This week on The Genetics Podcast, Patrick is joined by Samuli Ripatti, Director of the Institute for Molecular Medicine Finland (FIMM), Vice Director at HiLIFE, and Professor of Biometry at the University of Helsinki. They discuss Samuli’s research on lipid and cardiovascular genetics, how polygenic risk scores are moving into clinical care, and the power of the FinnGen biobank.
Show Notes:
0:00 Intro to The Genetics Podcast
00:59 Welcome to Samuli
01:48 Samuli’s path from statistics to genetics at the beginning of a new era
03:09 Remembering Leena Peltonen and the Human Genetics Summer School
05:46 Samuli’s research in lipid and cardiovascular genetics and the power of collaboration
09:14 Integrating polygenic risk scores into cardiovascular and breast cancer care
14:52 Using medication history in FinnGen to uncover cardiometabolic genetics and predict treatment patterns
18:50 The future of polygenic risk scores in predicting prognosis and guiding treatment
21:21 The confounding effect of treatment in genetic studies
23:14 Overview of FinnGen and its impact on genetics and drug discovery
27:04 The next 5 years in proteomics and molecular profiling to move beyond associations
29:56 Using polygenic risk scores in clinical trials
31:41 Future directions, from refining phenotypes in large biobanks to piloting clinical applications of polygenic risk scores
34:04 Scaling population biobanks versus deep phenotyping and why the future requires both
35:29 Closing remarks
Find out more
Genetic predictors of lifelong medication-use patterns in cardiometabolic diseases (https://www.nature.com/articles/s41591-022-02122-5)
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