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June 4, 2025 41 mins

Blood has always been the essence of healing. But what happens when we harness its regenerative power in concentrated form? In this captivating conversation with Dr. Rick Myron, we explore the revolutionary world of Platelet-Rich Fibrin (PRF) technology and how it's transforming both dentistry and facial aesthetics.

Dr. Myron's journey from a small-town science fair competitor to a globally recognized researcher exemplifies the perfect marriage between clinical practice and scientific innovation. With 19 years of university education spanning dentistry, medicine, and advanced cell biology, he brings unparalleled expertise to the conversation about regenerative technologies. His work bridges a critical gap in American medicine—the separation between researchers and clinicians—allowing him to develop practical solutions for everyday clinical challenges.

The discussion demystifies the science behind PRF, explaining how this technology improves upon its predecessor (PRP) by eliminating anticoagulants and working with the body's natural healing mechanisms. While traditional PRP disrupts the essential clotting process, PRF preserves it, resulting in consistently superior clinical outcomes across thousands of comparative studies. We explore specific applications in dentistry, from extraction sites and implant procedures to sinus grafting, where PRF significantly enhances healing in challenging low-blood-flow environments.

Perhaps most surprisingly, Dr. Myron reveals how PRF has created a lucrative revenue stream for dental practices through facial aesthetic applications. Treatments like the "vampire facial" (popularized by celebrities) utilize a patient's own blood components to rejuvenate skin naturally, without foreign substances. These procedures cost practices roughly $50 in materials but command $700-1,100 per treatment, with patients returning regularly for maintenance—making them more profitable than many traditional dental procedures.

Whether you're a clinician looking to incorporate cutting-edge regenerative techniques or simply fascinated by how science is revolutionizing healing, this episode offers valuable insights into how your own blood might be the ultimate medicine. Ready to transform your understanding of regenerative therapy and possibly your practice's bottom line?

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Episode Transcript

Available transcripts are automatically generated. Complete accuracy is not guaranteed.
Dr. Tyler Tolbert (00:01):
My name is Dr Tyler Tolbert and I'm Dr Soren
Poppy, and you're listening tothe Fix Podcast, your source for
all things implant dentistry.
All right, and welcome back tothe Fix Podcast.
We are on with a very esteemedguest today.
So, as you guys know, we alwaysreach out to our audience to
hear about different things thatpeople are interested in,
things that we could canvas alittle bit better.

(00:22):
And, you know, one thing thatSoren and I, uh can talk about
for days is heart tissue, and wecan talk about how to do, um,
you know, placing implants in anative bone, doing remote
anchorage, all these differentthings that are, um, you know,
it's sort of the more commonthings that we think about with
full arch.
But some of the things that wekind of gloss over a lot,

(00:46):
partially due to our own naivete, is soft tissue stuff and PRF
and other regenerative materialsand different methods that we
have out there.
Even though we do actuallyutilize some of these things in
our clinics, we don't alwaysfeel that we have the type of
expertise necessary to reallytalk about it, and so a name
that just kept coming up for uswas Dr Rick Myron, who is a huge
innovator, pioneer in the worldof PRF and its various
applications in medicine anddentistry, and it's really

(01:08):
transformed what we're able todo with you know, a patient's
own blood and their own body andhow that can help us out with
different regenerativetechniques that are good adjunct
to full-arch treatment and allkinds of other kinds of things
that you know we're aware of andalso not aware of.
So I'm super excited to welcomeDr Rick Myron onto the show.
Thank you so much for coming onand I'm really looking forward

(01:29):
to this one.

Dr. Richard Myron (01:30):
Absolutely, as am I, and thank you guys for
the invitation.

Dr. Tyler Tolbert (01:33):
Yeah, no, absolutely.
So I mean, this is a, this is asubject that you know.
I I've definitely I've got afew friends that are just
absolute PRF nerds and when Ihad first reached out to you and
you were gracious enough tocome onto the show, I reached
out to Dr Sean Land, a reallygood, close friend of mine,
really really into regenerativedentistry and I think he

(01:54):
actually went to one of yourcourses at one time.
But he is a huge, huge fan andhe helped us out with putting
together some questions andthings like that and I just know
he's, he's spoken, uh, sohighly of you and I it's just so
great to have you on Um, so wedid put together a few things,
but I was hoping that, um, justfor the folks at home, uh, if
you wouldn't mind just kind ofcanvassing a little bit about
you, where you're coming from,your education, um, I tried to

(02:16):
read off your, your biographybefore you came on here and
there were so many awards that Ijust I felt they would come a
lot better, um, you know, out ofyour mouth than mine.

Dr. Richard Myron (02:26):
Yeah, um, you know it's kind of a different
story to tell, uh, because I'mnot a normal dentist by any
means and most people know mefor the research that we do.
And uh, I like to start fromthe very beginning.
Um, I grew up in a very, verysmall city in North Bay, ontario
, and uh, it's about 400kilometers north of Toronto, so
it's way up in the north.
There's not a lot to do there.

(02:48):
And when I got to high school,our science teacher was actually
an ex-dropout of the Universityof Toronto in the science
department.
He got so frustrated withacademics that he decided that
he was going to go teach highschool back in his hometown of
North Bay.
So when I was 13, my scienceteacher was a university

(03:09):
professor who had writtenhundreds of papers and now he
was going to start teaching us,you know, basic grade nine
science and what he did with thetop students.
I mean, it's a crazy story nowthat I look back on it, but what
he did with the top students ishe had us enrolled in some
science fair projects and so inthe summer months he would hire
us to do these differentresearch projects and I was

(03:30):
basically doing like hiscontinued university type
research at 13, 14 years old,for two months every summer,
where I had these jobs in thelab, and that's the huge leg up.
So we're now competing at thesenational science fairs in Canada
Our school's winning firstplace in every single division
you can imagine and I'm gettingto travel around doing

(03:52):
conferences, conference talks atthese science fairs I'm now
doing, by the time I'm 17,international conferences and
competitions in Sweden andSwitzerland and I did some in
Chicago.
And so by the time I got to 18years old and I was going to
apply for university, of courseI had decent grades, but I had
all these extra accolades.
I won academic scholarships,full ride to wherever I wanted

(04:15):
to go, and in university, as youguys probably remember, in
undergrad you try and get thescience research job if you want
to go to medicine or dentistry.
Right, it was very commonduring our summer months we try
and do little projects.
So of course I alreadypublished like peer reviewed
articles at 18 years old with myhigh school teacher, and so I
got every summer job that Iwanted, you know, direct pass to

(04:37):
go to dentistry.
And so you know, looking back Ididn't realize how special it
was and how lucky I was.
But because I was doing this, Ijust had a knack for science.
I was always doing it when Ifinished dental school which is
what I always wanted to do wasbe a dentist.
When I finished, I pursued, alsoat the same time, a master's in
cell biology.
I was very interested in dentalimplants.

(04:58):
So I was doing actuallyresearch projects where we were
taking Stroman implants implantsand we were coding this back in
2006, trying to figure a way toget growth factors on a surface
of a dental implant.
So I was doing work with PDGF,bmp2, enamel matrix proteins,
etc.
I had published a couple ofgood articles there and in 2009,

(05:20):
I won a full scholarship andthis is very unique for Canada
but the Canadian government theygive a full ride for you to go
anywhere you want in the worldand they pay for everything.
Wow.
So five years, they'll pay forall my tuition fees.
They'll pay for all my livingexpenses, all my conference fees
.
Only five people get this awardevery year and I won one of

(05:40):
them.
So I'm like a green ticket nowand I'm like like I can go to
any school, they don't have topay me anything and I'll be a
phd and and you know, I did aphd in molecular cell biology.
Well, I went to all thesedifferent schools and I was
trying to decide where I wasgoing to spend the next five
years of my life.
I went to harvard, I went tomichigan, I went to germany,
switzerland, italy, and when Iwent to burn switzerland and

(06:01):
that's the school that's mostaffiliated with Stroman I was
like man, this is the place thatmade sense.
That's where Danny Boozer was,that's where Tony Schooley and
Klaus Lange a lot of big legendsin the space and they are 30
minutes away from Stromanheadquarters and 45 minutes away
from Nobel biocare headquarters, and so the these huge, massive
companies want to collaboratelocally, and so I stayed there.

(06:24):
For seven years, I pursued perio, as well as a PhD in molecular
and cell biology, and my lifewas just literally living in the
lab most days and then spendingone or two days a week in the
clinic doing perio work.
We developed a lot ofbiomaterials along the way, and
then I moved back to NorthAmerica in 2016, located in

(06:44):
Floridaida, and then, did youknow, I set up a research lab
and our job is literally try toget materials fda cleared as
fast as possible and bring newtechnologies to dentists.
So you know that's a little bitof who I am.
You know it's hard to puttogether in a few few sentences
yeah, it's amazing that that'sthe.
That's the abridged version, youknow yeah, you know I obviously

(07:09):
am very passionate for what Ido and people that take my
courses, you know they, theyunderstand like I put a lot of
time and energy into, into, youknow, really making sure that
we're doing things that are welldone.
And you know what people forgetis like if you guys are using
dental implants and biomaterialsand membranes and this and that
like those materials beforethey were ever launched to

(07:30):
market and you guys ever got achance to use them.
Four years before that westarted preclinical research to
get FDA clearance.
So like, right now I'mliterally testing Stroman
implants that are going to belaunched to market in 2029.
And a guy like me has to take,you know, cells and seed them on
the implants and make sure thatcells behave properly on the

(07:51):
implant surfaces and that'lltake about a year to do.
And then we'll do the firstanimal study in 2026.
And that is usually a largeanimal model, so it's got to be
a dog, it's got to be a mini pigor a monkey, and those are huge
projects.
They take a year, year and ahalf, to complete and when we
finish that then the FDA says OK, you guys get a checkmark.
You know, you can now go to thenext step and do the very first

(08:13):
human study, and then it'll be2027.
We do the first ever study withthese new stromal implants and
then, after doing a randomizedclinical study, then finally
they get FDA cleared.
So in my office, 95% of thethings that I do is not, it's
not materials that you guys haveaccess to, it's not things that

(08:33):
are FDA cleared.
Right, it's all kind of wherethe future of dentistry is going
, and so I get to live in thisworld where we need to have,
obviously, special IRBpermission, which means the
universities have to approve,you know, say this is ethical,
they've done the preclinicalwork, and then you know all
these, all these new toys andnew tools you know we bring to
market.
So, yeah, our team's prettyexcited about being able to do

(08:55):
these projects.

Dr. Soren Paape (08:56):
Yeah, that's an amazing story.
Very cool that you have accessto that and really, really cool
that you know you're, you'rewalking around and you know so
much more about the industryeven you know than we do, right,
because you're you're fouryears ahead of a lot of people.
What would be that transition?
You know you talked a lot aboutkind of the, the stepwise that

(09:20):
you've taken to get to whereyou're at in the career.
Now I'd love to hear a littlebit about you know where PRF,
prp kind of fit into that, andwhat you're doing as far as your
courses and how it evolved intothat.

Dr. Richard Myron (09:33):
Yeah, I think even dating back to before the
courses were started.
So in 2011, we understood and Iwas in Switzerland from 2009 to
16, this pure F world was goingto be a big thing, and so we
started to do research projectsbecause there was not a lot of
like very good work out there.
You know how do you spin yourprotocols, what's RPM versus

(09:56):
G-force, you know how much timedo you spend, what kind of tubes
do you use.
All this stuff was back thenwas nobody knew anything right.
So we decided that we weregoing to start pursuing this,
knowing that maybe in the futureit would probably be a big
field.
And so, as we were publishingmore and more work and really I
think the year 2015, 2016, 17,around those years, we had

(10:19):
published a series of, you know,many different articles.
It was becoming more and morepopular, to the point where we
started doing courses on on thetechnology, and so that's how it
basically started and, honestly, I love.
I love, obviously teaching aswell.
It's a lot of fun for me.
But back then, a lot of peopledon't realize, like, how low and

(10:41):
how small the academic salariesare for people like me, and so
you know I had graduated.
So imagine I had an undergradcompleted in bmsc, I had done my
dental degree, I had a master'sin cell biology, a phd
molecular and cell biology and aperiod a lot of letters.
Okay, before I could do myperio degree, I had to redo

(11:04):
dentistry or medicine.
So I actually studied medicinein Switzerland as well, okay, so
I did 19 years university andwhen I moved to, when I moved
from Switzerland back to um tous and I wanted to be in Florida
, cause, growing up in Canada, alot of people move and retire
to Florida.
So my parents actually live inFlorida now, as does my brother,
and, uh, you know, I sat withthe dean.

(11:25):
I said you know, I really wantto live here.
This is my school, I know, atNova Southeast University.
It wasn't like a highlyreputable school right, it's not
like the Harvard's or Michiganbut I was like I really don't
care, my lab will have thereputation it needs to attract
people to courses and publishgood data.
She sat me down and she's likeyou know, dr Myron, I'm looking
at your CV here.
You're a dentist from Canada.

(11:46):
That degree doesn't count hereand you did it in the French
speaking part, so you can't evenapply for you know you can't
even write the boards.
You're going to have to redotwo years.
Your perio degree is not validhere.
You did it in Switzerland.
It's top school in the world.
But you know you're not aperiodontist.
Uh, you're not a dentist,you're a PhD and you spent your

(12:06):
entire life in school.
You have one year experience ofreal professional life.
All your years were spent inuniversity and you're a one year
postdoc and your startingsalary is going to be $50,000.

Dr. Tyler Tolbert (12:18):
Just just reduced all of that to $50,000 a
year on the on the on the uh onthe subject of really just
provenance of all these thingsand they just wouldn't recognize
it.
That's.

Dr. Richard Myron (12:29):
Florida.
Yeah, so I had obviously done alot of years of university and
I had to pay back some studentloans and stuff and I was like I
can hardly even live off this.
I mean, you know, it'sborderline impossible.
But with the Dean no-transcriptpuref course it immensely

(13:13):
benefited me.
I now do puref in my practicelike these people are very few
and far between.

Dr. Tyler Tolbert (13:18):
So yeah well, I certainly appreciate you for,
you know, sticking it outthrough all that time, uh, to
get as educated as you did andto have had as little reward I
mean to actually be recognizedthere at Nova when you first
started, and everything I meanthat's just it takes quite a bit
of perseverance and dedicationto what you're passionate about
and you've certainly benefited,you know the whole field of

(13:39):
dentistry and beyond for thatpassion, so that definitely I
appreciate you.
Delaying gratification for solong, that that's pretty cool.
That's really good, yeah, yeah.

Dr. Richard Myron (13:51):
We, yeah, yeah, you know I always say in
the research world, you know, Ithink the biggest mistake that
happens in the United States andthis was a little bit and you
guys can really pitch in andgive me your feedback.
But when I went from Canada orNorth America to Canada, united
States to Switzerland, there wasa big difference in the way
research was performed.

(14:12):
And I want your opinion on thisbecause I have a very, very
different background.
There are so many researchersin all the dental schools in the
United States.
They don't, they're notactually clinicians.
Right, when you think of thedental schools, you're either a
clinical person and you're doinglike no research or minimal
research, or you're a researcherand you're a PhD and you don't

(14:33):
know what it's like to work in aprivate practice or how
difficult that is or what it'slike to treat patients.
So all these people are doingthis research on map kinase
pathways and osteoclasts.
This and you know it's got verylittle clinical relevance.
And when I went to Bern,switzerland, danny Boozer sat me
down.
He, rick, you are no longergoing to do research like that.
You are going to do researchthat's going to benefit patient

(14:56):
care in three to four years.
Otherwise there's no point indoing that.
And so when I got back here, youknow I was shocked because I
think I'm one of the only peoplethat I've ever met that does
like, is like a real researcher,right?
I'm not talking a guy that has15, 20 papers, I'm talking
people that have hundreds ofpublications, et cetera, but
also works in a clinicalpractice.

(15:17):
You know they're few and farbetween, and if you don't work
in a clinical practice, you haveno idea how to ask the right
research questions, like now.
I started to ask, like how do Iactually spin blood to get more
platelets in the cells?
I'm a cell biologist.
Let's figure out a way to getmore platelets in the cells.
I'm a cell biologist.
Let's figure out a way to getmore platelets in this upper
puref layer so that we can gohelp.
You know all of our colleagueswhen they're trying to treat
their patients right, yeah, I, Ihaven't.

Dr. Soren Paape (15:38):
I haven't seen it personally, right, like, I
see a lot of dentists that, um,will they hear about the newest
research?
Right, they hear, like in thefixed world, that four implants
work.
You can, you can load aprosthetic on four implants and
then they go and they just do it.
But there's not a lot of peoplehere, at least that I know in
the close proximity with us andwe talk with a lot of, you know,

(16:00):
top implant dentists and not asingle one of them is doing
research.
Right, they're profiting off ofthe research that's been done
and gracious enough to you,right, that you spent all this
time to develop these conceptslike PRF and stuff to benefit
clinicians and the patients thatare getting the treatment done.
But you're totally right, inthe United States I feel like

(16:21):
it's far and few between ofpeople who are actually doing
the research and then applyingit on a day-to-day basis.

Dr. Richard Myron (16:31):
Yeah, and I think that's a little bit of a
drawback in this country, butit's not.
It's not the fault, right, it'snot the fault of anybody.
It's that when you graduatelike there's no, let's go, you
know, spend thirty thousanddollars, make thirty thousand
dollars a year and go to apostdoc and learn how to do
research, this, and that youjust can't afford to do that.
The deaths are too big and youcan go, and yeah, and that was

(16:54):
going to be my response is thatyou can't come.

Dr. Soren Paape (16:56):
I mean, there's when I came out of dental
school, right, and I was on thehigher end, it was, I think I
came out of school with like 360to 400 000 in student loans,
and now there's peoplegraduating and with nyu, if
you're including the livingcosts, that are seven million
dollars, and I mean sevenfigures in debt, over a million
dollars in debt, and it's likethey just don't have the means

(17:17):
to take a pay cut to do researchand stuff they have to practice
clinically, otherwise they'renot going to be able to pay for
the loans that they got.

Dr. Tyler Tolbert (17:27):
Yeah, I mean, there's definitely a lack of
financial incentives to go intothe academic world and
contribute to that greater body.
And I definitely appreciate toothat in Switzerland there was
this approach of you're going tobe a hybridized doctor, because
you are directly thinking aboutwhat are the clinical
applications of what I'm doing,not being so mired into cell
pathways et cetera, whereas herein America it's totally

(17:52):
polarized.
I mean, you're either clinicaland that's that's your world,
and you will go into PubMed justto kind of support an argument
you're having with someone onFacebook, or you live in that
research world and there's notreally much of a world in
between to actually bridge thatgap.
And so on one side you havepeople who are clinically
applying things that have beenresearched 10-15 years ago.
One side, you have people whoare clinically applying things

(18:13):
that have been researched 10, 15years ago, and then you have
people that are researchingthings aren't going to come
about for another 10, 15 yearsand there's nobody that is
really living between thoseworlds, because the financial
incentives just it doesn'treally make a whole lot of sense
.

Dr. Richard Myron (18:25):
There's not a whole lot of marriage between
the two and I think that stiflesinnovation innovation and I
think also the because of thedebt as well, and all and just
the way that things go.
Now you know, like if I was toask you guys a question, name
five of the your top favoriteimplantologists that have more

(18:46):
than 50 papers yeah, give me,give me just a moment to pull up
chat GPT for a second.

Dr. Tyler Tolbert (18:52):
Yeah.

Dr. Richard Myron (19:00):
Yeah, in the U S, sorry, in the U S right.
So it's difficult to find right.
But, like, the reason why youknow a Dr Michael Picos has been
so well recognized in implantdentistry is because when he was
my age, right, he was actuallypublishing papers, as was Craig
Misch and those guys, so thatgeneration did a little bit more
.
I don't feel like it's possibletoday for a young person

(19:21):
graduating with the debts thatjust says like oh, I'm really
excited to play with BMP2.
I'm going to go write aresearch paper on it and design
this study and get an IRBapproval and spend all this time
making literally zero dollarsbecause you're interested to
find out if BMP2 works or not.
Right, there's there.
It's very, very challenging andyou know you won't find those

(19:42):
people.
But I can go into ByrneUniversity and I could probably
count 20 people that aresuperstar clinicians that all
have over 100 papers easily inone university, right?

Dr. Tyler Tolbert (19:52):
so that's a big, big difference to be in
that environment and livingthere like that for, yeah, we
wonder why generation is comingout of that small country and
not from us.

Dr. Soren Paape (20:00):
So, yeah, yeah and then you, and then you come
out of it and here you come hereand they're like oh yeah, well,
you still don't get a license,clearly don't value anything you
did elsewhere.
Well, rick, that's an amazingstory.
I really appreciate you goinginto depth about your background
, your accolades, and I wouldlove to kind of get into talking

(20:23):
about PRP.
Prf, and I think a good placeto start there is.
There's probably a lot ofpeople here that just don't
really understand what it is ingeneral, so it'd be great if you
could just start with thebasics.
You know what PRP is, why it'sbeneficial, what are the uses
for it.
How do we transition into PRF,why is that beneficial, what are

(20:44):
the uses for it and how can youknow how can clinicians use
this in their everyday life, andthen maybe talk a little bit
about where they would get thatinformation, like things like
your course right, that theywould be able to apply that.

Dr. Richard Myron (20:59):
Yeah, so when I start, even when I do
education courses to doctors orpatients, I try and simplify
things as much as possible soit's easy to digest and
understand.
We have an amazing intrinsicability to heal ourselves, right
?
Like you and I.
I always give the same examples.
We can be in the kitchen andwe're sitting there cutting
cucumbers and all of a sudden,you know, you cut your finger.

(21:19):
Let's say, it's pretty amazingto think you're actually going
to heal all by yourself, right?
You don't need these growthfactors and this and that to
heal.
Your body has an innate abilityto heal itself.
And how does that happen?
Well, you have bloodcirculating and the main
proteins are fibrinogen andthrombin and when that gets
exposed to air and oxygen, aclot will form and then cells

(21:41):
get trapped in the clot, growthfactors get trapped in the clot
and then over the next 21 or sodays you're going to heal.
But it all relies on the bloodflow to these areas.
And the unfortunate thing is,as we age, our blood flow is
continuing to go down Right andour blood vessels are getting
smaller.
And I always say this in ourfacial aesthetics courses, like

(22:03):
the reason why females they lookthey have these cute, chubby
cheeks when they're young andeverything's nice and elevated.
And what happens as they age?
You don't pump enough bloodflow into the area anymore.
You can't maintain that fattissue.
This starts breaking down, thiswill fall.
Then you start having deepnasolabial folds, marionette
lines, so on and so forth.
And really, when blood flow isreally reduced and as you age,

(22:27):
like I said, what happens toyour?
You know beats per minute.
Right, you have 220 beats perminute when you're an athlete
and 20 years old and it goesdown by 10 every single year,
every decade, and by the timeyou're 70, you know your max

(22:47):
heart rate is like 150, 140 andit's very bad for diabetics.
Where do diabetics typicallyhave problems?
That's right, furthest placeaway from your heart.
So you or I always give thesame examples you can.
We could be playing tennis andget blisters on our feet.
No problem, we heal up.
Just fine.
A diabetic person, they're notgoing to heal and that can
become an ulcer.
They may not even know thatthey have this like defect.
That's this size and this thickbecause they don't bleed,

(23:09):
there's no blood there, and ifthey get infected, you know
that's amputation.
And so bob marks, who's theinventor professor at um in
miami, jackson Jackson Hospital,who's retired now he came up
with the concept and he said youknow what?
I know that those patients withthese diabetes and I know these
ONJ cases there's no blood flowhere and so all I'm going to do

(23:32):
is I'm just going to take a fewtubes of blood from the
hospital.
I'm just going to drop theblood and bring the blood to the
area, okay, inject it aroundthe periphery of the defect,
splashing blood on the surface,and just bathe it in blood and
bring the cells there becausethe body can't do it.
And, sure enough, the patientstarted to heal.
And then, you know, then hethought let's put this in a
centrifuge.

(23:53):
I know what cells go wherelight cells go to the top, heavy
cells go go to the bottom, andnow in a 10 ML tube you can
super concentrate one CC withall of the platelets.
So you have like a tenfoldincrease in these platelets.
And when they took that andthey started to inject that
around the peripheries and useit in ONJ cases and grafting

(24:13):
cases, et cetera, they realizedthat healing was happening a lot
faster.
And that's when they called thetechnology platelet-rich plasma
, prp.
Okay.
So then it's used in manyfields of medicine.
I always say we use it a lot indentistry.
Dentists invented thistechnology, so we've been ahead
of the curve forever since itstarted.

(24:34):
But the two areas that reallymade this technology boom was
first being sports medicine.
Right, you've got your $20million a year quarterback for
the Miami Dolphins.
He gets a meniscus tear.
He's told he's going to be outfor six to seven months.
Why are you out?
Why does it take so long forpeople to heal their knees and

(24:54):
their Achilles, et cetera?
Answer low blood flow.
It's not like your cartilageand your knees are just filled
with running blood at all times,so it takes a really long time
to heal.
So they said well, we got, yougot a blood flow problem.
We have a blood flow solution.
Let's take the PRP injected inthis pro athletes knee and then
healing started to happen.
And then that went on the newsyou had your $20 million a year

(25:16):
athlete back on the playingfield in three or four months.
Everybody's like what the helldid you do?
And he's saying I did this, allnatural PRP stuff.
So now everybody's starting toknow what PRP is.
And the second area which madeit even more popular was facial
aesthetics.
They started to realize that,hey, back then they were doing
these microneedling treatmentsuh, with vitamin C and

(25:37):
hyaluronic acid.
And one doctor one day said whydon't I use this PRP stuff?
I'll put it on the face andthen microneedle it in, so it's
almost like getting a tattoo.
When you put tattoo and the inkunder the skin, it stays there
forever.
So they said, instead ofputting a tattoo with ink, let's
do the same procedure, butlet's put some PRP in there.
And that worked incredibly well.

(25:58):
And then he called thetechnique.
Well, he called the techniquevampire facial, which is one of
the top five trademarks in termsof value in all of medicine,
which is just unbelievable.
And then celebrities wanted todo more and more of these
treatments.
And then there was onecelebrity in particular, that

(26:21):
went online and posted I've donemicroneedling with prp.
Her name was kim kardashian.
She posted that, yeah, and shemade it super popular.
One post online.
Now I always joke around.
I say every female over the ageof two years old now wants you
know this vampire facial and sovery, very popular.
Now, last question what is thedifference between PRF and PRP?

(26:42):
Because we get asked thisquestion all the time.
When you fill that tube up in ahospital, like Bob Marks did
years ago, you always see whatdoes the phlebotomist do?
They take the tube of blood andthey do this, right, what are
they doing they?
They cannot put blood in aregular tube with no
anticoagulants inside becauseit'll clot in two or three
minutes.
So there's no way you couldtake that tube and send it to a

(27:03):
blood lab and say, hey, gomeasure my vitamin d levels and
blood cell counts etc.
Not possible.
So they have to put theanti-clotting factors in the
tube and then do this.
So when you take that andthat's prp and you spin it down
and you and you draw that up andyou inject your pro athlete's
knee, yes, you get all thebenefits, the growth factors.
We know it helps with healing.

(27:23):
But scientists, clinicalscientists, have known right
from the beginning there's alittle bit of negativity here.
Why?
Because you're putting ananti-clotting factor inside.
Right, like the cucumberexample.
Right, when you cut yourself,what is the single first, most
important step to healing?
A clot needs to form.
If you don't clot, you willnever heal.

(27:46):
Okay, so that's an extremelyimportant step to healing.
And so what was done?
There was a modification of thetubes and the tube surface and
what they've done is they'vemade these tubes more
hydrophobic, which is waterrepelling.
So, just like a dental implantsurface, that's a you guys have
heard Shirley of SLA active andnoble active right Hydrophilic

(28:07):
surfaces.
The more water loving it is,the more blood gets drawn to the
surface, the faster it's goingto clot, degranulate the
platelets and fasteroscinegration.
Okay, the opposite is true.
If you don't want something toclot, you make the two balls
very hydrophobic.
No chemicals.
Now you can put PureF in thattube and it'll stay liquid for

(28:28):
up to four hours.
So now we'll do the same spincycles like we do in PRP, if we
want to.
Instead of using the chemicals,we're using a hydrophobic tube
surface.
I can do everything in underfour hours easily.
I can drop the platelet richlayer and now I inject it in my
pro athlete's knee and, justlike prp, I get all the benefits

(28:49):
.
That sells the growth factors,but I also get a clot to form,
and clotting is the single first, most important step to healing
.
So there have been thousands ofpapers that have compared PRP
to PRF and every study so farhas shown that.
PRF is better than.

Dr. Tyler Tolbert (29:03):
PRP.
So my follow-up to that thenare there still indications for
PRP over PRF in any of thesetypes of modalities, or is it
just altogether superior?
I?

Dr. Richard Myron (29:13):
see, okay, yeah, altogether superior.
Yeah, every field In fact,you'll still see a lot of people
that will use PRP, and two morecommon places is facial
aesthetics and sports medicine.
So you'll still see, you know,orthopedic surgeons using PRP.
The reason why is the PRF.

(29:35):
It's hard to get into thesemarkets because the companies
that have been established andaround for a very long time
selling PRP.
They don't want to switch toPRF, and the reason why is most
PRP kits are like a hundred and120 bucks.
The PRF tubes are a dollar each, and so they're still making a
huge amount of money sellingthese PRP kits to their doctors,

(29:58):
and so they never get reallyintroduced to PRF.

Dr. Soren Paape (30:01):
Wow, can you talk a little bit about because
in I'd love.
First this is more of like apersonal thing I'm curious on
facial applications for dentistsfor facial cosmetics with PRF,
and then I'm also, and then I'dlove for you to go into where

(30:21):
dentists can use PRF in theirsurgical applications clinically
.

Dr. Richard Myron (30:28):
Okay, I'll answer the dental question first
and then we'll talk about howwe got into facial aesthetics.
So in dentistry we know todaythat PRF is better for soft
tissue than for bone.
Okay, it helps with soft tissuebut of course it'll still help
with bone and it greatlyenhances the quality of handling
because when you make stickybone you know your particles are

(30:49):
all kind of together.
It just makes your life a loteasier.
So common places, you knowextraction sites, just making
sticky bone for your extractionsite and even using it for soft
tissue over top of it.
We use it all the time for softtissue around dental implants,
any GBR procedures.
We do sinus grafting and then ofcourse recession coverage.
You can use it as well undercertain indications.

(31:11):
So really there's a lot ofapplications for it and I wrote
an entire 400 page textbookunderstanding, understanding
platelet rich fibrin, which goesover all the data and you know
really the highest evidence,meta-analysis of these
systematic reviews of randomizedclinical studies.
So there's been, you know,hundreds, thousands of papers
that have been published on thisand so really there's a lot of

(31:33):
applications.
But when people start I justsay extractions, third molars,
round implants, soft tissues youknow those are common places to
start and you know, as you getmore advanced in your surgery,
like Dr Picos, who I teach quiteclosely with you know he always
says in a sinus grafting courselike I have not done a sinus

(31:54):
grafting case without PRF inlike over a decade, he's just
like, it just makes your life somuch, much easier.
It helps with thevascularization in this
relatively low blood flow areabecause when you go to a sinus
on an x-ray it's literally justa big black hole with no blood
flow and that's why it takes solong.
We gotta wait six to eightmonths.
We don't have blood flow there.

Dr. Tyler Tolbert (32:12):
So you know, by adding in these blood flow,
and that's specific to likemaking the sticky bone itself,
or is that like a membraneapplication, or what is that
specific for sinus lifts?

Dr. Richard Myron (32:26):
okay, yeah, it's really the sticky bone.
Um, you can't use it as abarrier membrane, as you guys
know, uh, because it doesn'tlast long enough until the
extended puref was created.
Um, we can talk about that alittle bit later, but you know,
that's how.
That's how it's being utilizedprimarily in dentistry the
facial application.

(32:46):
You know I can share the storyif we have the time.
How I got into it it's kind ofa crazy story, but when I was
working.
So, going back to my story,right 2016, I moved here.
2018, I finally get the abilityto work as a dentist right.
So in 2018, I start as anassociate and all I'm going to
do is these perio and implantcases out of a pretty busy

(33:08):
practice.
The guy's name's Michael Kanner.
Dr Kanner is located in Floridaand he's like the dentist of a
dentist, of a dentist and his60s now and he's got this nice
big practice with 16 ops, threeassociates, and I'm going to get
fed basically all the periocases one or two days a week
that I work there.
I start doing that over a smallamount of time and at the same

(33:30):
time, when I'm teaching puref todentists, about 20 percent of
the people are asking myself andmy brother actually created
PRFEDU, so he and I work veryclosely together, obviously, and
he's getting asked all the timedo you teach PRF and facial
aesthetics?
And I'm like dude, no, like,I'm a hardcore, hardcore

(33:50):
biologist.
And I love implants like getaway from me, right?
So yeah, that's how it started.
But we just kept getting askedover and over and over again.
And then one day I had thisreally nice lady fly from Greece
all the way to Miami to take aone-day PRF course as a plastic

(34:11):
surgeon.
And what was she doing inAthens?
She was doing a hair transplantand a fellowship there, and
she's sitting in the front rowand I'm like what the hell are
you doing here?
Like, are you lost?
What's going on?
And she's like no, no, dr Myron, I've been teaching PRP courses

(34:32):
for 14 years to plasticsurgeons.
We're doing research right nowand trying to regrow hair with
this stuff.
And I read your paper,injectable Platelet-Rich Fibrin,
which was published in 2016.
That was the first time that westarted realizing we could use
a liquid version, and Ipublished the first paper with
Dr Joseph Shakrun in 2016 calledInjectable Platelet-Rich Fiber

(34:54):
and Opportunities inRegenerative Dentistry.
So she saw the paper.
She's like I don't care aboutall this dental stuff you guys
are talking about, but when youexplain it in the paper not
using the anti-clotting factorsand the anticoagulants et cetera
that makes so much sense to me.
So I'm here and we had donesome data of like where do the
cells go, etc.

(35:14):
And what concentrations.
She's like I was wondering if,after the course, you can sit
down with me.
I want you to help me developprotocols for injecting in the
face, where to inject and how.
I was like I can tell you theprotocols.
I have no idea how to inject.
She's like I told her she'slike all right if I tell you I
need six milliliters of plateletconcentrates with one million

(35:34):
platelets per cc.
Can you help me figure that out?
I was like absolutely, I haveall the data.
We sat through it.
We said okay, kathy, if youspin exactly at this protocol
and grab exactly this layer fromthese three tubes, you'll grab
two cc's each.
You'll get exactly what youneed.
Okay, she went back to Greece.
Now she get exactly what youneed.

(35:55):
Okay, she went back to greece.
Now she's ordering 600 pureftubes a month.
Yeah, a month.
Okay.
So we're like what the hell isthis person doing?
Right?
So one day my brother says to mehe's like let's just call dr
davies.
We're like she's like sixmonths into this, she's ordered
something like 3 000 tubes.
I'm this must be workingextremely well, because she
wouldn't be ordering this much.
So, yeah, she says it'sunbelievable.

(36:20):
I think it's working probablythree times better than PRP is
what our early research isshowing.
Um, yeah, we love it.
I'm doing all my Instagram.
People is what she calls themall the time, the Instagrammers,
the people that want to lookbetter at posting these stupid
photos online.
But she's like there's tons ofthem there, they love this stuff
.
And I was like, oh, okay, cool.

(36:40):
I was like you know, dr Davies,I'm getting asked to do a lot
of these PRF courses in facialaesthetics.
Would you be interested indoing a two day program with me
where I'll teach the science ofplatelet concentrates, you teach
how to do the injections, thenwe'll do a hands-on?
I think it would be quitepopular, but most of our
audience is going to be dennis.

(37:01):
Is that okay with you?
She's like absolutely, drmarion, I'd love to be
affiliated with your researchgroup.
I have all the respect in theworld for you.
I'd love to do it.
So I said, okay, great, mybrother sends out an email to
everybody that I had trained and, um, we had, we capped at 32
people.
We sold out the course in fourhours.

Dr. Tyler Tolbert (37:22):
One email blast all right, taylor swift.
So I was like okay so we do thecourse.

Dr. Richard Myron (37:28):
Oh, yes, we do the course and um it, it went
extremely well and it was a lotof fun.
People really like doing themicroneedling and practicing on
each other, etc.
It's all safe, it's all natural.
Think of how safe this is.
You can't be allergic to yourown blood, you can't have a
foreign body reaction, you can'tcause a vascular occlusion, you
can't do any damage, really,and so it was a huge success.

(37:53):
But then the difference was isthat these dentists that had
taken this course here versusthe other, my other courses they
were calling my brother andsaying you know, I started doing
these vampire facial typetreatments in my office and a
couple of these puref injectionswere exactly what was
recommended.
You charge $700 to do thetreatment microneedling with PRF
which, by the way, can bedelegated entirely to a dental

(38:15):
assistant, so they can legallydo that.
You don't even have to doanything, and it's $700.
When we add the PRF injections,we charge $1,100.
But you tell Dr Myron, thesecases don't even cost us $50.
We don't even have to do mostof the procedure.
My dental assistant does allthe blood draw.

(38:36):
My dental assistant does allthe spinning.
My dental assistant does allthe microneedling.
I go in for two minutes, injecta few places.
I made $1,100.
And these people just likeBotox.
They're coming back every fourto six months to do another
treatment and they're spendinglike $3,000 a year doing these
treatments every year.
It's like doing dental hygiene,but this is skin hygiene and
it's extremely profitable.
And you tell Dr Marin thatsince I took that course I made

(38:59):
an extra $200,000, $300,000 thisyear doing this.
It's been one of the biggestmoneymakers for my practice.
So I'm like, holy shit, nobodyever says hey, I started doing
PRF in dentistry and I all of asudden am making an extra
$200,000.
Dr Kanner, the owner, he's had alot of people do Botox in his

(39:22):
office and fillers come and goover the years as associates, so
he knows that people want to doit.
But then when that one doctorleft we didn't have another
doctor doing botox.
So one day he said, dr marion,do you mind if I come to the
facial course?
I want to go meet dr davies.
And we started running thiscourse every every four months.
Okay, because it was it's ourmost popular course and it grew

(39:42):
every single time we did it.
The next time there was 40people, the next time there was
50 people.
And what was happening?
We do no marketing.
What was happening was a doctorlike yourself took the course.
You're making an extra $200,000.
Now You're telling your buddyhey, you got to go take Dr
Marin's facial aesthetics coursebecause you can add a lot of
extra income by offering thesetypes of services.
So the course now, like lastNovember, we had 300 people

(40:09):
attend this course and we haveone coming up in April.
We already have over 200 people.
I expect there'll be 250 peoplethere.
Hundred people attend thiscourse and we have one coming up
in April.
We already have over 200 people.
I expect there'll be 250 peoplethere.
And so it's grown, you know,exponentially.
Because of the fact that youknow people are making a lot of
extra money and it's fun, right,when you go to your staff, like
a lot of people just do theseservices on a Friday because
it's a lot of fun.
And so, yeah, it was.

(40:31):
And I did the same thing, evenperio.
I said, okay, dr Cantor, drCantor, after the course that
you need to start doing these.
I said, no problem, we starteddoing them Fridays in the office
and I just kept getting busierand busier doing these
treatments because, let's faceit, more people want to do
facial aesthetics.
The patients versus.
You know a connective tissuegraft right and so you know it

(40:53):
grew quite naturally,organically, in the practice and
to this day, like I said, it'sour most popular.

Dr. Soren Paape (40:59):
Yeah, it's amazing, it's.
I'm looking it up right now,april 24th, you know you might
see me there.
To be honest, sounds fantastic.
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