ICU Ed and Todd-Cast

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Episode 93! In this episode we go over TOWAR or "Prehospital Resuscitation with Type O Whole Blood for Trauma and Hemorrhage" by Sperry et all published in NEJM and "Remote Multicomponent Rehabilitation in Intensive Care Unit Survivors" published by O'Neill et al in JAMA both in May 2026 and presented at the ATS International Conference! Then we talk a little bit ...

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Episode 92! In this episode we talk about "Restrictive vs Liberal Physical Restraint Strategies in Critically Ill Patients" published in JAMA by Sonneville et al April 2026!

R2D2 (pubmed): https://pubmed.ncbi.nlm.nih.gov/41841304/

R2D2 (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2846726

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Episode 91! In this episode we talk about "Dexmedetomidine for treatment of hyperactive delirium in non-intubated ICU patients" published by Godet et al in Intensive Care Medicine October of 2025! We are going to be on a one article per episode kick for a while but hope to get back to normal programming soon!

4D: https://pubmed.ncbi.nlm.nih.gov/41160116/

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Episode 90! In this episode we talk about the 2026 Surviving Sepsis Campaign Guidelines lead by Prescott et all and published in Critical Care Medicine in March of 2026! We review all that's new and all that's changed

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Episode 89! In this episode we talk about HI-PEITHO or catheter directed thrombolysis versus conventional anticoagulation for intermediate risk pulmonary embolism. This was published in the New England Journal of Medicine by Rosenfield et al.

HI-PEITHO: http://nejm.org/doi/full/10.1056/NEJMoa2516567

HI-PEITHO (pubmed): https://pubmed.ncbi.nlm.nih.gov/41910345/

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Episodes 88! In this episode we talk about guidelines recently released for the management of pulmonary embolism and cardiac arrest! A little hap hazard of an episode as we jump around from topic to topic but good to highlight things that are new and things that are changing!

PE: https://pubmed.ncbi.nlm.nih.gov/41712898/

CPR: https://pubmed.ncbi.nlm.nih.gov/41122893...

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Episode 87! In this episode we talk about Albumin with two related studies, ALBIOS ("Albumin replacement in patients with severe sepsis or septic shock" by Caironi et al) and ARISS ("Albumin Replacement Therapy in Septic Shock" by Sakr et al)

ALBIOS: https://pubmed.ncbi.nlm.nih.gov/24635772/

ARISS: https://pubmed.ncbi.nlm.nih.gov/41712212/

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Episode 86! In this episode we talk about endotracheal tubes or "Hospital and long-term outcomes for subglottic suction and polyurethane cuff versus standard endotracheal tubes in emergency intubation" published in Lancet Respiratory Medicine February 2026 by Treggiari et al.

Pubmed: https://pubmed.ncbi.nlm.nih.gov/41319662/

LRM: https://www.thelancet.com/journals/l...

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Episode 85! In this episode we go over LIBERATE-D or "A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury" by Liu et al in JAMA 2026. We have the second author, Eddie Siew, on with us to discuss!

LIBERATE-D (pubmed): https://pubmed.ncbi.nlm.nih.gov/41201895/

LIBERATE-D (JAMA): https://jamanetwork.com/journals/jama/...

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Episode 84! In this episode we finish up our discussion of the articles presented with the CCR Down Under Conference with ACTiVE (close loop ventilation) and CLIP2 (cryopreserved platelets for surgical bleeding). Both are neutral trials at best, so we took them both pretty short.

ACTiVE: https://pubmed.ncbi.nlm.nih.gov/41361939/

ACTiVE (JAMA): https://jamanetwork.co...

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Episode 83! Only one article this episode since Todd is feeling a little under the weather, but still a good discussion!

ImmunoSep (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2842634

ImmunoSep (pubmed): https://pubmed.ncbi.nlm.nih.gov/41359996/

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Back by popular demand, year in review! Or probably better titled "Our Favorite Articles of the Year" but I kept the title from last year. A smattering of papers and topics in this one ranging from avalanche survival, to intubation, to cardiac resuscitation and more. 

Happy New Year everyone! We will see you in 2026, thanks for listening and spending sometime ...

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Episode 81! In this episode we talk to Yonathan Fruend the senior author on the MODS study looking at a single questions approach to ruling out pulmonary embolism in the emergency department. This is not our typical patient population but this is a good episode, don't miss this one!

MODS: https://pubmed.ncbi.nlm.nih.gov/41135553/

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We start our Critical Care Reviews Down Under coverage with RSI talking with the first author of the "Ketamine versus Etomidate for Adults Receiving Emergency Endotrachael Intubation", Jonathan Casey! We will pick up the rest of our CCR Down Under Coverage after the holiday break!

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Episode 79! We talk all about perfusion with arterial lines in EVERDAC and personalized resuscitation with ANDROMEDA SHOCK 2! 

EVERDAC: https://pubmed.ncbi.nlm.nih.gov/41159885/

EVERDAC (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2502136

ANDROMEDA SHOCK 2: https://pubmed.ncbi.nlm.nih.gov/41159835/

ANDROMEDA SHOCK 2(JAMA): https://jamanetwork.com/journals/jama/...

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Episode 78! We start our discussion of the trials that drop with ESICM with the much anticipated BICAR-ICU 2! Then we talk briefly about some changes to the SOFA score with the new SOFA-2 score. 

BICAR-ICU2: https://pubmed.ncbi.nlm.nih.gov/41159812/

BICAR-ICU 2 (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2840824

SOFA-2: https://pubmed.ncbi.nlm.nih....

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Episode 77! We will start on ESICM coverage next episode. In this episode we talk about WFIT or "A Randomized Controlled Trial of a Post-ICU Telehealth Care Model" by Bakhru et al published in the blue journal September 2025! A long discussion but a good one!

WFIT: https://pubmed.ncbi.nlm.nih.gov/40532205/

Editorial: https://pubmed.ncbi.nlm.nih.gov/40700738/

ICU Reco...

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We were LIVE from the CHEST Annual Meeting 2025! Thanks to everyone who came out and stuck around to chat afterwards. We cover a lot of ground including some conference and Chicago related banter (~8 minutes if you wanted to skip to the learning!)

High frequency oscillation: https://pubmed.ncbi.nlm.nih.gov/40983167/

MELLOW: https://pubmed.ncbi.nlm.nih.gov/39800236/

C...

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Episode 75! We talk about melatonin! We highlight MELLOW because it has the best acronym (by Burry et al in CHEST 2025). Then we dive into our mailbag!

MELLOW: https://pubmed.ncbi.nlm.nih.gov/39800236/

DEMEL: https://pubmed.ncbi.nlm.nih.gov/40608082/

Meta-analysis: https://pubmed.ncbi.nlm.nih.gov/40662882/

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