CHRONIC GRAFT VERSUS HOST DISEASE | Dr. Michael Verneris | cGVHD Pediatric Considerations

In this episode our hosts Katie McMurry, PharmD (US Transplant MSL) and Amber Lawson, PharmD (US Transplant MSL) have a conversation with Dr. Michael Verneris, MD. Dr. Verneris is a Professor of Pediatrics and the Barton Family Endowed Chair of Bone Marrow Transplant at the University of Colorado Denver School of Medicine. He also serves as the Director of Bone Marrow Transplantation and Cellular Therapy at the Children’s Hospital Colorado. In addition, he is currently serving as Vice Chair of the Pediatric Blood and Marrow Transplant Consortium (PBMTC).  Dr. Verneris will take us through some of the impacts socioeconomic status has on hematopoietic cell transplant outcomes in the pediatric population as well as some of the data gaps that need to be addressed going forward in this patient population.  

Supporting Literature and References: 

1. “Neighborhood poverty and pediatric allogeneic hematopoietic cell transplantation outcomes: a CIBMTR analysis”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845011/ 
2. “Prevalence and Impact of Financial Hardship among New England Pediatric Stem Cell Transplantation Families” https://pubmed.ncbi.nlm.nih.gov/25445021/  
3. “Social determinants of health predict health outcomes following pediatric allogeneic hematopoietic stem cell transplant” https://pubmed.ncbi.nlm.nih.gov/38302730/  
4. “Social regulation of human gene expression: mechanisms and implications for public health” https://pubmed.ncbi.nlm.nih.gov/23927506/   
5. “The conserved transcriptional response to adversity” https://pubmed.ncbi.nlm.nih.gov/31592179/   
6. “Alterations in leukocyte transcriptional control pathway activity associated with major depressive disorder and antidepressant treatment” https://pubmed.ncbi.nlm.nih.gov/27219347/  
7. “Low socioeconomic status, adverse gene expression profiles, and clinical outcomes in hematopoietic stem cell transplant recipients” https://pubmed.ncbi.nlm.nih.gov/26286914/  
8. “Molecular correlates of socioeconomic status and clinical outcomes following hematopoietic cell transplantation for leukemia” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859844/  
9. “The health risk of social disadvantage is transplantable into a new host” https://pubmed.ncbi.nlm.nih.gov/39008669/   
10. “Mindfulness-Based Stress Reduction training reduces loneliness and pro-inflammatory gene expression in older adults: A small randomized controlled trial” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635809/  
11. “Yogic meditation reverses NF-kappa B and IRF-related transcri

This program is non-promotional and sponsored by Sanofi. Presenter(s) were compensated and/or received an honorarium from Sanofi in connection with this program. This program does not constitute an endorsement by Sanofi of any particular organization or its programming. Additional resources and information may be available and should be investigated.

This podcast is intended for US residents only. Sanofi does not provide medical advice, diagnosis, or treatment. The health information contained herein is provided for general educational purposes only. Your healthcare professional is the best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.