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June 13, 2025 5 mins

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The Structured Clinical Interview for DSM-5 (SCID-5) stands as a cornerstone in modern mental health assessment, offering clinicians and researchers a sophisticated tool that marries systematic evaluation with clinical flexibility. 

This semi-structured interview masterfully balances the precision of standardized questioning with the nuance of open-ended exploration, allowing mental health professionals to gather essential diagnostic information while honoring each client's unique lived experience. The approach creates space for clients to describe their symptoms in their own words, ensuring both diagnostic accuracy and therapeutic rapport.

Recognizing diverse professional needs, the SCID-5 comes in three specialized formats: the streamlined Clinician Version (SCID-5-CV) for daily practice, the comprehensive Research Version (SCID-5-RV) for academic studies, and the rigorous Clinical Trials Version (SCID-5-CT) for standardized research protocols. The clinician version includes ten meticulously organized diagnostic modules covering 39 common mental health conditions, from major depression and anxiety disorders to substance use problems and ADHD, while screening for 17 additional disorders.

The interview process unfolds naturally, beginning with an introductory conversation that establishes rapport while gathering crucial background information. As the assessment progresses, clinicians follow decision trees that mirror expert diagnostic reasoning, systematically evaluating potential diagnoses based on DSM-5 criteria. This methodical approach empowers professionals to make evidence-based diagnostic determinations while remaining responsive to new information that may emerge throughout treatment.

Join us as we explore how this remarkable diagnostic tool transforms mental health assessment, creating a bridge between standardized criteria and clinical wisdom that ultimately leads to better outcomes for those seeking care. Subscribe now for more insights into the cutting-edge approaches shaping modern mental healthcare.

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Stacy Frost (00:00):
The Structured Clinical Interview for the DSM,
commonly referred to as theSCID-5, stands as one of the
most widely used and trusteddiagnostic tools in mental
health assessment today.
Designed to provide cliniciansand researchers with a
systematic approach todiagnosing mental disorders, the
SCID-5 bridges the gap betweenthe clinical acumen of a

(00:22):
practitioner and the rigorouscriteria set forth by the
Diagnostic and StatisticalManual of Mental Disorders.
At its core, the SCID-5 is asemi-structured interview.
This format artfully combinesthe reliability of structured
questions, those that requireclear yes or no answers, with
the flexibility of unstructured,open-ended questions that allow

(00:45):
clients to describe theirexperiences in their own words.
This balance ensures thatessential diagnostic information
is collected, while also givingspace for clients to share the
nuances of their lives, symptomsand histories.
Recognizing the diverse needsof mental health professionals
and researchers, the SCID-5 hasbeen developed into three

(01:06):
distinct versions.
The clinician version, known asSCID-5-CV, is tailored for
everyday use in clinicalpractice.
The research version, orSCID-5-RV, offers even greater
detail and flexibility forscientific studies.
Finally, the clinical trialsversion SCID-5-CT is designed to

(01:29):
meet the stringent requirementsof research trials, ensuring
consistency and accuracy acrosslarge participant groups.
Focusing on the clinicianversion, the SCID-5-CV, it
encompasses 10 diagnosticmodules, each dedicated to a
specific category of mentalhealth disorders.
These modules collectivelycover 39 of the most commonly

(01:51):
encountered diagnoses inclinical settings, such as major
depressive disorder,generalized anxiety disorder,
bipolar disorders and adjustmentdisorder and adjustment
disorder.
Additionally, the SCID-5-CVscreens for 17 other significant
conditions, including bulimia,anorexia, hoarding disorder and

(02:16):
intermittent explosive disorder.
Each module is organized by thetype of disorder it addresses.
For example, module A coversmood episodes and persistent
depressive disorder.
Module B focuses on psychoticand associated symptoms.
The other modules are Module CDifferential Diagnosis of
Psychotic Disorders.
Module D Differential Diagnosisof Mood Disorders.

(02:38):
Module E Substance UseDisorders.
Module F Anxiety Disorders.
Module G Obsessive-CompulsiveDisorder and Post-Traumatic
Stress Disorder.
Module H Adult AttentionDeficit and Hyperactivity
Disorder.
Module I Screening for OtherCurrent Disorders.

(03:00):
Model J Adjustment Disorder.
These modules delve into areassuch as anxiety disorders,
obsessive-compulsive and relateddisorders, substance use
disorders, adhd in adults andmore.
The structure ensures that theinterview can be tailored to the
unique presentation of eachclient rather than following a

(03:22):
rigid, one-size-fits-all script.
The SCID-5 interview begins withan introductory overview, a
crucial phase that typicallylasts between 15 and 30 minutes.
During this time, the clinicianacts as both investigator and
ally, gathering essentialbackground information, while
also building a rapport with theclient, gathering essential

(03:44):
background information, whilealso building a rapport with the
client.
Open-ended questions dominatethis stage, allowing the client
to describe their currentconcerns, symptoms and personal
history in their own words.
As the conversation unfolds,the clinician listens for clues,
indicating which diagnosticmodules may be relevant, taking
note of any symptoms or patternsthat align with specific
disorders.
Once the introductory phase iscomplete, the clinician reviews

(04:07):
the information collected andselects the appropriate
diagnostic modules.
For instance, if a clientdescribes persistent anxiety,
the clinician might proceed toModule F, which addresses
anxiety disorders.
Here the interview shifts to amore structured format a series
of direct yes or no questionsthat correspond to the DSM-5

(04:30):
diagnostic criteria.
If the client answers yes to aparticular question, the
clinician may ask for additionaldetails or examples, ensuring
that each affirmative responseis supported by sufficient
evidence.
This process is meticulous.
Clinicians are trained to onlyendorse a symptom when they are
confident it meets the DSM'sstandards.
As the interview progresses,the clinician systematically

(04:54):
rules in or out potentialdiagnoses, following decision
trees that mimic the carefuldifferential diagnostic work of
experienced practitioners.
When the interview concludesthe clinician differential
diagnostic work of experiencedpractitioners.
When the interview concludes,the clinician completes a
diagnostic summary score sheetdocumenting the diagnoses
indicated by the client'sresponses.
Importantly, the SCID-5 processencourages the use of

(05:15):
collateral information, such asreferral notes, previous medical
records and observations fromfamily members, to ensure a
comprehensive understanding ofthe client's condition.
Should new information ariseafter the interview, clinicians
are advised to revisit and, ifnecessary, update their
diagnostic conclusions.
Through its structured yetflexible approach, the SCID-5

(05:40):
empowers clinicians andresearchers alike to make
accurate, evidence-baseddiagnoses, fostering better
outcomes for clients andadvancing the understanding of
mental health disorders.
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