into whatever theyneed to be.
So, basically, the term is undifferentiated.
So then as soon as they get into the body oryour body technically has them within the bone
(06:34):
marrow, it's gonna use them where needed.
Right?
You injure your your soft tissue muscle tendon,it's gonna become tendon.
You have, a disorder with the the vasculature,it's gonna become artery tissue.
Right?
And so this dual capacity allows them to play acrucial role in the body's repair and
maintenance systems.
They can develop into many different cell typesin the body, especially during early life and
(06:56):
growth.
So at young ages, the body is producing massamounts of stem cells to build you and to
create that new tissue.
And so there's really four types that thatyou're gonna hear about or or see or that are
available, I should say.
And so let's just touch on those real quick.
So kind of the most popular is, like, embryonicstem cells.
Now these are derived from early stage embryos,specifically the inner cell mass of a
(07:21):
blastocyst, which is typically around five dayspost fertilization.
And so these are pluripotent, meaning that theycan differentiate into all cell types of the
adult body.
This characteristic makes them invaluable fordevelopmental studies and potential therapeutic
applications.
So due to this versatility, ESCs areextensively used in research to understand
(07:44):
early human development, and they're beingexplored as regenerative medicine.
The next type is adult stem cells or what wewould call somatic or tissue specific stem
cells.
So these are located in various tissuesthroughout the body, such as bone marrow
primarily, as well as the brain and the liver.
So they remain in a what's called a quiescentstate until they are activated during some type
(08:10):
of disease or tissue injury or inflammation.
So unlike embryonic stem cells, adult stemcells are are typically multipotent, meaning
they can differentiate, but only into a limitedtype of cell.
So, for example, like a hematopoietic stem cellin the marrow can become various blood cells,
but it's not gonna become a neural cell or a ora muscle cell.
(08:34):
Right?
And so applications for these are currentlyused in treatments like bone marrow transplants
for leukemia patients.
Research is ongoing to expand the therapeuticpotential for these as well for other things.
The next type is what we call inducedpluripotent stem cells.
So these are actually generated byreprogramming the adult somatic cells, such as
(08:57):
skin fibroblast to then an embryonic stem cellstate, through the induction of specific genes.
So these are a little bit more modified.
Right?
And so these exhibit that pluripotency, whichis similar to the embryonic, allowing them to
differentiate into any cell type.
And, honestly, this is groundbreaking becauseit's it's allowed for more avenues in
(09:18):
personalized medicine.
And, you know, the the applications for thisare usually in disease modeling, drug
discovery, and and there's a lot of promisefor, using these for cell therapy as well,
potentially reducing, like, immune rejectionrisks.
Right?
When you put something into the body, is thebody gonna accept it or reject it?
That's always something to consider.
(09:39):
And then the final form is the mesenchymal stemcells, and these are found in various tissues
including bone marrow, adipose tissue, andumbilical cord tissue.
And these are multipotent as well, so they candifferentiate into bone, cartilage, muscle, and
fat cells, and they actually do have animmunomodulatory and anti inflammatory
(10:01):
property.
So it's very important.
These are mostly the type of stem cells that wekind of work with within our kind of
boundaries, and would focus on.
And so they're widely studied for theregenerative capabilities as well, specifically
in things like orthopedic injuries, autoimmunedisease, cardiovascular conditions, and they're
(10:21):
currently being used in clinical applicationsas regenerative medicine for treating
osteoarthritis, degenerative disc or jointdisease, and tissue healing.
And so these have, you know, vast, applicationsfor longevity as well.
And so, you know, within personalized medicine,which we talk about a lot, which is where we
can just kind of do you know, explore theboundaries of what our body can do, these have
(10:45):
a great, tremendous, use.
So, you know, understanding the distinctcharacteristics and potentials of each type is
fundamental for how we advance this thisregenerative medicine, you know, field.
And so developing different therapeuticstrategies.
And then, you know, the research is ongoing tocontinue to unlock these capabilities aiming to
(11:06):
translate these findings into effectiveclinical applications, down the line.
So that's, you know, that's just the differenttypes of stem cells that are out there and,
that you can see obviously being researched,but then also now being applied to different
treatments.
Yeah.
And there's many different applications of stemcell therapy, and I'm just gonna dive into a
(11:27):
few here.
So the FDA has approved, stem cell treatments,and these are the ones.
So the most widely used and FDA approved stemcell therapies is hematopoietic.
So stem cell transplantation, it's also knownas HSCT, primarily used to treat blood
disorders such as leukemia, lymphoma, andcertain immune system deficiencies.
(11:50):
This therapy involves transplanting healthyhematopoietic stem cells from the bone marrow
or peripheral blood to replace damaged ordiseased cells.
Emerging applications in regenerative medicine,research in stem cells is rapidly expanding as
Alfred doctor Alfred said, showing promise in avariety of chronic and degenerative conditions.
(12:15):
As mentioned before, the number one beingcardiovascular disease.
Studies suggest that stem cells could helpgenerate heart tissue after myocardial
infarction, which is a heart attack.
Early trials indicate that mesenchymal stemcells, also known as SMCs, may improve heart
function and reduce scar tissue.
That was from the Journal of American Collegeof Cardiology in 2020.
(12:39):
So stem cells and what's the future of thismedicine, or is it just hype?
So neurological disorders.
Experimental therapies using stem cells arebeing explored for stroke recovery, Parkinson's
disease, and Alzheimer's, which preliminaryresults showing improved cognitive and motor
functions in animal models.
(12:59):
So this was coming from Frontiers inNeuroscience in 2021.
So there's a lot of research that is behindthis.
And where you wanna focus the use of stem cellsfor tissue and joint healing.
So that's that's where we're going into theregenerative side, and we really wanna dive
into this.
So one of the most exciting frontiers in stemcell therapy is it's in orthopedic and
(13:21):
musculoskeletal conditions.
This is where we see the biggest impact for ourpatients at Alessi Functional Health.
So research shows that mesenchymal stells, alsoknown as MSCs, derived from bone marrow or the
umbilical cord tissue can regenerate damagedcartilage, tendons, and ligaments offering a
naturally minimally invasive alternative tosurgery.
(13:44):
So it's reducing the inflammation.
So joint pain and osteoporosis.
A study published in stem cells translationmedicine in 2019 found that MSC injection
significantly improved pain and function inknee osteoporosis patients with long lasting
effects.
So another thing is tendon injuries.
(14:06):
A lot of tendon injuries, sports relatedinjuries that could date back to high school
days, college days, whatever it might be, butMSCs have shown to promise an accelerated
healing conditions like a rotator cuff andAchilles injury, and that was from the American
Journal of Sports and Medicine in 2020.
So longevity and antiaging.
(14:26):
Stem cells are also being studied for theirrole in promoting tissue repair, reducing
inflammation, and improving overallcardiovascular health.
Key components of longevity and healthy aging.
So MSCs have been found to secrete bioactivemolecules that promote tissue regeneration and
modulate the immune system.
(14:49):
So here in conclusion, understanding thedistinct characteristics and potentials of
these stem cells is fundamental for advancingregenerative medicine and developing novel
therapeutic strategies.
The exciting applications of stem cells andjoint tissue healing combined with their
potential to enhance longevity offer a glimpseinto the future of personalized natural health
(15:12):
care.
So ongoing research continues to unlock theircapabilities, but aiming to translate these
findings into effective clinical applicationsfor the pain free future.
Yeah.
That's right, man.
And like you said, like, old injuries thatcould be that's what we see all the time.
Somebody had something that was from a longtime ago.
Hey.
I got in a car accident ten years ago, and theyhad a cervical sprain or a lumbar sprain plus
(15:37):
some degenerative disc, and now it's snowballedinto severely degenerative spinal condition.
These have applications for restoring thattissue ten years later.
It's amazing.
And so it's like the body's always healing.
The body's always turning over new tissue.
And if you can add to that, right, you can putsome gasoline on the fire.
You're gonna speed that up, obviously.
(15:58):
And so, you know, there's, you know, there'ssignificant advancements being made in this
field, and that's kind of, you know, the nextlittle little piece we wanna talk about here.
And, you know, some of this applies to whatwe're we're doing and some of this doesn't, but
either way, there's some really cool studiesbeing done specifically, like, one is is and I
wanted to highlight this.
A phase one trial showed the safety of stemcells in treating vision loss from a condition
(16:22):
called retinitis pigmentosa, basically wherethe the the retina starts to get kind of worn
and degenerative over time.
And so people are losing their vision or thevision's becoming less effective.
This can restore that.
So it's pretty amazing what they're doing, andthis was from the journal stem cells,
translational medicine in 2021.
Another really cool one was, Australianscientists conducting a world first trial
(16:47):
aiming to restore movement in paralyzedpatients by implement implanting their own stem
cells into injury sites within the spinal cord.
And so this came from the Lancet of neurologyjust couple years ago in 2023, and it suggests
that patients had regained partial motorfunction, improved quality of life from these,
stem cells.
And so the cool thing, man, is, like, what ison the horizon and really kinda like what the
(17:11):
market and and patient outcomes can are arecoming from this.
And so the global stem cell market is projectedto grow from 18,900,000,000.0 in 2024 to
54,700,000,000.0 in 2033, which is a growthrate of about 12.6%.
And this is according to Grand View Research in2024.
(17:31):
And this growth is driven by, obviously,increased investment into regenerative
medicine, but also the rising prevalence ofchronic disease.
Right?
And then the advancement in in the need fordifferent technologies.
So the patient success rates that that we canexpect preliminary data from clinics, like DVC
(17:53):
STEM suggest that approximately eighty sevenpoint five percent of patients have report
sustained improvements within three months oftherapy.
And that's amazing, I mean, especially with themesenchymal based therapies.
And this led to significant pain reduction andfunctional improvement in seventy eight percent
of osteoarthritis patients.
That is a huge number and very exciting for us.
(18:14):
Right?
And we already get amazing outcomes with ourpatients, but the limited few that we maybe are
are are hitting kind of a wall with, this willbe able to then obviously take them to the next
level.
And so these findings really highlight thattransformative potential that stem cell therapy
has in regenerative medicine and the promisingfuture for patient outcomes as well.
(18:35):
And so we we discussed in a previous episodehow the incorporation of stem cell therapy
along with our natural and alternative healingmodalities is really gonna amplify the results
that we can achieve with our patients, helpingthem to avoid things like spinal surgery and
recurrent steroid injections and ultimatelywhat's called pain management, which is
managing someone's pain and symptoms for a longtime.
(18:58):
Right?
And we do the opposite in our clinic.
We want to get people back to health andultimately live in that pain free future.
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(20:27):
I think these are some of the crucial things totalk about, and then this going coincides with
our interpretation of what the legality comesfrom.
So we wanna always consider the ethicalconsiderations, for our patients and then also
the regulatory landscape.
Whether it might be it might be one of thosescenarios where, they're wrong.
(20:48):
Right?
The FDA seems it seems to be wrong a lot oftimes.
But we wanna make sure we're in a regulatorylandscape that coincides, with how we're
treating our patients.
Right?
So, of course, with anything of this nature,there's an ethical debate all the time.
And the use of stem cells ensuring therapiesare done in the right way, that is not harmful
(21:11):
or unethical.
So let's dive a little bit into the embryonicstem cells, such as the controversy over
destroying embryos for research purposes andthe legal restrictions in many countries right
now.
So there's a lot of unregulated clinics outthere.
Right?
So you definitely need a deep dive and do yourown research.
(21:34):
And there's a fine line between offeringcutting edge therapies and preying on desperate
people.
So too many of our clinics too many of theclinics out there make big promises without
delivering those results.
What frustrates me is when these places chargetens of thousand dollars for treatments that
have zero clinical backing.
So LSE Functional Health, our priority is topractice with integrity always, only offering
(21:58):
treatments backed by solid science.
That's why we have Health Dakota, and we bringyou what is science backed.
Right?
If we can't stand behind it 100%, we won'toffer it.
Simple as that.
So clinics in The US and abroad offerunapproved therapies for 10 to $15,000 often
with no scientific backing.
(22:19):
Talked about a few where they're diluting someof their stem cell production.
We wanna make sure they're hyper focused andthey're gonna get to that pain free future.
That's why people are taking stem cells forthat regenerative therapy.
So the AFDA issued a warning in 2021 againstunproven stem cell treatments.
And, only 29% of the stem cells advertisedonline had supporting clinical evidence, and
(22:44):
that was according to JAMA in the 2021, whichis why we partner with a company that provides
the highest biologically available stem cellsthat have been researched for purity and
delivered at a cost that is feasible for ourpatients.
So that is one thing to note.
Right now, where we're in the realm of researchwith stem cells, these aren't covered by
(23:08):
insurance.
Right?
Insurance typically is going to be morereactive care than it is proactive care.
So this is really taking you taking your bodyand your health very seriously when you're when
you're willing to explore these opportunitiesof what's step cells might, do for you.
So patient safety is paramount, and we alwaysstress the importance of informed consent that
(23:29):
our patients know that they're what they arereceiving and verify their credentials as well
as published outcomes.
Yeah.
That's huge, man.
And, you know, this is a statement I'm about tosay that maybe gets our show banned.
But but it's like, insurance wants people tostay in a moderately sick condition because
that's how they can profit off of them.
And what I tell every single patient who asksthese insurance questions, like, why is
(23:53):
insurance not cover alternative?
That kind of stuff.
I'm like, your number one insurance isultimately, like, knowing what your body is
doing and and and making those proactivechoices.
Right?
Eating healthy, exercising, moving, gettingadequate sleep.
That is your insurance.
Right?
That is your insurance against chronic disease.
Right?
You don't need a company, a multimillionbillion dollar company who's, you know, taking
(24:16):
money from people all the time to tell you, youknow, how to stay healthy.
Right?
And they don't ultimately do that anyway.
So your number one insurance is be your ownadvocate.
And then, obviously, emergencies happen andstuff like that.
So having backup is cool, but I think I'm gonnachallenge listeners to think a little bit
differently about what health insurance is.
(24:37):
Right?
It shouldn't be, oh, if my health insurancecovers it, I can do it.
You you you shouldn't think that way becauseyou're gonna limit yourself to a box of, like,
now I only do things when somebody tells mewhat I can do, and I'm not thinking
proactively.
I'm thinking reactively like you said, versus,okay, the health insurance is there as a backup
if I get into a major accident or somethingcatastrophic happens.
(25:00):
But I am being proactive about my health,eating healthy, moving, and doing all the
things to focus on longevity that then I needthe insurance less.
Right?
And full transparency here, I don't use healthinsurance.
I don't have it.
My health insurance is the way that I operate,and I have I focus on maintaining some
supplemental income for the back end of that ifsomething were to happen.
(25:20):
Right?
But that's just a state of of where I'm atright now.
I'm not telling people to do that.
I'm not advocating that.
I'm just saying that that's it take a differentapproach to how we think about things and
ultimately be your own health insurance first.
Right?
And so, you know, to to kinda, like, summarizeon this, man, like, the the the the clinic that
we partnered with and that we're gonna beproviding these stem cells from, they are, I
(25:44):
mean, hands down, probably some of the bestpeople we've ever met.
They're just, like, all they care about is,like, okay.
What is the patient outcome?
Right?
What is what is gonna benefit the person, notus?
And and so we're able to get, like, a a reallygood kind of financial, cost breakdown for our
patients, something that can be affordable andultimately get them the outcomes that they
don't have to feel like they're, you know,going crazy out of pocket and that thing.
(26:08):
And also the the stem cells that they use, Imean, I was just going through the research and
and all the the literature that they providedfor us.
Hands down, the best that you can get in thiscountry, you know, and probably in the world if
if anything because they're using stem cellsthat are not altered.
A lot of these these companies like you hadjust mentioned are going to dilute and expand
(26:30):
the cells.
So when they expand the cell, the cellenlarges, it makes it look like there's more,
but there's actually less.
They're just expanded versus they useunexpanded, and so the cells are in their
natural state.
They're gonna be more effective, and they'regonna go to the place that need to be and
actually get the job done.
So, you know, that's important to us.
It's like we don't want to skim, but we wedon't wanna use a watered down product.
(26:55):
Right?
So making sure we're delivering the highestpotentially valuable, product that we can for
our patients because that's all we care about.
So, you know, in summary, really, to what wetalked about, stem cell therapy holds
significant promise, but requires some cautiousoptimism as well.
Right?
Making sure you're you're doing the rightresearch behind what kind of product you're
(27:17):
putting into your body and using a a providerthat cares about you, not just their their
wallet.
And so making sure we're consulting qualifiedhealth care professionals before we consider
this.
What are the options?
Is this right for me?
All of that.
And so, you know, may making sure we're stayinginformed.
Yeah.
We always wanna stay informed, stay up to datewith the latest research.
(27:38):
That's why listening to this podcast is gonnahelp, when you wanna stay informed about the
latest trends and activities of what it meansfor your health.
So stem cell therapy, you know, holdsincredible potential, but it's not a magic
bullet.
It's up to you.
Right?
You have to use, the stem cells, actively.
(27:58):
Where stem cells gonna are gonna get the mostproduction is when you're exercising, when
you're doing the maintenance in terms of yourstructural imbalances and a lot realigning
those.
Right?
Then your body's kinetically fueling that.
Your cardiovascular system's able to pumpfreely, and you'll be able to tune with your
central nervous system.
So those are important things.
And as always, we seek out ethical providerswho prioritize patient safety and evidence
(28:22):
based care.
As always, if you're enjoying this podcast,please like, subscribe, and share the show with
anyone who's considering alternative treatmentsand wants to stay ahead of the curve and help
the health of science.
Great word, man.
And as always, head over to Alessifxhealth.com.
(28:42):
Sign up for our newsletter.
This is gonna keep you informed on everythingthat we're doing, the latest and greatest in
natural health care and regenerative medicine.
You can also explore more of our resources onthat page as well, and send any questions you
have to ask at alesi f x health dot com.
We would love to answer them and highlightthose on a future episode for you to keep you
(29:03):
informed and keep you knowledgeable on thissubject.
As always, stay curious, stay empowered, andremember that your health is in your hands.
Thank you for tuning in to Health Decoded,where we break down the truth about all things
health and empower you to take charge of yourwell-being.
If you found value in today's episode, pleasesubscribe, leave a review, and share it with
(29:28):
someone who needs to hear this.
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