The Myeloma Minutes

This episode introduces Talquetamab - a newly approved bispecific antibody for relapsed myeloma - explaining how it works, who it’s for, and what side effects patients should expect and prepare for.

📌Key Takeaways:

• Talquetamab is a brand-new treatment targeting GPRC5D - offering another effective option after several previous therapies.
• Early side effects like fever, blood pressure changes or confusion are monitored closely a...

Sean Molloy, renown spinal surgeon at the Royal National Orthopaedic Hospital (RNOH) NHS Trust in Stanmore explains how tailored bracing, breakthrough bone healing in myeloma, physiotherapy and minimally invasive vertebroplasty can transform pain, mobility and long-term spinal stability.

📌Key Takeaways:

• A brace can act like “nature’s own surgery”, guiding powerful myeloma-driven bone regrowth to prevent long-term spinal col...

Dr Jam & Sally unpack what neuropathy is, why it happens in myeloma treatment, and how patients can recognise, prevent and manage it to protect their quality of life.

📌Key Takeaways:

• Know the signs early – tingling, numbness or pain shouldn’t be ignored; speak up before symptoms worsen.
• Treatment can be adjusted – modern dosing and combinations make neuropathy less common and more manageable.
• You don’t have to live with i...

Dr Jam & Sally unpack what remission, relapse and refractory disease truly mean for people living with myeloma — and explore how close we are to talking about cure.

📌Key Takeaways:

• Remission ≠ cure – myeloma can be controlled for years, even if it never fully disappears.
• Monitoring matters – blood tests, bone marrow checks and scans together tell the full story.
• Hope is growing – deeper remissions and new tests mean “fu...

This episode unpacks the complex world of myeloma genetics - what high and standard risk really mean, how these tests guide treatment, and how future advances could lead to truly personalised care with Sarah Gooding.

Sarah is a colleague, and an Honorary Consultant Haematologist, based in Oxford.

📌Key Takeaways:

• Your myeloma is unique - genetic tests help doctors understand how it may behave and respond to treatment.
• High-r...

This episode features Dr Sophie Castell, CEO of Myeloma UK, sharing insights into the charity’s vital work in research, advocacy, patient support, and tackling inequalities in myeloma care.

📌Key Takeaways:

• Survival rates for myeloma have quadrupled — and living well is now as important as living longer.

• Myeloma UK drives progress from early diagnosis to survivorship, always keeping patients’ voices central.

• The new “Kno...

Welcome to The Myeloma Minutes.  We've now moved to a fortnightly release schedule, so you can now hear us every-other Thursday.

This episode explains the newly approved four-drug treatment (Isatuximab, Velcade, Lenalidomide and Dexamethasone) for older people with myeloma who are not eligible for a stem cell transplant.

📌Key Takeaways:

• This four-drug ‘quadruplet’ can keep myeloma under control for many years — even in older ...

Welcome to The Myeloma Minutes.  We've now moved to a fortnightly release schedule, so you can now hear us every-other Thursday.

This episode explores bispecific antibodies — how they work, the benefits they bring, and the key side effects patients and carers need to know about.

📌Key Takeaways:

• Bispecific antibodies ‘wake up’ your immune system to fight myeloma — and response rates are higher than ever before.
• Early side effe...

Welcome to The Myeloma Minutes.  We've now moved to a fortnightly release schedule, so you can now hear us every-other Thursday.

Specialist nurse Alex Scott walks patients and carers through every step of the autologous stem cell transplant process, from preparation to recovery, with clarity, compassion, and practical advice.

📌Key Takeaways:

• It’s not just medical – emotional and practical support is essential to navigating a ...

Welcome to The Myeloma Minutes.  We've now moved to a fortnightly release schedule, so you can now hear us every-other Thursday.

This episode explores what happens after a stem cell transplant in multiple myeloma, focusing on consolidation and maintenance treatments - especially the use of lenalidomide - and how these therapies aim to sustain remission and quality of life.

📌Key Takeaways:

• Maintenance therapy isn't just more t...

Welcome to The Myeloma Minutes.  We've now moved to a fortnightly release schedule, so you can now hear us every-other Thursday.

This episode walks you through every stage of an autologous stem cell transplant for myeloma - from preparation and chemotherapy to recovery and going home.

📌Key Takeaways:

• You’ll get high-dose chemotherapy (melphalan) followed by your own stem cells - not someone else’s.
• Expect a tough week of diar...

Welcome to The Myeloma Minutes.  We've now moved to a fortnightly release schedule, so you can now hear us every-other Thursday. 

During this episode, Jam & Sally give an in-depth, patient-friendly guide to stem cell mobilisation - the essential step before undergoing an autologous stem cell transplant for multiple myeloma.

📌Key Takeaways:

• Stem cells are collected from your blood - not your bone marrow - thanks to cleve...

Welcome to The Myeloma Minutes.  

During this episode, Jam & Sally talk about a ground-breaking new combination therapy for multiple myeloma available on the NHS from this week.  They highlight how it works, who it’s for, and what patients need to know.

📌Key Takeaways:

• A new 'Trojan horse' drug is now approved on the NHS for first relapse myeloma.

• Treatment is effective, flexible — and may only be needed every few mon...

Welcome to The Myeloma Minutes.  

This episode explores the standard treatment for older or transplant-ineligible patients with myeloma, focusing on the DRD regimen, its side effects, and supportive care options.

📌Key points:

• The DRD combo (Daratumumab, Lenalidomide, Dexamethasone) can keep myeloma controlled for years—even in older patients.

• Steroids are powerful but often reduced or stopped early to improve quality of l...

Welcome to The Myeloma Minutes.  

This episode guides you as a patient or carer through induction therapy for myeloma, focusing on the DVTD regimen, its side effects, supportive treatments, and how to manage them.

💡You'll learn:

• How four powerful drugs work together to fight myeloma — and why you don’t need to suffer through side effects.

• That neuropathy is reasonably common, but catching it early can prevent long-term da...

Welcome to The Myeloma Minutes.  

During this episode, Drs Jam and Sally provide a clear and compassionate guide to first-line treatment for multiple myeloma. 

💡You'll learn:

• About 'induction', 'consolidation' and 'maintenance'—and why they matter.
• Why pathways can often be dictated by age/health.
• ...And that the aim isn’t just survival—it’s living well with myeloma.

This podcast is for informational purposes only ...

Welcome to The Myeloma Minutes.  

This episode explores how bone disease affects people with multiple myeloma and how bisphosphonates like zolendronic acid can help manage pain, prevent fractures, and support treatment.

📌 Three Big Takeaways

• Bone disease isn’t inevitable in myeloma—but needs fast action when it strikes!

• Zolendronic acid can protect your bones and support myeloma treatment—learn how and when it’s used.

• C...

Welcome to The Myeloma Minutes.  

Dr Shaheel Bhuva, a radiologist (and long term colleague of Jam)  joins Drs Jam and Sally to demystify scans in myeloma—explaining what they show, when they're used, and he'll dispel some myths around harmful amounts of radiation! 

3 Key Teakaways:

• Not all bone damage shows up on X-rays—some scans reveal disease before symptoms begin.
• MRI and PET-CT scans can detect myeloma earlier and help ...

Welcome to The Myeloma Minutes.  

During this episode Jam and Sally deep dive into Smouldering Myeloma—explaining what it is, how it’s monitored, the emotional toll of uncertainty, and what patients and carers can expect from evolving research and care approaches.  Conversation points include: 

• Smouldering myeloma is a precancerous condition and it needs careful monitoring to catch changes early.

• Understanding your risk lev...