The Suspect? Inborn Errors of Immunity

"The key to the diagnosis of these disorders is the suspicion of these disorders."

— Dr. Luis Murguia Favela

Immune dysregulation isn’t just about infections—autoimmunity, inflammation, and even malignancy can be clues that something deeper is at play. With over 500 known inborn errors of immunity, allergists are increasingly on the front lines of identifying these conditions. But when should we suspect immune dysregulation, and what does cutting-edge treatment look like today?

Dr. Mariam Hanna is joined by Dr. Luis Murguia Favela, pediatric immunologist and founding chair of the Clinical Immunology Network for Canada, to break down the growing world of immune dysregulation and how allergists can spot it.

On this episode:

• What is immune dysregulation? How inborn errors of immunity have expanded far beyond primary immune deficiencies.
• The 11th warning sign: Why early-onset, unusual, or difficult-to-treat autoimmunity, inflammation, or malignancy should raise red flags.
• Not just for kids: Many inborn errors of immunity present in childhood, but 30% of cases emerge in adults—and often go unrecognized.
• Suspicion before sequencing: Why a strong clinical suspicion is more important than access to genetic testing.
• Targeted treatments and the future of immunology: From biologics to gene therapy, where immune dysregulation treatment is headed.

With a growing number of identified inborn errors of immunity, the role of allergists in spotting immune dysregulation has never been more critical. Be suspicious, always.

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The Allergist is produced for CSACI by PodCraft Productions