Solving the Puzzle with Dr. Datis Kharrazian

Solving the Puzzle with Dr. Datis Kharrazian

Solving the Puzzle with Dr. Datis Kharrazian is based on more than 20 years of Dr. Kharrazian's experience working with autoimmune and brain health patients throughout the U.S. and Europe, exhaustive review of the scientific research, and protocols he has innovated through trial and error in working with complex patient cases. Dr. Kharrazian discusses evidence-based models incorporating diet, nutrition, and lifestyle — protocols hard won through decades of working with tough, complex patient cases. His goal is to help teach you effective models for so-called “mystery” symptoms and conditions so you can regain control of your health and life. Hashimoto's: Solving the Puzzle, is a new online course from Dr. Kharrazian, who is the originator of evidence-based strategies for managing autoimmune Hashimoto's hypothyroidism. This course has the most complete and current information for managing Hashimoto's available. You can find more information at drknews.com. Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

Episodes

May 20, 2026 28 mins

In today’s episode, we dive into the “clinical faces of fatigue.” Join Datis Kharrazian as we explore why some individuals never fully recover from illnesses or injuries, the intricate link between mood and brain energy, and why two patients with similar medical conditions like anemia can have vastly different experiences of fatigue.


We’ll unravel how mitochondrial dysfunctions, both inherited and acquired, lie at the heart of c...

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In this episode, functional medicine clinician Dr. Rajka Milanovic Galbraith dive into the world of peptides for recovery, exploring both oral and injectable options. She breaks down the latest clinical insights on popular peptides like BPC157, KPV, Lorazatide, TB4, and PeptiStrong, sharing case studies and practical strategies for supporting gut health, autoimmune recovery, muscle maintenance, and post-injury healing. Whether you'...

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In this episode, Rajka Milanovic Galbraith, MD, dives into nutrigenetics and its transformative impact on mental health and chronic conditions. Using real-life patient stories, Dr. Galbraith illustrates how genetic insights and targeted nutrient support can unlock profound change. We’ll explore personalized approaches from thought leaders like Amy Yasko, Ben Lynch, William Walsh, and Bob Miller, discussing practical protocols for m...

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In this episode, we dive into the world of oxidative stress, GST gene patterns, and hormone genetics, uncovering how these factors influence chronic illness and overall health. You'll hear about innovative testing strategies, gene patterns seen in chronically unwell patients, and real-world case studies that illustrate the practical steps clinicians can take to restore health and balance.


Whether you're a healthcare professional...

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In this episode with Dr. Datis Kharrazian, we dive into the mechanisms that underlie pain, exploring key terms like nociception, hyperalgesia, allodynia, and sensitization. You'll learn how pain signals travel through first, second, and third order neurons, why some injuries result in referral pain, and how chemical mediators and the sympathetic nervous system amplify pain perception.


We’ll break down how the brain interprets, l...

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Today, we're diving into the often overlooked signs and symptoms of micronutrient deficiencies, from vitamins A, D, and K to magnesium, zinc, and beyond. You'll discover how subtle clues like gritty eyes, dream recall, muscle cramps, and even pink tongues can signal deeper nutritional gaps impacting mood, energy, and neurological health. Whether you're a practitioner seeking a sharper clinical eye or simply want to optimize your we...

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In this episode, we’re diving into the world of skin health, from what radiant, healthy skin should look like to the many signals our skin can send about underlying health issues. We'll explore common skin manifestations, nutritional deficiencies, and practical strategies to support skin, from dryness and discoloration to eczema, rosacea, and more. Whether you're a practitioner or someone interested in optimizing your own health, t...

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In this Practitioner Spotlight episode, we sit down with Dr. Darla Booth, a seasoned chiropractor and functional medicine practitioner based in Los Gatos, California. Over the past 20 years, Dr. Booth has transitioned her practice to focus on complex functional medicine cases, with a special emphasis on autoimmunity. Join us as Dr. Booth shares how discovering autoimmune markers in her own and her daughter’s bloodwork inspired a de...

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In this episode, Dr. Liz Lipski, a leader in clinical nutrition and author of Digestive Wellness dives into the foundational practice of nutrition-focused physical assessment.


Dr. Lipski explains how simple observations like cracks in a friend’s tongue over dinner or dark circles under a child’s eyes, can become powerful clues in solving chronic and complex health puzzles. She emphasizes the importance of integrating physical as...

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In today’s episode, we’re diving into the impact of mitochondria on chronic conditions like fatigue, pain, and depression. You’ll hear why optimizing basic factors like sleep, movement, and stable blood sugar isn’t just “wellness” advice, but can actually be game changers for patients struggling with conditions such as leaky gut, Hashimoto’s, fibromyalgia, or neuropathic pain.


Datis Kharrazian unpacks the science behind mitochon...

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In this episode, Dr. Kharrazian dives into one of the most challenging and important topics facing both patients and practitioners: chronic fatigue and pain syndromes.


If you've ever wondered why fatigue and pain are such stubborn and complex complaints, or why so many patients feel stuck despite having normal lab results, this conversation is for you. Dr. Kharrazian explores the critical role of cellular energy production—speci...

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Dr. Dave Rakel introduces the ECHO model for medical decision making, a practical framework that evaluates four key factors: Efficacy (evidence of benefit), Cost, Harm (evidence of harm), and Opinion (patient preferences and bias). He emphasizes that treatment decisions should balance not only how well something works, but also its potential risks and its alignment with patient values.

He explains his evidence-versus-harm rating sys...

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In this lecture, Dr. Dave Rakel explores the placebo effect—"the ability to stimulate self-healing without deception"—and reveals how perception, connection, and empathy are among the most powerful healing mechanisms available to practitioners.


Dr. Rakel unpacks the neuroscience of perception, showing how our conditioned minds create physical responses that determine health or disease. He shares groundbreaking research: optimist...

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In this Practitioner Spotlight, Dr. Dave Boyton—a Cincinnati-based functional medicine specialist—shares how he transformed his practice by integrating neurological assessment with functional medicine. After his wife was misdiagnosed with multiple autoimmune conditions, Dr. Boynton dove deep into functional medicine and discovered what most practitioners miss: the neurological component.


Dr. Boyton reveals why hypoglycemia isn't...

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In this episode, our guest speaker, certified physician assistant Danielle Valoras explores breast implant illness (BII)—a clinical reality that remains widely misunderstood despite affecting millions of women. She unpacks why BII lacks an official diagnosis code, yet presents with a consistent constellation of symptoms, including fatigue, brain fog, joint pain, rashes, anxiety, and autoimmune-like conditions that are frequently mi...

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In this episode, our guest speaker, certified physician assistant Danielle Valoras explores the essential role of the lymphatic system in women with breast implants. She explains how the lymphatic system serves as the body's drainage and immune defense network, and how disruptions in lymph flow, particularly from foreign objects such as silicone implants, can trigger a cascade of chronic inflammation, hormone imbalance, and systemi...

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In this episode, certified physician assistant Danielle Valoras shares her expertise cultivated from over two decades in medicine—and a decade devoted to functional medicine—by diving into an issue affecting millions: breast implants and their true impact on women’s health. Drawing from both scientific research and her firsthand clinical experience working with the breast implant population for the past eight years, Danielle Valora...

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In this episode, Dr. Yousef Elyaman breaks down the essential nutritional strategies for reversing fatty liver disease—from macronutrient optimization to the evidence-based power of the Mediterranean diet—making complex dietary interventions immediately actionable for practitioners and patients.


We explore why replacing carbohydrates with protein and saturated fats with unsaturated fats reduces hepatic fat content, how over 10,0...

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In this episode, Dr. Yousef Elyaman breaks down the essential mathematics of metabolism—from calculating basal metabolic rate to understanding the 3,500-calorie rule for weight loss—making complex concepts immediately actionable for practitioners and patients.


We explore the critical distinction between fat loss and muscle preservation, why body composition matters more than the number on the scale, and how strategic protein int...

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In this episode, Dr. Yousef Elyaman, a leading functional medicine doctor, takes us into the pathogenesis of fatty liver disease, sharing his expertise on the underlying imbalances and physiological mechanisms that contribute to this complex condition.


We explore how functional medicine looks beyond traditional diagnostics and treatments, focusing instead on the root causes—whether that’s insulin resistance, genetics, diet, gut ...

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