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April 21, 2025 65 mins

Does a daily glass of wine really keep the cardiologist away? It’s a claim we’ve all heard: light to moderate drinking is good for your heart. But is it science or just a convenient excuse for happy hour? In this episode, we dive into the history behind this claim, discuss the challenges of observational studies and statistical adjustment, and explore attempts at randomized trials and natural experiments to get to the bottom of this boozy debate. Grab your drink—or maybe don’t—and join us!


Statistical topics

  • Statistical Adjustment
  • Regression
  • Residual and Unmeasured Confounding
  • Randomized Trials
  • Multiple Testing
  • Outcome Switching
  • Mendelian Randomization 


Methodological morals
“Statistical adjustment cannot erase all confounding.”

“When you can’t experiment on people, let Nature experiment on people.”


Citations


Page with more details on the CASCADE trial


Kristin and Regina’s online courses: 


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