This week on The Genetics Podcast, Patrick is joined by Dr. Euan Ashley, Chair of the Department of Medicine at Stanford, founder of various biotech companies, and author of The Genome Odyssey: Medical Mysteries and the Incredible Quest to Solve Them. They discuss Euan’s groundbreaking work on ultra-rapid genome sequencing and how widespread sequencing, wearables, and AI could shape the future of preventive medicine and human performance.
Show Notes:
00:00 Intro to The Genetics Podcast
01:00 Welcome to Euan
01:50 A pivotal case in Euan’s career involving diagnosing a newborn experiencing cardiac arrest
06:41 How Euan’s team worked towards a record of eight hours from clinical sample to diagnosis
10:05 Hurdles that need to be overcome before ultra-rapid sequencing workflows can be widely used in clinical settings
11:40 Considerations around widespread genetic screening in newborns
16:10 Weighing utility and uncertainty in genetic testing for disease
19:17 Steps to a future where widespread genetic testing is economically viable
23:54 New frontiers of clinical genomics, including integration with electronic health records (EHRs) and wearables
28:24 The physiology and genetics of athletic performance and the inspiration behind the ELITE study
33:54 Psychological drivers and effects of human performance
37:57 Euan’s interest in generative AI for developing novel therapies
41:32 Closing remarks
Find out more
The Ashley Lab (https://ashleylab.stanford.edu/)
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