Let's Talk Alzheimer's

Let's Talk Alzheimer's

Welcome to Let’s Talk Alzheimer’s, your place to go for trusted insights from leading scientists and medical experts. Get the latest information on diagnosis, risk reduction, clinical trials, and the latest treatments. Presented by BrightFocus Foundation's Alzheimer's Disease Research program.

Episodes

August 20, 2026 21 mins
Agitation is one of the most common and challenging symptoms of Alzheimer’s disease, often causing distress for both individuals living with dementia and their caregivers. Dr. Brent Forester explains what causes agitation, how it may appear in different forms, and the latest approaches for managing symptoms—including non-drug strategies and newly approved treatments. For a deeper dive into vascular dementia, watch our ...
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Vascular dementia is the second-most common form of dementia and often develops after a stroke. In this episode, Dr. Jason Hinman of UCLA explains how disrupted blood flow to the brain can lead to cognitive decline, how vascular dementia differs from (and often overlaps with) Alzheimer’s disease, and what the latest research means for prevention and treatment. For a deeper dive into vascular dementia, watch our full conversa...
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Could the trillions of bacteria in your gut affect your brain health and risk for Alzheimer’s disease? Emerging research suggests the gut microbiome may play an important role in inflammation and brain function. In this episode, Dr. Beau Ances of Washington University in St. Louis explains the growing science behind the gut-brain connection, how gut health may influence dementia risk, and practical steps that may help support...
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Could bacteria linked to gum disease play a role in Alzheimer’s disease? Emerging science suggests that P. gingivalis, a bacterium associated with gum disease, may contribute to inflammation and brain damage linked to Alzheimer’s disease. In this episode, Dr. Michael J. Detke of Lighthouse Pharma discusses the SPRING clinical trial and the investigational oral drug LHP588, which is being studied as a potential way to r...
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Exciting advances in understanding Alzheimer’s biology, genetics, and biomarkers are driving new medicines, devices, and prevention strategies. In 2025 alone, 182 clinical trials evaluated 138 novel drugs for Alzheimer’s disease. In this episode, leading expert Dr. Jeffrey Cummings from the University of Nevada Las Vegas shares an insider’s look at the rapidly evolving Alzheimer’s treatment pipeline and wha...
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Can everyday lifestyle choices really protect your memory? Dr. Laura Baker, professor at Wake Forest University School of Medicine, shares insights from the groundbreaking U.S. POINTER trial—the largest study of its kind exploring how lifestyle changes impact brain health. She breaks down how factors like exercise, nutrition, cognitive engagement, and social connection work together, and what practical steps you can take to r...

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Detecting subtle changes in memory or thinking can be unsettling, but understanding what’s behind those changes can lead to critical early diagnosis—or even rule out Alzheimer’s altogether. In this episode, behavioral neurologist Dr. Sharon Cohen, medical director at Toronto Memory Program, explains the early signs and symptoms of Alzheimer’s disease, medical conditions that can mimic dementia, and how to st...

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Just three years ago, there were no FDA-approved treatments that targeted the underlying causes of Alzheimer’s—only medications that modified symptoms. Today, two FDA-approved therapies—Leqembi (lecanemab) and Kisunla (donanemab)—clear amyloid protein from the brain, targeting a potential cause of the disease. Dr. Armen J. Moughamian, a neurologist and medical director of the Ray Dolby Brain Health Center at...

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