The Alzheimer’s Solution Revolution Podcast

Episode #22—Where We Left Off

I’ll begin this episode by sharing an excerpt of the primary outcome from study #1 that I reviewed in part #1—#22—of this two part episode series.

In that study, the authors found “a positive association between OC [plasma osteocalcin levels] and working memory capacity, executive functioning and global cognition scores.”

Study #2—Excerpt

Th...

Hello once again!

This is your host Ralph Sanchez, and welcome to episode #22 and indeed, it has been much too long between this episode and the last one.

I have been busy with new book projects on the key underlying risk factors for late-onset Alzheimer’s disease that are unique to women.

I’ll have an announcement on when those books will be available here soon, and frankly, I'm looking forward to ...

Welcome!

This is your host Ralph Sanchez, and this is episode #21, I am expanding on the last episode, #20, titled: “Estrogen Deficiency and Cardiometabolic Disease Underlies a Woman's Greater Risk for Alzheimer's Disease”.

 This episode—part two of this two-part episode series—on the linkages between perimenopausal and postmenopausal estrogen declines in women and the risk for age-related disorders&mdash...

Welcome!

This is your host Ralph Sanchez, and this is episode #20 here at The Alzheimer's Solution Revolution podcast channel.

Today we are expanding on and diving a little deeper into two primary risk factors associated with an increased risk for dementia and late-onset Alzheimer's disease (LOAD) in women—cardiometabolic disease and postmenopausal estrogen deficiency in women.

In my book, and in episode #10 here on this channel...

Summary

Hello and welcome to episode #19!

This is Ralph Sanchez and today I’ll be talking the outcomes of two recent studies that investigated the potential use of Viagra and Cialis in the risk reduction for late-onset Alzheimer’s disease (LOAD).

I was in part inspired to provide an overview on these two recent studies as they are cautionary tales on how many studies do not include the interrelated factors that are essenti...

Summary

Welcome!

This is Ralph Sanchez and today I’ll be expanding on the last two episodes—#16 & #17—in this special brain detoxification series. This is the third or part three in that series.

In our last two brain detoxification episodes I described the pathways of beta-amyloid and tau protein transport and clearance from the brain, and in their degradation in the liver in what I describe as the liver-brain ax...

Summary

Hello and welcome to episode #17!

This is Ralph Sanchez and today I’ll be expanding on the first episode’s overview with regard to beta-amyloid and tau protein clearance and detoxification.

If you did not catch that episode (#16), I provided an in-depth overview on the role of the blood brain barrier (BBB) and the glymphatic system in clearing and transporting toxic beta-amyloid and tau protein from the brain.

In to...

Summary

Hello and welcome to episode #16!

Today I’ll be describing an elemental aspect in maintaining a healthy brain as you age and preventing the cognitive decline that is associated with unhealthy aging and the risk for Alzheimer’s disease as you age—brain detoxification.

Because brain detoxification mechanisms are a very complex review, I will provide it in three parts–this episode and the next two.

 No...

Episode #15 summary

Today, I'll review the formulations and research that illustrates the role of medical foods which are a unique classification of formulations that are approved by the FDA.

Additionally, I will speak to the potential value of nutraceuticals and supplemental food-derived products in supporting cognitive health in aging individuals at risk for late-onset Alzheimer's disease (LOAD).

And what are medical foods?

Medical f...

Summary

In today’s episode (#14), I’ll be providing an in depth overview one of the most powerful factors that underlies healthy body and brain aging—DIET!

Indeed, healthy foods provide key nutrients and phytochemicals work to optimize cognitive function, and protect against dementia and Alzheimer’s in aging.

However, since dietary therapies and specific foods in those diets that are linked to healthy aging is ...

Summary

Today I am very much looking forward to pod-talking about one of the most important components associated with accelerated aging processes, and in the risk for Alzheimer’s disease— the decline and inhibition of critical energy metabolism systems of the body and brain.

Many studies have shown that alterations in mitochondrial energy metabolism, or bioenergetics, have been linked to numerous disorders that disrupt n...

Summary

This episode (#12) continues the overview of neurosteroids and their critical function in the protection and enhancement of cognitive function.

In episode #11, I reviewed the role of “Testosterone, Progesterone and Allopregnanolone—Critical and Timely Neurosteroid Interventions in the Risk Reduction of Alzheimer's Disease.”, and this podcast I'll add DHEA and pregnenolone to that overview.

The focus today wil...

In women, how important of a role does progesterone play in cognitive function?

While a number of studies have shown that estrogen replacement therapy in women is protective against the risk for late-onset Alzheimer's disease (LOAD), only a few studies have demonstrated that progesterone also benefits cognitive function.

Indeed, progesterone could be important in preserving cognitive function in women as they age—particularly i...

In the U.S., two-thirds of diagnosed cases of dementia and Alzheimer's disease are women.

A number of studies have shown that lower estrogen levels "before, during, and after menopause" is a risk for late-onset Alzheimer's disease.

However, the risk factors associated with declining estrogen levels and late-onset Alzheimer's disease in women as they age is not widely known.

Estrogen is a regulator of glucose metabolism in women and br...

The Gut-Brain Axis—what does that connection represent?

Well, the gut-brain connection is often described as a bidirectional highway that is linked to many cause and effect health consequences, and many studies have explored the impact of the gut environment and microbiome on brain health in that gut-brain dynamic.

Indeed, the role of the gut-brain axis is a significant factor in the risk for numerous health disorders throughou...

Today in episode # 8 I'll be reviewing the role of hypertension, obesity, type 2 diabetes and heart disease (cardiometabolic disease), and insulin resistance in your risk for late-onset Alzheimer's disease (LOAD).

The metabolic and biochemical pathways by which cardiometabolic disease increases the risk for dementia and Alzheimer's later life is the central theme in my book: The Diabetic Brain in Alzheimer's Disease.

The book thoroug...

How does you unique genome increase the risk for Alzheimer's disease as you age?

In todays episode—#7, I’ll be giving a comprehensive overview on the APOE gene, the ApoE4 genetic variant, and other genes and their genetic variants linked to the risk for late-onset Alzheimer's Disease (LOAD), and how, when, and why Alzheimer's takes root in certain individuals that are carriers of these genes and the variants associated w...

Welcome, everyone! 

This is Ralph Sanchez, and I am so pleased to bring you episode #6 to you here at the Alzheimer's Solution Revolution Channel. 

I am very much looking forward to today's topic, which is centered on the assessment of risk biomarkers for late-onset Alzheimer's disease. 

I'll begin this overview with a question.

Has your physician ever advised you on the possibility that you might be at an increa...

In the fifth episode of The Alzheimer’s Solutions Revolution podcast with Ralph Sanchez, I talk with my co-host Susan Brender, as we continue with our special podcast series called Think Ahead.

In this week’s episode, I'll provide an overview on the role of tau protein and neurofibrillary tangles (tau tangles) in the progression and development of late-onset Alzheimer's disease (LOAD).

The toxic accumulation of tau tangl...