Calocurb: A Natural Alternative to GLP-1 Injectables | 048 - It Has to Be Me

Episode Transcript
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Tess Masters (00:00):
Oh, Sarah, I am so excited to talk about callow curb, which is taking the world by storm. So first of all, let's just start at the beginning. Can you explain what callow curb is and what the active ingredient is?

Sarah Kennedy (00:14):
Sure, Tess, look, I will start at the beginning, because I well, I think it's fascinating. It started in 2010 when a group of very talented scientists, government scientists, had a hypothesis that they would find a natural or a plant based natural extract that suppressed appetite. Now why did they have this hypothesis? It came from both historical reasons. So historical being in times of famine, Scottish people chewed very, very bitter berries to suppress their appetite. In the Kalahari Desert tribesmen chewed very bitter before they went out hunting. That was actually the origin of foodia. And this all suppressed appetite. And also, there'd been this 2010 some recent work done in raps on British substances reducing appetite. So they put in a grant for the from the government, and it was called foods for appetite control. It came back. And, you know, like no one actually thinks it, but New Zealand has an obesity problem as well, and they got a $20 million grant for this. For this, what they put in this hypothesis, they started. Now bear with me, because it gets a bit more interesting. But they started, and they took 300 biopsies from the human gastrointestinal tract. It was absolutely hilarious how they got them, because the chief scientist had to go around and hang and hang out in hospital lovers and ask people who were going to have a biopsy, either a gastro biopsy or a colonoscopy, you know, if they'd give him some cells. Well, not said no, because they had to be non disease people. Anyway, he finally got the 300 biopsies, and they mapped the bitter taste receptors right down through the gastrointestinal tract. Now that had not been done before, so we all know we have bitter taste buds on our tongue, but not through our gastrointestinal trap. And why? What's important is when you bitter to our taste buds, often meant toxic. So it's an evolutionary mechanism of our body to to reject bitter things. So if you put them on your tongue, you're going to spit it up. If you put it into your stomach, you might feel nauseous or you may want to eat more, because your body is either trying to get rid of it or get you to eat more food. So you dissipate that potential toxin. But if it goes into your upper intestinal tract, you're going to stimulate the release of natural appetite, suppressing hormones that been GLP one, CCK and P YY. So this, so they mapped them all down. They proved that these intestinal cells, or these intestinal bit of taste buds, released GLP one, CCK and pyyy. So that was great that they had that. That was two years later. They then built a high throughput model, or endocrine using these cells as endocrine model, and they tested over 1000 natural extracts on it. So what could make these food extracts or natural plant based extract? What could make these Express? Well, not unsurprisingly, only two, two substances made them express. One was a potato oxalate. That may be good, but it's poisonous, so you'd be dead. Not so good. Not so good. Maybe thin, but dead. Um, one was a hops extractor, and this was sort of the Eureka. So they then went and tested 50 other hops extract to get the penultimate one that expressed the most. And it really did. And then they did dose dependencies, they did a whole lot of things, and then they formulated it into capsules. Being scientists, as scientists are, they actually took it themselves for a while and did a whole lot of things. So that was great. And then in 2016 they took it into its first human clinical because they knew it worked in the laboratory

and on themselves and on

themselves, but they didn't know would it work in a, you know, double blind PLACEBO clinical. So this was quite a large 130, men, all of. Were cannulated so they could take blood over these periods. And it was, it was a big clinical trial, so 30 men or cannulated. They gave what was not even a name, then a capsule with the active ingredient. They'd called this hops track. They called a Marissa. They gave them that an hour before an ad libitum or an eat till your full lunch, and an eat till your full snack. And they measured the bloods so CCK, which is a very potent appetite suppressing hormone and GLP, one they stimulated at 600% above base level. Whoa, PYY, at 400 now, why that's so important is, you know, a lot of things say, Oh, I activate GLP one. Well, yes, they do. Everything activates GLP one. It's a natural feedback mechanism. But unless you get it above 400% you're not going to get any behavioral change whatsoever. So they got these massive, massive biologically statistical elevations. And then they obviously measured calorie intake, and they got, on average, an 18% reduction in calorie intake. So then they had the mode of action they knew it worked by giving this extractive they knew it worked. They knew it stimulated the appetite, suppressing hormones, and they knew it reduced calories. Now, you gotta remember that was in 2016 so that was long before the ozempic we COVID, yeah, um, no one was talking about it. Then they approached me in 2017 you know, from my background in running companies and natural health companies and nutritional companies, and said, What would you do with it? I was so entranced by the science. I've never seen that amount of science in this category, you know, because we do know, this category has been plagued by a lot of either chunky or, you know, not, not, not backed by science, or things that just aren't that great, you know, like stomach fillers or, yeah, you know, or laxatives, or, you know, even caffeinated, you know, hyper. So we're not, but this, this was, this was imitating your natural physiological response. So I said, Hey, I like it so much. I want it so, you know, then went through the process of, you know, raising money, forming a team, doing all of that, and launching on the market in 2018 I would say, you know, it grew well, but the understanding of people On the physiology of weight management is incredibly low. So if you say to people, I'm stimulating your hormones or your appetite suppressing hormones that are going to tell your brain that you're full, they're like what you can sort of thing. So we grew, but the huge breakthrough for us was in 2021, when we go V was approved by the FDA for treatment of obesity. Novo Nordisk spent a billion dollars on advertising. Wow. They took up 239,000 doctors to lunch and dinner. They literally, they literally educated the market on the atiology or on what cause, what is weight, what causes weight and what is it about? And you know, I really thank them for that, because, you know the doctrine that we have always lived by where you know it's exercise and diet and you just don't have the willpower. It's just wrong, wrong, wrong. And so many people have lived with a stigma and self hatred because they lack will power. They don't that is one part of it, willpower. Have got nothing to do with it. And so they educated the market. So after that, you know, our job became easier.

Wow. So I want to just drill further on, on the supply chain, part of this now, so and, and also these clinical trials. So you say that the original trial was 30 men, then you had a clinical trial for women, correct? Because so many of the trials are just about males, and we know that the female market is absolutely huge, and women want to get in on this. So I'm interested in what. And with the way that you then tested it on women,

yeah, so great. And it's probably one of the ones I'm the most proud of. We then went on and did a clinical. You always do clinicals, your first clinicals, and men, because they don't have hormone, well, they do have a few hormones, but so we did what we called a hunger trial, because we had the physiological we had the mode of action, but we then had to get that do a hunger measurement. So we did it in men, first 30 men, I think it was again. And remember, people would say these are small trials, but when you do a clinical trial, it has to be what they call COVID, which means that is the amount of people you are allowed to use that will give you a statistically significant result. If you're going to get one ethic boards would not allow you to do more. I just want to say that, because everyone goes, Oh, that's a small trial, whereas actually the only that is the amount you can use anyway. So 30 men, and it was a 24 hour water only fast, and we gave Calico but 16 hours and 20 hours, and we measured their hunger, and we got an 80% reduction in increased hunger. So by 24 hours, they were compared to placebo, they were 80% less hungry. So massive, because that last eight hours of a 24 hour fast is extremely difficult. We then repeated that in females. And as I said, why females are more difficult and take a lot longer is because with 30 women, we had to line up their menstrual cycle on the exact day, same exact day, same day of the week, three times with 34 and that was over COVID. So, I mean, so that's 30 women doing it three times on the same time in their menstrual cycle on the same day of the week. So obviously it's going to miss some anyway. Wow, 18 months and quarter of a million dollars. But, oh, I'm so proud of it. Well, firstly, it showed, you know, women aren't little men. Big factor here. Second thing is, women are more responsive to GLP. One, we really Yeah, and we think there's a reason for that, but we got 100% decrease in increased hunger. So they were no more hungry at 20 This is compared to placebo at 24 hours and they were at 16 hours. But the one that really blew me away, we got 120% decrease in craving. So they were craving less at 24 hours, and they were at 16 hours. Wow. We then gave them an eight to their full meal at the end, and we got a 14 and a half percent reduction in calorie intake, which, remember, was four hours after they'd last taken Calico. So it just shows the length of time it works for. So Why would women be more Why would women be more responsive to GLP one look, there are many theories, but it is thought to be a protective mechanism for women, if they carry fetuses, so they're not going to eat anything toxic, so they're right mechanism. The second thing that made me very excited was not only the reduction in hunger, but craving. Craving, on average, a woman will will eat 250 calories more in her luteal phase of her menstrual cycle, and up to 600 calories. So this is what we call, colloquially, you know, premenstrual. You know, I'm feeling premenstrual. I want to eat chocolate, I want to do water. And this is just craving now, it in turn, is natural, because you might have the possibility of fertilizing that egg and impregnating it. So your body is saying, oh, eat more, because you're going to ovulate that egg and you may need that energy. But of course, we're not going to do that every month. So every month, you know, you get this average of 250 calories more because your body is telling you to so I think Calico can really not just help people make healthy choices, but can help them in particular times, you know, of the month, and particularly women. So yeah, it was a long trial. It was an expensive trial. I think I ran my chief researcher the government one probably every day for the last three months going, have you got a result? Have you got a result? But, yeah, it was worth it because it was over COVID. So that's the three human clinicals we're on to our fourth human clinical now, which is our large. System, and that is 150 people, men and women. So not just little men, men and women and BMI. So body mass index between 25 and 35 and it's over six months with a three month follow up. And we're meeting, when meeting, measuring body composition, blood glucose, GLP, one levels, and of course, a major one is for us as weight loss. So that will be finished in the last half of this year. So that's a big trial. That's $2 million so, yeah,

wow. So people are already using this in the United States widely. So I was asking you about your supply chain. So a lot of these so called, you know, natural supplements, whatever, you know, they're packaged in China. They're, you know, we don't know what's going on over there, right? Yours is all done in the United States, right? No,

well, we grow the extract in New Zealand, right? Yes, one of the most beautiful places called mocha. So it's a hops flower, and we extract the hops flower, it almost looks like a a honey. So very sticky, very thick honey, which we package and then we send to the US. Okay? It's encapsulated in the US and by a company called Lonza, which is one of the largest capsule manufacturers in the world. And it's an FDA, GMP, NH, I don't know. It's got everything behind it. I've been through it, it's, it's a it's a fabulous plant, and it's encapsulated in a delayed release cap. And why it's in a delayed release because we want it to go down and it deposits in the upper intestine, and that's where it disperses. So it has to be so we have a patent around our formulation, which is granted in America and Australia and penned in Europe, and the capsule we put it in is patented as well. We then bottle and label in America and sell in America.

Okay, so it's the hops is grown in New Zealand, and then it's sent to America. And so what else is in the capsule? I mean, I know it's a proprietary formula, but in a general

sense, on a capsule. And you know, I love it that it's patented. It only took us six years. It's a long process. Wow. Is Amara state being the hops extractor? Yes. So a Mara, meaning bitter and sat, meaning satiation. Only a scientist could think of that, because, yeah, everyone else can pronounce it. So I've heard it's called so many things, but that was the scientist. So Amara sake, then the hops extract a vegetable oil, which helps it disperse in the upper duodenum, otherwise it'll sort of go through and not really activate. So it needs to disperse partly, and then rosemary and at a small amount, which is a natural preservative. So you've got three natural ingredients that we know the we know the providence of, or where they come from, each one, and each of them are tested. So yeah. So the rotary comes from Spain, the vegetable oil from America, and the Americ state from New Zealand, so vegetarian, the whole thing's vegetarian, vegan and so on like that,

and gluten free and all the rest of

it. I just want people listening to understand you will never taste the bitterness unless you chewed the tablet, which would be silly, um, you will never taste it. All we're doing is stimulating these little taste receptors that sit in your intestinal tract, and we're stimulating it as it goes down. So you're getting this prolonged I think the other important thing is it is targeted at the catastropin question, or trap, so we don't literally, 99% of it is digested in the lower colon or broken down in the lower colon, less than 1% in the bloodstream, so it doesn't interfere with the liver, it doesn't interfere with the kidneys, and it won't interfere with medications. You know, the only contraindication we would say, would be if you had an inflammatory gastrointestinal so a Crohn's disease, or an IBD or something like that, because you've got an inflamed and gastrointestinal system. So you don't want to, you don't want to be doing anything to it. Basically, yeah, that makes

complete sense. So how do we take it? You were talking about an hour before meals. Do you have to take multiple capsules a day? What's the recommendation how we would use it? Like

a on the label and on the box, we say, take an hour before lunch and dinner, right? Two main meals, you know, to get an eight to get your portion control right. So that just makes it easy for people to think about it in portion control. But there are many ways to take it. I mean, I intermittent faster, and I always say, because I'm lazy, it's the easiest thing for me to do. So I added, you know, it's just an easy thing, particularly with traveling. So I take mine at about nine o'clock, eight or nine o'clock in the morning, and that sees me right through to lunch time. You know, I'm totally fine. I'm not thinking about lunch. I can walk past those muffins, I can walk past that morning tea and not worry about it. So I can do that. And also, I'm going to eat a smaller lunch. I'm not going to overeat or have rebound eating. So I take it like that for other people, like, let's talk about cravings during the menstrual cycle. You know, I would probably, when you know you're going to have those cravings, I'd probably take it in that week, or I'd take it before dinner, because it'll last right through, and it'll stop that chocolate truck craving after dinner. If people are going to exercise, we say, take it, you know, an hour before you exercise, because often you'll come out of exercise and you'll be revenuelessly hungry, which isn't a bad thing, because you've used energy, and your body is saying, hey, you've used up energy. Have some more. But this will just, we say, don't waste your workout. So typically, two hours, I'm sorry, an hour before a main meal. And just on the with it, we we have an onboarding program because of one a day for two days and two a day for two days, and then you get up to the full dosage, which is two before lunch into before dinner. Now, the reason we say this is that everyone this is a biologically active product, right? So 5% of people, we're very upfront about that when they first take it, will get a laxative effect or a softening stool effect. And this is it's actually a good thing, because your body say, Hey, you're getting this increase of these hormones being released. So it's actually you've got a functioning gut, brain access, yeah, 90% of people like me, you won't have anything. And maybe in that top 5% you might need to take three at top dosage, but for that 90% you sit in the middle and you know about it like it's like a pharmaceutical. Everyone has a different a different way. They adapt to them, and that's the same as this. So we do have an onboarding program, which we always say, take on an empty stomach. The reason being is you want it to go through your upper digestive system. You don't want it to be stopped in the stomach and take it with a glass of water.

And so is this something where you do your onboarding and then you start taking it, and then you work up to the full dosage, which, for the typical person, is two before lunch, to before dinner. So is this something that you can also take sporadically? Yeah, whenever you feel like it like, how does that work? Like for someone that's listening going, well, I don't want to be a slave to be taking four of those every day for the rest of my life. Yeah, where? Where's the where's the flexibility in this? For somebody,

utter flexibility, and like, I only take it once a day, unless I'm going to be eating out late at night, and then I think, Oh God, I'm going to be eating at eight o'clock, you know, I'm traveling or something. I'll take one now so I'm not ravenous by then. But, you know, a lot of people come in and out of it. You know, they're going on holiday. Mind you, I think it's we start to take it on holiday, but they're going something and that they're like, no, no, I don't want to do that. So I'm going to take my Calicut, and you know, it's perfect for that. So well, my jeans are getting a bit tighter, or something like that,

you know. So you can go on and off it and just use it as a tool. So for example, if you were going on a family holiday and you actually were feeling like at your ideal weight, and you didn't want to eat everything in sight on your trip to Paris for a week or something. You wanted to eat a little bit, but not a ton. Could I take it for that week and then maybe not take it for a few months? How does that

work? Totally and utterly and that time, wow, for me for traveling, I think it's unbelievable. Like, you know, I travel a lot, but particularly in the US, and that's just a standby for me, because, you know, I'm on planes, or I'm in airports, and I'm surrounded, as you can imagine, by, you know, not that great of food, and I'm still going to eat, I'm just not going to eat as much. I think that's. Point, I'm not You're not food. You're not going to do that because we are compared to a synthetic, right? And we can talk about that compared to a synthetic injectable, that you are at a high level of. GLP, one for 24, hours a day, for seven days. Mm, remember, we work for six hours and we stimulate GLP one when you need it, that's either to suppress your hunger or to eat less, and we follow the body's normal rhythm of it. So, yeah, absolutely. And that's See, that's the fabric we do have people, lots of people, who have been on it for for years, and they just, it's their multi but it's, I hate to say it's a multivitamin, but it's a multivitamin for the modern world, because and it's

also just a tool in a greater toolkit. It's just one tool in a toolkit. I love this. How would you compare yourself to some other things that have gained a lot of traction and in the market, like barbering and things like that. Like, how would you compare to something somebody else might, might have been taking

sure Bucha does nothing to GLP, one, okay, let's get that straight. Berberine levels, blood glucose. It is used as a blood glucose level, but it does nothing for GLP, one. It works in a, it works in a, a metabolic way, but blood glucose, so it kind of levels blood glucose. That is what Berberine does. So Berberine is not going to do anything to DLP on, it does nothing, and it shouldn't ever purport to do anything for your hunger or your craving.

Um, and thank you so much for clarifying that, because there's so much misinformation about all of this stuff. You know when you see it online, your neighbor might be taking it. Oh, yeah, I'm doing this as an appetite suppressant and and all the correct information gets lost along the way. So I do want to dive into what you were just touching upon, the difference between GLP one agonist injections and Calico, and just the differing science and the way that it is administered, the way that it's released in the body. I I'd love to just really clear up some misinformation about all of that as well, because, you know, we're now learning that these agonist injections are dose dependent, and that people are taking it at these extremely elevated dosages, and that actually now they're having more success micro dosing and bringing the dosages down. And I know that you're watching this space so closely so So talk us through that.

Yeah. Well, let me first tell you about the difference. So an injectable, a GLP one injectable, or GLP one receptor agonist they're called. They are a synthetic they have, they have copied our natural GLP one, right? And they've copied it, and they've changed one molecule so it's, it is it lasts for seven days in the body. Normally, your GLP one would last for two minutes, right? And that our Marissa works because we're activating all of these little taste buds right the way down through so we're sort of firing them as they go down. Think of a pinball machine. We're like that a synthetic injecting it into you. So it's in your bloodstream. We are in the intestinal tract, and we're stimulating that, but it is high for seven days now. There's nothing wrong with that, other than it is that what we would call a Supra Supra physic, that is a word, by the way, the scientists are telling me, and I'm looking, I'm like, did you make that up? Or something? That's actually a word. Obviously, it's a science Word, and the super physiological level, and that high for seven days, for seven days, till it's finally broken down. So you have high GLP, one when you're asleep, you know, and all of these things when you don't need it. And of course, you know, there are many side effects with it, because at a very high level that that is, you will get, you start getting to this bio toxicity level where you will feel nausea, you will feel, you know, you will have vomiting, you will have these different reactions as a horrendous because it's at A very, very, very high level. So we are completely natural. We are just stimulating your natural. GLP, one, however, you know, I think to what you were saying, we we're finding it the most fascinating Since 2021 22 you know, we've been used in three ways. One is, of course, you know, the most obvious with as an alternative. You know, I don't want to inject myself. I can't afford it seems too extreme to me, or I just can't take the side effects. So we are an alternative. Let me just back up from that semi glutide witches would go V or ozempic, more commonly known, it, on average, reduces calories by 24% per day. As I said, we're at 18% if you take it as instructive, so going back, so as an alternative. The second one, which is really interesting, and doctors are using it. We didn't promote it in microdosing, so they're doing this micro dosing of these very low levels, these micro dosing of these very low levels of whether it be semi glutide or Troy petite at the lowest level, and they're given Calico at the same time. So you're getting this exogenous, so synthetic hormone, but you're also stimulating your natural hormone.

Wow. So they're doing a hybrid, yeah.

And then the third one, which I think is the most, well, they're all interesting, but this one is when you're titrating people off the injectables. Because, you know, there's been a lot so bringing them off the injectables. There's been a lot of public health there's been a lot of news or information about this weight regain and rebound. Over two thirds of people, and probably more, because that was only measured over 62 weeks rebound in their way, so 75% of people rebound, and possibly more. Now there's multiple reasons for that, but one of the reasons is that when you're on a external hormone, when you're on a synthetic hormone, you suppress your natural hormones. Of course, your body doesn't need to produce them, because you're taking it externally. And this is what we're seeing with, you know, we see it with steroids, we see it with testosterone, we see it with everything. And this is actually clinically known. You're suppressant. So when you come off the injectables, your natural gut brain axis is zero, so no wonder your hunger. So it's not all the reason. Part of the reason your hunger is going to go bang, and you are going to be like, Wow, and you've got no stop button. You haven't even got your natural stop button in there. So they're using Calico as people come off as this wonderful maintenance dose. And there's two reasons for that, as I said, physiologically, to kick start that gut brain access to get that natural GLP. One working again. And the other thing is people have, and they just done this paper about how people have this fear and hopelessness coming off these injectables, so this real fear. So we're not only giving them a physiological kickstart, but we're also giving them something to take away that feeling of hopelessness, because when you come off, there is no maintenance in there. There is no lower dosage, you literally come off. So yeah, so three ways, and yeah, it's been extraordinary. And we just did a 50 patient trial in the US with a large practitioner using it in those three ways, and he's had sensational results. So 10 were on just Calicut. 22 were on 23 were on micro dosing. And I think 23 or whatever we're on, don't think that adds up. It's something like that. Yeah. And all of them were great. It's been written up now to be published, and all of them have maintained their weight loss

Unknown (34:04):
just incredible.

So you were talking before about Big Pharma taking out hundreds of 1000s of doctors to wine and dine them, educate them about the science and get their little script pads out to to recommend these, these farm pharmaceutical intervention strategies. What are you going to do as the the little David versus Goliath in this story about getting it to more doctors, like the one that's doing this trial, and getting these incredible results? Is it just one doctor at a time? Or what's going to be your your strategy for that? Yeah,

it's a great question. So we go through the practitioner channel as well. I was in America 12 times last year, so literally, every month, don't tell immigration that will probably

Unknown (34:58):
as long as you leave it I think they can.

At and we would have gone to probably 18 different conferences. So we go to conferences. We have speakers that speak about us. We publish papers. We, yeah, we do it. We so we have, you know, Kol doctors, key opinion leader doctors that we use. We have conferences, we have speakers, we have white papers. We have published papers, we have advertising where we can but, you know, it is a pay to play. We are doing our series, a round at the moment, which is accelerating, but So raising more money, which is exhilarating but terrifying at the same place time. So, you know, literally, we the biggest comment we get is, why haven't we heard of you before? Right? Why have we heard of you? And, you know, if you look at what Nova did, they spent a billion dollars, yeah, so we're not going to spend that. But how they've educated the market. Thank you. Thank you. But how do we get that message out there? And you know, as I said, conferences, $10,000 US to attend a speaker, 20 to $50,000 clinical trials, as I said, So, 2 million. Yeah, 2 million. So, yeah. So we're not at the glove. But the big thing for me, Tess, and I think hopefully for people, people listening, is there is nothing to take people off the injectables. There is no maintenance that's effective and affordable. And effective and affordable is the point. Hey, I don't feel so desperate coming off these because I have something that I can work with and I can work more on. And let's talk about that. I can work more now on my what my diet should be. You know, an injectable will make you have an extreme. I'm not interested in food. I'm not interested in I can eat tiny portions, literally, because I want to survive right when you come off, you have to, you really want to be thinking about, what am I eating? What am I eating? How am I behaving? What are my triggers? So I just give Calico gives you that safety net to think about that to make healthier choices, because you're not going from no food to completely ravenous. You can start making those healthier choices and adapting your lifestyle to that.

You know, one of the big differentiating things amongst all the things that you've been talking about is not only that it's synthetic versus natural, but also that it's the injectables are going into your bloodstream. They're affecting your other organs. They're in your blood. They're mixing up with all the other stuff, right? So anything that has an effect has a side effect, and it keeps going on systemically around the body. It has all these other effects. And obviously, the side effects have a widely documenting, and we're widely documented, and we're discovering more every day. You talked about how Calico stays in the gastrointestinal tract and does not go into the bloodstream. You talked about how 5% of people may experience a laxative effect and maybe adapting their dosage according to the symptoms that they may experience. What if somebody

run off, or it'll like 24 to 48 hours and and usually go, but you know, they may be the lucky people that are just a one, yeah. Yeah.

So and look, that's that's true of any supplement, any drug, any you know there's always going to you don't know how it's going to affect you in any particular circumstance. That's true of anything that we might take because everything that has an effect has a side effect, potentially. What are some of the other things that you've seen for people to be aware of. When taking calorie curve, you talked about taking it on an empty stomach, with water, that sort of stuff. What else do we need to be aware of? You

know, that's that's about it. I know it sounds but some people may get a burp, but if you're a guy, they don't, you know, make it a little bit of reboot. But if you're a guy, you don't mind because, like, a beer dude,

it's like a badge of honor, just because we're from New Zealand and Australia. That's hilarious. Oh, that's so funny. That's so funny. So
so you have not had any other documented side effects so far, other than those handful of what I would consider fairly innocuous things, yeah,

if you win, if you Google it, we had one purported allergic reaction of 2018 we took that extremely seriously, and we went through a, we forget what an allergy doctors called my son. Yes, very important doctor, and we did a whole thing on it, and he literally called it an idiosyncratic reaction reaction, but that's been out of hundreds of 1000s, so I never want to play it down, because, you know, this was reported in 2018 but I'd also say hops, which go into our beer, have been drunk for centuries. So it's inherent safety is, is, you know, we have drunk it for years. Australian and New Zealand has drunk a lot of it.

Unknown (40:44):
That is, that is so

true. But out of hundreds of 1000s of people that have taken it, that one case is, as you say, is completely as well,

because if you've got herbalist or naturopaths out listening, they'll say, Well, what about the phyto estrogen and hops? Using CO two carbon dioxide, super critical extraction, you remove all of the organic material so you have no organic material. You are left with the alpha and beta acid, plus a small amount of essential acid. So the alpha and beta acids give you the bittering and beer, and the essential oils, which are tiny, give you that flavoring and beer. So no organic material and no Fauci I love

that you're anticipating the questions. I love it. You've got, you've got this down, baby, you're like, anticipating what I'm going to ask next. So it's available in the US, it's available in New Zealand. It's about to be available in Australia, and you, you just alluded to being available in Europe next. So what, what are you looking at in terms of the timeline for Europeans being able to access access?

Oh, well, we're doing a trial in the UK, literally starting in March. So that's a trial there, and we have our TGA and all still approval in Australia. So we're looking at the second half. It is available in Australia through New Zealand. It's just a slightly longer postage and but we have our approval, regulatory approval in Australia, and we are getting our regulations in Canada. But, you know,

so exciting. So when will it be available in Canada? Do you anticipate? Oh, listen,

I talked to the regulatory consultants the other day, and one that an application they put in a couple of weeks before us had just had some feedback. So I'm literally hoping any week now, oh, wow, Canadian practitioners and Canadians are asking us the whole time because, you know, it goes across the border, and then it gets stopped, and then a whole lot of things like that. So it's so much harder, and we'll be able to distribute then, you know, from Canada, I mean, obviously different labeling and so on like that. But you know, we have different labeling in every jurisdiction.

Yeah, look, I just love the testing that's already gone into this and will continue to go into this, and just the integrity with which you're navigating this, this entire space. So I know that this is personal for you, Sarah, so you have been using Calico in your personal life. This is very much your baby. You believe in the science of this so much, and you've been using it in your daily life, and you've been very open about how using Calico has changed their relationship with food. So can you take me inside of that and what you hope for other people now?

I think you know a founder always has a story behind it, because to start any company, you have to be literally insane or certifiable. And so, you know why? And I think because I had struggled with food since I was put on my first diet, I think when I was 10. And so I've struggled with food my whole life. And I'd say it's just love hate relationship. You know, you love it, you hate it, binging, yo yo, dieting, and it's just absolute, yeah, love and hate. And obviously, when I saw this, I love the science, but, and I started taking it, but I can honestly say I am at peace with food now, absolutely at peace. I like it. It's great. I can eat it. I just don't eat as much. So gone. If they're dreadful, yes, just, you know, it's I'm at peace. And so many people say to me, we take the noise out of their head. I think it's just even a bit more than that. And you know, you. Talk to so many people, and it doesn't just have to be women, it's men as well, and they can repeat this love, hate relationship. And just to be able to take that away and feel at peace like, you know, I I can walk past that muffin, or I don't have to grab it and eat it all down and then hate myself for it, even if I do want it, you know, I maybe only have half of it or a quarter of it. So, yeah, yeah, it's

I liked what you were saying earlier in our conversation about willpower, that it goes beyond that. And for so many years, you were just sort of told we don't have any willpower. You're weak, you know, or you know, you're just greedy, or whatever it is, and now we know that it goes well beyond that. And as you point out, the the millions and millions of dollars that went into research by these pharmaceutical companies has been a gift to educate us about GLP, one and these other hormones that affect our hunger and satiety and affect our ability to process sugar and metabolize and and just focusing on metabolic health, this conversation around this,

around this is lack of willpower, and, you know, go down just very quickly, go down to why it is. It's evolution, right? And we talked about bitterness and evolution, but evolution, our hunger is controlled by our hind brain, so when you when you decrease your calories by 25% your hunger actually doubles over four months. Now, that was an evolutionary trait that made us get out of the caves. Otherwise we'd all be lying there going, Yeah, you know what, it's a bit cold. Oh, you know what, it's raining. I don't want to go outside now. You know what? I'm okay, it's saying your body or your hind brain is saying, you get out there, you hunt for food, because you could be going into a famine, and your body or your physiology, fights to keep that metabolic state and where it is. So you know, when you try and diet and you reduce that calories, your your hind brain is sending these signals for you to eat, and you just need stress, hormones, alcohol, anything like that, and that forebrain just literally topples off, and off you go. You're off. You know how many times? Well, I don't know, but I know for me, how many times have you eating hot chips late at night,

Unknown (47:25):
more times than I would. I'd like to admit, but I if there was an hour left on Earth, I'd spend some of it eating french fries.

Things I'm saying, you know, that is your home brain going. Got you full break because you've been weakened, and I'm off. And here's those hot chips. So yeah, so this can help quieten that noise, but I'll go back to it. We are just a tool in a toolkit. You know, you have to think about everything and forgive yourself sometimes, but think about, you know, we are there just to assist you to make healthier choices.

So what's your dream for Calico? What's your big dream? I know that you took this over you. You this, this is, this is a big, big personal mission for you in in if I was Mary Poppins and I was going to pull stuff out of my carpet bag, what? What would it be? And you're

Unknown (48:24):
going to fly away and you're on grammar,

of course,

no, what would it be? You know, what I want to get away from. It's about just weight and weight loss. This is about, as I said to you, it's about every day being able to help you. You may not take it at a lower dose, but allow it every day to help you in the modern world, because we are our physiology is not going to change, right? We have evolved over 1000s and 1000s of years. It is not going to change. So what was an asset for us in evolution or in primeval times, is now a liability. So for me, it's about getting off. It's about a world where we're not just talking about weight loss, we're just talking about healthy choices and weight maintenance, and it's not about being skinny. It has been about healthy Yeah.

Well, I am excited to see where this goes. And I cannot wait to see for Calico to fully be available in Canada, Europe, Australia, the UK, all of these places, because I know after people here just the incredible science behind this product, everyone's going to want to get their hands on it. And of course, it's already exploding in the US. So I close every episode with the same question. So I'm going to ask you as Gosh as somebody who has just brought so many companies to the fore and just gone after stuff and has been a CEO to watch on so many lists in so many communities all these years, it's so inspiring for somebody that has a dream in their heart and they don't feel like they quite have. What it takes to make it happen. As somebody that makes stuff happen, what would you say to them?

I never, don't believe in yourself. I think always have the child like Wonder of the World and just, yeah, be kind to yourself. Does that make sense? You know, be kind to yourself, and always look at things with a child like wonder and think, Wow. You know, this is fun. I always say, you know, you're very kind about my career, but I always say it's a bit like a drunken spider on a slippery window screen. You know, it kind of goes from one to the other. I mean, it's been enormous fun, but it's also been things that have interested me, you know, absolutely fascinated me. And so I'd love to say I've been very lucky, but probably it was just the drunken spider.

Well, I think you're being very humble, but I do take your point of doing what you're drawn to, doing what you're passionate about, doing what you find fascinating with that child, like Wonder and and then taking action on it. Oh gosh. Thank you for this fabulous conversation. I'm so excited about Cal OCO,

thanks, Tessa. It's been great to talk to you.

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.css-14f5ked{margin:0;word-break:break-word;display:-webkit-box;-webkit-box-orient:vertical;box-orient:vertical;-webkit-line-clamp:2;overflow:hidden;}Calocurb: A Natural Alternative to GLP-1 Injectables | 048