Episode Transcript
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Kelli (00:31):
So I didn't know in doing
some of my research that
significant inflammation candegrade stem cells, especially
like early young stem cells.
And so I have a patient thathas fibromyalgia and chogrin's.
And so she has a lot of flaresof her chogrins.
And we were chatting this weekand kind of talking about some
(00:52):
other stuff.
And so I put her on NAD andI've put her on glutathione to
address some of herinflammation.
And she came back and wechatted about her labs, and I
put her on some other things toaddress some of her hormones,
some morein being one of them.
So, you know, really kind ofusing those peptides and peptide
stacking like we've talkedbefore to address an issues,
just because there's a ton ofresearch showing that that's
(01:13):
just really the gold standardright now.
But then going back, I wasdoing some research yesterday to
see what else we could do toaddress this just overwhelming
inflammation that her poor bodyis dealing with right now.
And so in my research and kindof going through it all, you
know, we talk a lot about stemcells, and you and I discuss a
lot of things about peptides andhow that can help to reverse
(01:35):
the sides of aging and not justanti-aging, but what that looks
like, you know, clinically.
And I didn't realize howsignificant, how much of a role
inflammation plays in degradingstem cells.
Did you know that?
I didn't know that.
Nicole (01:48):
I did not know that.
I did not know that.
I did not know that until youjust now said that.
But I will tell you that wetalked about last night on a
meeting that I was on about LDN,LDN, low dose naltrexone, and
about how really good it is foranti-inflammatory for those
fibromyalgia, for those chronicinflammatory processes for
(02:09):
patients who just have a normal,just you know, chronic
inflammation in general.
I mean, low dose naltrexone,like so for me, I take one
milligram twice a day.
One one milligram twice a day.
That's it.
That's it.
Like the normal dose, if youlook up naltrexone, it has, you
know, you use it for otherthings, of course, at the higher
doses, but at these microdoses,it does really, really good
(02:31):
things, and especially withaging.
So I think that with the stemcells that you're talking about,
being that you're now you'resaying, okay, inflammation can
break down your stem cells.
Now we need to attack theinflammation.
And so there's so many ways todo that with the peptides or
with the LDN.
There's so many ways now.
That's amazing.
Kelli (02:49):
Yeah.
And I didn't think I wasn'treally kind of putting those
pieces together.
You know, we go after thethings to try to boost their
stem cells.
But then when I was looking atstuff to target that
inflammation, it really kind ofput the whole thing in picture
for me.
I was like, now it starts tomake sense because then it
becomes this vicious cycle,right?
Inflammation, breaking downstem cells, you know, the
(03:09):
degradation of stem cells,causing more inflammation,
causing more breakdown.
It's just like she's in thisyo-yo and trying to try to get
her off that hamster wheel.
It really was a good, a reallygood, you know, mind-blowing
experience for me yesterdaygoing through all of that stuff.
And so I really started kind ofgoing down that down that
pathway.
But I know you, Nicole, havedone a lot of research and
(03:31):
you're really kind of hype onLDN.
So let's start out today justtalking about LDN.
So for everyone that's justjoining us, welcome.
Welcome to another episode ofTattoos and Telehealth.
I'm Kelly White, uh, boardcertified family nurse
practitioner.
And this is my great friend,colleague, and partner, Nicole
Baldwin.
She's also a board certifiedfamily nurse practitioner.
And our attorneys make us saythat this podcast does not at
(03:54):
all constitute a patientprovider relationship.
This is not at all medicaladvice.
We're just two gals.
As you can tell, chatting itup, we like to sit here and
visit and pick each other'sbrain and talk about some stuff.
So, Nicole, take off and tellus while we're on the subject,
all about LDN or low dosenaltrexone.
What does that mean?
What kind of role does it playin medicine and how do we get to
(04:14):
use it?
Nicole (04:15):
Yeah, sure.
So LDN has been around for areally long time.
LDN is low dose naltrexone.
So it's like a microdose ofnaltrexone.
Now, I have some patients.
I was on a podcast yesterday,and someone said, I mentioned
one of the patients said, Imentioned naltrexone, low dose
naltrexone to my in-personprovider, and they were like,
(04:35):
What?
And you know, not everyprovider knows everything.
And so you you have you have toknow that, right?
That's why we have specialists,and that's why we have you know
different things.
Nobody knows everything.
I grew up thinking that everydoctor, if you were a doctor,
you knew everything.
But as you know, as we you knowbecome adults, okay, not
everyone knows everything.
And so if you don't specializein it, you just don't know.
So it's nobody's fault.
(04:56):
But there's really not a lot ofproviders out there that know a
lot about low-dose naltrexone.
And naltrexone is um amedication that between one and
four milligrams has been hasbeen studied for a wide range of
conditions where immune, wherethey where they have patients
have immune dysregulation,chronic pain, inflammation.
(05:18):
So, like an example would befibromyalgia or chronic, you
know, chronic inflammation.
So the LDN works by it blocksthe opioid receptors, which
causes the body to upregulateproduction of endorphins, but
endorphins improve mood, butalso play an important role in
the immune system.
So immune modulation is one ofthe benefits.
(05:39):
Less of importance to numbertwo, anti-inflammatory effects.
So LDN reduces the activity ofthe immune cells in the brain
and the spinal cord thatcontribute to neuroinflammation.
So, like my dad, he struggleswith some memory.
And so I'm gonna get him on LDNbecause I think that that would
be super, super helpful if youhave a loved one that is
(06:03):
suffering from memory issues.
Where we are in science todayis you can't completely reverse,
you know, Alzheimer's ordementia or whatever, but the
sooner you get treatment, youcan slow it down, right?
So you can't go backwards.
So as we age, you know, ourmemory goes down.
But if you can catch it as itstarts to decline, it we can
(06:24):
level it off, right?
So LDN with thisanti-inflammatory effects, great
for neuroinflammation.
Also, LDN has been findinggreat results with conditions
like multiple sclerosis,fibromyalgia, chronic pain,
neuropathy, complex regionalpain syndrome.
It's been great with that.
Another thing that I use it foris long COVID for patients who
(06:46):
have a brain fog and fatiguewhere they either have chronic
fatigue syndrome or they havelong COVID.
I found that just like onemilligram twice a day or two
milligrams once a day has beensuper, super helpful for those
patients who just have thatbrain fog that they just have
not been able to come on theother side of.
There's been some research thatLDN has been uh shown to
(07:09):
benefit Crohn's disease,ulcerative colitis.
Those are autoimmuneconditions.
So rheumatoid psoriasis.
And so it, you know, I'm notsaying it's gonna heal
everything, but these are theseare conditions that we have to
manage, right?
You can't, you know,necessarily reverse Hashimoto's.
You can't re you know, youcan't uh cure Hashimoto's, you
(07:31):
can't cure rheumatoid arthritisnecessarily psoriasis.
You learn to manage it, and sothese autoimmune conditions that
patients have, the LDN is thatit's being studied that it's
showing to help balance theimmune system without the heavy
side effects ofimmunosuppressants, which that's
typically historically wheremedicine pushes you, because
(07:52):
that's the only option, one ofthe only options that medicine
has had is these strongimmunosuppressants, which aren't
good for you long term, theymake you feel absolutely
terrible and they not theyreally knock down your own
immune system.
So you're more prone to colds,flus, you know, viruses, things
like that.
So there's so many good things.
And I think as the world goesto a more holistic approach with
(08:15):
things, because let's be real,nobody trusts anybody, even in
the medical field, like we'reyou know, we're questioning
everything, but it's more of amicro dose of something that is
super, super safety profile,like super great safety profile.
But it also increases endorphinlevels that may improve mood,
sleep, and resilience to stress.
(08:35):
Some patients talk aboutreduced anxiety and depression
when on low dose trexum.
And so I know for I have seenit do amazing things for
anxiety.
And everybody's different.
Of course, everybody'sdifferent, but for safety
profile, it is well tolerated,minimal side effects, if any.
(08:56):
So typically, if you're goingto have a side effect, right?
Nothing comes without a risk.
You get in your car, there's arisk, but you wear your seatbelt
just in case, right?
So if you're gonna have a sideeffect, and this is typically at
the higher doses, it's gonna beheadaches with the first few
days that you start it, which II have not had a patient that's
had that with LDN, vivid dreamsagain at the higher doses,
(09:19):
insomnia, again at the higherdoses, but there is no
significant risk of dependency,unlike with the higher dosage of
different of differentmedications that would be used
for the same condition.
So it's certainly not a onesize, you know, fits all, but it
can it can be an amazing gamechanger for patients with
(09:39):
autoimmune, inflammatory painconditions, especially when
normal traditional therapiesaren't effective or poorly
tolerated.
So it is just doing amazingthings.
And I feel like it's not talkedabout enough, that there's not
enough education on it.
And I think it can replace alot of medications that patients
(10:00):
are on.
Patients are on, you know, thisthis medication for this, and
then this one for the sideeffects of this, and then this
one for this, and this one forthis.
And it seems like that this canbe helpful as an umbrella.
Kelli (10:12):
So you know, I d I don't
know about you, but you just
what you just said reminded meof how many times I see patients
that take a medication for apill for an ill, right?
And then they're on anothermedication to counteract the
side effects of that medication.
Not because they needed it foranything other than the side
effects of a medication thatthey were on.
And I'm like, how in the worldof any of this is this making
(10:35):
sense?
Because you could have justtreated this condition with this
either lifestyle change or thissupplement or this microdosing
or this this, and instead weadded this pill for the ill and
then this pill for the sideeffect of this pill.
And I'm like, you know, I Iit's just and then it's
continuous.
You know, yesterday, or maybeit was the day before yesterday,
I I I saw a patient and I endedup, I put her on an injectable
(10:59):
peptide in exchange for threepills.
I pulled her off of threemedications in exchange for one
injectable peptide.
And it's just it's situationslike that that I'm like, how in
the world did that make sense tosomebody else simply because
you were closed-minded toalternative treatment options
for patients?
(11:20):
I I don't understand thatthought process.
You know, she's she's you know,young and active and healthy
and just wants to stay activeand healthy.
And she was being, you know,tied down by all these
medications she's having totake.
And like it just in in no worlddoes that make sense.
We have options, you know.
Like you said, microdosing isvery, very popular.
It has always been around along time, but it's becoming
(11:43):
more and more popular.
And it's very it works, itworks, it's very safe.
And I don't understand why it'snot being utilized more often.
There's so much research outthere that shows that it's very
effective.
And when you can come off ofall of these medications, you
know, I see so many patients,especially, you know, with my
side gig, polypharmacy is a bigthing.
(12:03):
And if you can get them off ofsome of those medications in
exchange for something thattheir body made naturally when
they were younger, why not?
Nicole (12:11):
Yeah, yeah.
Like like NAD.
That's exactly your body madeit.
Your body still, right?
You still have NAD.
Yeah.
Which is a peptide, by the way,for those of you who haven't,
you know, jumped, jumped intothis or or you know, heard of
it, but look it up.
I mean, you guys, look it up,look it up, look up LDN, look up
NAD.
NAD is, you know, is a peptidethat our body naturally makes
(12:34):
between the age of 30 and 40,drops down to 50% of what we
had, hence the aging process.
So patients are looking forlongevity, they're looking for,
you know, they're wanting tostay healthy, get that quality
of life near the end.
You know, once we get 50, 60,70, it it really becomes about
quality of life, you know, andstarting earlier and knocking
(12:56):
down the inflammation andknocking down some of the
processes that just naturallyhappen with aging, especially
women.
You know, a lot of thingshappen with women with our
hormone decline, but but mentoo, just degenerative things,
you know, people people aregonna have your body gets old.
That's what degenerative, itstarts to degenerate.
And that's why you see the theold man or the old woman with
(13:17):
the walker, they're crunchedover, they're but their body is
deteriorating.
So these degenerative diseases,which are normal with aging,
you know, as our spine, thejoints between our spine, they
start, we start wearing themdown.
And that's why when we turn100, we're two inches shorter,
because the discs in our spinestart getting small because
(13:38):
we're wearing them out.
We're just we're wearing themout.
And so you know, aging is notpreventative.
I mean, it's not preventable,but if we can do things to slow
the process, the quality of lifecan be amazing.
You know, it can really, reallybe sustainable, really be, you
know, be sustainable throughthose those older, those, those
(14:00):
older golden years, but also forpeople who are super health
conscious, you know, younger butsuper health conscious, there's
more natural now.
Kelly and I we're Westernmedicine trained, right?
We get it, like we're Westernmedicine trained, but I think we
put so much value in what elseis out there.
We're curious.
(14:20):
What else is out there?
What can I offer for ourselvestry or guinea pig our families
that would have less sideeffects?
Less side effects, less risk,less all those things.
If if we can find somethingthat's it's gonna be less
harmful, we're all about it.
Kelli (14:43):
Well, guys, we hope that
this was helpful information.
You can always find us athamiltontelehealth.com.
You can look for our podcast attattoos and telehealth.
Please like, subscribe, share,follow, all the things.
And we look forward to seeingyou guys next time.
Thank you.