June 11, 2024 • 29 mins
Unlock the secrets to the body's second "miracle molecule," glutathione, in this eye-opening episode of Inflammation Nation. Ever wondered how antioxidants can help protect your cells from inflammation and oxidative stress? We promise you’ll leave understanding the sophisticated system your body uses to produce and recycle glutathione, and the pivotal roles amino acids like cysteine and glycine play. If you're a vegan or vegetarian, find out why meeting your protein needs is essential and how you can overcome the unique challenges of plant-based diets.
We'll demystify the complex relationship between oxidative stress, glutathione, and the integrity of your gut and brain barriers. Learn how maintaining optimal intracellular glutathione levels can prevent barrier breakdowns that lead to chronic conditions and autoimmunities. We cover vital lab tests such as Cyrix Labs Array 2 and Vibrant Labs Neural Zoomer, which can identify potential issues like leaky gut and leaky brain. Furthermore, discover the importance of immune system balance, especially the role of regulatory T cells and how their function relies on both glutathione and vitamin D. You'll also get practical advice on monitoring your glutathione status through GGT levels in blood tests.
Ready to boost your glutathione levels? We'll guide you through the most effective methods, from direct supplementation with acetylated and liposomal forms to the benefits of whey protein, N-acetylcysteine, glycine, and high-dose omega-3 fish oil. But that’s not all—personalized healthcare is key, and we delve into the importance of tailored lab tests and coaching programs. Explore how diet and lifestyle modifications can naturally support your health and wellness. Tune in for actionable insights and personalized strategies to elevate your health journey!
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Transcript
Episode Transcript
Available transcripts are automatically generated. Complete accuracy is not guaranteed.
Speaker 1 (00:02):
Hey everyone, welcome to the Inflammation Nation
podcast.
I'm your host, Dr SteveNoseberg.
Speaker 2 (00:08):
One of the greatest obstacles to crafting health and
wellness is identifying andcontrolling inflammation.
It's at the core of all complexand chronic diseases and it's
the driving mechanism thatunderlies the most common
symptoms that people like youstruggle to overcome.
Join us as we explore cuttingedge science and research to
give you the information andtools you need to create the
(00:28):
quality of life you want anddeserve.
And now here is the host ofInflammation Nation, dr Stephen
Nosworthy.
Speaker 1 (00:36):
Hey guys, welcome back to the podcast.
This is part two of our talkabout glutathione as another
miracle molecule.
In that last episode we justdid, I introduced glutathione as
my second miracle molecule andI shared that this is a
tripeptide molecule made up ofcysteine, glutamine and glycine,
(00:57):
all complex together, and wetalked about the primary role
that glutathione plays in yourbody, which is, as your major
antioxidant, the thing thatprotects your cells from
inflammation and from oxidativestress, also mentioned that your
liver makes and stores most ofthe glutathione in your body and
there's a balance between thelevels and storage what's in
(01:20):
circulation and what's inside ofyour cells.
And I also shared how not onlycan we make glutathione as
needed, we also have a way torecycle glutathione that has
already been used so that,essentially, we can reconstitute
it and use it over and overagain.
And the process of making andrecycling glutathione is
(01:40):
governed by the activity of aset of different enzymes, which
themselves are governed by thelevel of oxidative stress that
we have, and this is all part ofthe intelligent design of the
human body.
And how amazing is it that wehave a system designed to sense
when we have increased oxidativestress or when that gets too
(02:01):
high and responds to that byincreasing the production and
the recycling of glutathione,and that's pretty amazing, at
least I think so.
I also mentioned one specificenzyme last time, and that is
GGT.
And again, it's usually onlyordered on blood labs by your
medical doctor when they suspectthat you have gallbladder
(02:21):
disease, perhaps if they thinkyou're an alcoholic.
But the medical literatureshows many different studies
where we can use GGT levels as apotential marker for low
glutathione and hence the needto support that.
Now one more thing about theamino acids that make up
glutathione, before we talkabout some of the other roles
(02:42):
that it plays outside ofcontrolling oxidative stress.
If you remember, in theepisodes on nitric oxide, our
first miracle molecule, I talkedabout this thing called BH4 or
tetrahydrobiopterin as the ratelimiter for nitric oxide
production.
And this idea of a rate limiteris not unique to nitric oxide.
(03:04):
Pretty much every other systemin the human body has some kind
of a rate limiter is not uniqueto nitric oxide.
Pretty much every other systemin the human body has some kind
of a rate limiter, Otherwisefunction would get out of
control.
And for glutathione it turns outthat the levels and
availability of predominantlycysteine, but also glycine, two
of the three different aminoacids that make up glutathione.
Those levels determine how muchglutathione you make.
(03:26):
And where do thoserate-limiting amino acids come
from?
They come from the protein inyour diet.
So low protein intake ingeneral can reduce the
availability of these rawmaterials cysteine and glycine
that you can pull from to makemore glutathione, and if that
happens, then you won't be ableto neutralize even the typical
(03:49):
oxidative stress of just simplybeing alive and being
metabolically active, let alonethe increased oxidative stress
that comes from having varioushealth issues.
Now, I've talked a lot aboutdiet in this podcast.
I've talked about the pros andcons of different diet
approaches, and you know I makeno secret of the fact that I'm
not a huge fan of vegan dietsand I've gone through my
(04:11):
arguments about that in otherepisodes.
But one thing that we can addto the list is that since
plant-based protein sources areinherently low in both cysteine
and glycine inherently low inboth cysteine and glycine then
as a general rule, vegans andvegetarians or even omnivores on
a low protein intake they bydefault tend to have low
(04:33):
capacity to make glutathione ifwe compare them to people who
eat plenty of animal proteins.
And that's just the fact, andthis has been demonstrated in
multiple studies.
So, as a quick reminder,optimal protein intake is based
on your muscle mass, the type ofactivity you engage in.
So the more muscle you have andthe harder you use them, the
(04:56):
more protein you need.
And since we're all differentin size and activities, the
optimal range of protein intakeit's not a single number.
And activities the optimalrange of protein intake it's not
a single number.
It's somewhere between 0.6 and1.0 grams of protein per pound
of body weight.
And, as a general rule, if youhave more than 30 pounds of
excess body weight that you wantto lose, it's best to calculate
(05:17):
your protein intake needs notoff your current weight, but off
the weight that you feel likeyou should be, like your ideal
body weight.
Now the good news is that takingboth glycine and cysteine,
either separately or together,can increase your chance of
making glutathione enoughglutathione to offset your
(05:38):
oxidative stress.
So, again, as a general rule,number one, you need to be
eating adequate proteinthroughout the day, every day,
to make sure that you optimizemany health and longevity
factors, including your abilityto make glutathione to serve in
its many roles, and in somecases you may want or perhaps
need to supplement.
But here's a caveat Before youstart supplementing, make sure
(06:02):
you're eating enough protein.
That's probably the easiest andactually the most
cost-effective thing to do.
Remember that supplements aresupplements.
They are added to or inaddition to your base strategy
of eating well and moving well.
Those should be your twopriorities eat well and move
well.
So, having said all that, whatare the other rules of
(06:24):
glutathione?
Well, let's take them one byone.
This is not going to beexhausted.
I'm just going to hit somepoints of the most common roles
that glutathione serves.
So, first of all, glutathioneplays an integral role in two
different aspects ofdetoxification, or what might be
more technically termed asbiotransformation, but I'm just
(06:45):
going to use the word detoxbecause that's the word everyone
use.
So the first role indetoxification is actually in
what we call the second phase,or phase two, of liver detox.
Now, I've gone through thisagain before in other episodes
and I actually even have aself-paced learning course on my
website that you can findcalled 3D Detox.
(07:08):
I call it the new science ofdetox and I go through this in
great detail.
I'll go ahead and I'll put alink to that in the episode
description if you have anyinterest in going through that
learning module.
But when people talk about detox, you know they're usually
talking about the liver and thebuilt-in system the liver has
(07:28):
for processing toxins andhelping us to eliminate them.
Now we can get rid of toxins inmany ways.
We can get rid of it throughsweat, through the kidneys and
urine.
But our greatest strength inhandling toxins is through a
four-phase detox system thatstarts in the liver.
(07:50):
Now, very quickly, when a toxinhas to be cleared, the liver
first has to use enzymes toconvert it from a fat-soluble
form to a water-soluble form andthat lets it mix with the
liquid portion of bile from theliver so that we can export it
into the small intestines.
But once we're past that phaseone enzyme, once that enzyme
(08:13):
system does its job, we need todo one more thing to that toxin
in what's referred to as phasetwo conjugation.
So it goes phase one, then tophase two and then on to phase
three and four, and this wordconjugation refers to attaching
another molecule to the toxinsthat have passed through the
enzyme system of phase one, sothat the toxin now becomes
(08:37):
larger and heavier and can bemixed with bile that is again
made by your liver and once thetoxin passes through phases one
and two, it mixes with bile inphase three and that gets
exported into the gut where itgets eliminated in phase four,
which technically would be justsimply having a bowel movement.
But in this phase twoconjugation your liver has
(08:59):
several options to choose from.
To make the toxins coming outof phase one larger and heavier,
it can add different chemicalgroups to the original compound.
So, for example, it can add amethyl group, and the process of
methylation again involved inmany different things, but this
is how we process and metabolizeestrogens and testosterone, for
(09:22):
example.
Or we can add acetyl groups ora sulfur group.
But one of the most activeaspects of phase two conjugation
, this process of addingsomething to the toxin to make
it bigger and heavier, is whatwe call glutathione conjugation.
So a toxin comes out of phaseone and has a glutathione
(09:43):
molecule attached to it whichnot only makes it mixable with
bile but also neutralizes it sothat it now becomes non-reactive
.
So a toxin that has glutathioneto it attached to it generally
is considered non-reactive andcan't really cause many problems
, as opposed to a toxin that isfree-floating, so to speak.
(10:04):
It doesn't have glutathione orany other conjugate group added
to it.
That is going to cause a lotmore problems in terms of
oxidative stress and potentiallychanging your physiology and
damaging your cells.
So, going back to this idea ofglutathione conjugation as being
a critical part of phase twodetox, meaning that you know
just like again, we talked aboutthis before glutathione
(10:26):
attaches to nitric oxide anddeactivates it so that we can
prolong its half-life and let itcirculate to other tissues.
Glutathione attaches to thesephase one intermediates in the
liver, neutralizes them, so theycan't cause problems as they
are escorted hard to say thatword, escorted out of the body
(10:47):
through the gut.
Now, all of this happens in thecontext and the confines of the
liver and the GI system, but weknow that glutathione lives not
just in the liver, but it'salso in the bloodstream and it's
also in your cells and in thoseplaces glutathione does the
same thing.
But instead of callingglutathione a phase two
(11:07):
conjugate, which is reallyreferring to what it does inside
the liver, when we talk aboutglutathione and how it interacts
with toxins in the bloodstreamor in the cells, we call it a
chelator.
You've heard of chelationbefore cells.
We call it a chelator, you'veheard of chelation before.
And so, as glutathione floatsaround your blood and gets
transported inside your cells,it can latch onto things like
(11:27):
heavy metals or mold toxins.
Environmental chemicals canbind them, can neutralize them
and then helps us excrete themor get them out of the body.
And so glutathione actuallydoes double duty when it comes
to detox it works inside theliver and it works in the rest
of the body to clean up toxicjunk so that we can get rid of
it.
So you can imagine then backingup if we have a low protein
(11:51):
diet and we can't supply enoughcysteine or glycine in adequate
amounts to keep our glutathionelevels where they need to be, or
if we have a problem with anincreased toxic load that
depletes our glutathione.
Not only do we lose cellprotection, our toxin load
accumulates over time.
That depletes glutathione tothe point where it starts to
(12:11):
affect other systems andfunctions, and it can create
other problems, things thatwe're all concerned about, and
that would be things like leakygut and even leaky brain.
And that brings in the conceptof barrier systems.
And another critical role thatglutathione plays in health and
function is that it protects ourbarrier systems.
(12:31):
So let's talk about that for asecond.
What is a barrier?
Well, a barrier is designed todo one thing it's designed to
keep two spaces separate fromeach other and to control or
prevent things from one spacefrom getting into another.
And that's why your house oryour apartment or your condo has
a front door and it has windows, and the door has a lock on it,
(12:53):
because you get to control whocomes into your house.
You don't want random strangersoff the street walking into
your house uninvited, and so youput a barrier there that we
call a door and a lock.
And so the truth is the worldthat we all live in it's full of
toxins and pathogens that justthey want to get inside us and
(13:14):
infect us or poison us.
We live in and interact with atoxic and pathogen-laden world,
and the average person has heavymetals, they have environmental
chemicals, they have potentialpathogens already in their body
all the time, and our barriersprotect us by controlling what
gets into our bloodstream andhow we react to that, and it
(13:36):
does that through specializedcells that make up our skin,
that are part of the lining ofour intestinal system or the gut
, or the lining of the lungs andeven the lining of the blood
vessels that bring blood intoyour brain tissue.
Now, by comparison, there's farmore research on leaky gut than,
say, a leaky brain.
Or, to say it a different way,there's far more research on the
(14:00):
structure and function of thegut barrier as opposed to the
brain barrier.
So we'll just stick to that forthis episode.
But what research tells us isthat, with all the things that
can break our barriers down, wedon't lose integrity in those
barriers until the intracellularlevels of glutathione in that
tissue is depleted to the pointwhere it can't handle the
(14:23):
oxidative stress that causesdamage to the cells that make up
the barrier themselves.
And when that tissue breaksdown, we lose the integrity and
the function of the barriersystem.
So if you've ever been testedfor leaky gut or for leaky brain
, one thing that you canconclude is that at least those
tissues have an imbalance.
If you tested positive, Ishould say at least those
(14:46):
tissues have an imbalancebetween the oxidative stress
attacking them and how muchglutathione they need to defend
themselves.
Now, on that note, you can youknow testing related.
You can check out my lab shop.
You'll see their tests forleaky gut from a lab called
Cyrix Labs.
That's called array number two,and there's a leaky brain test
(15:07):
which I tend to get from anotherlab called Vibrant Labs as part
of a bigger test onneurological function, and
that's called the neural zoomertest.
So an array two from Cyrix Labsor the neural zoomer test from
Vibrant Labs will allow you totest for leaky gut and or leaky
brain.
Now, fixing a leaky gut andbrain is about more than just
(15:27):
simply taking glutathione.
In the bigger picture, you haveto find and fix the things that
caused it to begin with andthen use glutathione strategies
combined with other approachesbased on the entire picture.
Right, there are specificsupplements designed to help
heal the broken barriers in thegut, in the brain, et cetera.
But it's more than just simplytaking extra glutathione.
(15:48):
One of the key things when yourbarrier systems are not working
and when you're dealing withtoxic or pathogen loads is to
make sure your immune system isbalanced and controlled.
And now we get a chance to talkabout glutathione as part of
the system that helps us tocontrol that.
And that's because glutathioneis a potent trigger or supporter
(16:10):
of what we call regulatory Tcell function.
Now, these regulatory T cells Imight refer to them as Treg
cells.
These are unique immune cellsthat really they don't kill
infections, nor do they labelthem with antibodies.
Those functions come fromdifferent types of cells, but
(16:31):
these Treg cells are essentiallyconductors of your immune
response that directs otherparts of the immune system so
that they do the right job inthe right place at the right
time.
So think of the Treg cells asthe conductor, as the manager,
if you will, as the executivethat tells all the other parts
of the immune system what to do,how to do it and where and when
(16:51):
to do it.
And it's very common in chronicconditions, especially
autoimmunities, even things likemold toxicity or Lyme disease,
very common for these Treg cellsto be deficient.
For these Treg cells to bedeficient and when they are
deficient and you lose controlof your immune response, which
typically results in one ofseveral possible outcomes.
(17:14):
Number one an inability or adecreased ability to mount an
efficient immune response thatcan lead to things like
persistent or recurrentinfections.
You might have an inability ordecreased ability to calm down
an immune response which tendsto lead to ongoing and
increasing inflammation overtime.
And finally, you can have lackof control of any autoimmune
(17:38):
reactions that might be going onwithin your tissues, within
your systems.
And then you know.
Obviously none of theseoutcomes are good.
But on the good side, we do nowhave some solid lab testing
where we can get a handle onTreg cell function, and this is
called a lymphocyte map.
And lymphocytes are certaintypes of white blood cell and I
use this anytime I'm dealingwith complex and chronic illness
(18:02):
, particularly autoimmunities,for example, hashimoto's disease
.
I use it in most cases whereI'm working with someone who has
Lyme disease or co-infectionslike Bartonella, or if I'm
dealing with someone who hasmycotoxin or mold toxin illness
or problems with environmentalchemicals and there's a picture
of immune dysfunction anddysregulation as well.
(18:23):
And again, this is called thelymphocyte map.
But here's the connection.
These regulatory T cells areloaded with receptors not just
for glutathione but also forvitamin D, so in the case of a
glutathione deficiency, we canexpect your Treg cells to be
less capable and lessfunctioning.
(18:43):
So optimal glutathione is oftena strategy that we use
clinically to balance the immunesystem and to improve control
of autoimmunity as well as theinflammatory state.
All right, so I hope that'senough to convince you that
glutathione is indeed a miraclemolecule, and as I close out
(19:05):
this episode, I want to give yousome options for testing and
some things you can think aboutfor increasing glutathione
levels.
So let's talk about testingfirst.
So the first thing to rememberis that when you run regular
blood tests, you should ask yourdoctor to check your GGT levels
Again.
That's not part of routine labsfor most docs it is for me, but
I've just learned a lot overthe years, right, and so the
(19:33):
higher your GGT level is, evenwithin the normal reference
range, the more likely it isthat you have a problem with
glutathione.
The optimal value we wouldcertainly we want to see GGT in
the lower one-third of the labrange, probably preferably in
the lower one-quarter.
So if you take the lab range,divide it into four segments, it
should be towards the lower end.
Now we can also run a blood testfor glutathione.
There's only a few labs thatsupply this.
(19:55):
You can get a total glutathionedone at the big national labs
like LabCorp, for example, butthe problem is that when you
test only the total glutathionelevels, you can't tell the
difference between theglutathione that has been used
already and which is ready to beretrieved and recycled.
(20:16):
Remember that there is thisrecycling process which, if it's
not working effectively, allowsthe total glutathione to remain
the same, but it changes theratio between what's been used
and what's ready to go.
So, in essence, the totalglutathione is really kind of
only half the picture, andthat's why I like to use a test
called the Advanced OxidativeStress Test, from a lab called
(20:38):
Precision Point Diagnostics.
It gives me the totalglutathione level in the blood
plus the amount that has beenused, so that I can understand
whether or not my client isrecycling glutathione
appropriately.
Plus, it also gives me threeadditional markers of oxidative
stress.
There's more than three, butusually that's enough for us to
get a handle on things.
(20:59):
It tells me, number one, whatis their oxidative stress level.
Number two, what is their totalglutathione levels in relation
to their oxidative stress?
And number three do they have agood recycling capacity?
And that's a pretty robustunderstanding of somebody's
glutathione systems.
And again, this advancedoxidative stress test you can
(21:21):
check it out in my lab shop.
You can order it on your own.
You don't need a prescriptionfor that.
Results will come to youdirectly.
Now, finally, as we close, let'stalk about ways to increase
glutathione.
Number one you can takeglutathione directly.
Many different companies make aglutathione product.
There's different versions,many different types.
(21:43):
There's different ways todeliver it.
The most effective way toincrease your glutathione
directly through a pill or acapsule is using what's called
an acetylated form, and you canget that in a liquid.
Even a liposomal form would bebetter for absorbability, and so
(22:03):
what we call AC glutathione oracetylated glutathione,
especially in the liposomal form, by far has the best absorption
rate and the best probabilityof increasing the level of
glutathione inside your cells,better than anything else.
So if you're looking at theseproducts, look for acetylated
glutathione, look for liposomalforms.
Those are your best performers.
Acetylated glutathione, lookfor liposomal forms.
(22:24):
Those are your best performers.
Now that doesn't mean that oldschool forms, what we call
reduced glutathione, won't help.
We've used those for decadesbefore these more advanced
formulas came around.
It's just that now we havebetter tools Doesn't mean the
old tools are bad.
They're just not as good aswhat we have now.
And in research, dosing thesedifferent forms of glutathione
(22:48):
ranges anywhere from 500 to1,000 milligrams per day over a
period of several months tocorrect deficiencies and
imbalances.
And that's assuming that you'refinding and fixing the sources
of your oxidative stress.
Right.
If all you're doing is takingglutathione but you're not
finding the problem that'scausing the oxidative stress,
that's, in the long run, it's alosing battle.
You're just kind of patchingthings up Now.
(23:10):
If you don't want to or need totake glutathione directly, there
are some other ways to increaseglutathione that are pretty
tried and true.
Number one is to use a wheyprotein supplement.
We have many years of researchwhere different studies have
looked at different daily dosesof whey protein and found that
the amount of glutathione thatcomes out of it is actually
(23:31):
dose-dependent, meaning that ifyou're going to take 10 grams of
whey protein a day, you'regoing to get a little bit of
glutathione.
But if you eat, for example, 45grams of whey protein per day,
that can increase glutathionelevels by, say, up to 25%.
So lower whey protein intakehas less of an impact.
Higher has more of an impact.
(23:52):
But if you start getting morethan 45 grams per day of whey
protein intake, it doesn'tnecessarily mean that more is
better, but a little more isbetter than a little less.
So whey protein intake is one,and that's assuming you're okay
with dairy at least the wheyprotein intake is one, and
that's assuming you're okay withdairy at least the whey protein
fraction of that.
Another way to increase yourglutathione levels is through
(24:13):
supplementing withN-acetylcysteine and or glycine.
Right, research is a little bitmore variable here, showing
that different people responddifferently to even the same
dose or the same type ofsupplement.
Even some organ systems in thesame person responds differently
.
So if I take, you know,n-acetylcysteine, for example,
(24:35):
maybe I get increasedglutathione in my liver, but not
in my respiratory system or mylungs.
So we all have differentresponses.
It's not uniform, but as a roughguideline, taking somewhere
between three to five grams ofN-acetylcysteine sometimes you
will hear people call it NAC,n-a-c so three to five grams of
N-acetylcysteine and glycinecombined can be effective for
(24:58):
some people in some conditions,and you would want to split that
up over the day.
You don't really want to takeall of that at the same time.
You can do that, you know splitit between two different daily
doses.
And finally, just to give youone more thing to think about,
we have some research that saysfish oil shows some promise here
too, where high doses ofomega-3 in the range of 4,000
(25:20):
milligrams or four grams per dayyields some statistically
significant increases inglutathione.
Now, one of the problems withpeople taking fish oil is number
one they don't take goodquality fish oil.
And number two usually theirdose is way too low.
So we're talking when I say4,000 milligrams per day to
increase your glutathione levels.
(25:40):
That's not of the fish oil inits total.
That's the active ingredients,which we call EPA and DHA, and I
generally recommend to peopleat least 2,400 milligrams of EPA
plus DHA per day.
Now you can get this easily byeating sardines or mackerel,
anchovies, salmon, what we callthe SMASH fish, and SMASH is an
(26:05):
acronym.
Let me go through that Salmon,mackerel, anchovies, sardines
and herring.
These are the fish varietiesthat will maximize your omega-3
fatty acid intake and minimizethings like mercury and other
heavy metals that become aconcern when we start talking
about eating different fishvarieties.
(26:27):
Now, if you tool around theinternet, you're going to find
references to all kinds ofstrategies to increase
glutathione, from consuming morevitamin C to milk thistle to
even exercise and sleepstrategies.
But from a clinical standpoint,here's what I think is best.
Number one make sure you haveadequate protein in your diet.
Make sure you have adequatestomach acid to break down,
(26:50):
digest and absorb the proteinand give you the amino acid you
need.
Some people are eating enoughprotein, but their hydrochloric
acid status is not appropriate.
They can't break down theirproteins the way that we want.
It just kind of sits in theirgut and causes maldigestion.
If you need to get yourglutathione levels up quickly,
take a direct form ofglutathione for several months
(27:12):
and that would be youracetylated glutathione, or even
a reduced glutathione, but makesure it's in a liposomal form, a
liquid form.
But if you don't have an acuteneed to raise your levels
quickly and you just want toprotect yourself from an
antioxidant perspective, from animmune balance and controls
perspective, you can add acouple of scoops of a good
(27:34):
quality whey protein to yourdaily protein intake.
You can take some supplementalN-acetylcysteine and or glycine
and make sure you either eatsome fatty fish or take several
grams of fish oil per day, likeon the days you eat sardines,
for example, or mackerel.
You don't need to take fish oilbecause you're already getting
it from your food, but on thedays you're not eating fish,
(27:55):
make sure you take good qualityfish oil.
All right, let's call that awrap for this episode.
Don't forget to check out theLab Shop for direct lab pricing
on tests that I use in mypersonal coaching practice.
And if you feel like you needpersonalized touch, like a
personalized program, reach outto me.
Use the link in the descriptionor find the contact information
(28:16):
on my main website, which issimply wwwdrnoseworthycom.
That's drnoseworthycom.
There's a contact form therethat you can reach out to me and
that comes directly to my email.
All right guys, we'll be backagain to talk about the next
miracle molecule right here onthe Inflammation Nation.
This podcast is for generalinformational and educational
(28:39):
purposes only and does notconstitute the practice of
medicine in any form or capacity.
No doctor-patient relationshipis formed.
The use of the information inthis podcast or any materials
associated with or linked to thepodcast is at the listener's
own risk.
The content of this podcast isnot intended to be a substitute
(29:01):
for professional andpersonalized medical advice,
diagnosis or treatment, andlisteners should not disregard
or delay obtaining propermedical advice when a health
condition exists and warrantsthat.
And finally, functionalmedicine is not intended or
designed to treat disease, butrather is a natural approach to
support restoring health andwellness.
(29:23):
The use of diet and lifestylemodifications and nutritional
supplementation is supportivefor adjunctive care.
Hey everyone, welcome to the Inflammation Nation
podcast.
I'm your host, Dr SteveNoseberg.
Speaker 2 (00:08):
One of the greatest obstacles to crafting health and
wellness is identifying andcontrolling inflammation.
It's at the core of all complexand chronic diseases and it's
the driving mechanism thatunderlies the most common
symptoms that people like youstruggle to overcome.
Join us as we explore cuttingedge science and research to
give you the information andtools you need to create the
(00:28):
quality of life you want anddeserve.
And now here is the host ofInflammation Nation, dr Stephen
Nosworthy.
Speaker 1 (00:36):
Hey guys, welcome back to the podcast.
This is part two of our talkabout glutathione as another
miracle molecule.
In that last episode we justdid, I introduced glutathione as
my second miracle molecule andI shared that this is a
tripeptide molecule made up ofcysteine, glutamine and glycine,
(00:57):
all complex together, and wetalked about the primary role
that glutathione plays in yourbody, which is, as your major
antioxidant, the thing thatprotects your cells from
inflammation and from oxidativestress, also mentioned that your
liver makes and stores most ofthe glutathione in your body and
there's a balance between thelevels and storage what's in
(01:20):
circulation and what's inside ofyour cells.
And I also shared how not onlycan we make glutathione as
needed, we also have a way torecycle glutathione that has
already been used so that,essentially, we can reconstitute
it and use it over and overagain.
And the process of making andrecycling glutathione is
(01:40):
governed by the activity of aset of different enzymes, which
themselves are governed by thelevel of oxidative stress that
we have, and this is all part ofthe intelligent design of the
human body.
And how amazing is it that wehave a system designed to sense
when we have increased oxidativestress or when that gets too
(02:01):
high and responds to that byincreasing the production and
the recycling of glutathione,and that's pretty amazing, at
least I think so.
I also mentioned one specificenzyme last time, and that is
GGT.
And again, it's usually onlyordered on blood labs by your
medical doctor when they suspectthat you have gallbladder
(02:21):
disease, perhaps if they thinkyou're an alcoholic.
But the medical literatureshows many different studies
where we can use GGT levels as apotential marker for low
glutathione and hence the needto support that.
Now one more thing about theamino acids that make up
glutathione, before we talkabout some of the other roles
(02:42):
that it plays outside ofcontrolling oxidative stress.
If you remember, in theepisodes on nitric oxide, our
first miracle molecule, I talkedabout this thing called BH4 or
tetrahydrobiopterin as the ratelimiter for nitric oxide
production.
And this idea of a rate limiteris not unique to nitric oxide.
(03:04):
Pretty much every other systemin the human body has some kind
of a rate limiter is not uniqueto nitric oxide.
Pretty much every other systemin the human body has some kind
of a rate limiter, Otherwisefunction would get out of
control.
And for glutathione it turns outthat the levels and
availability of predominantlycysteine, but also glycine, two
of the three different aminoacids that make up glutathione.
Those levels determine how muchglutathione you make.
(03:26):
And where do thoserate-limiting amino acids come
from?
They come from the protein inyour diet.
So low protein intake ingeneral can reduce the
availability of these rawmaterials cysteine and glycine
that you can pull from to makemore glutathione, and if that
happens, then you won't be ableto neutralize even the typical
(03:49):
oxidative stress of just simplybeing alive and being
metabolically active, let alonethe increased oxidative stress
that comes from having varioushealth issues.
Now, I've talked a lot aboutdiet in this podcast.
I've talked about the pros andcons of different diet
approaches, and you know I makeno secret of the fact that I'm
not a huge fan of vegan dietsand I've gone through my
(04:11):
arguments about that in otherepisodes.
But one thing that we can addto the list is that since
plant-based protein sources areinherently low in both cysteine
and glycine inherently low inboth cysteine and glycine then
as a general rule, vegans andvegetarians or even omnivores on
a low protein intake they bydefault tend to have low
(04:33):
capacity to make glutathione ifwe compare them to people who
eat plenty of animal proteins.
And that's just the fact, andthis has been demonstrated in
multiple studies.
So, as a quick reminder,optimal protein intake is based
on your muscle mass, the type ofactivity you engage in.
So the more muscle you have andthe harder you use them, the
(04:56):
more protein you need.
And since we're all differentin size and activities, the
optimal range of protein intakeit's not a single number.
And activities the optimalrange of protein intake it's not
a single number.
It's somewhere between 0.6 and1.0 grams of protein per pound
of body weight.
And, as a general rule, if youhave more than 30 pounds of
excess body weight that you wantto lose, it's best to calculate
(05:17):
your protein intake needs notoff your current weight, but off
the weight that you feel likeyou should be, like your ideal
body weight.
Now the good news is that takingboth glycine and cysteine,
either separately or together,can increase your chance of
making glutathione enoughglutathione to offset your
(05:38):
oxidative stress.
So, again, as a general rule,number one, you need to be
eating adequate proteinthroughout the day, every day,
to make sure that you optimizemany health and longevity
factors, including your abilityto make glutathione to serve in
its many roles, and in somecases you may want or perhaps
need to supplement.
But here's a caveat Before youstart supplementing, make sure
(06:02):
you're eating enough protein.
That's probably the easiest andactually the most
cost-effective thing to do.
Remember that supplements aresupplements.
They are added to or inaddition to your base strategy
of eating well and moving well.
Those should be your twopriorities eat well and move
well.
So, having said all that, whatare the other rules of
(06:24):
glutathione?
Well, let's take them one byone.
This is not going to beexhausted.
I'm just going to hit somepoints of the most common roles
that glutathione serves.
So, first of all, glutathioneplays an integral role in two
different aspects ofdetoxification, or what might be
more technically termed asbiotransformation, but I'm just
(06:45):
going to use the word detoxbecause that's the word everyone
use.
So the first role indetoxification is actually in
what we call the second phase,or phase two, of liver detox.
Now, I've gone through thisagain before in other episodes
and I actually even have aself-paced learning course on my
website that you can findcalled 3D Detox.
(07:08):
I call it the new science ofdetox and I go through this in
great detail.
I'll go ahead and I'll put alink to that in the episode
description if you have anyinterest in going through that
learning module.
But when people talk about detox, you know they're usually
talking about the liver and thebuilt-in system the liver has
(07:28):
for processing toxins andhelping us to eliminate them.
Now we can get rid of toxins inmany ways.
We can get rid of it throughsweat, through the kidneys and
urine.
But our greatest strength inhandling toxins is through a
four-phase detox system thatstarts in the liver.
(07:50):
Now, very quickly, when a toxinhas to be cleared, the liver
first has to use enzymes toconvert it from a fat-soluble
form to a water-soluble form andthat lets it mix with the
liquid portion of bile from theliver so that we can export it
into the small intestines.
But once we're past that phaseone enzyme, once that enzyme
(08:13):
system does its job, we need todo one more thing to that toxin
in what's referred to as phasetwo conjugation.
So it goes phase one, then tophase two and then on to phase
three and four, and this wordconjugation refers to attaching
another molecule to the toxinsthat have passed through the
enzyme system of phase one, sothat the toxin now becomes
(08:37):
larger and heavier and can bemixed with bile that is again
made by your liver and once thetoxin passes through phases one
and two, it mixes with bile inphase three and that gets
exported into the gut where itgets eliminated in phase four,
which technically would be justsimply having a bowel movement.
But in this phase twoconjugation your liver has
(08:59):
several options to choose from.
To make the toxins coming outof phase one larger and heavier,
it can add different chemicalgroups to the original compound.
So, for example, it can add amethyl group, and the process of
methylation again involved inmany different things, but this
is how we process and metabolizeestrogens and testosterone, for
(09:22):
example.
Or we can add acetyl groups ora sulfur group.
But one of the most activeaspects of phase two conjugation
, this process of addingsomething to the toxin to make
it bigger and heavier, is whatwe call glutathione conjugation.
So a toxin comes out of phaseone and has a glutathione
(09:43):
molecule attached to it whichnot only makes it mixable with
bile but also neutralizes it sothat it now becomes non-reactive
.
So a toxin that has glutathioneto it attached to it generally
is considered non-reactive andcan't really cause many problems
, as opposed to a toxin that isfree-floating, so to speak.
(10:04):
It doesn't have glutathione orany other conjugate group added
to it.
That is going to cause a lotmore problems in terms of
oxidative stress and potentiallychanging your physiology and
damaging your cells.
So, going back to this idea ofglutathione conjugation as being
a critical part of phase twodetox, meaning that you know
just like again, we talked aboutthis before glutathione
(10:26):
attaches to nitric oxide anddeactivates it so that we can
prolong its half-life and let itcirculate to other tissues.
Glutathione attaches to thesephase one intermediates in the
liver, neutralizes them, so theycan't cause problems as they
are escorted hard to say thatword, escorted out of the body
(10:47):
through the gut.
Now, all of this happens in thecontext and the confines of the
liver and the GI system, but weknow that glutathione lives not
just in the liver, but it'salso in the bloodstream and it's
also in your cells and in thoseplaces glutathione does the
same thing.
But instead of callingglutathione a phase two
(11:07):
conjugate, which is reallyreferring to what it does inside
the liver, when we talk aboutglutathione and how it interacts
with toxins in the bloodstreamor in the cells, we call it a
chelator.
You've heard of chelationbefore cells.
We call it a chelator, you'veheard of chelation before.
And so, as glutathione floatsaround your blood and gets
transported inside your cells,it can latch onto things like
(11:27):
heavy metals or mold toxins.
Environmental chemicals canbind them, can neutralize them
and then helps us excrete themor get them out of the body.
And so glutathione actuallydoes double duty when it comes
to detox it works inside theliver and it works in the rest
of the body to clean up toxicjunk so that we can get rid of
it.
So you can imagine then backingup if we have a low protein
(11:51):
diet and we can't supply enoughcysteine or glycine in adequate
amounts to keep our glutathionelevels where they need to be, or
if we have a problem with anincreased toxic load that
depletes our glutathione.
Not only do we lose cellprotection, our toxin load
accumulates over time.
That depletes glutathione tothe point where it starts to
(12:11):
affect other systems andfunctions, and it can create
other problems, things thatwe're all concerned about, and
that would be things like leakygut and even leaky brain.
And that brings in the conceptof barrier systems.
And another critical role thatglutathione plays in health and
function is that it protects ourbarrier systems.
(12:31):
So let's talk about that for asecond.
What is a barrier?
Well, a barrier is designed todo one thing it's designed to
keep two spaces separate fromeach other and to control or
prevent things from one spacefrom getting into another.
And that's why your house oryour apartment or your condo has
a front door and it has windows, and the door has a lock on it,
(12:53):
because you get to control whocomes into your house.
You don't want random strangersoff the street walking into
your house uninvited, and so youput a barrier there that we
call a door and a lock.
And so the truth is the worldthat we all live in it's full of
toxins and pathogens that justthey want to get inside us and
(13:14):
infect us or poison us.
We live in and interact with atoxic and pathogen-laden world,
and the average person has heavymetals, they have environmental
chemicals, they have potentialpathogens already in their body
all the time, and our barriersprotect us by controlling what
gets into our bloodstream andhow we react to that, and it
(13:36):
does that through specializedcells that make up our skin,
that are part of the lining ofour intestinal system or the gut
, or the lining of the lungs andeven the lining of the blood
vessels that bring blood intoyour brain tissue.
Now, by comparison, there's farmore research on leaky gut than,
say, a leaky brain.
Or, to say it a different way,there's far more research on the
(14:00):
structure and function of thegut barrier as opposed to the
brain barrier.
So we'll just stick to that forthis episode.
But what research tells us isthat, with all the things that
can break our barriers down, wedon't lose integrity in those
barriers until the intracellularlevels of glutathione in that
tissue is depleted to the pointwhere it can't handle the
(14:23):
oxidative stress that causesdamage to the cells that make up
the barrier themselves.
And when that tissue breaksdown, we lose the integrity and
the function of the barriersystem.
So if you've ever been testedfor leaky gut or for leaky brain
, one thing that you canconclude is that at least those
tissues have an imbalance.
If you tested positive, Ishould say at least those
(14:46):
tissues have an imbalancebetween the oxidative stress
attacking them and how muchglutathione they need to defend
themselves.
Now, on that note, you can youknow testing related.
You can check out my lab shop.
You'll see their tests forleaky gut from a lab called
Cyrix Labs.
That's called array number two,and there's a leaky brain test
(15:07):
which I tend to get from anotherlab called Vibrant Labs as part
of a bigger test onneurological function, and
that's called the neural zoomertest.
So an array two from Cyrix Labsor the neural zoomer test from
Vibrant Labs will allow you totest for leaky gut and or leaky
brain.
Now, fixing a leaky gut andbrain is about more than just
(15:27):
simply taking glutathione.
In the bigger picture, you haveto find and fix the things that
caused it to begin with andthen use glutathione strategies
combined with other approachesbased on the entire picture.
Right, there are specificsupplements designed to help
heal the broken barriers in thegut, in the brain, et cetera.
But it's more than just simplytaking extra glutathione.
(15:48):
One of the key things when yourbarrier systems are not working
and when you're dealing withtoxic or pathogen loads is to
make sure your immune system isbalanced and controlled.
And now we get a chance to talkabout glutathione as part of
the system that helps us tocontrol that.
And that's because glutathioneis a potent trigger or supporter
(16:10):
of what we call regulatory Tcell function.
Now, these regulatory T cells Imight refer to them as Treg
cells.
These are unique immune cellsthat really they don't kill
infections, nor do they labelthem with antibodies.
Those functions come fromdifferent types of cells, but
(16:31):
these Treg cells are essentiallyconductors of your immune
response that directs otherparts of the immune system so
that they do the right job inthe right place at the right
time.
So think of the Treg cells asthe conductor, as the manager,
if you will, as the executivethat tells all the other parts
of the immune system what to do,how to do it and where and when
(16:51):
to do it.
And it's very common in chronicconditions, especially
autoimmunities, even things likemold toxicity or Lyme disease,
very common for these Treg cellsto be deficient.
For these Treg cells to bedeficient and when they are
deficient and you lose controlof your immune response, which
typically results in one ofseveral possible outcomes.
(17:14):
Number one an inability or adecreased ability to mount an
efficient immune response thatcan lead to things like
persistent or recurrentinfections.
You might have an inability ordecreased ability to calm down
an immune response which tendsto lead to ongoing and
increasing inflammation overtime.
And finally, you can have lackof control of any autoimmune
(17:38):
reactions that might be going onwithin your tissues, within
your systems.
And then you know.
Obviously none of theseoutcomes are good.
But on the good side, we do nowhave some solid lab testing
where we can get a handle onTreg cell function, and this is
called a lymphocyte map.
And lymphocytes are certaintypes of white blood cell and I
use this anytime I'm dealingwith complex and chronic illness
(18:02):
, particularly autoimmunities,for example, hashimoto's disease
.
I use it in most cases whereI'm working with someone who has
Lyme disease or co-infectionslike Bartonella, or if I'm
dealing with someone who hasmycotoxin or mold toxin illness
or problems with environmentalchemicals and there's a picture
of immune dysfunction anddysregulation as well.
(18:23):
And again, this is called thelymphocyte map.
But here's the connection.
These regulatory T cells areloaded with receptors not just
for glutathione but also forvitamin D, so in the case of a
glutathione deficiency, we canexpect your Treg cells to be
less capable and lessfunctioning.
(18:43):
So optimal glutathione is oftena strategy that we use
clinically to balance the immunesystem and to improve control
of autoimmunity as well as theinflammatory state.
All right, so I hope that'senough to convince you that
glutathione is indeed a miraclemolecule, and as I close out
(19:05):
this episode, I want to give yousome options for testing and
some things you can think aboutfor increasing glutathione
levels.
So let's talk about testingfirst.
So the first thing to rememberis that when you run regular
blood tests, you should ask yourdoctor to check your GGT levels
Again.
That's not part of routine labsfor most docs it is for me, but
I've just learned a lot overthe years, right, and so the
(19:33):
higher your GGT level is, evenwithin the normal reference
range, the more likely it isthat you have a problem with
glutathione.
The optimal value we wouldcertainly we want to see GGT in
the lower one-third of the labrange, probably preferably in
the lower one-quarter.
So if you take the lab range,divide it into four segments, it
should be towards the lower end.
Now we can also run a blood testfor glutathione.
There's only a few labs thatsupply this.
(19:55):
You can get a total glutathionedone at the big national labs
like LabCorp, for example, butthe problem is that when you
test only the total glutathionelevels, you can't tell the
difference between theglutathione that has been used
already and which is ready to beretrieved and recycled.
(20:16):
Remember that there is thisrecycling process which, if it's
not working effectively, allowsthe total glutathione to remain
the same, but it changes theratio between what's been used
and what's ready to go.
So, in essence, the totalglutathione is really kind of
only half the picture, andthat's why I like to use a test
called the Advanced OxidativeStress Test, from a lab called
(20:38):
Precision Point Diagnostics.
It gives me the totalglutathione level in the blood
plus the amount that has beenused, so that I can understand
whether or not my client isrecycling glutathione
appropriately.
Plus, it also gives me threeadditional markers of oxidative
stress.
There's more than three, butusually that's enough for us to
get a handle on things.
(20:59):
It tells me, number one, whatis their oxidative stress level.
Number two, what is their totalglutathione levels in relation
to their oxidative stress?
And number three do they have agood recycling capacity?
And that's a pretty robustunderstanding of somebody's
glutathione systems.
And again, this advancedoxidative stress test you can
(21:21):
check it out in my lab shop.
You can order it on your own.
You don't need a prescriptionfor that.
Results will come to youdirectly.
Now, finally, as we close, let'stalk about ways to increase
glutathione.
Number one you can takeglutathione directly.
Many different companies make aglutathione product.
There's different versions,many different types.
(21:43):
There's different ways todeliver it.
The most effective way toincrease your glutathione
directly through a pill or acapsule is using what's called
an acetylated form, and you canget that in a liquid.
Even a liposomal form would bebetter for absorbability, and so
(22:03):
what we call AC glutathione oracetylated glutathione,
especially in the liposomal form, by far has the best absorption
rate and the best probabilityof increasing the level of
glutathione inside your cells,better than anything else.
So if you're looking at theseproducts, look for acetylated
glutathione, look for liposomalforms.
Those are your best performers.
Acetylated glutathione, lookfor liposomal forms.
(22:24):
Those are your best performers.
Now that doesn't mean that oldschool forms, what we call
reduced glutathione, won't help.
We've used those for decadesbefore these more advanced
formulas came around.
It's just that now we havebetter tools Doesn't mean the
old tools are bad.
They're just not as good aswhat we have now.
And in research, dosing thesedifferent forms of glutathione
(22:48):
ranges anywhere from 500 to1,000 milligrams per day over a
period of several months tocorrect deficiencies and
imbalances.
And that's assuming that you'refinding and fixing the sources
of your oxidative stress.
Right.
If all you're doing is takingglutathione but you're not
finding the problem that'scausing the oxidative stress,
that's, in the long run, it's alosing battle.
You're just kind of patchingthings up Now.
(23:10):
If you don't want to or need totake glutathione directly, there
are some other ways to increaseglutathione that are pretty
tried and true.
Number one is to use a wheyprotein supplement.
We have many years of researchwhere different studies have
looked at different daily dosesof whey protein and found that
the amount of glutathione thatcomes out of it is actually
(23:31):
dose-dependent, meaning that ifyou're going to take 10 grams of
whey protein a day, you'regoing to get a little bit of
glutathione.
But if you eat, for example, 45grams of whey protein per day,
that can increase glutathionelevels by, say, up to 25%.
So lower whey protein intakehas less of an impact.
Higher has more of an impact.
(23:52):
But if you start getting morethan 45 grams per day of whey
protein intake, it doesn'tnecessarily mean that more is
better, but a little more isbetter than a little less.
So whey protein intake is one,and that's assuming you're okay
with dairy at least the wheyprotein intake is one, and
that's assuming you're okay withdairy at least the whey protein
fraction of that.
Another way to increase yourglutathione levels is through
(24:13):
supplementing withN-acetylcysteine and or glycine.
Right, research is a little bitmore variable here, showing
that different people responddifferently to even the same
dose or the same type ofsupplement.
Even some organ systems in thesame person responds differently
.
So if I take, you know,n-acetylcysteine, for example,
(24:35):
maybe I get increasedglutathione in my liver, but not
in my respiratory system or mylungs.
So we all have differentresponses.
It's not uniform, but as a roughguideline, taking somewhere
between three to five grams ofN-acetylcysteine sometimes you
will hear people call it NAC,n-a-c so three to five grams of
N-acetylcysteine and glycinecombined can be effective for
(24:58):
some people in some conditions,and you would want to split that
up over the day.
You don't really want to takeall of that at the same time.
You can do that, you know splitit between two different daily
doses.
And finally, just to give youone more thing to think about,
we have some research that saysfish oil shows some promise here
too, where high doses ofomega-3 in the range of 4,000
(25:20):
milligrams or four grams per dayyields some statistically
significant increases inglutathione.
Now, one of the problems withpeople taking fish oil is number
one they don't take goodquality fish oil.
And number two usually theirdose is way too low.
So we're talking when I say4,000 milligrams per day to
increase your glutathione levels.
(25:40):
That's not of the fish oil inits total.
That's the active ingredients,which we call EPA and DHA, and I
generally recommend to peopleat least 2,400 milligrams of EPA
plus DHA per day.
Now you can get this easily byeating sardines or mackerel,
anchovies, salmon, what we callthe SMASH fish, and SMASH is an
(26:05):
acronym.
Let me go through that Salmon,mackerel, anchovies, sardines
and herring.
These are the fish varietiesthat will maximize your omega-3
fatty acid intake and minimizethings like mercury and other
heavy metals that become aconcern when we start talking
about eating different fishvarieties.
(26:27):
Now, if you tool around theinternet, you're going to find
references to all kinds ofstrategies to increase
glutathione, from consuming morevitamin C to milk thistle to
even exercise and sleepstrategies.
But from a clinical standpoint,here's what I think is best.
Number one make sure you haveadequate protein in your diet.
Make sure you have adequatestomach acid to break down,
(26:50):
digest and absorb the proteinand give you the amino acid you
need.
Some people are eating enoughprotein, but their hydrochloric
acid status is not appropriate.
They can't break down theirproteins the way that we want.
It just kind of sits in theirgut and causes maldigestion.
If you need to get yourglutathione levels up quickly,
take a direct form ofglutathione for several months
(27:12):
and that would be youracetylated glutathione, or even
a reduced glutathione, but makesure it's in a liposomal form, a
liquid form.
But if you don't have an acuteneed to raise your levels
quickly and you just want toprotect yourself from an
antioxidant perspective, from animmune balance and controls
perspective, you can add acouple of scoops of a good
(27:34):
quality whey protein to yourdaily protein intake.
You can take some supplementalN-acetylcysteine and or glycine
and make sure you either eatsome fatty fish or take several
grams of fish oil per day, likeon the days you eat sardines,
for example, or mackerel.
You don't need to take fish oilbecause you're already getting
it from your food, but on thedays you're not eating fish,
(27:55):
make sure you take good qualityfish oil.
All right, let's call that awrap for this episode.
Don't forget to check out theLab Shop for direct lab pricing
on tests that I use in mypersonal coaching practice.
And if you feel like you needpersonalized touch, like a
personalized program, reach outto me.
Use the link in the descriptionor find the contact information
(28:16):
on my main website, which issimply wwwdrnoseworthycom.
That's drnoseworthycom.
There's a contact form therethat you can reach out to me and
that comes directly to my email.
All right guys, we'll be backagain to talk about the next
miracle molecule right here onthe Inflammation Nation.
This podcast is for generalinformational and educational
(28:39):
purposes only and does notconstitute the practice of
medicine in any form or capacity.
No doctor-patient relationshipis formed.
The use of the information inthis podcast or any materials
associated with or linked to thepodcast is at the listener's
own risk.
The content of this podcast isnot intended to be a substitute
(29:01):
for professional andpersonalized medical advice,
diagnosis or treatment, andlisteners should not disregard
or delay obtaining propermedical advice when a health
condition exists and warrantsthat.
And finally, functionalmedicine is not intended or
designed to treat disease, butrather is a natural approach to
support restoring health andwellness.
(29:23):
The use of diet and lifestylemodifications and nutritional
supplementation is supportivefor adjunctive care.
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Does hearing about a true crime case always leave you scouring the internet for the truth behind the story? Dive into your next mystery with Crime Junkie. Every Monday, join your host Ashley Flowers as she unravels all the details of infamous and underreported true crime cases with her best friend Brit Prawat. From cold cases to missing persons and heroes in our community who seek justice, Crime Junkie is your destination for theories and stories you won’t hear anywhere else. Whether you're a seasoned true crime enthusiast or new to the genre, you'll find yourself on the edge of your seat awaiting a new episode every Monday. If you can never get enough true crime... Congratulations, you’ve found your people. Follow to join a community of Crime Junkies! Crime Junkie is presented by audiochuck Media Company.
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If you've ever wanted to know about champagne, satanism, the Stonewall Uprising, chaos theory, LSD, El Nino, true crime and Rosa Parks, then look no further. Josh and Chuck have you covered.