Marco received a bachelor of arts in Linguistic Anthropology at Brown University, where he was intrigued by the relationship between communication, expression, and imagery. Santini worked at branding agencies in New York City before fully committing to the arts. His geometric style is expressed through spray paint, paint markers, window markers, acrylics, magazines, textiles and digital art.
Santini found his life purpose in 2018 to spread love and positivity as a conscious creator. He has expressed his thoughts through arts, education and volunteering, he speaks and paints at schools around the world, teaching students to explore their passions while turning negatives into positives. In 2019, Santini had his first solo show, entitled "Unity and Diversity" showcasing over a hundred works at 198 Allen Gallery in the lower east side of New York City.
His work has also been featured at the United Nations, Shore Club Miami, SLS, Art Basel Miami, and Bloomingdale's to name a few.