In this episode, we dive headfirst into the wild world of DIY genetic engineering, where mail-order CRISPR kits promise to put the power of DNA editing into the hands of literally anyone with an internet connection. Jimmy breaks down what CRISPR actually is (spoiler: it’s not a fancy air fryer), how scientists discovered it by stealing from bacteria, and why it’s both one of the greatest breakthroughs in modern science and a potential recipe for disaster when left in the hands of overconfident biohackers. From curing genetic diseases and revolutionizing food production to some guy in his garage trying to give himself superpowers, CRISPR is already reshaping the world in ways that range from incredible to mildly terrifying.
But with great power comes great responsibility—or at least, it should. As CRISPR continues to advance, ethical questions loom large: Should we edit out genetic diseases? What about designing the “perfect” baby? And who exactly should be allowed to tinker with the fundamental code of life? Jimmy unpacks the real-world stakes of gene editing, the potential for both breakthroughs and disasters, and most importantly—why just because you can order a CRISPR kit online doesn’t mean you should.
Stuff You Should Know
If you've ever wanted to know about champagne, satanism, the Stonewall Uprising, chaos theory, LSD, El Nino, true crime and Rosa Parks, then look no further. Josh and Chuck have you covered.
Cardiac Cowboys
The heart was always off-limits to surgeons. Cutting into it spelled instant death for the patient. That is, until a ragtag group of doctors scattered across the Midwest and Texas decided to throw out the rule book. Working in makeshift laboratories and home garages, using medical devices made from scavenged machine parts and beer tubes, these men and women invented the field of open heart surgery. Odds are, someone you know is alive because of them. So why has history left them behind? Presented by Chris Pine, CARDIAC COWBOYS tells the gripping true story behind the birth of heart surgery, and the young, Greatest Generation doctors who made it happen. For years, they competed and feuded, racing to be the first, the best, and the most prolific. Some appeared on the cover of Time Magazine, operated on kings and advised presidents. Others ended up disgraced, penniless, and convicted of felonies. Together, they ignited a revolution in medicine, and changed the world.
The Joe Rogan Experience
The official podcast of comedian Joe Rogan.