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January 22, 2025 56 mins

In this thought-provoking podcast, Christof Koch, Chief Scientist at the Tiny Blue Dot Foundation and former President of the Allen Institute for Brain Science, delves into one of humanity's most profound questions: What is consciousness, and where does it come from? With decades of experience studying the brain's mysteries, Koch offers insights into why consciousness is central to our existence and why understanding it is so challenging.

Koch explains that consciousness encompasses everything we feel, think, and perceive—it’s the very essence of being. Yet, science struggles to explain how physical processes in the brain give rise to subjective experiences. He discusses historical and modern theories, including Integrated Information Theory (IIT), which posits that consciousness emerges from the brain's complex connectivity and its ability to process information holistically.

The conversation also touches on the ethical implications of artificial intelligence. As machines become more intelligent and capable of mimicking human behavior, Koch cautions that they lack consciousness—the ability to "feel" or "be." This raises concerns about how we interact with increasingly human-like AI and the moral dilemmas of attributing consciousness to machines.

Koch reflects on his collaborations with prominent scientists, including Francis Crick, co-discoverer of DNA's structure, to pioneer the search for the neural correlates of consciousness. He describes groundbreaking experiments and the ongoing quest to map how specific brain regions generate conscious experiences.

The podcast concludes with a discussion of the future—whether AI could ever achieve consciousness and how our understanding of the brain might evolve. Koch’s message is clear: while consciousness remains a mystery, exploring it brings us closer to understanding what it means to be truly human.

Featuring:

Christof Koch, Chief Scientist at the Tiny Blue Dot Foundation and former President of the Allen Institute for Brain Science

Host:

Charles Raison, Psychiatrist, Professor at the University of Wisconsin-Madison and Emory University

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