My Favorite Learners Podcast - Pharmacokinetics: The ABCs of ADME Explained Simply

In this solo episode of My Favorite Learners, host Chloe Gomez, CRNA, breaks down the complex topic of pharmacokinetics in a clear and clinically relevant way. Designed for SRNAs, CRNAs, anesthesia residents, and anyone preparing for boards, this episode covers the foundational concept of "what the body does to the drug"—also known as ADME: Absorption, Distribution, Metabolism, and Excretion.

You'll learn:

• The bioavailability of common drug routes (IV, oral, IM, subQ, rectal)

• What influences distribution (lipid solubility, compartment models, volume of distribution)

• The difference between first-order and zero-order kinetics

• How hepatic metabolism works (Phase I & II, CYP450 system)

• What context-sensitive half-time means in real anesthesia cases

• How to think through renal clearance, clearance equations, and patient factors like age, temp, and comorbidities

This episode is packed with real-world analogies and board-style insights that bring pharmacokinetics to life—perfect for anyone learning how to time their anesthesia meds or fine-tune a propofol drip.

💡 Whether you're reviewing for your anesthesia pharmacology exam or improving your patient care in the OR, this episode will make a tough topic finally click.