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February 23, 2025 • 18 mins

Ever wondered how your brain takes out the trash? 🧠🚛 In this episode of Science Up!, we dive into the brain's waste disposal system—the glymphatic system—and how it keeps your neurons squeaky clean. But here's the twist: aging slows down this clean-up crew, potentially leading to cognitive decline.


🔬 Key Takeaways:

✅ The glymphatic system flushes out metabolic waste using cerebrospinal fluid (CSF).

✅ Aging disrupts blood flow, slows CSF circulation, and weakens immune clearance, making waste disposal less efficient.

✅ Poor sleep impairs brain cleaning, linking sleep deprivation to neurodegenerative diseases.

✅ Meningeal lymphatic vessels shrink with age, reducing CSF drainage efficiency.

✅ White matter integrity declines, affecting brain connectivity and cognitive speed.


The episode was hosted by Niraj Gupta & Muskan Mittal.


The Science up! podcast is now streaming on all music/podcast platforms like Spotify, Apple Podcasts, Gaana, JioSaavn. So Don't wait, go Science up! yourself!!


#Neuroscience #BrainHealth #GlymphaticSystem #AgingBrain #CognitiveDecline #Neuroimmunology #ScienceUp!

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