New research on LSD for generalized anxiety and what’s helpful about a psilocybin experience

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In today’s episode of the Psychedelic Therapy Frontiers podcast we discuss a paper recently published in JAMA (Journal of the American Medical Association) entitled, “Single Treatment With MM120 (Lysergide) in Generalized Anxiety Disorder: A Randomized Clinical Trial.” This is a report on the results from Mind Medicine’s phase 2b clinical trial that Reid and I both had the pleasure of working on at Numinus Network’s clinical trial site, Cedar Clinical Research. We discuss what GAD is, a brief history of LSD, why LSD might be helpful for anxiety, the study design, the difference between session monitoring vs psychedelic-assisted therapy, and more. Near the end of the episode we briefly discuss another recently published paper, this one on psilocybin and how the phenomenology of a psychedelic experience might contribute to positive psychological changes. 
For those of you who are new to the show, welcome! Psychedelic Therapy Frontiers is brought to you by Numinus Network and is hosted by Dr. Steve Thayer and Dr. Reid Robison.

https://jamanetwork.com/journals/jama/article-abstract/2838505

https://link.springer.com/article/10.1007/s43440-025-00742-5

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