Perspectives on Selected Hemophilia Research Presented at ISTH 2025: Nonfactor Replacement Therapies
The treatment of persons with hemophilia continues to evolve, with important advancements that address limitations with factor replacement such as diminished efficacy in patients with inhibitors and the burden of frequent intravenous administration. This 30-minute activity delves into the latest research presented at ISTH 2025, highlighting rebalancing agents and factor VIII mimetics. In addition to discussing details of each trial, Dr. von Drygalski shares her thoughts about its importance and relevance to clinical practice.
Episodes
Abstract 4: Effectiveness of emicizumab in hemophilia A: A 4th interim analysis of the real-world study EMIIL
Abstract 5: Prospective evaluation of a defined replacement protocol for peri-operative hemostasis in patients with severe hemophilia A with and without inhibitors on emicizumab prophylaxis undergoing elective major surgeries-final results. (EmiSurg Study)
Abstract 6: FRONTIER5 direct switch study: Safety of initiating Mim8 ...
Abstract 1: Association of antithrombin levels with efficacy of fitusiran prophylaxis in people with hemophilia A or B with and without inhibitors: a predictive modeling approach
Abstract 2: Annualized bleeding rates in hemophilia A/B and target joints: Concizumab explorer8 study
Abstract 3: Long-term efficacy of marstacimab in participants with severe hemophilia A or B without inhibitors
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