Prions Pt 1: Scrapie & FFI

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Hello Poison Friends! Welcome to our talk on prions and prion diseases. I feel I cannot do this topic justice by just telling you about the terrifying and thankfully rare diseases caused by infectious proteins. So we are going to talk about what a prion is, how humans discovered them, and how scientists and medical professionals identified what they were (relatively recently in fact).

This episode specifically deals with Scrapie, a prion disease found in sheep and Familial Fatal Insomnia, a hereditary disease found in humans (though, it may be sporadic in even rarer cases). Both of this fatal illnesses have been around at least a few centuries by now, but were often so rare they were not thought much of or misdiagnosed and forgotten about. Forgotten about until humans got greedy for more and better sheep in the case of Scrapie; for humans, until descendants of "cursed" families began to see familiar and terrifying symptoms popping up all around them, possibly for their own future as well. Imagine an illness that stops you from sleeping until you die. It slowly ravages your body, your mind, and leaves those around you either afraid or distant as they shun you entirely.

Let us discuss prions, where they come from, the diseases they cause, and how they cause them. Sweet Dreams, Poison Friends.

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