September 5, 2025 • 18 mins
Ulcerative colitis (UC) is more than just a gut condition—it’s a chronic inflammatory disease shaped by immune dysfunction, microbiome imbalances, and increased intestinal permeability. In this episode of The Health Pulse, we explore how dietary strategies—especially low-carbohydrate approaches—may play a complementary role alongside conventional treatments.
We break down how foods high in refined carbs, sugars, and ultra-processed ingredients can fuel harmful gut bacteria and systemic inflammation, potentially worsening UC symptoms. You’ll learn why low-carb diets may help reduce flare frequency by eliminating fermentable sugars, lowering insulin spikes, and naturally cutting out many dietary irritants.
But feeling better isn’t enough. We emphasize the importance of objective monitoring through lab tests like fecal calprotectin and CRP to distinguish between symptom relief and true biochemical remission. Patient reports, case studies, and emerging research suggest promise—but personalization is key.
If you or someone you love is navigating UC, this episode sheds light on the evolving role of nutrition in managing inflammatory bowel disease and offers practical tools for combining medical care with personalized lifestyle strategies.
📞 Need lab work done from the comfort of home? QLM offers fast, reliable mobile phlebotomy services—no clinic visit required.
📅 Book your appointment or learn more at:
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📧 Contact us: info@quicklabmobile.com
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Disclaimer: The information provided in this podcast is for informational purposes only and should not be considered medical advice. The content discussed is based on research, expert insights, and reputable sources, but it does not replace professional medical consultation, diagnosis, or treatment. We strive to present accurate and up-to-date information, medical research is constantly evolving. Listeners should always verify details with trusted health organizations, before making any health-related decisions. If you are experiencing a medical emergency, such as severe pain, difficulty breathing, or other urgent symptoms, call your local emergency services immediately. By listening to this podcast, you acknowledge that The Health Pulse and its creators are not responsible for any actions taken based on the content of this episode. Your health and well-being should always be guided by the advice of qualified medical professionals.
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Transcript
Episode Transcript
Available transcripts are automatically generated. Complete accuracy is not guaranteed.
Speaker 1 (00:01):
Welcome to the Health Pulse, your go-to source for
quick, actionable insights onhealth, wellness and diagnostics
.
Whether you're looking tooptimize your well-being or stay
informed about the latest inmedical testing, we've got you
covered.
Join us as we break down keyhealth topics in just minutes.
Let's dive in.
Speaker 2 (00:25):
Welcome to the Deep Dive, where we take your sources
and really try to unearth themost important insights.
Great to be here Today.
We're tackling a topic thathonestly touches many lives very
deeply ulcerative colitis andspecifically the surprising kind
of evolving role that diet,particularly low-carb approaches
(00:46):
, might play in managing it.
You've brought us a reallydetailed piece from QuickLab
Mobile, miami, which exploresthe latest thinking on nutrition
and inflammatory bowel disease,or IBD.
Speaker 3 (00:58):
That's right, the fascinating area.
Speaker 2 (01:00):
For so many people managing a chronic condition
like ulcerative colitis.
Well, it feels like a constantbattle, doesn't it?
Speaker 3 (01:06):
It really does day in , day out.
Speaker 2 (01:08):
Medications are obviously foundational.
They're the cornerstone.
But what if something asfundamental as you know the food
on your plate could seriouslyimpact your quality of life?
Speaker 3 (01:17):
Beyond just symptom relief, you mean.
Speaker 2 (01:19):
Exactly Beyond just feeling a bit better day to day.
Speaker 3 (01:21):
Well, it's really interesting how the conversation
around IBD is shifting.
Speaker 2 (01:25):
Yeah, how so.
Speaker 3 (01:26):
Our source today.
It really drills down into hownutrition, specifically these
low carbohydrate diets, isemerging as a potential
supportive strategy.
Speaker 2 (01:36):
Supportive.
Ok, not a magic bullet.
Speaker 3 (01:38):
Definitely not a cure let's be clear on that but
potentially a significant factorfor some people in managing
those awful flares and maybeimproving overall gut health.
Speaker 2 (01:47):
That evolution in thinking is precisely what we
want to get into today.
Speaker 3 (01:51):
Good.
Speaker 2 (01:51):
So our mission for this deep dive First let's
unpack what ulcerative colitisactually is, Then explore its
complex causes, the triggers,and then really take a close
look at the evidence forlow-carb diets.
Speaker 3 (02:04):
The good and the bad, so to speak.
Speaker 2 (02:05):
Exactly the promising stuff, but also the cautionary
notes and, crucially, whypersonalized lab testing is well
, probably essential if you'reconsidering these big dietary
changes.
Speaker 3 (02:16):
And that raises a really important question,
doesn't it?
How can individuals navigatethese emerging dietary ideas
safely and effectively?
What objective measures youknow beyond just I feel better
today can actually guide thosechoices?
Speaker 2 (02:29):
That's what we're aiming to unravel for you, so
let's start at the beginning.
Ulcerative colitis itself.
Speaker 3 (02:34):
Okay.
Speaker 2 (02:34):
Let's make sure everyone's on the same page.
What exactly is this condition?
Why is it such a challenge?
Speaker 3 (02:40):
Well, the source defines it clearly it's a
chronic inflammatory boweldisease, IBD.
Speaker 2 (02:46):
Okay.
Speaker 3 (02:47):
And it primarily affects the lining of the large
intestine, so the colon and therectum.
Speaker 2 (02:52):
Got it, and it's characterized by cycles right.
Speaker 3 (02:54):
Yeah.
Speaker 2 (02:55):
Not constant symptoms .
Speaker 3 (02:56):
That's right.
You have these periods calledflares.
That's when there's activeinflammation and symptoms really
kick in.
Speaker 2 (03:01):
I know.
Speaker 3 (03:02):
And then periods of remission where things quiet
down, offering some relief.
But the core issue, thepersistent inflammation and
those ulcers forming in thelining.
That's always sort of therepotentially Underlying yes, and
that leads to major digestiveproblems and sometimes issues
that go beyond the gut.
Speaker 2 (03:19):
Systemic issues, they call them.
Speaker 3 (03:20):
Exactly Affecting the whole body.
Speaker 2 (03:22):
So how does this even start?
What's happening inside?
The source points to a few keymechanisms.
Speaker 3 (03:29):
Yeah, it's complex.
First there's immunedysregulation.
Speaker 2 (03:32):
Meaning the immune system gets confused.
Speaker 3 (03:33):
Pretty much.
It mistakenly attacks the cellslining the colon.
That's what causes the chronicinflammation.
Speaker 2 (03:40):
And that attack damages the lining.
Speaker 3 (03:41):
Precisely.
It leads to ulcers and alsoincreases what's called
intestinal permeability.
Speaker 2 (03:47):
Ah, the leaky gut idea.
Speaker 3 (03:49):
That's the term often used.
Yes, Increased permeability.
Speaker 2 (03:53):
And then, as you said , that flare remission pattern,
yeah, the cycle.
Speaker 3 (03:56):
Right.
Symptoms come and go, which canbe really unpredictable and
frustrating for people livingwith it.
Speaker 2 (04:01):
Absolutely.
So what does this actually feellike for someone going through
it?
What are the common symptoms?
Speaker 3 (04:06):
Well, the source highlights several.
You've got the obviousdigestive issues first.
Speaker 2 (04:11):
Like diarrhea.
Speaker 3 (04:11):
Yeah, persistent diarrhea, often with blood or
mucus, which can be quitealarming, plus intense abdominal
cramping, bloating Sounds rough.
It is, but then there are alsothe systemic symptoms, things
that affect the whole body.
Speaker 2 (04:25):
Like what.
Speaker 3 (04:26):
Fatigue like deep, profound fatigue, unintended
weight loss, sometimes fever,even joint pain.
Speaker 2 (04:33):
Wow, joint pain from a gut issue.
Speaker 3 (04:35):
Yeah, it really shows how inflammation in one area
can have ripple effects.
Speaker 2 (04:39):
And because the gut isn't working right, you can end
up with nutrient deficiencies,right?
The source mentioned a few.
Speaker 3 (04:45):
Absolutely crucial point Iron deficiency is common,
leading to anemia.
Also B12, vitamin D and folate.
Speaker 2 (04:57):
These are vital nutrients the body struggles to
absorb properly.
When the colon is inflamed,okay, and it's not the same for
everyone, is it?
The severity varies.
Speaker 3 (05:02):
Hugely, and where it affects the colon varies too.
The source categorizes it.
Prectitis is just the rectum.
Speaker 2 (05:08):
The very end bit.
Speaker 3 (05:09):
Right, then left-sided colitis involves the
rectum and well, the left sideof the colon Makes sense.
Pancolitis means the entirecolon is affected, pan meaning
all.
Speaker 2 (05:19):
That sounds much more extensive.
Speaker 3 (05:20):
It is.
And then there's fulminantcolitis.
That's a severe, thankfullyrare form with really extensive
ulceration.
It's a medical emergency.
Speaker 2 (05:28):
Gosh, this really highlights why treatment needs
to be so personalized.
Speaker 3 (05:32):
Absolutely, which, as the source notes, is where lab
testing comes in monitoringdisease activity, nutritional
status, tailoring the approach.
Speaker 2 (05:41):
Okay, so that's what you see is.
Now let's get into the why, thecauses, the triggers.
This is where it gets reallyinteresting and maybe a bit
messy.
Speaker 3 (05:49):
It really is a complex web.
The source emphasizes it's notjust one thing.
It's a mix, an interplay ofimmune factors, environmental
stuff and, yes, genetics.
Speaker 2 (05:59):
Understanding.
These might help manage flares,perhaps guide lifestyle tweaks.
Speaker 3 (06:04):
That's the idea.
Let's break them down.
First, that immunedysregulation again.
The immune system attacking thecolon Right.
It produces thesepro-inflammatory messengers
called cytokines, things likeTNF-alpha, il-6.
You might hear these names inrelation to treatments.
Speaker 2 (06:19):
Like biologic drugs.
Speaker 3 (06:20):
Dr.
Exactly, Biologics often targetthese specific cytokines, but
and this is important the sourceemphasizes that diet and
lifestyle can also influencethis immune activation.
Speaker 2 (06:30):
Okay, interesting, what else?
Speaker 3 (06:32):
Dr Gut, microbiome imbalance.
This is huge, the trillions ofbacteria in your gut they're
critical.
In UC patients there's oftenless diversity, fewer types of
Good beneficial bacteria andmore of the pro-inflammatory
types.
It's out of balance ordysbiosis.
Speaker 2 (06:48):
And diet affects this balance.
Speaker 3 (06:50):
Directly.
The source explicitly statesthis is from the iScience
reference cited that high sugar,high processed diets worsen
dysbiosis.
Makes it worse, yeah Whereaslow carb and fiber balanced
diets may help restore gutbalance in some cases.
Emphasis on may in some cases.
Speaker 2 (07:08):
Right.
So what we eat literally feedsour gut bugs, influencing the
balance.
Speaker 3 (07:12):
Precisely, which leads us right into dietary
triggers.
Speaker 2 (07:16):
Ah, the food connection.
Speaker 3 (07:17):
The source makes a strong link here.
Diets high in refined carbs,sugar and seed oils can increase
intestinal inflammation.
Speaker 2 (07:25):
So white bread, sugary drinks, certain processed
oils.
Speaker 3 (07:29):
Those seem to be common culprits, according to
this research, and critically,ultra-processed foods may
disrupt the gut lining andworsen immune overactivation.
That's from the nutrientsreference.
Speaker 2 (07:39):
Ultra-processed, yeah , so things way beyond their
original state.
Lots of additives.
Speaker 3 (07:43):
Generally yes, Things with long ingredient lists.
You don't recognize Emulsifiers, artificial sweeteners, things
like that.
Speaker 2 (07:49):
And this is where the low-carb idea comes in as a
potential help.
Speaker 3 (07:52):
Exactly the thinking is that low-carb diets might
benefit some people with UC bywell several ways.
Speaker 1 (07:58):
Okay.
Speaker 3 (07:59):
Reducing those fermentable sugars that might be
feeding the bad bacteria, thedysbiosis.
Speaker 2 (08:04):
Right, shards them out maybe.
Speaker 3 (08:06):
Potentially Also lowering those big insulin
spikes you get after eating lotsof carbs.
Those spikes can contribute tosystemic inflammation.
Speaker 2 (08:13):
Ah, the whole body inflammation link again.
Speaker 3 (08:15):
Yes, and simply by avoiding many of those
ultra-processed foods andadditives that are often high in
carbs anyway.
Speaker 2 (08:22):
Makes sense.
What about non-dial factors?
Speaker 3 (08:25):
The source list environmental and lifestyle
factors too.
Chronic stress is a big one.
Speaker 2 (08:30):
We hear that a lot Stress impacts everything.
Speaker 3 (08:32):
It really seems to Also sleep deprivation.
Smoking definitely a riskfactor.
Alcohol and frequent antibioticuse which can disrupt the
microbiome.
Speaker 2 (08:41):
All things that can potentially worsen UC flares.
Speaker 3 (08:43):
Correct.
And finally, there's geneticsusceptibility.
Speaker 2 (08:47):
So genes do play a role.
Speaker 3 (08:48):
They do.
Certain genes like HLA, nod2,il-23r are associated with a
higher risk.
But and this is key the sourceclarifies while genetics set the
stage, environmental triggersoften determine disease
expression.
Speaker 2 (09:02):
I like that analogy Genetics loads the gun.
Speaker 3 (09:05):
But environment pulls the trigger.
It's a good way to think aboutit.
You might be predisposed, butlifestyle and environment can
make a huge difference.
Speaker 2 (09:13):
Okay, so putting this all together, what does it mean
for someone actually livingwith UC?
Especially when they sit downto eat?
Speaker 3 (09:20):
Well, the core message from the source is
pretty clear Nutrition plays areally significant role.
Speaker 2 (09:26):
In managing the inflammation.
Speaker 3 (09:27):
Yes, managing inflammation, trying to
rebalance that gut microbiomeand identifying those personal
symptom triggers.
Speaker 2 (09:34):
But again, not a cure in itself.
Speaker 3 (09:36):
Absolutely not.
Diet alone isn't a cure, butpersonalized dietary strategies
can be a powerful supportalongside medical treatments.
They can really improve qualityof life for some.
Speaker 2 (09:46):
And that's where this growing interest in low-carb,
even very low-carb orcarnivore-style diets comes from
.
Speaker 3 (09:52):
Exactly Because of those potential mechanisms, we
talked about reducingfermentable load, insulin spikes
, processed food intake.
Speaker 2 (09:59):
Now the source mentions patient reports and
case studies.
What did they find?
Speaker 3 (10:03):
This is where it gets quite compelling, though we
need caution.
The Frontiers reference citedmentions reports of UC patients
achieving symptom-free periodsOkay, and even descriptions of
long-term remission afteradopting very low-carb or
carnivore-style diets.
Speaker 2 (10:19):
Wow, that sounds significant.
Speaker 3 (10:22):
It does, and the proposed mechanisms are what
we've discussed Less fuel fordysbiosis, lower insulin spikes.
Avoiding gut irritants inprocessed foods.
Speaker 2 (10:31):
But and this feels like a big but is coming.
Speaker 3 (10:34):
It is.
Here's the critical point.
The source stresses this isearly evidence Promising yes.
Speaker 2 (10:39):
But not definitive proof.
Speaker 3 (10:41):
Exactly.
Most data come from small scalereports rather than large
controlled clinical trials.
We're talking observations,anecdotes, case studies,
powerful for individuals, butnot yet robust clinical evidence
for everyone.
Speaker 2 (10:54):
So it might work wonders for one person, but we
don't have the big studies yetto say it works broadly.
Speaker 3 (11:00):
Precisely.
And this leads to another keyquestion why might symptoms
improve?
Maybe dramatically, but it'sstill not considered a cure.
Speaker 2 (11:08):
Because UC is fundamentally an immune
condition.
Speaker 3 (11:11):
Exactly, it's a chronic immune-mediated
condition.
Removing a dietary trigger, sayspecific carbs, can absolutely
quiet down the inflammation andget symptoms under control.
Speaker 2 (11:22):
Which feels like remission.
Speaker 3 (11:24):
It feels like it and it might be symptomatic
remission, but the source warnsthe underlying immune activity
can still persist, even whensymptoms improve.
Speaker 2 (11:34):
Ah, so you could feel great, but the immune system
might still be subtly attackingthe colon lining.
Speaker 3 (11:40):
Potentially, yes.
The fire might be damped down,but the embers could still be
glowing.
Speaker 2 (11:44):
This is so important.
It's not just about how youfeel, absolutely not.
It's about just about how youfeel.
Speaker 3 (11:47):
Absolutely not.
It's about what's actuallyhappening physiologically.
Speaker 2 (11:50):
And that's why tracking biomarkers is critical.
Speaker 3 (11:53):
Yes, biomarkers give you an objective look inside
Things like fecal calprotectin.
Speaker 2 (11:57):
What's that measure?
Speaker 3 (11:58):
It directly measures inflammation in the gut.
High levels mean activeinflammation or CRPC, reactive
protein which is a more generalmarker of inflammation in the
body.
Tracking these helps confirm ifthe remission you're
experiencing is just symptomaticyou feel better or if it's
biochemical or even endoscopicremission, meaning the actual
(12:19):
inflammation markers or the viewduring a colonoscopy show
improvement.
Speaker 2 (12:23):
Feeling better versus being better internally Not
always the same thing.
Speaker 3 (12:27):
A crucial distinction in managing chronic illness.
Speaker 2 (12:30):
So when might these low-carb approaches be most
helpful?
According to the source, whomight benefit most?
Speaker 3 (12:37):
The source suggests a few scenarios Patients whose
flares seem clearly linked toeating high sugar or
ultra-processed foods.
Speaker 2 (12:44):
Okay, a direct trigger identified.
Speaker 3 (12:46):
Yes, or individuals who also have coexisting issues
like insulin resistance,metabolic syndrome or just
general trouble managing bloodsugar.
The diet might help on multiplefronts there.
Speaker 2 (12:57):
Right, tackling both issues.
Speaker 3 (12:58):
And also cases where specific types of carbs, like
high FODM meat foods or otherfermentable carbohydrates,
clearly worsen symptoms likebloating, diarrhea and cramping.
Speaker 2 (13:09):
So it's about matching the dietary strategy to
the individual's specificprofile and triggers.
Speaker 3 (13:14):
Personalization is key.
It's definitely not aone-size-fits-all approach.
Speaker 2 (13:18):
Which brings us to safety, because drastically
cutting carbs isn't withoutpotential downsides, is it?
The source includes safety andmonitoring considerations.
Speaker 3 (13:27):
Very important ones.
Low carb is not for everyone,especially extreme versions.
Speaker 2 (13:33):
Why not?
Speaker 3 (13:33):
Well remember those nutrient deficiencies common in
UC Iron, folate, vitamin D, b12.
Speaker 2 (13:40):
Yes.
Speaker 3 (13:41):
Severely restricting food groups could potentially
make those worse if you're notcareful about nutrient density.
Speaker 2 (13:45):
Okay, need to be mindful of getting enough key
nutrients.
Speaker 3 (13:48):
Absolutely.
Also, some very restrictiveapproaches, like some
carnivore-style diets, mightsignificantly reduce dietary
fiber and plant diversity.
Speaker 2 (13:57):
Which could impact the microbiome long-term.
That's a concern.
Speaker 3 (14:00):
yes, we know fiber diversity is generally good for
long-term microbiome health, sooverly restricting might have
unintended consequences down theroad.
Speaker 2 (14:09):
So careful planning and monitoring are essential if
you try this.
Speaker 3 (14:12):
Paramount, which loops back to objective testing.
Speaker 2 (14:14):
Right.
The source recommends trackingspecific markers before starting
and during a low-carb trial.
Speaker 3 (14:20):
Yes, you absolutely want to track inflammation,
fecal calprotectin and CRP.
Speaker 2 (14:27):
To see if the diet is actually calming the fire
Exactly.
Speaker 3 (14:30):
Then nutritional status vitamin D, b12, iron
panels, maybe folate.
Speaker 2 (14:35):
To make sure you're not becoming deficient.
Speaker 3 (14:37):
Correct and metabolic markers.
Fasting insulin, hba1c, maybe alipid panel?
Speaker 2 (14:44):
To monitor blood sugar control and metabolic
health.
Speaker 3 (14:46):
Precisely this data gives you and your doctor the
full picture.
Speaker 2 (14:50):
And this is where services that make testing
easier come into play.
Speaker 3 (14:53):
Absolutely.
The source highlights howservices like QuickLab Mobile
Miami, for example, can makethis kind of personalized
management easier by offeringconvenient, maybe even at home,
testing for these exact markers.
Speaker 2 (15:05):
Takes away some of the hassle of getting labs done
constantly.
Speaker 3 (15:08):
It can.
Yeah, they mention specificpanels covering these key areas
Inflammatory markers, crp, fecalcalprotectin, nutrient status,
iron, b12, folate, vit-d andmetabolic panels.
Insulin, hba1c lipids.
Speaker 2 (15:21):
So you get that objective data alongside how
you're feeling.
Speaker 3 (15:24):
Exactly, by combining your symptom tracking how you
feel with objective lab testing,what the data says you and your
health care provider can maketruly informed decisions.
Speaker 2 (15:34):
Is this low-carb approach genuinely improving the
underlying inflammation, or isit just masking symptoms?
Speaker 3 (15:41):
That's the million-dollar question.
It helps answer.
It allows you to manage yourhealth based on facts, not just
guesswork.
It's empowering.
Speaker 2 (15:47):
OK, so wrapping this deep dive up.
Yeah, it's clear, ulcerativecolitis is well incredibly
complex.
It's chronic.
It demands a reallypersonalized approach.
Speaker 3 (15:57):
No doubt about it.
Speaker 2 (15:58):
And while medications are and remain the foundation
of treatment.
Speaker 3 (16:02):
Absolutely.
Speaker 2 (16:03):
Nutrition and lifestyle strategies, including
maybe these low-carb or verylow-carb approaches for some,
might offer significant symptomrelief.
Speaker 3 (16:11):
And potentially improve quality of life.
Yes, for some patients.
Speaker 2 (16:15):
So what are the main takeaways for you, our listener?
Speaker 3 (16:17):
I think the key things are diet isn't a cure-all
, but removing or reducingcertain dietary triggers,
especially refined carbs andultra-processed foods, can help
calm inflammation and reduceflare frequency for many.
Speaker 2 (16:31):
But it's not guaranteed for everyone.
Speaker 3 (16:33):
No Responses vary hugely person to person.
What works wonders for onemight do nothing or even worsen
things for another.
Personalization is crucial.
Speaker 2 (16:43):
And maybe the biggest takeaway, objective monitoring
with lab testing is essential.
Speaker 3 (16:47):
Absolutely essential.
It's how you truly know ifsymptom improvements match up
with actual improvements ininflammation and nutrient levels
.
Speaker 2 (16:54):
It allows for informed choices, safe
adjustments, avoids flying blind.
Speaker 3 (16:59):
Right the source really hammers home the power of
combining that subjectivefeeling.
How am I doing with theobjective lab data?
What's really going on inside?
Speaker 2 (17:08):
Taking control based on facts.
Speaker 3 (17:10):
That's the goal managing your gut health
proactively and intelligently.
Speaker 2 (17:13):
So, as you reflect on this deep dive, here's
something to think about.
A provocative thought perhaps.
In this age where we haveaccess to so much information,
personalized medicine is growing.
If something as basic as yourdiet can significantly influence
a complex immune condition likeyou see what other areas of
your health might benefit fromlooking at objective data
(17:34):
combined with your ownexperience and being willing to
explore those individualizedstrategies.
Speaker 3 (17:39):
A powerful question to ponder.
It really opens uppossibilities for proactive
health management beyond justthis one condition.
Speaker 1 (17:52):
Thanks for tuning into the Health Pulse.
If you found this episodehelpful, don't forget to
subscribe and share it withsomeone who might benefit.
For more health insights anddiagnostics, visit us online at
wwwquicklabmobilecom.
Stay informed, stay healthy andwe'll catch you in the next
episode.
Welcome to the Health Pulse, your go-to source for
quick, actionable insights onhealth, wellness and diagnostics
.
Whether you're looking tooptimize your well-being or stay
informed about the latest inmedical testing, we've got you
covered.
Join us as we break down keyhealth topics in just minutes.
Let's dive in.
Speaker 2 (00:25):
Welcome to the Deep Dive, where we take your sources
and really try to unearth themost important insights.
Great to be here Today.
We're tackling a topic thathonestly touches many lives very
deeply ulcerative colitis andspecifically the surprising kind
of evolving role that diet,particularly low-carb approaches
(00:46):
, might play in managing it.
You've brought us a reallydetailed piece from QuickLab
Mobile, miami, which exploresthe latest thinking on nutrition
and inflammatory bowel disease,or IBD.
Speaker 3 (00:58):
That's right, the fascinating area.
Speaker 2 (01:00):
For so many people managing a chronic condition
like ulcerative colitis.
Well, it feels like a constantbattle, doesn't it?
Speaker 3 (01:06):
It really does day in , day out.
Speaker 2 (01:08):
Medications are obviously foundational.
They're the cornerstone.
But what if something asfundamental as you know the food
on your plate could seriouslyimpact your quality of life?
Speaker 3 (01:17):
Beyond just symptom relief, you mean.
Speaker 2 (01:19):
Exactly Beyond just feeling a bit better day to day.
Speaker 3 (01:21):
Well, it's really interesting how the conversation
around IBD is shifting.
Speaker 2 (01:25):
Yeah, how so.
Speaker 3 (01:26):
Our source today.
It really drills down into hownutrition, specifically these
low carbohydrate diets, isemerging as a potential
supportive strategy.
Speaker 2 (01:36):
Supportive.
Ok, not a magic bullet.
Speaker 3 (01:38):
Definitely not a cure let's be clear on that but
potentially a significant factorfor some people in managing
those awful flares and maybeimproving overall gut health.
Speaker 2 (01:47):
That evolution in thinking is precisely what we
want to get into today.
Speaker 3 (01:51):
Good.
Speaker 2 (01:51):
So our mission for this deep dive First let's
unpack what ulcerative colitisactually is, Then explore its
complex causes, the triggers,and then really take a close
look at the evidence forlow-carb diets.
Speaker 3 (02:04):
The good and the bad, so to speak.
Speaker 2 (02:05):
Exactly the promising stuff, but also the cautionary
notes and, crucially, whypersonalized lab testing is well
, probably essential if you'reconsidering these big dietary
changes.
Speaker 3 (02:16):
And that raises a really important question,
doesn't it?
How can individuals navigatethese emerging dietary ideas
safely and effectively?
What objective measures youknow beyond just I feel better
today can actually guide thosechoices?
Speaker 2 (02:29):
That's what we're aiming to unravel for you, so
let's start at the beginning.
Ulcerative colitis itself.
Speaker 3 (02:34):
Okay.
Speaker 2 (02:34):
Let's make sure everyone's on the same page.
What exactly is this condition?
Why is it such a challenge?
Speaker 3 (02:40):
Well, the source defines it clearly it's a
chronic inflammatory boweldisease, IBD.
Speaker 2 (02:46):
Okay.
Speaker 3 (02:47):
And it primarily affects the lining of the large
intestine, so the colon and therectum.
Speaker 2 (02:52):
Got it, and it's characterized by cycles right.
Speaker 3 (02:54):
Yeah.
Speaker 2 (02:55):
Not constant symptoms .
Speaker 3 (02:56):
That's right.
You have these periods calledflares.
That's when there's activeinflammation and symptoms really
kick in.
Speaker 2 (03:01):
I know.
Speaker 3 (03:02):
And then periods of remission where things quiet
down, offering some relief.
But the core issue, thepersistent inflammation and
those ulcers forming in thelining.
That's always sort of therepotentially Underlying yes, and
that leads to major digestiveproblems and sometimes issues
that go beyond the gut.
Speaker 2 (03:19):
Systemic issues, they call them.
Speaker 3 (03:20):
Exactly Affecting the whole body.
Speaker 2 (03:22):
So how does this even start?
What's happening inside?
The source points to a few keymechanisms.
Speaker 3 (03:29):
Yeah, it's complex.
First there's immunedysregulation.
Speaker 2 (03:32):
Meaning the immune system gets confused.
Speaker 3 (03:33):
Pretty much.
It mistakenly attacks the cellslining the colon.
That's what causes the chronicinflammation.
Speaker 2 (03:40):
And that attack damages the lining.
Speaker 3 (03:41):
Precisely.
It leads to ulcers and alsoincreases what's called
intestinal permeability.
Speaker 2 (03:47):
Ah, the leaky gut idea.
Speaker 3 (03:49):
That's the term often used.
Yes, Increased permeability.
Speaker 2 (03:53):
And then, as you said , that flare remission pattern,
yeah, the cycle.
Speaker 3 (03:56):
Right.
Symptoms come and go, which canbe really unpredictable and
frustrating for people livingwith it.
Speaker 2 (04:01):
Absolutely.
So what does this actually feellike for someone going through
it?
What are the common symptoms?
Speaker 3 (04:06):
Well, the source highlights several.
You've got the obviousdigestive issues first.
Speaker 2 (04:11):
Like diarrhea.
Speaker 3 (04:11):
Yeah, persistent diarrhea, often with blood or
mucus, which can be quitealarming, plus intense abdominal
cramping, bloating Sounds rough.
It is, but then there are alsothe systemic symptoms, things
that affect the whole body.
Speaker 2 (04:25):
Like what.
Speaker 3 (04:26):
Fatigue like deep, profound fatigue, unintended
weight loss, sometimes fever,even joint pain.
Speaker 2 (04:33):
Wow, joint pain from a gut issue.
Speaker 3 (04:35):
Yeah, it really shows how inflammation in one area
can have ripple effects.
Speaker 2 (04:39):
And because the gut isn't working right, you can end
up with nutrient deficiencies,right?
The source mentioned a few.
Speaker 3 (04:45):
Absolutely crucial point Iron deficiency is common,
leading to anemia.
Also B12, vitamin D and folate.
Speaker 2 (04:57):
These are vital nutrients the body struggles to
absorb properly.
When the colon is inflamed,okay, and it's not the same for
everyone, is it?
The severity varies.
Speaker 3 (05:02):
Hugely, and where it affects the colon varies too.
The source categorizes it.
Prectitis is just the rectum.
Speaker 2 (05:08):
The very end bit.
Speaker 3 (05:09):
Right, then left-sided colitis involves the
rectum and well, the left sideof the colon Makes sense.
Pancolitis means the entirecolon is affected, pan meaning
all.
Speaker 2 (05:19):
That sounds much more extensive.
Speaker 3 (05:20):
It is.
And then there's fulminantcolitis.
That's a severe, thankfullyrare form with really extensive
ulceration.
It's a medical emergency.
Speaker 2 (05:28):
Gosh, this really highlights why treatment needs
to be so personalized.
Speaker 3 (05:32):
Absolutely, which, as the source notes, is where lab
testing comes in monitoringdisease activity, nutritional
status, tailoring the approach.
Speaker 2 (05:41):
Okay, so that's what you see is.
Now let's get into the why, thecauses, the triggers.
This is where it gets reallyinteresting and maybe a bit
messy.
Speaker 3 (05:49):
It really is a complex web.
The source emphasizes it's notjust one thing.
It's a mix, an interplay ofimmune factors, environmental
stuff and, yes, genetics.
Speaker 2 (05:59):
Understanding.
These might help manage flares,perhaps guide lifestyle tweaks.
Speaker 3 (06:04):
That's the idea.
Let's break them down.
First, that immunedysregulation again.
The immune system attacking thecolon Right.
It produces thesepro-inflammatory messengers
called cytokines, things likeTNF-alpha, il-6.
You might hear these names inrelation to treatments.
Speaker 2 (06:19):
Like biologic drugs.
Speaker 3 (06:20):
Dr.
Exactly, Biologics often targetthese specific cytokines, but
and this is important the sourceemphasizes that diet and
lifestyle can also influencethis immune activation.
Speaker 2 (06:30):
Okay, interesting, what else?
Speaker 3 (06:32):
Dr Gut, microbiome imbalance.
This is huge, the trillions ofbacteria in your gut they're
critical.
In UC patients there's oftenless diversity, fewer types of
Good beneficial bacteria andmore of the pro-inflammatory
types.
It's out of balance ordysbiosis.
Speaker 2 (06:48):
And diet affects this balance.
Speaker 3 (06:50):
Directly.
The source explicitly statesthis is from the iScience
reference cited that high sugar,high processed diets worsen
dysbiosis.
Makes it worse, yeah Whereaslow carb and fiber balanced
diets may help restore gutbalance in some cases.
Emphasis on may in some cases.
Speaker 2 (07:08):
Right.
So what we eat literally feedsour gut bugs, influencing the
balance.
Speaker 3 (07:12):
Precisely, which leads us right into dietary
triggers.
Speaker 2 (07:16):
Ah, the food connection.
Speaker 3 (07:17):
The source makes a strong link here.
Diets high in refined carbs,sugar and seed oils can increase
intestinal inflammation.
Speaker 2 (07:25):
So white bread, sugary drinks, certain processed
oils.
Speaker 3 (07:29):
Those seem to be common culprits, according to
this research, and critically,ultra-processed foods may
disrupt the gut lining andworsen immune overactivation.
That's from the nutrientsreference.
Speaker 2 (07:39):
Ultra-processed, yeah , so things way beyond their
original state.
Lots of additives.
Speaker 3 (07:43):
Generally yes, Things with long ingredient lists.
You don't recognize Emulsifiers, artificial sweeteners, things
like that.
Speaker 2 (07:49):
And this is where the low-carb idea comes in as a
potential help.
Speaker 3 (07:52):
Exactly the thinking is that low-carb diets might
benefit some people with UC bywell several ways.
Speaker 1 (07:58):
Okay.
Speaker 3 (07:59):
Reducing those fermentable sugars that might be
feeding the bad bacteria, thedysbiosis.
Speaker 2 (08:04):
Right, shards them out maybe.
Speaker 3 (08:06):
Potentially Also lowering those big insulin
spikes you get after eating lotsof carbs.
Those spikes can contribute tosystemic inflammation.
Speaker 2 (08:13):
Ah, the whole body inflammation link again.
Speaker 3 (08:15):
Yes, and simply by avoiding many of those
ultra-processed foods andadditives that are often high in
carbs anyway.
Speaker 2 (08:22):
Makes sense.
What about non-dial factors?
Speaker 3 (08:25):
The source list environmental and lifestyle
factors too.
Chronic stress is a big one.
Speaker 2 (08:30):
We hear that a lot Stress impacts everything.
Speaker 3 (08:32):
It really seems to Also sleep deprivation.
Smoking definitely a riskfactor.
Alcohol and frequent antibioticuse which can disrupt the
microbiome.
Speaker 2 (08:41):
All things that can potentially worsen UC flares.
Speaker 3 (08:43):
Correct.
And finally, there's geneticsusceptibility.
Speaker 2 (08:47):
So genes do play a role.
Speaker 3 (08:48):
They do.
Certain genes like HLA, nod2,il-23r are associated with a
higher risk.
But and this is key the sourceclarifies while genetics set the
stage, environmental triggersoften determine disease
expression.
Speaker 2 (09:02):
I like that analogy Genetics loads the gun.
Speaker 3 (09:05):
But environment pulls the trigger.
It's a good way to think aboutit.
You might be predisposed, butlifestyle and environment can
make a huge difference.
Speaker 2 (09:13):
Okay, so putting this all together, what does it mean
for someone actually livingwith UC?
Especially when they sit downto eat?
Speaker 3 (09:20):
Well, the core message from the source is
pretty clear Nutrition plays areally significant role.
Speaker 2 (09:26):
In managing the inflammation.
Speaker 3 (09:27):
Yes, managing inflammation, trying to
rebalance that gut microbiomeand identifying those personal
symptom triggers.
Speaker 2 (09:34):
But again, not a cure in itself.
Speaker 3 (09:36):
Absolutely not.
Diet alone isn't a cure, butpersonalized dietary strategies
can be a powerful supportalongside medical treatments.
They can really improve qualityof life for some.
Speaker 2 (09:46):
And that's where this growing interest in low-carb,
even very low-carb orcarnivore-style diets comes from
.
Speaker 3 (09:52):
Exactly Because of those potential mechanisms, we
talked about reducingfermentable load, insulin spikes
, processed food intake.
Speaker 2 (09:59):
Now the source mentions patient reports and
case studies.
What did they find?
Speaker 3 (10:03):
This is where it gets quite compelling, though we
need caution.
The Frontiers reference citedmentions reports of UC patients
achieving symptom-free periodsOkay, and even descriptions of
long-term remission afteradopting very low-carb or
carnivore-style diets.
Speaker 2 (10:19):
Wow, that sounds significant.
Speaker 3 (10:22):
It does, and the proposed mechanisms are what
we've discussed Less fuel fordysbiosis, lower insulin spikes.
Avoiding gut irritants inprocessed foods.
Speaker 2 (10:31):
But and this feels like a big but is coming.
Speaker 3 (10:34):
It is.
Here's the critical point.
The source stresses this isearly evidence Promising yes.
Speaker 2 (10:39):
But not definitive proof.
Speaker 3 (10:41):
Exactly.
Most data come from small scalereports rather than large
controlled clinical trials.
We're talking observations,anecdotes, case studies,
powerful for individuals, butnot yet robust clinical evidence
for everyone.
Speaker 2 (10:54):
So it might work wonders for one person, but we
don't have the big studies yetto say it works broadly.
Speaker 3 (11:00):
Precisely.
And this leads to another keyquestion why might symptoms
improve?
Maybe dramatically, but it'sstill not considered a cure.
Speaker 2 (11:08):
Because UC is fundamentally an immune
condition.
Speaker 3 (11:11):
Exactly, it's a chronic immune-mediated
condition.
Removing a dietary trigger, sayspecific carbs, can absolutely
quiet down the inflammation andget symptoms under control.
Speaker 2 (11:22):
Which feels like remission.
Speaker 3 (11:24):
It feels like it and it might be symptomatic
remission, but the source warnsthe underlying immune activity
can still persist, even whensymptoms improve.
Speaker 2 (11:34):
Ah, so you could feel great, but the immune system
might still be subtly attackingthe colon lining.
Speaker 3 (11:40):
Potentially, yes.
The fire might be damped down,but the embers could still be
glowing.
Speaker 2 (11:44):
This is so important.
It's not just about how youfeel, absolutely not.
It's about just about how youfeel.
Speaker 3 (11:47):
Absolutely not.
It's about what's actuallyhappening physiologically.
Speaker 2 (11:50):
And that's why tracking biomarkers is critical.
Speaker 3 (11:53):
Yes, biomarkers give you an objective look inside
Things like fecal calprotectin.
Speaker 2 (11:57):
What's that measure?
Speaker 3 (11:58):
It directly measures inflammation in the gut.
High levels mean activeinflammation or CRPC, reactive
protein which is a more generalmarker of inflammation in the
body.
Tracking these helps confirm ifthe remission you're
experiencing is just symptomaticyou feel better or if it's
biochemical or even endoscopicremission, meaning the actual
(12:19):
inflammation markers or the viewduring a colonoscopy show
improvement.
Speaker 2 (12:23):
Feeling better versus being better internally Not
always the same thing.
Speaker 3 (12:27):
A crucial distinction in managing chronic illness.
Speaker 2 (12:30):
So when might these low-carb approaches be most
helpful?
According to the source, whomight benefit most?
Speaker 3 (12:37):
The source suggests a few scenarios Patients whose
flares seem clearly linked toeating high sugar or
ultra-processed foods.
Speaker 2 (12:44):
Okay, a direct trigger identified.
Speaker 3 (12:46):
Yes, or individuals who also have coexisting issues
like insulin resistance,metabolic syndrome or just
general trouble managing bloodsugar.
The diet might help on multiplefronts there.
Speaker 2 (12:57):
Right, tackling both issues.
Speaker 3 (12:58):
And also cases where specific types of carbs, like
high FODM meat foods or otherfermentable carbohydrates,
clearly worsen symptoms likebloating, diarrhea and cramping.
Speaker 2 (13:09):
So it's about matching the dietary strategy to
the individual's specificprofile and triggers.
Speaker 3 (13:14):
Personalization is key.
It's definitely not aone-size-fits-all approach.
Speaker 2 (13:18):
Which brings us to safety, because drastically
cutting carbs isn't withoutpotential downsides, is it?
The source includes safety andmonitoring considerations.
Speaker 3 (13:27):
Very important ones.
Low carb is not for everyone,especially extreme versions.
Speaker 2 (13:33):
Why not?
Speaker 3 (13:33):
Well remember those nutrient deficiencies common in
UC Iron, folate, vitamin D, b12.
Speaker 2 (13:40):
Yes.
Speaker 3 (13:41):
Severely restricting food groups could potentially
make those worse if you're notcareful about nutrient density.
Speaker 2 (13:45):
Okay, need to be mindful of getting enough key
nutrients.
Speaker 3 (13:48):
Absolutely.
Also, some very restrictiveapproaches, like some
carnivore-style diets, mightsignificantly reduce dietary
fiber and plant diversity.
Speaker 2 (13:57):
Which could impact the microbiome long-term.
That's a concern.
Speaker 3 (14:00):
yes, we know fiber diversity is generally good for
long-term microbiome health, sooverly restricting might have
unintended consequences down theroad.
Speaker 2 (14:09):
So careful planning and monitoring are essential if
you try this.
Speaker 3 (14:12):
Paramount, which loops back to objective testing.
Speaker 2 (14:14):
Right.
The source recommends trackingspecific markers before starting
and during a low-carb trial.
Speaker 3 (14:20):
Yes, you absolutely want to track inflammation,
fecal calprotectin and CRP.
Speaker 2 (14:27):
To see if the diet is actually calming the fire
Exactly.
Speaker 3 (14:30):
Then nutritional status vitamin D, b12, iron
panels, maybe folate.
Speaker 2 (14:35):
To make sure you're not becoming deficient.
Speaker 3 (14:37):
Correct and metabolic markers.
Fasting insulin, hba1c, maybe alipid panel?
Speaker 2 (14:44):
To monitor blood sugar control and metabolic
health.
Speaker 3 (14:46):
Precisely this data gives you and your doctor the
full picture.
Speaker 2 (14:50):
And this is where services that make testing
easier come into play.
Speaker 3 (14:53):
Absolutely.
The source highlights howservices like QuickLab Mobile
Miami, for example, can makethis kind of personalized
management easier by offeringconvenient, maybe even at home,
testing for these exact markers.
Speaker 2 (15:05):
Takes away some of the hassle of getting labs done
constantly.
Speaker 3 (15:08):
It can.
Yeah, they mention specificpanels covering these key areas
Inflammatory markers, crp, fecalcalprotectin, nutrient status,
iron, b12, folate, vit-d andmetabolic panels.
Insulin, hba1c lipids.
Speaker 2 (15:21):
So you get that objective data alongside how
you're feeling.
Speaker 3 (15:24):
Exactly, by combining your symptom tracking how you
feel with objective lab testing,what the data says you and your
health care provider can maketruly informed decisions.
Speaker 2 (15:34):
Is this low-carb approach genuinely improving the
underlying inflammation, or isit just masking symptoms?
Speaker 3 (15:41):
That's the million-dollar question.
It helps answer.
It allows you to manage yourhealth based on facts, not just
guesswork.
It's empowering.
Speaker 2 (15:47):
OK, so wrapping this deep dive up.
Yeah, it's clear, ulcerativecolitis is well incredibly
complex.
It's chronic.
It demands a reallypersonalized approach.
Speaker 3 (15:57):
No doubt about it.
Speaker 2 (15:58):
And while medications are and remain the foundation
of treatment.
Speaker 3 (16:02):
Absolutely.
Speaker 2 (16:03):
Nutrition and lifestyle strategies, including
maybe these low-carb or verylow-carb approaches for some,
might offer significant symptomrelief.
Speaker 3 (16:11):
And potentially improve quality of life.
Yes, for some patients.
Speaker 2 (16:15):
So what are the main takeaways for you, our listener?
Speaker 3 (16:17):
I think the key things are diet isn't a cure-all
, but removing or reducingcertain dietary triggers,
especially refined carbs andultra-processed foods, can help
calm inflammation and reduceflare frequency for many.
Speaker 2 (16:31):
But it's not guaranteed for everyone.
Speaker 3 (16:33):
No Responses vary hugely person to person.
What works wonders for onemight do nothing or even worsen
things for another.
Personalization is crucial.
Speaker 2 (16:43):
And maybe the biggest takeaway, objective monitoring
with lab testing is essential.
Speaker 3 (16:47):
Absolutely essential.
It's how you truly know ifsymptom improvements match up
with actual improvements ininflammation and nutrient levels
.
Speaker 2 (16:54):
It allows for informed choices, safe
adjustments, avoids flying blind.
Speaker 3 (16:59):
Right the source really hammers home the power of
combining that subjectivefeeling.
How am I doing with theobjective lab data?
What's really going on inside?
Speaker 2 (17:08):
Taking control based on facts.
Speaker 3 (17:10):
That's the goal managing your gut health
proactively and intelligently.
Speaker 2 (17:13):
So, as you reflect on this deep dive, here's
something to think about.
A provocative thought perhaps.
In this age where we haveaccess to so much information,
personalized medicine is growing.
If something as basic as yourdiet can significantly influence
a complex immune condition likeyou see what other areas of
your health might benefit fromlooking at objective data
(17:34):
combined with your ownexperience and being willing to
explore those individualizedstrategies.
Speaker 3 (17:39):
A powerful question to ponder.
It really opens uppossibilities for proactive
health management beyond justthis one condition.
Speaker 1 (17:52):
Thanks for tuning into the Health Pulse.
If you found this episodehelpful, don't forget to
subscribe and share it withsomeone who might benefit.
For more health insights anddiagnostics, visit us online at
wwwquicklabmobilecom.
Stay informed, stay healthy andwe'll catch you in the next
episode.
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