SPECIAL EPISODE - Personalized Vaccines Combat Melanoma

Today On Medical Grounds, we will be speaking with Dr. Jeffrey Weber of Isaac Perlmutter Cancer Center at NYU Langone Health. He is senior investigator of a phase two clinical trial for an mRNA melanoma vaccine. This vaccine has significantly reduced the recurrence of tumors in patients when combined with an immunotherapy drug. 

(00:48) Introducing Dr. Weber
(01:38) Melanoma mRNA vaccine
(04:14) How does an the vaccine work?
(06:34) First randomized trial
(07:38) Personalized medicine
(09:28) Side effects
(11:19) How is this vaccine similar to mRNA COVID vaccine?
(12:52) Bedside to bench to bedside approach
(14:34) How do patients get involved in clinical trials?
(16:23) Definition of "cure"
(17:52) Clinically meaningful endpoints
(18:49) What's next for mRNA cancer vaccines?
(19:38) Dr. Weber's personal cancer connection
(20:22) What keeps Dr. Weber up at night?

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