A Real Pain with Jesse Eisenberg

Jesse Eisenberg owes it all to an internet pop-up ad. A few years ago, while at an impasse with a screenplay about two friends on a trip to Mongolia, the writer-director and star of movies like The Social Network read an ad for “Auschwitz tours - with lunch.” And that jarring phrase unleashed an avalanche of ideas about, as he puts it, “the irony of wanting to connect to your ancestors’ pain but at the same time not being willing to experience any pain yourself: stay at the Radisson, eat your continental breakfast, have your croissant in the morning and your coffee in the van going to a concentration camp.” 

Skip forward to 2025, and the film unlocked in his imagination by that ad – A Real Pain – is an awards season frontrunner, nominated for Best Original Screenplay and Best Supporting Actor at this year’s Oscars. Its story of two cousins – David, played by Jesse, and Kieran Culkin as Benji – on a Holocaust “trauma trip” through Poland is a moving meditation on the shame it’s easy to feel in today’s world for feeling unsatisfied with life, when we think about the greater hardships our ancestors may have suffered. it’s devastating and deliriously funny in equal measure, not to mention bold in how it refuses an Eat Pray Love narrative of having international travel solve these characters’ problems back home. In A Real Pain, Culkin’s erratic livewire Benji ends up exactly back where he started – but we as an audience are changed. 

In the spoiler conversation you’re about to hear, Jesse tells me about how the film worsened rather than resolved his complicated feelings around what pain he’s entitled to feel. We get into that devastating final shot at the end of the film and why it is we feel the urge to connect to our pasts, with services like Ancestry and 23andMe. Listen out also for the parts of Jesse’s life he folded into the script – such as his use of medication and medication to tackle OCD and depression – and how Jesse reflects on the unanswerable question of, how much grief to allocate to the terrible situation in the world right now, before we cease functioning. It’s a fascinating chat about a fascinating film.

Script Apart is hosted by Al Horner and produced by Kamil Dymek. Follow us on Instagram, or email us on [e-mail].

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