In this comprehensive deep dive, Dr. Tony Ebel explores PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections) and PANS from a neurologically-focused perspective. Drawing from his extensive clinical experience treating hundreds of PANDAS cases, Dr. Ebel reveals why traditional biomedical and functional medicine approaches, while important, often fall short when not properly sequenced with nervous system care.
This episode challenges the conventional understanding that PANDAS begins in the gut, instead presenting compelling evidence that nervous system dysfunction is the root cause that then triggers the cascade of gut dysbiosis, immune dysfunction, and neuroinflammation. Dr. Ebel provides a detailed clinical protocol for healing, emphasizing the critical importance of addressing nervous system regulation first before implementing intensive biomedical interventions.
Key Topics & Timestamps
Introduction & PANDAS Overview [00:00:00 - 00:06:00]
- Definition and why PANDAS cases spike during seasonal transitions
- The "perfect storm" nature of PANDAS requiring deep understanding
Dr. Ebel's Background & The PANDAS Rollercoaster [00:06:00 - 00:16:00]
- Clinical experience with hundreds of PANDAS cases
- Personal story with his daughter's toxic exposure
- Setting realistic expectations: peaks, valleys, and signs of true healing
Why Current Approaches Fall Short [00:16:00 - 00:25:00]
- Traditional medicine limitations
- Functional medicine gets "one or two layers deep" but misses root cause
- Why families feel stuck despite "doing everything right"
The Root Cause: Nervous System First [00:25:00 - 00:36:00]
- Why gut-focused approaches miss the deeper issue
- Nervous system → gut → immune → inflammation cycle
- The reality of supplement overload and extreme restrictions
Finding the Right Practitioners & Protocol [00:36:00 - 00:50:00]
- Importance of expert-level care from neurologically-focused providers
- Why "full send" biomedical approaches too early make kids worse
- The 90-180 day nervous system stabilization period
Clinical Implementation: The Reset Approach [00:50:00 - 01:01:00]
- Pausing 80% of supplements while keeping basics
- Using INSiGHT scans to achieve neurological stability
- Realistic timeline: 1-3 year healing journey with proper sequencing
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