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August 6, 2025 11 mins

If your clients are gaining weight in their 40s or 50s despite clean eating and regular movement, it’s not simply “aging” or “hormones.”

In this episode of ReInvent Healthcare, Dr. Ritamarie explores a metabolic adaptation that occurs during midlife and alters how the body responds to glucose, insulin, and stress. There’s a multi-system shift that rewires fat storage, energy production, and appetite regulation.

What if one of the most overlooked drivers of insulin resistance in women is also one of the most correctable?

What’s Inside This Episode?

  • A surprising hormonal connection that rewires the body’s response to glucose and insulin
  • Why most blood sugar protocols fall short in midlife and what’s often missing
  • The under-discussed cascade that turns food into fat even when eating “healthy”
  • How specific plant-based foods and herbs can influence metabolic rhythm
  • Why personalizing protocols is non-negotiable during this life stage
  • Key markers to watch when tracking metabolic shifts in women 40+

Resources and Links

  • Download our FREE Metabolic Health Guide here
  • Join the Next-Level Health Practitioner Facebook group here for resources and community support
  • Visit INEMethod.com for advanced health practitioner training and clinical mentorship
  • Check out other podcast episodes here


References

  • Barros RP, Gustafsson JÅ. Estrogen and metabolic regulation. Cell Metab. 2011.
  • Mauvais-Jarvis F. Estrogen and androgen receptors in metabolic disease. Nat Rev Endocrinol. 2015.
  • Khan A, et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care. 2003.
  • Zhang Q, et al. Berberine reduces insulin resistance and improves glucose metabolism. Metabolism. 2008.

Li SS, et al. Flaxseed and hormonal modulation in women. Nutrients. 2021.

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