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January 20, 2025 25 mins

This third podcast episode in the series explores advanced understanding of primary hemophagocytic lymphohistiocytosis (HLH), focusing on its genetic basis, diagnostic innovations, and treatment strategies. The discussion highlights the pathophysiology of HLH as an interferon gamma (IFN-γ) driven disease, emphasizing the role of novel diagnostic tools such as flow cytometry and genetic panels. The panel also examines emerging therapies, including JAK inhibitors and IFN-γ monoclonal antibody (emapalumab), in improving outcomes for both primary and secondary HLH. Practical insights into balancing immunosuppression with efficacy offer guidance for optimizing patient care.

Launch Date: December 2, 2024

Release Date: December 2, 2024

Expiration Date: November 30, 2025

FACULTY

Scott Canna, MD

Assistant Professor of Pediatrics

Childrens Hospital of Philadelphia

Pui Lee, MD

Assistant Professor of Pediatrics

Boston Childrens Hospital

Ashish Kumar, MD, PhD

Professor of Pediatrics

Cincinnati Children’s Hospital Medical Center

This podcast provides accredited continuing education credits. To receive your credit, please read the accreditation information provided at this link below prior to listening to this podcast.

https://www.practicepointcme.com/CMEHome/conversations-in-ifn-y-driven-diseases-decoding-the-gamma-signal-1

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