Research Update: Atypical gut microbiota composition in a mouse model of developmental stuttering

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Researchers from the Delaware Stuttering Project at the University of Delaware—Dr. Ho Ming Chow, Associate Professor and principal investigator, Sayan Nanda, Ph.D. student, and Dr. Nicole Guarino, research scientist—join host Sara MacIntyre, M.A., CCC-SLP, to discuss their recent article, "Atypical gut microbiota composition in a mouse model of developmental stuttering," published in Scientific Reports (Nature Portfolio). Building upon previous genetic and mouse model research by Dr. Dennis Drayna and colleagues at the NIH [previous podcast episode with Dr. Drayna linked below for background], their study explores the potential link between developmental stuttering and the gut-brain connection by examining gut microbiota differences in GNPTAB mouse models.

In this episode, Dr. Chow, Sayan Nanda, and Dr. Guarino provide essential background context before walking through the study’s development, methodology, and key findings. They discuss the potential role of the microbiome in other neurodevelopmental conditions, the challenges of translating mouse model research to human studies, and the exciting directions for future research this study has prompted.

Article discussed:

• Nanda, S., Lamot, B., Guarino, N. et al. Atypical gut microbiota composition in a mouse model of developmental stuttering. Sci Rep 14, 23457 (2024). https://doi.org/10.1038/s41598-024-74766-x

Previous Stuttering Foundation Podcast episode referenced, 'Genetics and Stuttering with Dr. Dennis Drayna.'

Delaware Stuttering Project Webpage

Dr. Ho Ming Chow, Associate Professor at the University of Delaware and a principal investigator for the Delaware Stuttering Project, received his Bachelor’s and Master’s Degrees in Engineering at the University of Hong Kong. After working as an engineer for a few years, he became interested in studying human cognition and went to Germany for his doctoral study. He obtained his Ph.D. in Cognitive Sciences with an emphasis on Cognitive Psychology at the University of Osnabrück. He completed his postdoctoral training at the National Institutes of Health. Before joining the University of Delaware in 2019, he was a research faculty at the University of Michigan and Nemours Children’s Hospital, Delaware.

Sayan Nanda received his Master of Science in Data Informatics from the University of Southern California and his Bachelor of Technology in Computer Science and Engineering from the Manipal Institute of Technology. Sayan is currently a Ph.D. student in the Communication Sciences and Disorders department at the University of Delaware. Sayan is primarily interested in stuttering research and the application of statistics and machine learning techniques in the same. His focus is on neuroimaging.

Dr. Nicole Guarino is an adjunct faculty at the Department of Communication Sciences and Disorders, the University of Delaware. She received her PhD in Neuroscience from Thomas Jefferson University and her B.A. in Neuroscience from Franklin and Marshall College. She has been working in Dr. Chow’s lab since 2022 and is interested in the neurobiological bases of stuttering.