Sleep Unplugged with Dr. Chris Winter

“What do you think about peptides?” is one of the most common questions in the sleep clinic right now, and it’s about as answerable as “What do you think about sandwiches?” Insulin, Zepbound and a gray-market vial of BPC-157 are all peptides, but the word tells you nothing about what a molecule does or how well it’s been tested. In this episode we put the most popular “sleep peptides”...

Last November on Episode 178, we talked about three companies racing to bring orexin agonists to people with narcolepsy. In less than a year, one of those drugs has been approved, another company has been bought for billions, and the race now runs from the lab to the insurance company. In this episode we will:

• Break down the latest data from the SLEEP 2026 meeting in Baltimore, where each drug stands and when the rest might reac...

Imagine a sleep study where picturing yourself diving in a submarine boosted deep sleep by 81%, yet nobody slept a minute longer. It's a real result, and it points to an uncomfortable idea: with the right design, almost anything can be shown to "improve sleep." From free habits to FDA-approved pills to neurotech headbands, every claim has a study behind it, and how that study was built often matters more than the product being sold...

Dr. Valerie Cacho (@drvalsleepgal) joins me for another countdown of the Top 10 Sleep Threats, and her list asks a question we should all be asking more often: Have we actually figured out what is disrupting someone’s sleep? From peptides marketed as cures to the assumption that a woman’s fatigue is simply part of being a working mom, Valerie takes aim at the shortcuts that can delay an accurate diagnosis. In this episo...

A courtroom, an insurance formula, and a supermarket receipt don't usually belong in the same sentence — but together they answer the question this episode is built around: what does a bad night's sleep actually cost, in dollars, tonight? Not the economy. You. We take the number everyone quotes and can't act on — sleep deprivation costs the U.S. $411 billion a year — and rebuild it from the ground up using the dat...

A few days ago, we did an experiment to see how well AI could interview me about sleep. In this bonus episode, I reveal the original attempt which was a bit all over the place. The interview was much more personal and strange which we corrected by adjusting the prompt in the "official" episode, but I thought it might be funny to share the trial run. In this episode we will:

-Debate how much of my career success can reas...

What happens when the interviewer knows nearly everything you have said publicly and has zero fear of challenging or offending you? In this unusual episode of Sleep Unplugged, I turn over all control of the podcast to AI and let it ask the questions and dictate the program. The result is a surprisingly candid conversation about certainty, contradiction, expertise, and what an algorithm might see when it examines a career devoted to...

A Massachusetts courtroom just produced something that almost never survives into public record: a near-complete paper trail of one woman's psychiatric care in the three months before catastrophe. Her diary, her phone notes, and the testimony of every provider who tried to help her sleep all lead to a central question: what actually happens when insomnia and psychiatric illness feed each other, and how thin is the system supposed t...

Dr. Alison Kole is taking on sleepmaxxing, ChatGPT, and the sleep-industrial complex in her Top 10 Sleep Threat list. In this episode we will:

• Explore why patients sometimes arrive at the sleep clinic with their story and diagnosis already written
• Look at the fear of sleep studies, sleep apnea diagnoses, and outdated ideas about CPAP
• Ask why CBT-I remains underused despite being the gold-standard first-line treatment for chronic i...

Nobody blinks when a doctor says you'll be on blood pressure medication for the rest of your life. Say the same sentence about an antidepressant, or Zepbound, and responses are quite different. This episode digs into deprescribing, the fast-growing clinical movement around when and how to stop medications, and asks why some "forever drugs" get a cultural pass while others get moralized. In this episode we will:

• Separate the real...

Our current gig economy did not just create new jobs, it expanded a whole new category of night worker, from rideshare drivers to online freelancers to overnight fulfillment teams. Today (or tonight rather), our bodies are struggling to make the switch. In this episode we dig into what that circadian resistance actually costs your heart and metabolism long-term, and the handful of interventions that can actually shift it. In this e...

Nasal strips have been a fixture in pharmacy aisles and on athletes' faces for decades, sold on the promise of easier breathing, but the peer-reviewed evidence often tells a different story than the packaging does. We put nasal strips and internal dilators through the RCT wringer and sort out what these devices can and can't actually do, from your bedroom to the finish line. In this episode we will:

• Break down what the highest-q...

Ten million prescriptions a year, and most of them aren't for what the drug was built to treat. Seroquel started life as an antipsychotic — engineered to quiet psychosis, not close your eyes. Somewhere along the way it became one of the most common "off the record" sleep aids in America, riding on a side effect nobody set out to sell. The evidence behind that shift is thinner than most people assume — and Seroquel isn't...

Most "top sleep threats" lists stick to one lane — pediatric or adult, clinical or cultural. Dr. Funke Afolabi-Brown's list refuses to. It jumps from kids' airways to menopause to AI chatbots, and by the end a pattern emerges: the same symptom, in different bodies, keeps getting waved off as normal. In this episode we will:

• Work through pediatric snoring dismissed as harmless and untreated mouth breathing, and why both are...

Every June, thousands of sleep researchers descend on one city and quietly rewrite what we think we know about a third of our lives. This year it was Baltimore's turn, for the 40th annual SLEEP meeting — and the data that came out of it hits closer to home than usual: blood pressure, diabetes, teenage phones, and why "night owl" might really mean "lonely." Here are my Top 10 studies from SLEEP 2026 most likely to actually cha...

Deep sleep and REM sleep get lumped together as "good sleep," but they're almost opposite states — one is the quietest your brain gets all night, the other is nearly as active as being awake. In this episode we pull the two apart: how we stumbled onto each of them, what's happening chemically while they run, and why one of them quietly shrinks as we age while the other holds steadier. In this episode we will:

• Break down wh...

We tend to think of insomnia and sleep apnea as two completely different sleep disorders. One means you can't sleep. The other means you stop breathing. Simple, right? Not so fast. In reality, many people with sleep apnea don't complain about snoring or excessive daytime sleepiness. Instead, they complain that they wake up repeatedly throughout the night and can't stay asleep. In this episode we will:

• Explain why sleep apnea oft...

This week marks the 12th month we have put out the Top 10 Sleep Threats Power Rankings, and this week, we have a special guest assessor, Upneet Chawla, MD (@sleeping.beauty_md). Upneet is an internist and board-certified sleep specialist.  In this episode, she has graciously provided us her list. In this episode we will:

• Find out what Dr. Chawla thinks are the top threats to your sleep
• Incorporate abstracts from the 2026 Sle...

Sleep duration has always been the headline number in sleep science, but mounting research is pushing the conversation toward something less obvious: how consistent your timing is from night to night. In this episode we dig into a debate that's far from settled, and into a statistical trap that may be quietly distorting it. WIn this episode we will:

• Break down the four separable pillars of sleep health: duration, consistency, co...