Optimization Academy with Dr. Greg Jones

In this episode, Dr. Greg Jones sits down with Dr. Sharon Hausman-Cohen, Chief Medical Officer of IntelliXX DNA, to explore how medical genomics is transforming the way we understand heart disease, brain health, inflammation, and metabolism. Most people think genetics stops at traits like eye color or ancestry. Genomics goes much deeper—analyzing how thousands of genes interact to influence cardiovascular risk, cognitive function, ...

Dr. Jones dives into the world of MOTS-C, explaining its potential to enhance metabolic health. He highlights its role in peptide therapy to optimize healing and promote fat loss. This biohacking approach could be a key to longevity science and overall health.CHAPTERS00:00 What MOTS-c Is & Why It’s Unique00:37 How MOTS-c Works in the Cell01:12 Mitochondrial Benefits & Energy Support02:18 Key Benefits: Energy, Metabolism &am...

Platelet-Rich Plasma (PRP) is everywhere—but why does it help some patients and completely fail for others?

In this episode, Dr. Greg Jones sits down with Dr. Joe Albano, a nationally recognized expert in regenerative orthopedics, to break down why not all PRP is created equal. They explore the real reasons PRP fails, including missed diagnoses, incorrect platelet dosing, poor patient preparation, and inadequate after-care protocols...

Dr. Jones discusses using innovative therapies for patient healing, specifically noting benefits like reduced inflammation and boosted hair growth. He highlights the science behind GHK-Cu, especially its positive effects on skin care and collagen synthesis. Learn more about how GHK-Cu enhances skin.CHAPTERS00:00 Introduction to GHK Copper00:46 What Is GHK Copper and How It Works01:34 Skin Health and Anti-Aging Benefits02:15 Healing...

The bicarbonate buffer system plays a critical role in the body’s ability to maintain pH, manage inflammation, and support cellular healing—and in this episode, Dr. Greg Jones sits down with Dr. Mark Sircus to explore how restoring this natural bicarbonate buffering system may help slow aging and support the body’s capacity to heal chronic disease. Drawing from decades of clinical experience, Dr. Sircus explains how Natural Allopat...

Dr. Jones clarifies how the combination of CJC-1295 and Ipamorelin can enhance growth hormone production and release. He elucidates the science in this peptides explained video, highlighting the potential health benefits his patients have experienced with ipamorelin and peptide therapy. Understand how these growth hormone-stimulating compounds work together.CHAPTERS00:00 What Are CJC-1295 and Ipamorelin?01:00 How They Work Together...

Therapeutic Plasma Exchange (TPE) has quickly become one of the most discussed longevity tools, bridging traditional medicine with cutting-edge regenerative therapies. In this episode, Dr. Greg Jones sits down with Dr. John Layke—Beverly Hills plastic surgeon and leading longevity physician—to unpack the science, clinical applications, and real-world results behind TPE. 

Dr. Layke explains how TPE works, why it has been used for dec...

Discover how peptides work, what they can help with, and why they’re becoming one of the most powerful tools in functional and regenerative medicine. Dr. Greg Jones breaks down peptide safety, how they signal the body, the top peptides for weight loss, healing, cognition, immunity, and longevity — plus the different delivery methods like injections, oral options, nasal sprays, IVs, and topicals. CHAPTERS00:00 Introduction & Why...

In this episode, Dr. Jones is joined by Dr. Donald Layman, one of the world’s top experts in protein metabolism. They discuss what happens to our muscles as we age, why leucine is a key amino acid for building and repairing muscle, and the amount of protein needed to stay strong and healthy.

Dr. Layman also explains the differences between lifespan, longevity, and health span — and how muscle helps us stay active and independent as ...

In this episode, Dr. Greg Jones is joined by Dr. Tori Hudson, a naturopathic physician, educator, and one of the most respected voices in women’s health. With more than 40 years of experience, Dr. Hudson shares how women can better understand and support their hormones from puberty through menopause.

They talk about everything from PMS and birth control to perimenopause, menopause, and the recent “hormone prescribing frenzy.” Dr. Hu...

In this episode, Dr. Greg Jones talks with Dr. Tom Ingengno, a Doctor of Acupuncture, author of The Cupping Book, and founder of Charm City Integrative Health. Together, they explore the surprising science behind cupping therapy, from its ancient roots to how it’s finding a place in modern integrative medicine.

Dr. Tom shares how a family memory led him from pre-med to acupuncture, the evolution of cupping practices across cultures,...

In this episode, Dr. Jones sits down with Eric Stoffers, CEO and founder of BioXcellerator, a global leader in stem cell therapy and regenerative medicine. Stoffers is an international pioneer in health, immunity, and longevity, with a vision to make advanced therapies more accessible for patients with autoimmune, orthopedic, neurological, and degenerative conditions.

From his work at BioXcellerator to his leadership as Chairman of ...

In this episode, Dr. Greg Jones reconnects with Dr. Leonard Pastrana, pharmacist, educator, and co-founder of New Bio Age. Their conversation centers on VO₂ max, what it is, why it matters for healthspan, and how it’s becoming one of the most critical markers in longevity medicine.

They explain what VO₂ max measures, why traditional wearables often fall short, and how metabolic breath analysis provides real clinical data. You’ll hea...

In this episode, Dr. Jones talks again with Dr. Paul Anderson, naturopathic doctor, researcher, and teacher. He joined the podcast last year to talk about cholesterol and lipid labs. This time the focus is on NAD (Nicotinamide Adenine Dinucleotide) and why it matters for your health.

They explain what NAD does in the body, especially for energy, brain function, and recovery. You’ll hear how NAD levels drop as we age, how alcohol and...

In this episode, Dr. Jones is joined by Christina Finnerty, FNP-C—a functional medicine expert specializing in sleep disorders, hormonal health, and regenerative therapies.

Together, they uncover the far-reaching effects of untreated sleep apnea on your brain, heart, metabolism, and even your biological age. Christina shares how obstructive sleep apnea (OSA) accelerates aging, increases the risk of cardiovascular disease, and contri...

In this episode, Dr. Jones is joined by Dr. Lauren Fitzgerald—an anesthesiologist-turned-functional medicine leader—to uncover the myths, science, and clinical pearls around testosterone therapy in women.

They explore why testosterone matters far beyond libido, how symptoms of deficiency often get dismissed or misdiagnosed, and what dosing, delivery, and lab markers really tell us. From estrogen dominance to perimenopause, cognitive...

What if an anesthetic known for dental procedures could have a powerful effect on pain, inflammation, and nervous system regulation? Far beyond a numbing agent, Procaine is now being used as a powerful tool to reset the autonomic nervous system and treat chronic pain and stress at a cellular level.Joining me today is Lexi Yoo, a double board-certified Nurse Practitioner, IFM Certified Practitioner, and the founder of Yoo Direct Hea...

What if you could mimic the effects of exercise—without actually hitting the gym? In this episode, Dr. Jones sits down with Anthony Castore, one of the most respected performance and cellular medicine coaches in the country, to explore SLU-PP-332, a compound with powerful mitochondrial and metabolic benefits.Anthony is the founder of DRIVE Longevity Solutions and a Fellow of the SSRP Institute. With over 30 years of high-performanc...

In this episode, I am joined by Dr. Laura Lile — one of the few U.S. physicians dual-credentialed as both a Registered Pharmacist and a Medical Doctor — to explore how genomics is revolutionizing the future of preventative and precision medicine. Dr. Lile shares her journey from pharmacy innovator to longevity-focused clinician and breaks down how our genetic blueprint, when interpreted through tools like IntellxxDNA, can help guid...