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March 26, 2025 18 mins

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Insulin resistance presents a significant metabolic challenge that affects blood sugar regulation and contributes to type 2 diabetes when cells stop responding effectively to insulin signals.

• Functional medicine approaches address root causes rather than quick fixes
• GLP-1 hormones help regulate blood sugar by enhancing insulin secretion
• Natural methods like whole foods and fiber support metabolic health
• Strength training and aerobic exercise improve glucose uptake
• Chronic stress contributes significantly to weight gain and insulin resistance
• Sleep quality directly impacts metabolism and cortisol regulation
• Key symptoms include increased hunger, fatigue after meals, and difficulty losing weight
• Insulin resistance affects brain function and may contribute to dementia
• Diagnostic advances include metabolic scoring to determine insulin sensitivity
• Prevention strategies include anti-inflammatory foods and daily movement

For more resources on mindfulness, sleep optimization, and anti-inflammatory food lists, visit my website or reach out directly for personalized support.


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Episode Transcript

Available transcripts are automatically generated. Complete accuracy is not guaranteed.
Speaker 1 (00:02):
So we're talking about module two, functional
medicine approaches, type twodiabetes, insulin resistance,
and when we first initiallytalked about integrative
approaches in the metabolichealth type two diabetes, we're
talking about how do weunderstand insulin resistance.
What is that?
So type two diabetics andinsulin resistance is a real
metabolic dysfunction, metabolicchallenge for individuals, and

(00:26):
it plays a role in the GLP-1sbecause GLP-1 is for blood sugar
regulation and helps manage toreverse or helps manage these
conditions.
So when you understand thatinsulin resistance occurs when
the cells stop respondingeffectively to insulin instead
of being less, you know they'renot as sensitive then there's a

(00:48):
problem and a disconnect.
Glp-1s will help improveinsulin sensitivity, whether
it's medication or naturallyboosting it, and it's key in
targeting diabetes managementand just overall metabolic
health dysfunction, which is abig problem in today's society.
So integrative approaches tothis are type 2 diabetics.

(01:08):
It's a complex metabolicdisorder.
It's conditions influenced byinsulin resistance, inflammation
and lifestyle factors.
When I consider it as anintegrative approach, it's
combining conventional and afunctional strategies and this
is to address not just rootcause but to understand the
optimization of an individual sothat they can have long-term

(01:29):
quality management and not just,you know, a quick fix.
So insulin resistance occurswhen the body cells become less
responsive to insulin, sothey're leading to elevated
blood sugar levels.
There's that metabolicdysfunction.
The key driver is that it'slinked to poor diet, it's linked
to chronic stress, it's linkedto gut health imbalances and a

(01:52):
sedentary behavior.
When you put all this in therein addition I haven't added is
sleep.
You put those in there, thosekey components that is going to
affect your metabolic health.
Glp-1's glucagon-like peptide 1is a crucial hormone that helps
regulate this by enhancinginsulin secretion and slowing
gastric emptying, promotingsatai and helping the

(02:13):
medications, such as withsemiglutide, terzopatide and
lorturotide, gaining theattention in the diabetes
medications.
In addition, natural ways wehad spoken with about in the
previous module, like fiberfoods, fermented foods,
intermittent fasting, stressreduction, can all support GLP-1

(02:37):
management and GLP-1 metabolichealth.
So what's the role of this andhow does it regulate the blood
sugar?
So think, maintaining andstabilizing your blood sugar
within your body.
This can be done, not justmedication.
This is done by improving yourenergy, helping with cognition.
It's helps with your overallwellbeing.

(02:59):
And main strategies.
Here we are.
Let's think about it Wholenutrition, the more whole foods
you know, the more apples you'reeating.
The more oranges, the morebroccoli, um that have lower
glycemic index, such as um.
I'll give you many, you knowrecipes at the end of this,
these module, but think justeven basics, you know.

(03:20):
Apples, um little bit ofquality, high protein yogurts
with no sugars, um, carrots,even even though they have, uh,
anti-inflammatory foods.
There is a variety of fiberrich vegetables that are um,
quite well in improving yourinsulin and lowering um your

(03:43):
choice of protein and waterintake early in the morning,
targeting supplements ifnecessary for an individual.
Berberine is a low helping withregulating the blood sugar.
There's a lot of research onthat.
Magnesium, alpha-lipidic acidand certain probiotics are for
regulating the blood sugar.

(04:04):
Now, always exercise andmovement.
When you think about somestrength training and aerobic
exercise that will also uptickthe glucose but actually manage
some of the insulin resistance,depending upon what kind of
strength training and exercisethat you are doing for your
individual body and what year isavailable for you.
Stress and sleep management asI had briefly stated, is that

(04:27):
chronic stress can kill you.
Chronic stress is a bigcomponent of why individuals sit
with so much extra weight.
So they go not only withmedications or they're doing
these diets and plateau.
It's because they have at 10 to15 pounds of stress sitting
there, or inflammatory, um,individuals that have that extra

(04:52):
weight, um, things of helpingwith this is working on some
adaptogens and we'll go furtherinto questions on that.
But really think of it like youmanage that and you balance
that on a daily basis, whetherit's breath, work, adaptogens,
you know um quiet time, reset,then you will do better.

(05:15):
And then um sleep.
Sleep is so important.
We just don't really realizehow it affects our metabolism,
affects our cortisol levels andinsulin regulation.
So see how that is for you,mindfulness is like super
important and effectiveness, Imean.
That's something why I, youknow, call this mindfully
integrative and it's reallyabout being mindful in many ways

(05:36):
of your life and finding thatfor yourself.
So how do you do this?
In like a holistic,personalized approach, you're
addressing more of what isunderlying.
You know what is the reasons.
Is it inflammation?
Is it gut health, hormoneimbalance, is it lifestyle
factors?
What can we do to do that?
You know how do we manage itand you know it's not that

(05:58):
you're may completely reverseyour diabetes, but you are going
to manage it.
You're trying to become notdiabetic, you're trying to not
have insulin resistance.
Then we want to have asustainable long-term life and
we can do that with you knowthese approaches and these
strategies.
Overall, you know it is acomplex metabolic dysfunction

(06:20):
between type two diabetes,prediabetes and metabolic issues
.
But the best ways to look at itis really trying to see, by
taking some of these strategiesand making them your own, and
how that would work for you.
So think of it as once you getthere you'll be at another level

(06:42):
and I think it really kind ofgets you to the next level
Because, thinking about whyyou're getting insulin
resistance, most people don'teven realize why.
So insulin resistance occursbecause the pancreas compensates
by producing more insulin andforces the glucose into the

(07:03):
cells.
The overproduction can work fora while, then it keeps the
blood sugar levels normal, butover time the pancreas may
struggle to keep up, leading toa higher blood sugar levels and
eventually prediabetes or type 2diabetes.
Factors that contribute toinsulin resistance poor diet,
excessive intake of refinedcarbohydrates, lack of physical

(07:27):
health, like physical activity,which we spoke to, what will be
helpful?
Obesity, especially in thevisceral fat.
So think about that donut, thatsurrounding area around your
belly.
Chronic stress, elevatedcortisol levels can promote
insulin resistance andincreasing blood sugar and
improving insulin function.
Sleep deprivation, um hormoneimbalances, um toxin toxin

(07:50):
exposure.
So things um hormone imbalancesof, like PCOS, metabolic
dysfunction, um your eventestosterone dysregulation,
estrogen or progesteroneirregularity, toxin exposures,
such as environmental there's alot of endocrine disrupting
things that are out there infood products and receipts, in

(08:13):
the environment, the airpollution and such.
And how do you know?
You even have insulinresistance.
So main key components of thisare increased hunger, cravings
of sugar and food fatigue aftera meal, difficulty losing weight
, brain fog or troubleconcentrating, high fasting

(08:36):
blood sugar levels, darkeningpatches of skin in the areas.
Elevated triglycerides, low HDLjust considered supposedly the
better of the cholesterols thatyou would have.
Complications.
You can manifest into type 2diabetes, you can end up with
metabolic syndrome.
You will be pre-diabetic.
Cardiovascular issues, fattyliver issues, pcos for females,

(09:04):
hashimoto's.
Insulin resistance can or theycall it also hyperinsulinemia,
which is an excess of insulinwithin the body can cause an
array of health issues that needto be balanced.
How do you reverse it or atleast modify it more on the
natural side?
If we're not taking the GLP-1s?
I know people are going to askme on a regular what do you do

(09:27):
Now?
Like I said before, glp-1s is atool.
It's mimicking.
These medications are mimickingways that our body has already
produced this.
And how do we do that?
So ways of reversing insulinresistance and getting yourself
back into the right balance isadopt a low glycemic,
anti-inflammatory diet.

(09:47):
I will have a list of foods andanti-inflammatory diet at the
end of these modules that youcan take a look at and you can
see prioritizing whole foods,nutrient dense foods.
Instead of thinking about whatI have to take away, think about
what I can put into my dietthat will be optimal, putting in
the right pack of protein,reducing the carbohydrates and

(10:10):
sugar.
You know, if it's too sweet,it's probably not good for you.
You know, having that once in awhile is okay, but having it
every single day, not a greatidea.
It just becomes somethingthat's problematic.
How do we manage our stress?
Managing your stress?
I have many videos onmindfulness, meditations, sleep,

(10:32):
relaxation and lowering thecortisol.
This is done in many differentways, whether it's breathing,
meditation, movement, yoga, youname it.
It's there.
If you want more information,reach out to me, but I also have
a lot on my website or onpodcast, and, of course, reach

(10:54):
out for more.
Now.
Optimizing your sleep I think Ihave a podcast just alone on
sleep and the importance ofsleep.
I will talk about this day inand day out on lifestyle
management.
So we will.
You know some of it will seemlike repetitive, but I promise
you, the more you understand thesimplicity of some of it and
the like, the mindful ways eachday you will do.

(11:15):
So well, consider supplementslike magnesium, berberine,
chromium, um, aflopectic acidand anastol.
That's also very effective forthose with um, insulin
sensitivity or PCOS.
And then intermittent fasting.
Now, that varies for eachperson, so that's time
restricted eating.
And that also varies from mento women.
Um, for the most part.

(11:36):
Think of it like if it's darkout, stop eating.
If it's light out, you can eat.
Think of it like if it's darkout, stop eating.
If it's light out, you can eat.
That's a circadian rhythm.
Intermittent fasting, or youcan do like a 12 hour fast, so
seven in the morning to maybeseven at night.
Stop eating big heavy mealsabout two to three hours before
you go to sleep.
Insulin resistance occursbecause you know it's in the

(12:01):
cells, it's particularly in themuscles and the liver and the
fat is just.
You know it's in the cells,it's particularly in the muscles
and the liver and the fat isjust, you know, building up and
what happens is that glucose andglucagon is not being
metabolized in the liver andeventually it will turn into fat
.
And it is just.
I mean, insulin is key to, youknow, allowing glucose to enter

(12:22):
the cells and make energy.
But when you have insulinresistance, the cells become
less sensitive and it signalsthe glucose in the bloodstream
rather than being usedefficiently in the body for
energy.
So then it ends up being fatand ends up just being in.
You know inflammatory processesin different parts of the body
and the pancreas and the liverare overworked.

(12:43):
So when insulin resistanceoccurs, the pancreas compensates
by producing more and moreinsulin and forces the glucose
back into those cells, whichthen in turn more sugar is in
the cells, more, you know, andeverything's struggling and then
you become eventuallypre-diabetic, other metabolic
dysfunctions and type twodiabetes.
So it's just one of those thingswhere you know you're trying to

(13:06):
improve this, you know notchange it.
So how do we do this?
Like I've said previous, youknow the top lifestyle
management needs and then fromthere we're, you know, working
on the ways to become insulinsensitive.
So I mean, the research hasshown that, um, insulin

(13:28):
resistance is very, very big inour society now and it's due to
foods, it's due to environmentaland it's due to us not changing
our lifestyle.
Um, medicine protocols to dobetter?
Um, yeah, in the research alsothere's a lot on the

(14:09):
inflammatory pathways.
So issues with the insulinresistance within the body, how
can this be influenced overall?
Obviously, dietary things andthings that you choose not
having ultra processed foods andI had briefly discussed, you
know, physical activity andtiming.

(14:30):
So like intermittent fasting,exercise and how to.
That would help not only justwith your glucose metabolism but
also let's consider it, regularexercise in improving your
insulin signaling.
So then it helps with youroverall brain function.

(14:50):
Because they have stated youknow, there's more and more
research that the insulin getsexcess within the body.
Eventually that excess becomesdementia and they consider it
like the type three diabetes,which is dementia of the brain
because there's so much synapsesof irregular signals and an

(15:10):
overflow, and there has beenmore and more research that that
has happened.
More diagnostic advances to helpus know if you're insulin
sensitive or if you're insulinresistant.
That there's a metabolic scorethat you can get.
Usually, when I am giving labwork to individuals, there is
through the labs that you canfind someone's insulin

(15:32):
resistance score and see ifthey're more insulin sensitive
or more insulin resistant.
If they're low in the 25percentile then they're more
insulin sensitive.
They'll start reaching up intothe 50, 60, and 70 percentile.
That means most of their bodyand their blood stream has more
glucose and it's causing theminsulin resistance and it's a
problem.
So that does have to beaddressed and it's super

(15:55):
important or they will causemore and more inflammatory
issues.
Other biomarkers that have comeup that can be used to check for
fasting insulin are derived.
Usually if I look up fastinginsulin or I look up it's called
SpinaGR.
It's not usually done in normalblood work.

(16:16):
You have to go usually to anendocrinologist and that's
really demonstrates by anindividual usually that has
already have diabetes or goingtoward that direction.
More ways of prevention forinsulin resistance are
incorporating more foods thatare helping your body, you know,

(16:36):
get rid of that excess or nothaving as much of the,
minimizing the process,minimizing the ant-sex sugar.
So, of course, engaging inphysical activity, that movement
every single day, and earlydetection is always helpful.
So you know how can you do that.
You know each person isdifferent, but the main goal
think of it as I'm trying tostabilize my body and the less

(17:00):
junk that I have in there andthe more protein and, let's say,
balanced macronutrients withinmy body, I will have less of
this insulin resistance overalland it benefits you from
long-term other illnesses.
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