How Jim Rutt Bridges Nonprofit Tech, Venture Capital, and Cybersecurity

Guest Introduction

Jim Rutt serves as the Chief Information Officer and Chief Information Security Officer of The Dana Foundation, a nonprofit focused on advancing neuroscience and neuroethics. With a career spanning healthcare, finance, and pharmaceuticals, Jim has built a reputation for driving digital transformation and bridging enterprise IT with mission-driven organizations. Over his 15 years at Dana, he has overseen a full cloud migration, guided innovation strategy, and aligned IT operations with the foundation’s mission of exploring the ethical implications of brain–computer interfaces and artificial intelligence. Beyond his nonprofit role, Jim also serves as a startup advisor and venture partner at 645 Ventures, where he helps emerging companies refine their market strategies and scale successfully.

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Here's a Glimpse of What You'll Learn

• How The Dana Foundation evolved from arts and education into neuroscience and neuroethics

• The unique funding model of endowment-based nonprofits and its operational implications

• Why working in a nonprofit technology leadership role offers both professional and personal fulfillment

• Jim’s role as a startup advisor and venture partner with 645 Ventures

• The importance of customer alignment for early-stage tech companies

• How AI is transforming both security risks and security solutions

• Why empathy and human-centered approaches remain critical in cybersecurity strategy

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In This Episode

Jim Rutt begins by sharing the history of The Dana Foundation, tracing its roots back to 1950 and its evolution into supporting neuroscience and neuroethics research. Unlike commercial enterprises, Dana operates on an endowment model, allowing its funding and mission to remain insulated from typical market cycles. For Jim, the value of working in a nonprofit setting lies in the ability to “go to bed at night feeling good” knowing that his work directly supports the greater good of science and society.

The conversation then pivots to Jim’s parallel career in venture capital. He explains how his leadership in Dana’s early digital transformation exposed him to innovative startups and venture networks. Over time, he became an advisor to funds and founders, eventually joining 645 Ventures as a venture partner. He describes how his advisory role is less about technical architecture and more about sharpening go-to-market strategies, aligning initial customer profiles, and validating pain points for early adoption. Notably, Jim has helped guide companies like Axonius and Cyberhaven, both of which achieved unicorn status.

Matthew and Jim also explore the pressing challenges of cybersecurity in the age of AI. Jim emphasizes that while AI brings powerful defensive innovations, it also enables more sophisticated phishing, business email compromise, and ransomware attacks. He raises the need for more human-focused security approaches, including involving end users directly in security programs rather than treating them as passive participants. For Jim, empathy is a critical component of modern IT leadership—an attribute he believes technology alone can never replicate.

Finally, Jim reflects on his career journey from marketing into IT, sparked by the release of Windows 95. He highlights the value of beginning in customer-facing roles like help desk support and stresses that technology leaders must not neglect the human dimension of security and innovation. As the episode closes, Jim underscores The Dana Foundation’s emerging role in AI ethics, advocating for principles that prioritize human well-being and social good in the face of rapid technological change.