June 9, 2025 • 23 mins
Berberine is trending—but not always for the right reasons. Labeled “Nature’s Ozempic” online, it’s often misunderstood. In this episode of Mindful Objective, we explore what Berberine actually is, how it works, and when it may support your body, especially through a functional, data-driven lens.
We unpack the science behind Berberine’s impact on metabolic balance, gut health, and cardiovascular markers. From supporting healthy insulin and glucose levels to microbial diversity in the gut, Berberine can be a powerful short-term tool—but it’s not a magic fix or drug replacement.
You’ll learn:
What Berberine really does and how it supports AMPK activation
When it might help with blood sugar, cholesterol, or digestion
What lab markers—like fasting insulin, GI-MAP, or liver enzymes—can guide safe, effective use
How to time Berberine with meals, how long to take it, and who should avoid it
Why retesting and symptom tracking are essential for long-term results
We emphasize using testing—not trends—to make informed decisions. With clear guidance on dosage, safety, and cycling, this episode helps you explore Berberine’s potential without falling for the hype.
This show is for educational purposes only and is not medical advice. Always consult your provider.
Explore functional lab kits and practitioner-grade supplements at 20% off at mindfulobjective.com.
🎧 Tune in now—and if you’re ready to get real answers, visit MindfulObjective.com to explore functional gut testing and personalized healing protocols.
📝 Disclaimer: This podcast is for informational purposes only and does not diagnose, treat, or cure any disease. Always consult a healthcare professional before making dietary changes. By listening to this podcast, you acknowledge that you understand and agree to this disclaimer.
📍If today’s conversation helped reframe your symptoms or sparked a question of your own, share the episode with someone who could benefit. For more insights, resources, and ways to connect, visit mindfulobjective.com or follow along on social media @mindfulobjective.
📍Submit a show question at https://mindfulobjective.com/podcasts
Healing doesn’t happen all at once, but each question, each step, and each small win adds up. This episode is a reminder that the answers you’re seeking often begin by asking the right questions.
Stay Well!
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Transcript
Episode Transcript
Available transcripts are automatically generated. Complete accuracy is not guaranteed.
(00:00):
Welcome to Mindful Objective, the podcast where we explore the
root causes of health concerns and help you restore balance.
I'm your host, Doctor Daniel Sproule, integrative health
practitioner professor, and today we're unpacking the truth
about Berberine, which is one ofthe most talked about natural
compounds in the Wellness world right now.
You've probably seen it hyped upas a natural alternative to
medication, but the real story is much deeper and far more
(00:23):
practical. From blood sugar and digestion
to microbial. From blood sugar and digestion
to microbial balance and lipid support, Berberine may offer a
multi system support when used with intention.
This podcast for educational purposes only.
We did not diagnose, treat or cure any illness or disease so
let's get into it. Berberine is naturally occurring
(00:44):
compound found in a group of plants, most notably Burberry
golden seal, and another one would be Goth red.
It's a bright yellow alkaloid compound that has been
traditionally used in generations in a herbal medicine
systems such as traditional Chinese medicine and Ayurveda.
What's interesting about berberine though is it stood to
(01:06):
test the time not just because of tradition, but because it's
emerging research that suggests it may support a range of health
functions. Today, many integrated
practitioners consider berberinewhen helping individuals focus
on improving areas such as metabolic Wellness, gut balance,
and cardiovascular support. So let's be clear though,
berberine is not a treatment or cure for any disease.
(01:27):
It's a botanical compound that may help the body's natural
system maintain balance. For example, berberines often
use short term Wellness protocols designed to support
blood sugar metabolism, gut microbial balance, or healthy
cholesterol levels. You might have seen berberine
trending online recently or for a while, with terms like natural
Ozempic being used. While that makes for a catchy
(01:49):
headline, it's not an accurate comparison.
Ozempic is a prescription medication that works by
mimicking GLP one, which is a hormone involved in regulating
insulin secretion and appetite. Berberine, on the other hand,
does not act like AGLP 1, and itdoesn't have the same effects.
It supports metabolic function through mechanisms such as AMPK
(02:10):
activation. This is a cellular energy
regulator, sometimes referred tothe body's metabolic master
switch. That's quite different from how
a prescription GLP one operates.From integrative health
standpoint, using Berberian responsibly means understanding
its role with a broader Wellnessstrategy, not using it as a
standalone fix. And this all starts with data,
(02:31):
right? Functional lab testing, which we
always breach on. So functional lab testing can
help determine whether Berberianis even appropriate for your
situation. Here are some of the markers
that might help guide your decision.
Fasting glucose and insulin. This can show early patterns of
blood sugar dysregulation. Hemoglobin A1C.
This always gives the insight into long term glucose patterns.
(02:54):
C Reactive protein. You may see this as HS, DASH,
CRP. This may reflect underlying
inflammatory trends. GI MAP or other stool testing.
This can help identify microbialimbalances and overgrowths.
A lipid panel. This provides context on
cholesterol and triglyceride levels.
So this type of testing doesn't diagnose disease but can help
(03:17):
you guide more personalized and proactive health strategy.
It helps answer questions such as is my blood sugar truly
elevated? Are you dealing with microbial
imbalances in your gut? Are your lipids trending in the
direction that might benefit from nutritional support?
Berberine may be helpful ally for someone with balanced blood
sugar, minimal gut concerns, or stable lipids.
(03:37):
It may not be offer much traditional benefit.
That's why individualized recommendations are always key.
You see, so many people just jump on board and they hear
about a supplement, they take it, they may not even need it,
nor maybe causing more damage. So that's why we look at the
data. Let's test.
Also keep in mind that botanicals like berberine are
typically used short term basis.It's not meant to be taken
(03:59):
indefinitely, especially withoutthe guidance of a practitioner.
In most cases, it's incorporating the protocols
lasting anywhere from usually 6 to 12 weeks, after which re
evaluation is essential. So let's talk about one of the
most popular areas where berberine is discussed, blood
sugar balance and metabolic health.
This is a space where many people hope to avoid more
(04:19):
serious complications later in life and we're supportive
strategies can make significant difference when used with the
right time. Blood sugar regulation is a core
function in bodies metabolism. It impacts energy, mood,
cravings, sleep, weight and evenlong term cardiovascular health.
For some individuals, patterns of elevated glucose and insulin
levels can remain unnoticed for years before symptoms become
(04:41):
apparent. By the time someone is told
they're borderline or pre diabetic, the underlying
imbalances may have been building for a while, and
usually this is years and years.This is where compounds like
berberine get attention. Some early research suggests
berberine may support healthy insulin sensitivity and glucose
metabolism. It appears to influence how
cells use glucose, possibly making them more efficient
(05:03):
absorbing and storing energy. One proposed mechanism through
AMPK activation, which may help your body regulate how it stores
and burns fuel. But let's make it practical,
right? From an integrative health
perspective, berberine may be considered in someone's Wellness
plan if they're showing patternssuch as regular energy crashes
after meals, increased cravings,particularly for sugar or carbs,
(05:26):
difficulty losing weight despiteeffort, a trend in rising
fasting glucose even if it's still technically within range.
We focus on optimal and the lastone be elevated insulin levels.
Although those symptoms are common, they don't always
indicate the same underlying 'cause there's many different
issues out there. That's why functional lab
testing is so helpful. It moves us beyond the
(05:47):
guesswork. Some of the most useful tests in
this context would be fasting glucose, which is a snapshot of
your blood sugar at rest. Another one would be fasting
insulin. High fasting insulin can point
to insulin resistance long before glucose rises.
Hemoglobin A1C reflects the average blood sugar over the
(06:08):
past two to three months. Another one would be cortisol
rhythm test. So because chronic stress can
raise blood sugar, testing cortisol via saliva or dried
urine, such as a Dutch test, canbe helpful in individuals with
elevated markers and persistent symptoms.
Berberine may be used short termto support metabolic
recalibration. However, it's never a
(06:28):
replacement for foundational strategies.
And what would this be? Such as optimizing protein
intake, reducing refined carbohydrates, improving sleep
quality and improving movement throughout the day.
Get up and walk. It's also important to highlight
that berberine is not a one-size-fits-all solution.
Some individuals with very sensitive digestion, for
(06:48):
instance, may not tolerate it well.
And if blood sugar is already atthe lower end, taking this
compound can further reduce glucose, which will lead to
fatigue, dizziness and brain fog.
And not everything's a benefit. Instead of seeing this as a
quick fix, consider Berberring temporary as a support tool,
something to help the body resetwhile addressing its root
causes. Ideally, it's used in
(07:09):
combination with lifestyle strategies and reevaluated after
a few months to assess whether it's even necessary anymore.
And that's what we say all the time.
Don't just take a supplement blindly.
You want to monitor progress through repeated lab testing.
Maybe you need to do these 8 to 12 weeks.
This can help provide clarity and how well your body is
responded. Is it working for you as an
(07:30):
individual? You may see improved insulin
sensitivity, probably fewer energy crashes, and for sure a
lot of people expand reduced cravings, but only if the
underlying systems are ready to respond to that Berberine.
Bottom line, when used with intention, berberine is a
powerful support tool, but only if you really need it.
While berberine is often discussed in the context of
(07:52):
blood sugar, it's historically used as primary digestive
support. So now let's talk more about how
it's traditionally used. While berberine is often
discussed in the context for blood sugar, it's historically
used primary for digestive support. 1 Tradition In Chinese
medicine and Ayurveda, berberinecontaining herbs were used to
support the bowels microbial balance and relief from
(08:13):
occasional digestive upset. Today, many integrative health
practitioners still turn to Berberine puts potential role in
supporting a healthy gastrointestinal environment.
Now let's talk more about how berberine may assist with gut
health and why lab testing can help determine if it's a good
fit for you. Your gastrointestinal system is
a home of trillions of microorganisms, bacteria, fungi
(08:36):
and more, all which impact digestion, nutrient absorption,
immune function and even your mood.
An imbalance in this ecosystem is sometimes referred to
dysbiosis, which may contribute to symptoms such as which we all
are aware of bloating, regular bowel movements, skin issues,
food sensitivities, brain fog, and another one will be fatigue
(08:58):
after eating. How many times do you eat and
get so tired? Berberine has shown in
preliminary studies to help support microbial balance.
When it's not used to kill specific organisms, it may
naturally help support a healthier terrain by encouraging
micro biodiversity. It also disrupt bacteria
biofilms which is a protective layer that makes bacteria more
resistant. It also supporting your body's
(09:19):
natural defenses against Candidaand certain gram negative
bacteria. It helps maintain integrity in
the gut lining on functional protocols.
Berberina sometimes paired with other plant based agents such as
oregano oil, caprylic acid, black walnut, garlic extract and
Sacromyos bilardi, which is a probiotic yeast.
These combinations are usually used short term for gut reset
(09:41):
protocols and these usually lastfour to 8 weeks before
transitioning to a more restorative plan involving
probiotics, mucosal support, nutrient replenishment.
Before starting any type of gut balancing protocol, it's best to
get the sense of what's actuallygoing on in your digestive
tract. That's where functional stool
testing and other microbial assessments come in.
These don't diagnose disease butcan help provide insight into
(10:03):
trends like overgrowth, undergrowth, inflammation,
digestive insufficiencies. Some of the most informative gut
related labs include GI MAP. This provides DNA based insight
into bacteria, yeast, parasites and markers, inflammation and
digestive function. And we have another one, Genova
GI effects. This is similar to the GI MAP
(10:24):
with added insight into short chain fatty acid production
enzyme output. Another one which we always talk
about is organic acid test, the O test.
This is a urine test that measures metabolic byproducts of
yeast bacteria. It can flag things like
orebinos, which is associated with yeast overgrowth, and then
again which is linked to proteinfermentation.
When practitioners have this data, we can make more precise
(10:46):
recommendations. For example, suppose your stool
test reveals elevated levels of opportunist bacteria.
In that case, berberine may be used as short term support.
If instead the test reveals low beneficial bacteria, gut
inflammation, a different approach might be more
appropriate for you. So different kind of
considerations. As with any supplement,
berberine may not be well tolerated by everyone.
(11:08):
Some individuals report temporary side effects such as
loose stools or urgency, nausea when taking on empty stomach,
changes in appetite, fatigue if blood sugar drops too low.
That's why gut protocols should be personalized and monitored.
You're an individual. You're not going to have the
same symptom always as your neighbor.
You're not going to have the same reaction.
It's not going to work the same,right?
(11:29):
So it's based on your individualself and why you need to test.
Taking berberine without knowingyour current microbial status
can sometimes worsen symptoms, especially if your system's
already sensitive or depleted. Again, berberine may be helpful
by tentacle for support and gut health and microbial balance,
but this is for a defined periodof time, not forever.
(11:50):
It should also be a part of a larger protocol and you should
have support from a health practitioner to guide you on
that path. Do that lab testing, understand
where it's needed, and what's the proper dose for you
specifically. Used thoughtfully, it can be
part of a comprehensive gut reset strategy that includes A
dietary changes, targeted supplementation, and eventual
(12:11):
gut restoration. Just make sure you're working
from data, not just guessing. Now let's talk about a broader
view of berberine. While berberine is widely known
for the support of metabolic health and digestion, there's
growing interest on how it may also assist the body's natural
ability to maintain healthy lipid levels and liver function.
This is the area where many people are quietly concerned.
(12:33):
Perhaps their cholesterol is trending upward or their liver
enzymes are slightly elevated onroutine blood work, but they
haven't met the criteria for diagnosis from their medical
doctor. These are the Gray zones where
integrative tools like berberinemight be a part of a broader
support strategy. So let's take a closer look at
what research suggests and how testing can guide whether
berberine is appropriate for your case.
(12:54):
Emerging evidence suggests that berberine may influence several
mechanisms involved in lipid metabolism and liver enzyme
regulation. From integrated standpoint, this
includes supporting healthy LDL levels.
Berberine may help promote LDL receptor expression in the
liver, which encourages cholesterol clearance from the
bloodstream, encouraging balanced triglycerides in HDL.
(13:15):
This is in some individual shortterm use of berberine may be
associated with improved lipid panels when combined with
dietary and lifestyle changes, assisting with non alcoholic
fatty liver support. Again, it's not treatment, but
berberine may help support normal liver enzyme levels and
reduce oxidative stress in the liver, which is often areas of
concern for individuals with suboptimal liver functions.
(13:38):
It's essential to note that these benefits are not
guaranteed and the berberine should not be used as a
substitute of medical intervention when necessary.
Instead, it may be part of a comprehensive approach that
includes nutrition, physical activity, stretch management and
regular monitoring. So what lab markers might guide
berberine use? Integrated practitioners often
look at a variety of labs, not asingle lab.
(14:00):
Not just check for the disease, but to catch trends early.
Some of the markers may suggest role for liver and
cardiovascular support, such as a lipid panel, LDL, low density
lipoprotein. High levels can suggest a need
for lipid support HDL high density lipoprotein.
Lower levels may indicate reduced cardiovascular
resistance triglycerides. Elevated levels may reflect
(14:24):
insulin sensitivity issues or liver strain liver enzymes
ASTALT or AST. Elevated levels are early signs
of liver strain even without symptoms.
GGT This is another helpful liver marker, especially in
relation to oxidative stress or bile flow.
Inflammatory markers such as high sensitivity C reactive
(14:45):
protein is often used to assess systematic inflammation,
including cardiovascular inflammation.
Ferritin, while often known as amarker for iron storage, high
ferritin can also suggest inflammation or oxidative stress
will be lipoprotein. This is in gaining more
popularity in the market. These are more advanced lipid
markers that may offer additional cardiovascular
(15:06):
insight. So if someone's lab work shows a
pattern elevated triglycerides, borderline high LDL, or liver
enzyme trends that aren't ideal,berberine may be considered as
part of a short term support protocol.
Let's understand why it matters.While berberine may support
these areas, it's never the onlyanswer.
For example, increasing fiber intake through vegetables,
legumes, and flaxseed may support cholesterol balance.
(15:29):
Healthy fats from sources like wild caught salmon, olive oil
and avocados are essential for supporting HDL and reducing
inflammation. Reducing processed foods,
alcohol and added sugars can make a significant impact on
both liver and heart health. This is probably one of the
areas that's hardest for people to give up.
But got to give up that processed food, right?
Look for Whole Foods. Just as in other areas,
(15:52):
berberine should be used under guidance with a practitioner,
especially if someone's taking medication that affects
cholesterol or liver functions or blood pressure.
Some individuals may also experience side effects if the
dose is too high or use long term.
Reevaluation is key. As with other uses, most
practitioners recommend retesting labs after 8 to 12
(16:12):
weeks of using berberine, especially if it started to
support lipid or liver trends. If markers improved, great, It
may be time to shift focus to maintenance.
If they don't, it could indicateneed to reassess other lifestyle
factors. Are you still eating processed
foods? Are you still eating all this
garbage, or is it just not working for you?
(16:33):
Is there another issue? So there's a lot of different
strategies that need to be discussed.
That's why it's always great to work with the integrative health
practitioner. If you need any help or
guidancemindfulobjective.com, don't hesitate to reach out.
And finally, what we need to talk about is timing, dosage and
monitoring your response. Natural supplements can offer
great support, but only when used intentionally.
(16:55):
That's especially true for berberine.
What's widely available and considered plant based.
Berberine is potent and interacts with complex systems
like your blood sugar regulation, liver function,
digestion, microbial balance. Using it safely means
understanding when it's appropriate, how long to use it,
what to monitor, and when to stop.
Let's walk through how to approach berberine as a tool
(17:16):
now. Long term crutch.
So typical usage and dosage guidelines.
Most supplement protocols recommend berberine, 500
milligram taken two to three times daily, ideally with meals
to reduce digestive comfort. For myself, when I take it, I
take 500 milligrams in the morning and an empty stomach and
usually 500 milligrams in the evening, maybe 30 minutes before
(17:39):
food. But that's for my specific self.
I feel it works better for me. And a lot of other people get a
very bad stomach upset by takingan empty stomach and other
people do well, so it's trial and error.
This amount is typically used for a limited period, again
ranging from 4 to 12 weeks. Depend on individual needs and
response. Berberine has a pretty short
(18:01):
half life, so spreading out the dose throughout the day with
breakfast and dinner may help maintain steady support.
Some individuals may start with 250 milligram once daily and
gradually increase to assess tolerance, especially if they're
sensitive to supplements. For myself, I'm sensitive to
supplements so I always start slow.
So at least start with that single low dose.
(18:21):
See how you do. Make sure you don't have any
reactions. I'll make sure you still feel OK
and then you know, maybe the next day you increase your dose
to the proper dose. So that said, there's no
one-size-fits-all dosage and more is not always better.
Higher doses can lead to unwind side effects or over suppression
of certain pathways, especially individuals with already stable
(18:42):
blood sugar sensitive digestion.While Berberange generally well
tolerated, it's not suitable foreveryone.
Some groups should use extra caution or consult with a
licensed practitioner before use.
People with very low fasting glucose or low blood pressure.
Those currently using medications for diabetes,
cholesterol, or blood pressure. Individuals taking
(19:04):
antidepressants or medications that influence liver
detoxification. Pregnant and breastfeeding
individuals. Berberine is not recommended in
these cases. Now on to possible side effects.
Although many tolerate it well, berberine can cause side
effects, particularly at higher dosage when taking an empty
stomach. Again, I do not have an issue,
(19:24):
but others do. Could cause nausea, cramping,
loose stool or diarrhea, dizziness or fatigue, especially
for those already with low bloodsugar, headaches or appetite
changes. The thing for me is usually
everything triggers a headache or migraine, but berberine does
not for me. If the systems persist or
worsen, it might be a sign that berberine may not be the right
(19:46):
tool for you or the dosage needsadjusting.
Always discontinue use and consult a healthcare
professional if you experience any adverse side effects.
Let's talk about what to track while taking it to evaluate how
your body is responding. Functional lab testing is the
best ally right before starting berberine.
It's smart to establish baselinemarkers depending on your
(20:07):
Wellness goals. You know those can include
fasting glucose, insulin. This would be used for metabolic
support GI testing which is GI map or O test for microbial
balance. Lipid panels and liver enzymes.
You use this for cardiovascular,liver support that high reactive
CRP or ferritin for inflammatorystatus.
(20:29):
Again after 8 to 12 weeks. Retesting gives objective data.
Are your numbers improving? Are your symptoms resolving?
Is your energy more stable and digestive smoother?
These questions matter just as much as the numbers, right?
Subjective tracking can help too.
You might keep short term weeklylog which includes how you feel,
eating after meals, digestive comfort, sugar, carb cravings,
(20:54):
mental clarity or mood, your sleep quality.
Sometimes improvements aren't captured in labs, but they
become evident and daily experience.
On the flip side, if nothing improves or you feel worse,
that's worth paying attention totoo.
This is when now that's worth paying attention to.
(21:14):
Now let's talk about cycling andwhen to pause.
Berberine is not meant for continuous indefinite use.
It's most effective when used strategically in short burst
supported by lifestyle nutritional adjustments paired
with proper evaluation both at the start and at the end.
After 8 to 12 week protocol, youknow you may want to take a
break for two to four weeks. This allows your body to re
(21:35):
establish balance on its own andhelp prevent desensitization to
the effects. If berberine was used for gut
support and you may transition to gut restoring agents like
probiotics, L glutamine or zinc.If it was used for blood sugar
management, the focus might be on protein rich meals, strength
training or sleep optimization. In other words, berberine is not
the end of the journey. It's a tool that opens a door to
(21:57):
deeper healing. More isn't always better.
Smarter, more personalized use is now the final take away.
Berberine can offer a meaningfulsupport for blood sugar balance,
microbial harmony, and lipid metabolism, but only when used
with purpose. Respect its purpose.
Respect its potency and monetaryresponse.
(22:19):
More isn't always better. Smarter, more personalized use
is. So as we wrap up today's episode
of Mindful Objective, I hope you're walking away with clearer
perspective on berberine, not asa trend, but as a strategic
Wellness tool when used in the right context.
It's not about jumping on what'spopular.
It's about understanding your body, using real data, and
selecting targeted support that aligns with your goals.
(22:41):
Whether you're working with support, balanced blood sugar,
gut function, or lipid metabolism, berberine may play a
role, but it's not a replacementfor solid habits or proper
guidance. Nutrition is #1 are you eating
proper? As a reminder, this podcast, for
informational purposes only, does not constitute medical
advice. Always consult your healthcare
provider before making health decisions or changes to your
(23:02):
routine. But if you're dealing with sugar
cravings, energy dips, gut discomfort, or have labs that
don't feel optimal, don't guess test.
Our at home functional lab kits can help uncover what your body
actually needs. And remember, our professional
grade supplements are always 20%off retail, offering better
quality and a lower cost than major online stores.
(23:24):
The reason we're doing this is to help people heal.
As always, thanks for joining ustoday.
If you found this episode helpful, share with someone
navigating their own health journey.
If you haven't already, please give us a five star review so we
can move U to list and help others heal.
Our goal is to help educate and heal people.
Ass it on O. Until next time, stay curious,
(23:44):
stay empowered, stay mindful, and stay well.
Welcome to Mindful Objective, the podcast where we explore the
root causes of health concerns and help you restore balance.
I'm your host, Doctor Daniel Sproule, integrative health
practitioner professor, and today we're unpacking the truth
about Berberine, which is one ofthe most talked about natural
compounds in the Wellness world right now.
You've probably seen it hyped upas a natural alternative to
medication, but the real story is much deeper and far more
(00:23):
practical. From blood sugar and digestion
to microbial. From blood sugar and digestion
to microbial balance and lipid support, Berberine may offer a
multi system support when used with intention.
This podcast for educational purposes only.
We did not diagnose, treat or cure any illness or disease so
let's get into it. Berberine is naturally occurring
(00:44):
compound found in a group of plants, most notably Burberry
golden seal, and another one would be Goth red.
It's a bright yellow alkaloid compound that has been
traditionally used in generations in a herbal medicine
systems such as traditional Chinese medicine and Ayurveda.
What's interesting about berberine though is it stood to
(01:06):
test the time not just because of tradition, but because it's
emerging research that suggests it may support a range of health
functions. Today, many integrated
practitioners consider berberinewhen helping individuals focus
on improving areas such as metabolic Wellness, gut balance,
and cardiovascular support. So let's be clear though,
berberine is not a treatment or cure for any disease.
(01:27):
It's a botanical compound that may help the body's natural
system maintain balance. For example, berberines often
use short term Wellness protocols designed to support
blood sugar metabolism, gut microbial balance, or healthy
cholesterol levels. You might have seen berberine
trending online recently or for a while, with terms like natural
Ozempic being used. While that makes for a catchy
(01:49):
headline, it's not an accurate comparison.
Ozempic is a prescription medication that works by
mimicking GLP one, which is a hormone involved in regulating
insulin secretion and appetite. Berberine, on the other hand,
does not act like AGLP 1, and itdoesn't have the same effects.
It supports metabolic function through mechanisms such as AMPK
(02:10):
activation. This is a cellular energy
regulator, sometimes referred tothe body's metabolic master
switch. That's quite different from how
a prescription GLP one operates.From integrative health
standpoint, using Berberian responsibly means understanding
its role with a broader Wellnessstrategy, not using it as a
standalone fix. And this all starts with data,
(02:31):
right? Functional lab testing, which we
always breach on. So functional lab testing can
help determine whether Berberianis even appropriate for your
situation. Here are some of the markers
that might help guide your decision.
Fasting glucose and insulin. This can show early patterns of
blood sugar dysregulation. Hemoglobin A1C.
This always gives the insight into long term glucose patterns.
(02:54):
C Reactive protein. You may see this as HS, DASH,
CRP. This may reflect underlying
inflammatory trends. GI MAP or other stool testing.
This can help identify microbialimbalances and overgrowths.
A lipid panel. This provides context on
cholesterol and triglyceride levels.
So this type of testing doesn't diagnose disease but can help
(03:17):
you guide more personalized and proactive health strategy.
It helps answer questions such as is my blood sugar truly
elevated? Are you dealing with microbial
imbalances in your gut? Are your lipids trending in the
direction that might benefit from nutritional support?
Berberine may be helpful ally for someone with balanced blood
sugar, minimal gut concerns, or stable lipids.
(03:37):
It may not be offer much traditional benefit.
That's why individualized recommendations are always key.
You see, so many people just jump on board and they hear
about a supplement, they take it, they may not even need it,
nor maybe causing more damage. So that's why we look at the
data. Let's test.
Also keep in mind that botanicals like berberine are
typically used short term basis.It's not meant to be taken
(03:59):
indefinitely, especially withoutthe guidance of a practitioner.
In most cases, it's incorporating the protocols
lasting anywhere from usually 6 to 12 weeks, after which re
evaluation is essential. So let's talk about one of the
most popular areas where berberine is discussed, blood
sugar balance and metabolic health.
This is a space where many people hope to avoid more
(04:19):
serious complications later in life and we're supportive
strategies can make significant difference when used with the
right time. Blood sugar regulation is a core
function in bodies metabolism. It impacts energy, mood,
cravings, sleep, weight and evenlong term cardiovascular health.
For some individuals, patterns of elevated glucose and insulin
levels can remain unnoticed for years before symptoms become
(04:41):
apparent. By the time someone is told
they're borderline or pre diabetic, the underlying
imbalances may have been building for a while, and
usually this is years and years.This is where compounds like
berberine get attention. Some early research suggests
berberine may support healthy insulin sensitivity and glucose
metabolism. It appears to influence how
cells use glucose, possibly making them more efficient
(05:03):
absorbing and storing energy. One proposed mechanism through
AMPK activation, which may help your body regulate how it stores
and burns fuel. But let's make it practical,
right? From an integrative health
perspective, berberine may be considered in someone's Wellness
plan if they're showing patternssuch as regular energy crashes
after meals, increased cravings,particularly for sugar or carbs,
(05:26):
difficulty losing weight despiteeffort, a trend in rising
fasting glucose even if it's still technically within range.
We focus on optimal and the lastone be elevated insulin levels.
Although those symptoms are common, they don't always
indicate the same underlying 'cause there's many different
issues out there. That's why functional lab
testing is so helpful. It moves us beyond the
(05:47):
guesswork. Some of the most useful tests in
this context would be fasting glucose, which is a snapshot of
your blood sugar at rest. Another one would be fasting
insulin. High fasting insulin can point
to insulin resistance long before glucose rises.
Hemoglobin A1C reflects the average blood sugar over the
(06:08):
past two to three months. Another one would be cortisol
rhythm test. So because chronic stress can
raise blood sugar, testing cortisol via saliva or dried
urine, such as a Dutch test, canbe helpful in individuals with
elevated markers and persistent symptoms.
Berberine may be used short termto support metabolic
recalibration. However, it's never a
(06:28):
replacement for foundational strategies.
And what would this be? Such as optimizing protein
intake, reducing refined carbohydrates, improving sleep
quality and improving movement throughout the day.
Get up and walk. It's also important to highlight
that berberine is not a one-size-fits-all solution.
Some individuals with very sensitive digestion, for
(06:48):
instance, may not tolerate it well.
And if blood sugar is already atthe lower end, taking this
compound can further reduce glucose, which will lead to
fatigue, dizziness and brain fog.
And not everything's a benefit. Instead of seeing this as a
quick fix, consider Berberring temporary as a support tool,
something to help the body resetwhile addressing its root
causes. Ideally, it's used in
(07:09):
combination with lifestyle strategies and reevaluated after
a few months to assess whether it's even necessary anymore.
And that's what we say all the time.
Don't just take a supplement blindly.
You want to monitor progress through repeated lab testing.
Maybe you need to do these 8 to 12 weeks.
This can help provide clarity and how well your body is
responded. Is it working for you as an
(07:30):
individual? You may see improved insulin
sensitivity, probably fewer energy crashes, and for sure a
lot of people expand reduced cravings, but only if the
underlying systems are ready to respond to that Berberine.
Bottom line, when used with intention, berberine is a
powerful support tool, but only if you really need it.
While berberine is often discussed in the context of
(07:52):
blood sugar, it's historically used as primary digestive
support. So now let's talk more about how
it's traditionally used. While berberine is often
discussed in the context for blood sugar, it's historically
used primary for digestive support. 1 Tradition In Chinese
medicine and Ayurveda, berberinecontaining herbs were used to
support the bowels microbial balance and relief from
(08:13):
occasional digestive upset. Today, many integrative health
practitioners still turn to Berberine puts potential role in
supporting a healthy gastrointestinal environment.
Now let's talk more about how berberine may assist with gut
health and why lab testing can help determine if it's a good
fit for you. Your gastrointestinal system is
a home of trillions of microorganisms, bacteria, fungi
(08:36):
and more, all which impact digestion, nutrient absorption,
immune function and even your mood.
An imbalance in this ecosystem is sometimes referred to
dysbiosis, which may contribute to symptoms such as which we all
are aware of bloating, regular bowel movements, skin issues,
food sensitivities, brain fog, and another one will be fatigue
(08:58):
after eating. How many times do you eat and
get so tired? Berberine has shown in
preliminary studies to help support microbial balance.
When it's not used to kill specific organisms, it may
naturally help support a healthier terrain by encouraging
micro biodiversity. It also disrupt bacteria
biofilms which is a protective layer that makes bacteria more
resistant. It also supporting your body's
(09:19):
natural defenses against Candidaand certain gram negative
bacteria. It helps maintain integrity in
the gut lining on functional protocols.
Berberina sometimes paired with other plant based agents such as
oregano oil, caprylic acid, black walnut, garlic extract and
Sacromyos bilardi, which is a probiotic yeast.
These combinations are usually used short term for gut reset
(09:41):
protocols and these usually lastfour to 8 weeks before
transitioning to a more restorative plan involving
probiotics, mucosal support, nutrient replenishment.
Before starting any type of gut balancing protocol, it's best to
get the sense of what's actuallygoing on in your digestive
tract. That's where functional stool
testing and other microbial assessments come in.
These don't diagnose disease butcan help provide insight into
(10:03):
trends like overgrowth, undergrowth, inflammation,
digestive insufficiencies. Some of the most informative gut
related labs include GI MAP. This provides DNA based insight
into bacteria, yeast, parasites and markers, inflammation and
digestive function. And we have another one, Genova
GI effects. This is similar to the GI MAP
(10:24):
with added insight into short chain fatty acid production
enzyme output. Another one which we always talk
about is organic acid test, the O test.
This is a urine test that measures metabolic byproducts of
yeast bacteria. It can flag things like
orebinos, which is associated with yeast overgrowth, and then
again which is linked to proteinfermentation.
When practitioners have this data, we can make more precise
(10:46):
recommendations. For example, suppose your stool
test reveals elevated levels of opportunist bacteria.
In that case, berberine may be used as short term support.
If instead the test reveals low beneficial bacteria, gut
inflammation, a different approach might be more
appropriate for you. So different kind of
considerations. As with any supplement,
berberine may not be well tolerated by everyone.
(11:08):
Some individuals report temporary side effects such as
loose stools or urgency, nausea when taking on empty stomach,
changes in appetite, fatigue if blood sugar drops too low.
That's why gut protocols should be personalized and monitored.
You're an individual. You're not going to have the
same symptom always as your neighbor.
You're not going to have the same reaction.
It's not going to work the same,right?
(11:29):
So it's based on your individualself and why you need to test.
Taking berberine without knowingyour current microbial status
can sometimes worsen symptoms, especially if your system's
already sensitive or depleted. Again, berberine may be helpful
by tentacle for support and gut health and microbial balance,
but this is for a defined periodof time, not forever.
(11:50):
It should also be a part of a larger protocol and you should
have support from a health practitioner to guide you on
that path. Do that lab testing, understand
where it's needed, and what's the proper dose for you
specifically. Used thoughtfully, it can be
part of a comprehensive gut reset strategy that includes A
dietary changes, targeted supplementation, and eventual
(12:11):
gut restoration. Just make sure you're working
from data, not just guessing. Now let's talk about a broader
view of berberine. While berberine is widely known
for the support of metabolic health and digestion, there's
growing interest on how it may also assist the body's natural
ability to maintain healthy lipid levels and liver function.
This is the area where many people are quietly concerned.
(12:33):
Perhaps their cholesterol is trending upward or their liver
enzymes are slightly elevated onroutine blood work, but they
haven't met the criteria for diagnosis from their medical
doctor. These are the Gray zones where
integrative tools like berberinemight be a part of a broader
support strategy. So let's take a closer look at
what research suggests and how testing can guide whether
berberine is appropriate for your case.
(12:54):
Emerging evidence suggests that berberine may influence several
mechanisms involved in lipid metabolism and liver enzyme
regulation. From integrated standpoint, this
includes supporting healthy LDL levels.
Berberine may help promote LDL receptor expression in the
liver, which encourages cholesterol clearance from the
bloodstream, encouraging balanced triglycerides in HDL.
(13:15):
This is in some individual shortterm use of berberine may be
associated with improved lipid panels when combined with
dietary and lifestyle changes, assisting with non alcoholic
fatty liver support. Again, it's not treatment, but
berberine may help support normal liver enzyme levels and
reduce oxidative stress in the liver, which is often areas of
concern for individuals with suboptimal liver functions.
(13:38):
It's essential to note that these benefits are not
guaranteed and the berberine should not be used as a
substitute of medical intervention when necessary.
Instead, it may be part of a comprehensive approach that
includes nutrition, physical activity, stretch management and
regular monitoring. So what lab markers might guide
berberine use? Integrated practitioners often
look at a variety of labs, not asingle lab.
(14:00):
Not just check for the disease, but to catch trends early.
Some of the markers may suggest role for liver and
cardiovascular support, such as a lipid panel, LDL, low density
lipoprotein. High levels can suggest a need
for lipid support HDL high density lipoprotein.
Lower levels may indicate reduced cardiovascular
resistance triglycerides. Elevated levels may reflect
(14:24):
insulin sensitivity issues or liver strain liver enzymes
ASTALT or AST. Elevated levels are early signs
of liver strain even without symptoms.
GGT This is another helpful liver marker, especially in
relation to oxidative stress or bile flow.
Inflammatory markers such as high sensitivity C reactive
(14:45):
protein is often used to assess systematic inflammation,
including cardiovascular inflammation.
Ferritin, while often known as amarker for iron storage, high
ferritin can also suggest inflammation or oxidative stress
will be lipoprotein. This is in gaining more
popularity in the market. These are more advanced lipid
markers that may offer additional cardiovascular
(15:06):
insight. So if someone's lab work shows a
pattern elevated triglycerides, borderline high LDL, or liver
enzyme trends that aren't ideal,berberine may be considered as
part of a short term support protocol.
Let's understand why it matters.While berberine may support
these areas, it's never the onlyanswer.
For example, increasing fiber intake through vegetables,
legumes, and flaxseed may support cholesterol balance.
(15:29):
Healthy fats from sources like wild caught salmon, olive oil
and avocados are essential for supporting HDL and reducing
inflammation. Reducing processed foods,
alcohol and added sugars can make a significant impact on
both liver and heart health. This is probably one of the
areas that's hardest for people to give up.
But got to give up that processed food, right?
Look for Whole Foods. Just as in other areas,
(15:52):
berberine should be used under guidance with a practitioner,
especially if someone's taking medication that affects
cholesterol or liver functions or blood pressure.
Some individuals may also experience side effects if the
dose is too high or use long term.
Reevaluation is key. As with other uses, most
practitioners recommend retesting labs after 8 to 12
(16:12):
weeks of using berberine, especially if it started to
support lipid or liver trends. If markers improved, great, It
may be time to shift focus to maintenance.
If they don't, it could indicateneed to reassess other lifestyle
factors. Are you still eating processed
foods? Are you still eating all this
garbage, or is it just not working for you?
(16:33):
Is there another issue? So there's a lot of different
strategies that need to be discussed.
That's why it's always great to work with the integrative health
practitioner. If you need any help or
guidancemindfulobjective.com, don't hesitate to reach out.
And finally, what we need to talk about is timing, dosage and
monitoring your response. Natural supplements can offer
great support, but only when used intentionally.
(16:55):
That's especially true for berberine.
What's widely available and considered plant based.
Berberine is potent and interacts with complex systems
like your blood sugar regulation, liver function,
digestion, microbial balance. Using it safely means
understanding when it's appropriate, how long to use it,
what to monitor, and when to stop.
Let's walk through how to approach berberine as a tool
(17:16):
now. Long term crutch.
So typical usage and dosage guidelines.
Most supplement protocols recommend berberine, 500
milligram taken two to three times daily, ideally with meals
to reduce digestive comfort. For myself, when I take it, I
take 500 milligrams in the morning and an empty stomach and
usually 500 milligrams in the evening, maybe 30 minutes before
(17:39):
food. But that's for my specific self.
I feel it works better for me. And a lot of other people get a
very bad stomach upset by takingan empty stomach and other
people do well, so it's trial and error.
This amount is typically used for a limited period, again
ranging from 4 to 12 weeks. Depend on individual needs and
response. Berberine has a pretty short
(18:01):
half life, so spreading out the dose throughout the day with
breakfast and dinner may help maintain steady support.
Some individuals may start with 250 milligram once daily and
gradually increase to assess tolerance, especially if they're
sensitive to supplements. For myself, I'm sensitive to
supplements so I always start slow.
So at least start with that single low dose.
(18:21):
See how you do. Make sure you don't have any
reactions. I'll make sure you still feel OK
and then you know, maybe the next day you increase your dose
to the proper dose. So that said, there's no
one-size-fits-all dosage and more is not always better.
Higher doses can lead to unwind side effects or over suppression
of certain pathways, especially individuals with already stable
(18:42):
blood sugar sensitive digestion.While Berberange generally well
tolerated, it's not suitable foreveryone.
Some groups should use extra caution or consult with a
licensed practitioner before use.
People with very low fasting glucose or low blood pressure.
Those currently using medications for diabetes,
cholesterol, or blood pressure. Individuals taking
(19:04):
antidepressants or medications that influence liver
detoxification. Pregnant and breastfeeding
individuals. Berberine is not recommended in
these cases. Now on to possible side effects.
Although many tolerate it well, berberine can cause side
effects, particularly at higher dosage when taking an empty
stomach. Again, I do not have an issue,
(19:24):
but others do. Could cause nausea, cramping,
loose stool or diarrhea, dizziness or fatigue, especially
for those already with low bloodsugar, headaches or appetite
changes. The thing for me is usually
everything triggers a headache or migraine, but berberine does
not for me. If the systems persist or
worsen, it might be a sign that berberine may not be the right
(19:46):
tool for you or the dosage needsadjusting.
Always discontinue use and consult a healthcare
professional if you experience any adverse side effects.
Let's talk about what to track while taking it to evaluate how
your body is responding. Functional lab testing is the
best ally right before starting berberine.
It's smart to establish baselinemarkers depending on your
(20:07):
Wellness goals. You know those can include
fasting glucose, insulin. This would be used for metabolic
support GI testing which is GI map or O test for microbial
balance. Lipid panels and liver enzymes.
You use this for cardiovascular,liver support that high reactive
CRP or ferritin for inflammatorystatus.
(20:29):
Again after 8 to 12 weeks. Retesting gives objective data.
Are your numbers improving? Are your symptoms resolving?
Is your energy more stable and digestive smoother?
These questions matter just as much as the numbers, right?
Subjective tracking can help too.
You might keep short term weeklylog which includes how you feel,
eating after meals, digestive comfort, sugar, carb cravings,
(20:54):
mental clarity or mood, your sleep quality.
Sometimes improvements aren't captured in labs, but they
become evident and daily experience.
On the flip side, if nothing improves or you feel worse,
that's worth paying attention totoo.
This is when now that's worth paying attention to.
(21:14):
Now let's talk about cycling andwhen to pause.
Berberine is not meant for continuous indefinite use.
It's most effective when used strategically in short burst
supported by lifestyle nutritional adjustments paired
with proper evaluation both at the start and at the end.
After 8 to 12 week protocol, youknow you may want to take a
break for two to four weeks. This allows your body to re
(21:35):
establish balance on its own andhelp prevent desensitization to
the effects. If berberine was used for gut
support and you may transition to gut restoring agents like
probiotics, L glutamine or zinc.If it was used for blood sugar
management, the focus might be on protein rich meals, strength
training or sleep optimization. In other words, berberine is not
the end of the journey. It's a tool that opens a door to
(21:57):
deeper healing. More isn't always better.
Smarter, more personalized use is now the final take away.
Berberine can offer a meaningfulsupport for blood sugar balance,
microbial harmony, and lipid metabolism, but only when used
with purpose. Respect its purpose.
Respect its potency and monetaryresponse.
(22:19):
More isn't always better. Smarter, more personalized use
is. So as we wrap up today's episode
of Mindful Objective, I hope you're walking away with clearer
perspective on berberine, not asa trend, but as a strategic
Wellness tool when used in the right context.
It's not about jumping on what'spopular.
It's about understanding your body, using real data, and
selecting targeted support that aligns with your goals.
(22:41):
Whether you're working with support, balanced blood sugar,
gut function, or lipid metabolism, berberine may play a
role, but it's not a replacementfor solid habits or proper
guidance. Nutrition is #1 are you eating
proper? As a reminder, this podcast, for
informational purposes only, does not constitute medical
advice. Always consult your healthcare
provider before making health decisions or changes to your
(23:02):
routine. But if you're dealing with sugar
cravings, energy dips, gut discomfort, or have labs that
don't feel optimal, don't guess test.
Our at home functional lab kits can help uncover what your body
actually needs. And remember, our professional
grade supplements are always 20%off retail, offering better
quality and a lower cost than major online stores.
(23:24):
The reason we're doing this is to help people heal.
As always, thanks for joining ustoday.
If you found this episode helpful, share with someone
navigating their own health journey.
If you haven't already, please give us a five star review so we
can move U to list and help others heal.
Our goal is to help educate and heal people.
Ass it on O. Until next time, stay curious,
(23:44):
stay empowered, stay mindful, and stay well.
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