RhAPPcast

In this episode of RhAPPcast, the official podcast of Rheumatology Advanced Practice Providers, host Amanda Mixon, PA-C, is joined by Jessica Glennie, CNP, as they discuss key interstitial lung disease (ILD) updates from the 2026 EULAR Congress in the first episode of a special three-part RhAPP Up series.

They explore the healthcare and financial impact of connective tissue disease-associated ILD (CTD-ILD), highlighting why early di...

Stay ahead of the latest advancements in rheumatology with this in-depth RhAPPcast episode exploring TYK2 inhibition and its expanding role in immune-mediated diseases. Hosted by Amanda Mixon, PA-C, this episode features expert insights from Danielle Gatti-Palumbo, PharmD, and Jennifer Mylod, DNP, as they break down the science behind TYK2 signaling within the JAK-STAT pathway and its clinical relevance in conditions like psoriatic...

Explore the latest evidence in obesity management in this journal club review of the SURMOUNT-5 clinical trial, presented by Bharati Bhardwaja, PharmD, from Kaiser Permanente Colorado. This video breaks down a Phase 3b randomized trial comparing tirzepatide and semaglutide in adults with obesity without type 2 diabetes, highlighting key efficacy and safety outcomes over 72 weeks.

Learn how tirzepatide demonstrated superior weight l...

In this educational Medication Review, Claudia Rivera-Salas, DNP, provides a practical overview of deucravacitinib and its role in the treatment of immune-mediated diseases such as psoriatic arthritis and plaque psoriasis. This video highlights why deucravacitinib, a selective TYK2 inhibitor, is gaining attention for its unique mechanism of action and ease of use in clinical practice.

Learn how deucravacitinib stands out as a once-...

Discover how obesity impacts outcomes in psoriatic arthritis in this insightful episode featuring expert perspectives from rheumatology clinicians, Amanda Mixon, PA-C and Jeannette Hart, PA-C. This discussion explores the growing recognition of obesity as a chronic, pro-inflammatory condition that not only worsens joint symptoms and physical function but also reduces treatment response in patients with psoriatic arthritis.

Learn pr...

In this educational FAQ video, Iris Zink, NP, a rheumatology nurse practitioner, provides a comprehensive overview of the TYK2/STAT signaling pathway and its immunologic role in autoimmune diseases like systemic lupus erythematosus (SLE) and Sjögren’s disease. Drawing from clinical experience and real-world insights, Iris explains how dysregulated cytokine signaling—particularly involving type 1 interferon, interleukin-...

In this episode of RhAPPcast, the official podcast of the Rheumatology Advanced Practice Providers, host Amanda Mixon, PA-C, is joined by rheumatology experts Heather Finlayson, PA-C, and Stacey Johnson, NP, to discuss one of the most challenging aspects of rheumatology care: ensuring patient access to advanced therapies. This conversation explores the complexities of Medicare formularies, prior authorizations, step edits, tier pla...

In this FAQ video, Christy Vath, PA-C of Seattle Rheumatology Associates, breaks down the concept of minimal disease activity (MDA) in psoriatic arthritis (PsA) and explores how deucravacitinib performs in achieving this important treatment target at 52 weeks. With the evolution of targeted biologic therapies since the late 1990s, treatment goals in PsA have shifted toward objective, measurable outcomes like MDA—an establishe...

In this FAQ video, Shannon Ghizzoni, PA-C, of Columbus Arthritis Center reviews the latest guidance on managing obesity in patients with psoriatic arthritis. Referencing the 2018 American College of Rheumatology (ACR) and National Psoriasis Foundation recommendations, she explains why weight loss is conditionally recommended for overweight and obese patients with psoriatic arthritis and how adiposity contributes to systemic inflamm...

In this episode of RhAPPcast, the official podcast of Rheumatology Advanced Practice Providers, host Amanda Mixon and Bonnie Smeryage, NP, explore the real-world impact of X-linked hypophosphatemia (XLH) through a powerful patient perspective. Featuring Shannon Sharp, a patient ambassador with Kyowa Kirin, this discussion dives into the genetic basis, diagnostic challenges, and lifelong burden of XLH—a rare, chronic metabolic...

Explore the safety profile of tirzepatide in this clinician-focused medication review led by Bharati Bhardwaja, PharmD, a rheumatology clinical pharmacist at Kaiser Permanente Colorado. This video provides a comprehensive overview of common adverse effects associated with tirzepatide, including gastrointestinal symptoms such as nausea, diarrhea, constipation, abdominal pain, and decreased appetite, as well as other reactions like i...

Learn the recommended starting dose and titration strategy for tirzepatide in this medication review featuring Jennifer Mylod, DNP, from Arizona Arthritis & Rheumatology Associates in Phoenix, Arizona. This video provides a practical, clinician-focused overview of how to initiate tirzepatide at 2.5 mg once weekly to improve gastrointestinal tolerability and patient adherence, followed by a structured dose escalation approach. V...

Stay up to date with the latest advancements in psoriatic arthritis treatment in this journal club review featuring Jessica Farrell, PharmD, from Albany Medical Center. This video explores a Phase 3 SOLSTICE clinical trial evaluating the efficacy and safety of guselkumab in patients with active psoriatic arthritis who had an inadequate response to a prior TNF inhibitor.

The discussion highlights key clinical outcomes, including ACR...

In this educational FAQ video, Wendy Simmons, PA-C from Carolina Arthritis Associates, shares expert insights on hypophosphatasia (HPP)—a rare genetic metabolic bone disorder that is frequently underrecognized in rheumatology practice. With over 25 years of experience in rheumatology and specialization in osteoporosis, she highlights how HPP is characterized by low alkaline phosphatase levels and impaired bone mineralization,...

Explore the mechanism of action of tirzepatide in this comprehensive medication review led by Bharati Bhardwaja, PharmD, from Kaiser Permanente Colorado. This video breaks down how tirzepatide, a first-in-class dual incretin receptor agonist, targets both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors to improve metabolic outcomes. Learn how this once-weekly injectable therapy is FD...

Danielle Gatti-Palumbo, PharmD reviews the phase 3 APEX trial evaluating Guselkumab in patients with active psoriatic arthritis (PsA), highlighting its role in reducing inflammation, improving clinical outcomes, and preventing structural joint damage. The discussion emphasizes the importance of early biologic intervention in a disease that can quickly lead to irreversible damage and disability.

Results show that guselkumab signific...

In this episode of RhAPPcast, host Amanda Mixon PA-C, is joined by Wendy Simmons, PA-C, they explore the diagnostic challenges of hypophosphatasia (HPP), a rare genetic metabolic bone disease that is frequently overlooked or misdiagnosed. Mixon and Simmons discuss key clinical red flags, including persistently low alkaline phosphatase, fracture patterns, dental history, and musculoskeletal pain that can mimic more common conditions...

In this Journal Club Review, Eileen Lydon, NP, a rheumatology provider at NYU Hospital, discusses the challenges of diagnosing hypophosphatasia (HPP) in adults, based on a 2023 Osteoporosis International publication from the HPP International Working Group. HPP is a rare genetic metabolic bone disease characterized by low alkaline phosphatase levels and highly variable, non-specific symptoms such as fractures, chronic musculoskelet...

In this educational video, Shannon Ghizzoni, a physician assistant at Columbus Arthritis Center, explores the impact of weight reduction on disease activity and treatment outcomes in Psoriatic Arthritis. This discussion highlights the strong connection between obesity—particularly visceral fat—and increased inflammation in patients with psoriatic arthritis and psoriasis.

Learn how excess adipose tissue contributes to a ...