June 10, 2025 • 31 mins
Are we approaching fasting all wrong? In this fascinating conversation with Dr. Joseph Antoun, MD-PhD and CEO of L-Nutra, we dive deep into the science of cellular rejuvenation through fasting-mimicking diets—a revolutionary approach backed by research from 18 universities including Harvard, Stanford, and Mayo Clinic.
Dr. Antoun challenges conventional wisdom about intermittent fasting, explaining why skipping breakfast might actually work against longevity goals. Instead, he advocates for "front-loading" your fasting period—finishing dinner by 7pm and eating breakfast the next morning—to align with your body's natural hormonal rhythms and metabolic needs.
The true magic happens when we explore ProLon, L-Nutra's pioneering 5-day fasting-mimicking food program. Unlike traditional fasting, this scientifically formulated nutrition plan keeps you eating while your body enters a deep fasting state, triggering cellular "autophagy"—the Nobel Prize-winning self-cleaning and rejuvenation process that starts around day three. Research published in Nature shows three cycles can reverse biological age by 2.5 years.
Perhaps most groundbreaking is the application for chronic disease management through the new L-Nutra Health platform. Clinical trials demonstrate two-thirds of diabetes patients reduced medication within six months of following their protocol—just five days monthly of specialized nutrition with physician and dietician support. Health economic studies show insurers break even in just ten months, creating a rare alignment between patient outcomes and financial incentives.
Whether you're seeking longevity, weight management, or a science-based approach to metabolic health, this conversation illuminates how precisely formulated nutrition can activate your body's innate healing mechanisms—potentially changing your relationship with food, fasting, and cellular aging.
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Transcript
Episode Transcript
Available transcripts are automatically generated. Complete accuracy is not guaranteed.
Justin Politti (00:02):
Welcome to the Reverse Mullet Healthcare
Podcast by BP2 Health.
We are here at ACLM Conferencein Orlando 2024.
I'm Justin Politti.
I'm Dave Pavlik.
Ellen Brown (00:12):
I'm Ellen Brown and I know it's hard for those of
you watching live or therecorded video version that
Justin's hard to recognizebecause he has sunglasses and
the mullet wig on.
So if you didn't recognizeJustin, it's the real Justin,
the real deal.
Yeah, but we're here with aspecial guest, so tell us about
yourself.
Joseph Antoun (00:29):
Hey everyone, this is Dr Joseph Antoun.
Thanks for having me here today.
Yeah, thanks for being here.
Hopefully we're going to changesomebody's life.
I always wish that in mypodcast.
Ellen Brown (00:38):
So I'm super pumped that you're here.
See, dave and Justin don't evenknow I'm always pulling stuff
out, but in my journey oflearning really deeply about
health at a different level,walter Longo's work was very
instrumental.
It was like the Zach Bush onthe soil side and Walter on the
longevity side and it was likethis whole sort of trifecta
(01:02):
ritual with all of his podcastguests.
Justin Politti (01:04):
There's a lot of inside baseball going on on
that side of the table.
Yeah, it's my job.
Ellen Brown (01:08):
But and so a number of fact.
I will take a picture and I'llsend it to my girlfriend.
So a number of my friends haveutilized Prolon and I want to
hear about your new producttoday but have used Prolon for
health reasons, not to try tolose weight, but truly for
cellular restoration andautophagy and all the things
(01:30):
that Prolon does, and so I feellike I have like a legend in
here talking to you live at theLifestyle Medicine Conference.
Joseph Antoun (01:39):
I feel useless because you know it better than
I do.
Ellen Brown (01:41):
No, no, no, no, no.
I, I just, wanted to share thatbecause I think sometimes when
somebody comes on the podcastand talks about a product or an
intervention, sometimesimmediately people are like, oh,
it's something somebody'strying to tell me.
But you guys really are apioneer in a different type of
intervention than most.
Joseph Antoun (02:02):
Thank you very much, and I did promise we're
going to change somebody's lifeand we will.
Through this next 20 minuteswe're going to talk about this
Quick introduction.
My name is Joseph Anton.
I'm an MD-PhD.
I wanted to cure patients.
This is why I went to med schooland then I discovered like most
of you probably learned at somepoint, that we're taught to
(02:22):
give a lot of pills.
First we practice sick care,because we meet people after
they're sick, not before, andthen we give them a bunch of
four or five pills.
And I used to tease my attendee.
I would say, hey, what is theexpiry date of the prescription?
I used to tease them at thehospital.
There's no expiry.
They have to refill it everymonth.
They say, yeah, for the rest oftheir lives.
Yes, refill it every month.
(02:42):
They say, yeah, For the rest oftheir lives.
Yes, and maybe we're going toadd to this right.
And so I rebelled against thatsystem.
I went into first.
I thought I'll do prevention.
So I did health policy andpublic health and figured out
that most people know already.
Prevention they should eathealthy exercise.
There was no new news.
As we say, and you're alwayscompeting with the product,
(03:03):
right, Should I go to the gym orshould I sit in front of
Netflix?
Should I eat a plant-based or?
This burger looks good, right.
Justin Politti (03:11):
Choices.
Joseph Antoun (03:16):
It's choices, but the product is the bad product
and it's against choices.
And I was like, why don't wecome up with a product that is
healthy, that is preventative,that is going to help people and
compete product to product?
And so I looked for what peopledo every day and it's food Eat
every day of your life three tofive times.
And we decided to turn food asan asset of longevity, because
we know people will comply.
(03:36):
They eat food every day, theday they're born to the day they
die.
It's unfortunate that thistrillion, multi-trillion dollar
industry is governed bymarketing and by theories and
not true science.
So we gathered a team ofscientists.
Our founder you mentioned hisname, Dr Walter Longo is
probably the leading expert inlongevity around the world.
We gathered 18 universitiesbehind us Harvard, USC, Stanford
(04:02):
, Mayo Clinic and we starteddoing developing food
formulations as we develop drugs, mice trials and then human
trials in order to prove what wehave that is going to bring.
Food is longevity and food ismedicine.
So, after 23 years of research,we have developed two platforms
of nutrition technologies.
These technologies areessential for longevity or for
(04:25):
for medicine.
In the main one and youmentioned the main pro one our
main discovery is what we call afasting, mimicking nutrition, a
five-day food that we give toyou it's a very precise
formulation that we ship it toyour house.
You open the box there's fivedays of food and you eat it over
five days.
Your body doesn't know you'reeating, so it's called a fasting
(04:46):
, mimicking nutrition.
Ellen Brown (04:47):
Oh, but you do know it when you do it.
Yes, you do feel it I will gettexts from somebody and go.
Joseph Antoun (04:52):
I'm on day three of Prolong.
Yes, you're going to feel itand the concept is when the body
thinks you're not eating, ofcourse you're losing a lot of
weight, which a lot of peoplelove, but that's not the main
concept.
The main concept is the body onthe first two days has a lot of
reserve fat and glycogen.
You consume those, right.
It's like if you run a company,you don't have funding.
(05:12):
You go to your bank and you useyour savings and check in a car
when you consume your bankaccount.
So you're on day three offasting and you're in a crisis.
Say, you have a company and youspend your money.
You're in a crisis mode.
You go and you restructure thecompany.
You start fixing.
It's like, okay, I'm not doingwell because my sales department
, my marketing department, mysupply chain.
(05:33):
So the buddy on day three tellsthe cells we're in a crisis,
you got to fix yourself.
Every cell goes through thisprocess called cellular
rejuvenation.
In science we call it autophagy, self-eat, self-rejuvenate, and
it won the Nobel Prize inMedicine in 2016.
It's a big big thing.
Now.
It's just we know autophagy,what it does to the body, which
(05:53):
is reverse, the bio-age, but wenever had a product.
So that process of autophagy,which again won that Nobel Prize
in Medicine in 2016, is pushingevery cell of the body to clean
, detox, fix the inside,rejuvenate and again, I always
compare it to a company tryingto restructure.
Whatever is going wrong, we tryto fix it and for the first
(06:14):
time now we, as humans, we havea technology in nutrition called
Prolon or the fasting mimickingdiet.
This is the core technologythat we sell to help you eat
three to five days and benefitsfrom the cell rejuvenation, so
you can.
Why we want to help you eatthree to five days in benefits
from the standard ofrejuvenation, so you can.
Why we want to rejuvenate cells.
The goal is to really, a littlebit, take your biological age
backwards.
We want you and I always usethis expression, we want you to
(06:36):
be younger than your age.
Why is that so?
90% of us will die out of fourhealth conditions that all
age-related diabetes, type 2,alzheimer's, cardiovascular and
cancer.
Right, you're not going to getAlzheimer's at age 20, you're
going to get first heart attackat age 30, et cetera, et cetera.
So the goal is to keep yourcells younger than your coach.
And that's true prevention,because we're giving you,
(06:59):
hopefully, extra the chance.
We cannot promise people aregoing to get longer, but we're
giving them best chances fortheir cells to stay younger than
their age and a little bit awayfrom the onset of chronic
conditions.
So that ProLon for promotinglongevity is a consumer product.
You buy it, you do it threetimes per year.
You only need to do it threetimes per year.
It's five days, three times peryear.
You're only doing 15 times 15days per year.
(07:20):
Anyone can do it 365 days.
We priced it exactly as theprice of food for five days, so
at $175,.
The average American food,beverage and supplement spends
around that number within fivedays.
So it's a cost neutral.
I really emphasize this becausepeople should do ProLon three
times per year.
I haven't seen any product thatcan reduce the cells, help you
lose the weight and help a lotof people.
(07:41):
So that's the concept forlongevity.
The sales help you lose theweight and help a lot of people.
So that's the concept forlongevity.
The second concept samefascinating technology.
We said okay, wait a second.
So you're running a company.
You're now have no revenues, nofunds.
You're going to restructure,you're going to fix If you know
that I don't have revenuesbecause my sales team is not
doing a great job.
You start fixing there, right,right.
(08:02):
So what we learned is that ifyou have diabetes, for example,
if you have cancer, if you haveall that, the body is saying
okay, I know what's going wrong,let me try to fix.
And we started with diabetes.
We've done a lot of trials ondiabetes and what we're saying
is that patients taking thefasting-mimicking diet within
six months so this is just fivedays a month, every month
(08:22):
because you have a healthcondition, you do it every month
, once a month.
Within six months, two thirdsof them are dropping one pill.
Ellen Brown (08:30):
And it's ketosis Like.
When you were talking aboutthis, I was like right, bingo,
ketosis, right.
One of the most effectiveinsulin resistant reversal tools
is ketosis, which Proline doesa beautiful job of putting you
into ketosis.
I mean it's far more than that.
You're like please stop.
Justin Politti (08:44):
But what's the benefit for somebody not like me
and I'm not on the inside, butI've done intermittent fasting.
What's the difference?
In wide intervals?
How is this better than doingit without consuming Prolon?
Joseph Antoun (08:56):
Two fantastic questions.
Quickly answer the ketosis.
The ketosis is the metaboliclow-carb stage, but again
there's a cellular rejuvenation.
Yes, so diabetes has three rootcauses and I love when you and
I were chatting before you saidroot cause right why medicines
fail in diabetes or why evenketogenic diet In the long term
they do fail in diabetes.
Yep, because they all treat oneroot cause, which is insulin
(09:17):
resistance High carb, high fat,insulin resistance.
But diabetes has two other rootcauses.
The second one is muscle lossright, because if you maintain
high muscle, you're burning thecarbs.
Number three is very importantis aging.
We, the four of us, maybe wehad the same actually, maybe
we're eating bigger volumes offood 15 years ago and we're
skinnier, right?
So aging is behind.
(09:39):
If you eat bad at age 27, youburn it.
If you eat bad at age 27, right?
Ellen Brown (09:43):
you burn it.
Yeah, it's bad at age 55.
There's a lot more grease inyour 20s, so yes, remember blood
sugar, insulin resistance andand fat this.
Joseph Antoun (09:55):
Yes, drugs do that, glp1 do that, ketosis do
that.
But but they're not enough ismuscle.
Keep the muscle high to burnthe carbs and age it.
And this is why thefasting-inducing diet is hidden
all through your conscience.
Rejuvenate the age of the cells.
You're biologically younger.
You're not 27 chronologically,but you're close to it
biologically.
Your cells can burn, yourmuscle is active and muscle
(10:16):
protection, your muscle protectswith the fasting.
Ellen Brown (10:18):
Yeah, absolutely.
So that's the big.
So now Justin's question abouthow this is different than just
doing intermittent fasting.
Joseph Antoun (10:25):
So, justin, when you do intermittent fasting, say
you're skipping breakfast anddelaying a little bit too much.
I don't know if you do the16-hour or the 18-hour 24-hour.
It has to be 23 and a half,because you're eating.
Ellen Brown (10:36):
That's a true fast 24, yep what?
Justin Politti (10:38):
you're doing is called OMAD.
Joseph Antoun (10:41):
Omad, the one meal a day, yep, what you're
doing, yep, which is very badfor longevity.
There you go and I'll tell youwhy.
And I'll tell you why.
We studied the first 13 yearsbefore we developed the fasting.
We were a water fasting, so westudied the entire fasting
science.
It's coming from Walter Longo.
It is.
(11:06):
We started as Waterfast, so wewere a proponent and then, when
it failed at some certain point,we developed the nutrition.
It's actually the NationalInstitute of Health that gave us
funds to develop a fastingcommunity.
It wasn't either a businessproject or anything.
We were studying fasting.
So I'll tell you a little bitabout the trick.
So when you wake up in themorning is when you're thinking.
Your brain needs the mostcalories because you're thinking
, you're going to work, you'rewalking, you're exercising, if
(11:28):
you go to the gym, etc.
This is the need to havecalories and with intermittent
fasting, you're starving thebody when the need is there.
That's why in the afternoon youstart feeling weak a little bit
or dizzy, but you're starvingthe body when it doesn't eat.
Then you go and you eat.
Evening time when you go backfrom work, right, and evening
time when you eat you're goingafter that to sleep, right, and
(11:48):
when you sleep is is the leastneed for calories.
So what the body says is likeokay, I just got a bunch of
calories, her brain isstruggling, the kidneys are, so
the essential organs have beenstruggling for 14 hours and now
I got a calories.
Let me talk about right, theit's.
It's the concept of bingeeating.
And then I I will start, I'msleeping, I'm not burning that.
So when you eat a lot in theevening time, say at four, five,
(12:10):
six, seven, your insulin spikesand your igf spikes, so these
are anabolic there, and when yousleep you're anabolic, meaning
you retain what you eat soyou're giving the calories when
the body is in storage mode,rather than the body is in the
catabolic and it's spending.
So what happens?
You do it Now.
If you're starting by beingvery obese or carrying
overweight, you have high bloodsugar.
(12:31):
It helps some people becauseit's still starving.
It's starving what you don'twant to starve, which is the
essential organ, and it'sfeeding fat.
But still it's better thaneating bad all day.
Ellen Brown (12:42):
Right or eating too much.
Joseph Antoun (12:43):
Overall, yeah, some people say I do OMAD, I do
16 hours.
It helped me.
Of course it's going to helpyou, because if you're
overweight or if you had a verybad diet, it will help.
But what I'm trying to say isyou got to do it in transition
and then you got to move to abetter state.
Better state is eat in themorning, eat a light dinner,
sleep on a little bit emptystomach At night.
You're not storing the excessfat and when you wake up in the
morning you're catabolic.
(13:04):
You're spending Whatever youeat.
You spend your little.
When you sleep, the hormones ofstorage are up, so you're doing
12 to 14 hours of fasting, butthey actually start.
We call it front-ended.
They start at 7 pm, don't eatafter 7, and then eat the next
day at 9.
You did 14 hours, but you didit exactly when the body doesn't
need the food and is trying tostore.
On an empty stomach doesn'tstore and the next day, whatever
(13:25):
you eat, you spend it.
That's the better way of doingthe intermittent fasting.
Ellen Brown (13:28):
So tell us.
I have two questions.
So one, the fast mimicking diet, the FMD.
I want to talk a little bitmore about the science of that
versus intermittent fastingright, and I know you're hitting
on that.
But this idea, because to me,the reality, so like when you do
Prolon, because I don't thinkyou guys have done it before you
know well you talk about I'mnot going to steal the thunder,
but you'll explain the product,but it's.
It is very much like you'regetting little bursts of food
(13:51):
throughout the day and they'revery specific in their dietary,
you know contents to again putyour body into a certain state
of ketosis, but also to thatcellular, you know, to autophagy
, right.
But what I was going to ask istell us to this new diabetic
intervention that you all havecreated and launching, which is,
I think, l-neutral health right.
Because I think everybody knowsL-neutral for Prolon.
(14:12):
But now you've got L-neutralhealth and I'm also wondering
I'm going to see if I how manyquestions you can remember at
once is does that allow you togo from being just a consumer
product to be a B2C throughmedical prescriptions?
Right now, all of a sudden, youcan help people from an access,
because right now, if you don'thave the cash to pay $175 for
Prolon, you don't get it.
(14:32):
So does this also put you allin a position where now, if
you're getting a prescriptionfor food, you can actually seek
the L-Nutra Health version?
All that and you had a question.
Justin Politti (14:41):
Well, so I did the Peter Atiyah fasting app for
a long time.
I don't do it, yeah, zero.
I don't do it anymore and Ihave a broader eating window now
than I did when I first started.
So I've modified.
But my question was on that app, you can't get into ketosis at
14 hours, like you've got to gomuch longer.
Ellen Brown (14:59):
Right, which is why it's five days.
Justin Politti (15:00):
Yeah, like you've got to go much longer,
right which?
Ellen Brown (15:01):
is why it's five days.
Yeah well, so I guess are you?
Justin Politti (15:02):
how does that work?
Like getting into ketosis inthe eating period of time that
the window that you have andpeter left the app and it
actually changed his mind.
Joseph Antoun (15:09):
I don't know, yeah, that's a whole interesting
story this is where we go,because he read our science
right this is where we go backis is we've had enough of books
and theories, just read thescience, and the science is
clear, and so I'm going to closethe intermittent fasting
question, to close that chatterand go back to diabetes.
So it's not to get to anyketosis, because you both are
hitting on ketosis.
There's a shallow ketosis thatmost people get into when you do
(15:32):
intermittent fasting, when youdo a ketogenic diet right.
But it's a shallow ketosis,right.
Fasting is a deep ketosis andwhat you need you need to go
deep to help the cellsrejuvenate exactly so the
biggest difference between toanswer your questions is, if you
skip a meal, you're not goingto rejuvenate the cells you're
going to just say okay, let's goback to the company example,
(15:53):
like okay, you know I need amillion dollar to operate my
company.
I need 2,000 calories to operatein my body.
You give me the check, fourhours late I have some checking
as I come.
So you're saying, okay, I have alittle bit of fat, you can have
a lot of it, but you lose alittle bit of glycogen, you're
done, you don't need to go, youdon't get into crisis.
So the big difference between afive-day prolonged fasting
(16:15):
versus the intermittent fastingis the crisis Got you.
Prolongon induces a deep fastand a crisis so that the cells
rejuvenate and heal andhopefully give you a very good
path to longevity.
Intermittent fasting helps you,on a shorter, on a shorter, to
lose some weight, balance yourmetabolism.
But then you got to do it right.
(16:36):
You got to do the front endstop dinner early and still have
your breakfast.
Breakfast is, I mean, there's abig battle, oh, but breakfast
and and and.
Again it's marketing dominatingthe breakfast and there's many
articles showing not the mostimportant meal of the day it is,
it is it is you should do.
You should eat breakfast, butyou should still do fasting.
(16:56):
Like, how am I going to dofasting?
It's because it's dinner.
Get your dinner early, seveno'clock, even if you eat your
breakfast at eight, nine or ten.
You already did 14 hours offasting.
That's already incredible.
This is the best.
I always tell people that ifyou want to do something right
for longevity, sleep a littlebit hungry or sleep a little bit
of it, which is the mostdifficult things to do in our
(17:17):
life.
Most people are obese, have 60diets and counseling and, if you
go deep, deep, they're stressedeating at night because they're
finishing their late their workbecause they're stressed, and
they're at work because they'resitting in front of a movie with
their significant other andthey're snacking.
Ellen Brown (17:32):
It goes back to the whole concept of satiety.
I think we just have completelylost touch with even talking
about it.
And when you introduce thatconcept it's like, oh yeah, if I
eat to feel satisfied, changeis the game.
Joseph Antoun (17:43):
Yeah, and when you eat late at night, because
it matches our lifestyle and ourstress and our staying late now
with the movies and the work,they say oh, it's easy for me to
intermittent fast because I'mnot hungry in the morning.
Of course you're not hungry.
You ate late at night.
You had reflux, so your throatis a little bit burning.
You don't have appetite in themorning, so intermittent fasting
took off by skipping breakfastbecause it was the easy thing to
(18:04):
do, but it's the wrong thing todo from a longevity perspective
.
Justin Politti (18:06):
Yeah, so you're saying go to bed a little bit
hungry too.
You said that a couple of times.
Is there anything related tolike portion control and what
you're consuming, likethroughout the window Of?
Joseph Antoun (18:16):
course.
So in the past we used to sayone calorie in, one calorie out.
Sorry, it's not perfectly right, but it matters.
Obviously, if you eat a lot ofcalories, you're going to have
to play with timing and exerciseto burn it, but it's not always
.
Actually, what we're saying isto prove that one calorie in at
night is going to be stored.
One calorie when you're workingthroughout the day is going to
go to the path of utility, right, yeah, yeah, because hormonally
(18:38):
, when you sleep, your growthhormone is up, insulin and
morning are up, so you want tostore.
During the day you want tospend, so there's differential
use of calories.
It's not equal.
But of course you don't want toeat a lot and you can assume
you're going to lose weightregardless if you do.
Ellen Brown (18:53):
In terms of this, so wait, before you jump into
the other day thoughts comments,because I know this is like
we're getting into the territorythat you guys rib me on all the
time.
Rib you.
Yeah, you guys rib me.
It's cool.
It's cool about the wearables.
I'm the weird sister, no no.
I'm going to go look it up,ProLon, because I'm interested.
I should have brought the box Iactually have a ProLon at home
(19:14):
that I haven't put at home.
Joseph Antoun (19:15):
Something I'd like to try.
Yeah, to conclude and simplify,because we're getting to some.
For some people it sometimesgets confusing.
Remember, fasting is good whendone right, which is an early
dinner, and still have yourbreakfast.
So you're doing that 12 to 14hours.
We call it circadian fast andthere's a lot more to it,
meaning the sun is down, you'restopping to eat.
You're sleeping well at night,because when you eat late and
(19:36):
you sleep, you don't sleep well.
Right, you have your nightmarebecause your body is working
while your brain is trying tosleep.
We don't realize that your bodyis working right.
There's digestion.
You don't feel it because youdon't have a sensory or nervous
system, but it's working.
So the brain cannot sleep, soit actually impacts your sleep.
It impacts your energy.
The next day you spend lesstime, calories, you exercise
(19:57):
less, you pick up more weight.
And this is where a lot ofintermittent fasters.
They end up saying it helped mea little bit, because the first
5% is easy to use, and then Igot stuck and then I stopped
that's the story of 90% of itand do it right.
It just keeps helping you.
So circadian fasting when thesun is down, have your last meal
, get your breakfast.
You wake up.
Believe me, hungry.
Everyone tells me and I used tobe that I wake up.
(20:17):
I'm not hungry.
This is why I do You'll behungry if you don't eat, you'll
wake up hungry and you want toeat.
And you'll see your body goingperfect.
It's not just eating, it'ssleeping at night.
It's like the biology ofrejuvenating the organs Instead
of having them work at night,they'll sleep at night, they'll
(20:39):
rejuvenate.
So it's five days, the maingoal why to go fight?
It's food, but preciselyformulated to keep you in a
fasting state, in a true fast,not a ketosis, a true fast, and
the goal is to rejuvenateyourself so that you live a
healthier and better life.
We just published in Nature,six months ago Nature is the
number one science journal ofthe world.
We just published an articleshowing if you do three
prologues, you're reversing yourbio-age score by 2.5 years.
(21:02):
If you do it three times peryear, every year between age 50
and 70, it's 11 years of bio-age.
This is big.
We're not promising people theycan live 11 years, but we're
saying we're the age of thecells.
You might die from an accident,you might still develop a
cancer, but we're saying from anage correlated health
conditions, the four big killers.
Justin Politti (21:20):
We're giving you a better chance to keep them so
you use the term true fastingversus fasting, which my night,
well, I always thought fastingwas just water or maybe some
coffee without anything else init.
So you know, for a little bitof caffeine, but what?
What is a true fast versus whatI'm doing?
What I did, yeah, so what?
Joseph Antoun (21:39):
you what?
What you do, which isnon-ingestion of food, is a true
fast, versus what I'm doing orwhat I did.
Yeah, so what you do, which isnon-ingestion of food, is a true
fast.
What we do is fasting with food, is what we call a
physiological fast.
So we developed a nutritionformulation that we looked at
the cells, at the radars, theradars of the cell, how the cell
detects food.
There are three radars sittingon the cell that detects food.
We call them nutrient sensingpathways.
(22:00):
So we studied them the PKA, theTOR and the RAS pathway and we
figured out a formulation thatdoesn't over-trigger the pathway
.
So the cell is getting fedwithout recognizing that it's
getting fed.
This is why it's called afasting-mimicking diet,
physiological fast not a truefast, but it's a big discovery.
So we have now 134 patents onit and 40 clinical trials.
(22:21):
It's a physiological trial,gotcha, but it makes fasting
healthy, because you don't wantto go on a water fast.
Why we developed it?
Because when we learned that torejuvenate the cells you need
at least three days, nobodywants to water fast for three
days.
Actually, you can faint, youcan feel weak.
(22:47):
So it came out of necessity.
You can't work out very well.
At the end of the day, youcannot go to work, yeah.
So this is why it's the US,it's the taxpayers, that
actually came to us to developus and USC to develop the
fasting.
It was out of necessity to havepeople cross a long fast to
benefit themselves withoutfeeling so hungry or so weak.
Ellen Brown (22:55):
And, by the way, you're not supposed to work out
hard when you do ProLine, so itis.
Justin Politti (22:59):
That I don't like.
Ellen Brown (22:59):
That has supposed to work out hard when you do pro
line, so it is that has been abarrier that has been a barrier
for me in the past of doing it,because it's like, no, I'm
somewhere and I want to be ableto go ride my bike or run or
whatever, and I don't want totake five days to not you know,
but you take a week off ofexercise while you're doing this
is that the suggestion no, youcan.
Joseph Antoun (23:14):
You can do your weight lifting, you do your
pilates, your yoga, but don'trun like a marathon.
Justin Politti (23:20):
All right, so I could do my HIIT classes or
whatever.
Ellen Brown (23:24):
That might be kind of like running a marathon.
Joseph Antoun (23:25):
It's a little different, just think that
you're getting half of thecalories that you would
typically get, so you've got toadjust to that.
Justin Politti (23:31):
I'm not sure if you're doing damage or basically
undoing what you're trying todo while you're working out too
hard.
Joseph Antoun (23:36):
You're not undoing but you're getting
yourself.
If you spend a lot of calories,you're taking the risk of
hyperglycemia, because if youwant, you don't want to
overspend Diabetes.
Ellen Brown (23:47):
Alnutra.
Joseph Antoun (23:47):
Health no passing out.
You said something you said forthose who cannot pay the $175,
maybe the medical program gets.
Ellen Brown (23:58):
I was just curious, it's my hypothesis, hypothesis.
Joseph Antoun (24:00):
It's one of my biggest fights today.
The 175 dollars right, becausewe priced it to be neutral.
That people always think oh,they go to the website, they go
to prolo and my first they say,okay, should I pay 175 or not?
The studies show that theaverage us citizen spends on
food, so beverage and supplementlet me be clear.
Ellen Brown (24:20):
I'm talking about the med five days.
I'm talking about the Medicaidpopulation.
So I'm talking about those thatare below the federal poverty
level, that maybe they're onSNAP, maybe they're on.
So there is.
I don't want to say they'renecessarily food insecure, but
they're in that.
Justin Politti (24:35):
Does HSA cover this right?
Prolon HSA FSA yes, okay.
Joseph Antoun (24:42):
Sorry, I just wanted to clarify that because
that's also the perception.
When people come and buy foodfrom from us, prolon or the
others, they're thinkingsometimes they think it's a cost
.
We actually price them to swapthe cost of whatever they would
buy.
Yeah, so in the us, when youknow we're in la la, is even
more expensive.
The average person spends 200on food and beverage and we per
week.
Ellen Brown (25:01):
And what's the new store?
Air One, the new fancy store inLA, air One.
Joseph Antoun (25:07):
Yeah, At Air One you spend $1,000.
Ellen Brown (25:09):
Exactly.
Joseph Antoun (25:10):
I'm just trying to say that when somebody goes
to buy Prolon, keep in mind thatyou don't need to buy other
foods for the five days.
It's just, instead of going toWhole Foods, paying Whole Foods
whatever, you pay for five days,you just buy it's your meal for
the week.
Justin Politti (25:23):
It's a swap of the cost.
Joseph Antoun (25:25):
Now I'm very passionate to help the Medicaid
patients and the poor patients.
By the way, even today, if theycontact us and they want a
heavy discount, we do that.
Okay, we're very passionate.
Our founder, professor WalterLongo, that you mentioned he
actually donates 100% of hisshares to the CreateCruiseFund
mission.
We're a company with a mission.
We're not here to just generateprofits.
(25:46):
No, we're a company driven byMD, phds, doctors and PhDs and a
big mission goal of changingpeople's lives.
So we will not say no, even ifI have to give it for free for a
patient, I will do that for apatient.
As a CEO, I'm 100% behind that.
What we did with doctors.
So we have over 12,000 doctorsin the US registered with us.
(26:08):
So when a doctor because mostlyMedicaid patients or,
unfortunately, the lower theincome, the higher correlation
of having a health condition.
Ellen Brown (26:15):
Oh, absolutely.
Joseph Antoun (26:21):
So through doctors, we actually, if you go
to a doctor and you get a codewith ProLon, you're getting the
box for $130 to $150, dependingon how many good, which is
cheaper.
If you divide that by 15 meals,five days, three meals a day,
it's $5 to $7 a day, which iswhat even a Medicaid patient
would spend on a burger and oron whatever food they give them.
Even for that, but our goalultimately is reimbursement.
So we just launched you talkedabout diabetes we just launched
(26:43):
a big program called L-NeutralHealth.
L-l is longevity dash, neutrallongevity through nutrition
L-NeutralHealthcom.
And the program is calledDiabetes Regression and
Remission.
So it's the five days.
Like Polon, it's the five-dayfasting and vegan diet, but we
have a dietician supervision anda doctor supervision, so it's a
full program.
And what we help people withpatients with diabetes or
(27:06):
pre-diabetes or blood pressure,any metabolic condition, we help
them do five days a month oversix months and then to maintain
the benefits, it's a quarterafter that.
Okay, what we're showing andthis is the first time in
history of medicine two-thirdsof the patients within six
months, two-thirds will drop thedose of their medication or
(27:28):
will drop a full meditation,two-thirds.
And then we're showing that ifon average, it seems every six
months, when we say six months,it's just five days a month.
We're not talking about changeyour lifestyle.
Eat healthy.
There's no eat healthy orexercise in between, nothing,
just five days a month.
And we have two trials.
Now we did another trial for 12months and it's showing similar
(27:48):
results.
You're decreasing insulin,you're decreasing blood sugar,
you're decreasing Hb1c and youdecrease the need of diabetes.
So ACLM, the Association ofLifestyle Medicine, the American
College of Lifestyle Medicine,the Endocrine Society and the
American Dietetic Association,they got together and they
created a claim for us calleddiabetes regression going
(28:12):
backwards, and diabetesremission meaning you read no
more medication because diabetestreatment and cure is an FDA
approved pharma claim.
Diabetes regression andremission is for programs like
ourselves, because diabetestreatment and cure is an
FDA-approved pharmacling.
Diabetes regression andremission is for programs like
ourselves, where we applynutritional intervention to
regress the patient or to takethem off medication.
We call it regression andremission and the program is
just $250 a month.
(28:33):
Again, $250 is not an extracost.
We're swapping your food andwe're giving you a dietician and
a physician for only $250.
Is taking patients offmedication we just published
last week in Value in Health Foreveryone listening to us today
who works at a hospital orhealth system or insurance we
just published an article inValue in Health, which is a top
(28:55):
health economic journal it's theofficial journal of Hisport
showing that if a payer pays$250 to $350, even per month, on
the diabetes program, they willbreak even on month 10.
So within the first year, if ahospital, if a health system, if
an insurer pays $4,000 and evenmore than $250 for our program,
(29:15):
they will break even on month10 because their savings on
their medication and theirsaving on complication there's
no programs that you can savecosts on the chronic disease.
Ellen Brown (29:28):
So, based on all the work that we do in
value-based care on a medicareadvantage population, I would
argue that if you are, if youare regressing and remitting
diabetes, from the research wewe have in the data we have, you
would be looking at somebodywho's costing about their about,
let's say it's about 25 000 ayear in costs.
When that gets remitted youdrop in half, so that's a 4x
(29:51):
return.
So if somebody's spending, youknow, three thousand dollars a
year on your program but they'resaying twelve thousand dollars
a year in cost, that's a 4xreturn for that payer that's
investing in your program withinthe same year.
Joseph Antoun (30:03):
You cannot reverse all the side effects no,
no it's a tema, but after westudied, that's what I'm talking
about we.
We showed 44 000 ultimateinvestment easy 44 000 on a
payer that a lot of players say,hey, I had no patients for two
and a half to four years.
I could, so it was so importantto show savings in year one.
Absolutely Every insurance,every pay one day on year one.
(30:24):
And this is the first time yourpatient is going backwards
rather than forwards.
So you're hitting that yourdoctor is so happy their patient
is getting year limit andreverse and the period is happy.
It's the first time we alignedall three in America and we're
doing the right thing.
It's a metabolic disease.
You treat it with the true, Imean think about it.
Justin Politti (30:44):
It's a real cause.
Joseph Antoun (30:45):
It takes me 30 minutes to explain it all the
time, and then one sentencesummarizes it right you overeat,
you age, you become diabetic.
How you can reverse the fastestand overeating status?
That's why we're making fastingis the fastest way.
Ellen Brown (30:59):
It is.
It is, it is, and it's a lotless expensive than glyphs.
So anyways, well, yeah you guyshave any questions?
Justin Politti (31:07):
no, I don't try that.
So how do I?
Ellen Brown (31:08):
get my hands on some prolon, yeah, yeah I think,
I think you can be helped overhere how you can get your hands
on some prolon.
Joseph Antoun (31:15):
So for everyone who wants to just do it, for
weight and longevity andcellular rejuvenation, do it
three times per year.
Prolonlifecom For those thatare interested in pre-diabetes,
diabetes or other metabolicconditions.
Healthutrahealthcom is the wayyou can find the support there
Outstanding Well.
Justin Politti (31:30):
Thanks for joining us.
It was super fun.
Thank you Appreciate it.
Ellen Brown (31:33):
All right, take care.
Thank you very much.
Welcome to the Reverse Mullet Healthcare
Podcast by BP2 Health.
We are here at ACLM Conferencein Orlando 2024.
I'm Justin Politti.
I'm Dave Pavlik.
Ellen Brown (00:12):
I'm Ellen Brown and I know it's hard for those of
you watching live or therecorded video version that
Justin's hard to recognizebecause he has sunglasses and
the mullet wig on.
So if you didn't recognizeJustin, it's the real Justin,
the real deal.
Yeah, but we're here with aspecial guest, so tell us about
yourself.
Joseph Antoun (00:29):
Hey everyone, this is Dr Joseph Antoun.
Thanks for having me here today.
Yeah, thanks for being here.
Hopefully we're going to changesomebody's life.
I always wish that in mypodcast.
Ellen Brown (00:38):
So I'm super pumped that you're here.
See, dave and Justin don't evenknow I'm always pulling stuff
out, but in my journey oflearning really deeply about
health at a different level,walter Longo's work was very
instrumental.
It was like the Zach Bush onthe soil side and Walter on the
longevity side and it was likethis whole sort of trifecta
(01:02):
ritual with all of his podcastguests.
Justin Politti (01:04):
There's a lot of inside baseball going on on
that side of the table.
Yeah, it's my job.
Ellen Brown (01:08):
But and so a number of fact.
I will take a picture and I'llsend it to my girlfriend.
So a number of my friends haveutilized Prolon and I want to
hear about your new producttoday but have used Prolon for
health reasons, not to try tolose weight, but truly for
cellular restoration andautophagy and all the things
(01:30):
that Prolon does, and so I feellike I have like a legend in
here talking to you live at theLifestyle Medicine Conference.
Joseph Antoun (01:39):
I feel useless because you know it better than
I do.
Ellen Brown (01:41):
No, no, no, no, no.
I, I just, wanted to share thatbecause I think sometimes when
somebody comes on the podcastand talks about a product or an
intervention, sometimesimmediately people are like, oh,
it's something somebody'strying to tell me.
But you guys really are apioneer in a different type of
intervention than most.
Joseph Antoun (02:02):
Thank you very much, and I did promise we're
going to change somebody's lifeand we will.
Through this next 20 minuteswe're going to talk about this
Quick introduction.
My name is Joseph Anton.
I'm an MD-PhD.
I wanted to cure patients.
This is why I went to med schooland then I discovered like most
of you probably learned at somepoint, that we're taught to
(02:22):
give a lot of pills.
First we practice sick care,because we meet people after
they're sick, not before, andthen we give them a bunch of
four or five pills.
And I used to tease my attendee.
I would say, hey, what is theexpiry date of the prescription?
I used to tease them at thehospital.
There's no expiry.
They have to refill it everymonth.
They say, yeah, for the rest oftheir lives.
Yes, refill it every month.
(02:42):
They say, yeah, For the rest oftheir lives.
Yes, and maybe we're going toadd to this right.
And so I rebelled against thatsystem.
I went into first.
I thought I'll do prevention.
So I did health policy andpublic health and figured out
that most people know already.
Prevention they should eathealthy exercise.
There was no new news.
As we say, and you're alwayscompeting with the product,
(03:03):
right, Should I go to the gym orshould I sit in front of
Netflix?
Should I eat a plant-based or?
This burger looks good, right.
Justin Politti (03:11):
Choices.
Joseph Antoun (03:16):
It's choices, but the product is the bad product
and it's against choices.
And I was like, why don't wecome up with a product that is
healthy, that is preventative,that is going to help people and
compete product to product?
And so I looked for what peopledo every day and it's food Eat
every day of your life three tofive times.
And we decided to turn food asan asset of longevity, because
we know people will comply.
(03:36):
They eat food every day, theday they're born to the day they
die.
It's unfortunate that thistrillion, multi-trillion dollar
industry is governed bymarketing and by theories and
not true science.
So we gathered a team ofscientists.
Our founder you mentioned hisname, Dr Walter Longo is
probably the leading expert inlongevity around the world.
We gathered 18 universitiesbehind us Harvard, USC, Stanford
(04:02):
, Mayo Clinic and we starteddoing developing food
formulations as we develop drugs, mice trials and then human
trials in order to prove what wehave that is going to bring.
Food is longevity and food ismedicine.
So, after 23 years of research,we have developed two platforms
of nutrition technologies.
These technologies areessential for longevity or for
(04:25):
for medicine.
In the main one and youmentioned the main pro one our
main discovery is what we call afasting, mimicking nutrition, a
five-day food that we give toyou it's a very precise
formulation that we ship it toyour house.
You open the box there's fivedays of food and you eat it over
five days.
Your body doesn't know you'reeating, so it's called a fasting
(04:46):
, mimicking nutrition.
Ellen Brown (04:47):
Oh, but you do know it when you do it.
Yes, you do feel it I will gettexts from somebody and go.
Joseph Antoun (04:52):
I'm on day three of Prolong.
Yes, you're going to feel itand the concept is when the body
thinks you're not eating, ofcourse you're losing a lot of
weight, which a lot of peoplelove, but that's not the main
concept.
The main concept is the body onthe first two days has a lot of
reserve fat and glycogen.
You consume those, right.
It's like if you run a company,you don't have funding.
(05:12):
You go to your bank and you useyour savings and check in a car
when you consume your bankaccount.
So you're on day three offasting and you're in a crisis.
Say, you have a company and youspend your money.
You're in a crisis mode.
You go and you restructure thecompany.
You start fixing.
It's like, okay, I'm not doingwell because my sales department
, my marketing department, mysupply chain.
(05:33):
So the buddy on day three tellsthe cells we're in a crisis,
you got to fix yourself.
Every cell goes through thisprocess called cellular
rejuvenation.
In science we call it autophagy, self-eat, self-rejuvenate, and
it won the Nobel Prize inMedicine in 2016.
It's a big big thing.
Now.
It's just we know autophagy,what it does to the body, which
(05:53):
is reverse, the bio-age, but wenever had a product.
So that process of autophagy,which again won that Nobel Prize
in Medicine in 2016, is pushingevery cell of the body to clean
, detox, fix the inside,rejuvenate and again, I always
compare it to a company tryingto restructure.
Whatever is going wrong, we tryto fix it and for the first
(06:14):
time now we, as humans, we havea technology in nutrition called
Prolon or the fasting mimickingdiet.
This is the core technologythat we sell to help you eat
three to five days and benefitsfrom the cell rejuvenation, so
you can.
Why we want to help you eatthree to five days in benefits
from the standard ofrejuvenation, so you can.
Why we want to rejuvenate cells.
The goal is to really, a littlebit, take your biological age
backwards.
We want you and I always usethis expression, we want you to
(06:36):
be younger than your age.
Why is that so?
90% of us will die out of fourhealth conditions that all
age-related diabetes, type 2,alzheimer's, cardiovascular and
cancer.
Right, you're not going to getAlzheimer's at age 20, you're
going to get first heart attackat age 30, et cetera, et cetera.
So the goal is to keep yourcells younger than your coach.
And that's true prevention,because we're giving you,
(06:59):
hopefully, extra the chance.
We cannot promise people aregoing to get longer, but we're
giving them best chances fortheir cells to stay younger than
their age and a little bit awayfrom the onset of chronic
conditions.
So that ProLon for promotinglongevity is a consumer product.
You buy it, you do it threetimes per year.
You only need to do it threetimes per year.
It's five days, three times peryear.
You're only doing 15 times 15days per year.
(07:20):
Anyone can do it 365 days.
We priced it exactly as theprice of food for five days, so
at $175,.
The average American food,beverage and supplement spends
around that number within fivedays.
So it's a cost neutral.
I really emphasize this becausepeople should do ProLon three
times per year.
I haven't seen any product thatcan reduce the cells, help you
lose the weight and help a lotof people.
(07:41):
So that's the concept forlongevity.
The sales help you lose theweight and help a lot of people.
So that's the concept forlongevity.
The second concept samefascinating technology.
We said okay, wait a second.
So you're running a company.
You're now have no revenues, nofunds.
You're going to restructure,you're going to fix If you know
that I don't have revenuesbecause my sales team is not
doing a great job.
You start fixing there, right,right.
(08:02):
So what we learned is that ifyou have diabetes, for example,
if you have cancer, if you haveall that, the body is saying
okay, I know what's going wrong,let me try to fix.
And we started with diabetes.
We've done a lot of trials ondiabetes and what we're saying
is that patients taking thefasting-mimicking diet within
six months so this is just fivedays a month, every month
(08:22):
because you have a healthcondition, you do it every month
, once a month.
Within six months, two thirdsof them are dropping one pill.
Ellen Brown (08:30):
And it's ketosis Like.
When you were talking aboutthis, I was like right, bingo,
ketosis, right.
One of the most effectiveinsulin resistant reversal tools
is ketosis, which Proline doesa beautiful job of putting you
into ketosis.
I mean it's far more than that.
You're like please stop.
Justin Politti (08:44):
But what's the benefit for somebody not like me
and I'm not on the inside, butI've done intermittent fasting.
What's the difference?
In wide intervals?
How is this better than doingit without consuming Prolon?
Joseph Antoun (08:56):
Two fantastic questions.
Quickly answer the ketosis.
The ketosis is the metaboliclow-carb stage, but again
there's a cellular rejuvenation.
Yes, so diabetes has three rootcauses and I love when you and
I were chatting before you saidroot cause right why medicines
fail in diabetes or why evenketogenic diet In the long term
they do fail in diabetes.
Yep, because they all treat oneroot cause, which is insulin
(09:17):
resistance High carb, high fat,insulin resistance.
But diabetes has two other rootcauses.
The second one is muscle lossright, because if you maintain
high muscle, you're burning thecarbs.
Number three is very importantis aging.
We, the four of us, maybe wehad the same actually, maybe
we're eating bigger volumes offood 15 years ago and we're
skinnier, right?
So aging is behind.
(09:39):
If you eat bad at age 27, youburn it.
If you eat bad at age 27, right?
Ellen Brown (09:43):
you burn it.
Yeah, it's bad at age 55.
There's a lot more grease inyour 20s, so yes, remember blood
sugar, insulin resistance andand fat this.
Joseph Antoun (09:55):
Yes, drugs do that, glp1 do that, ketosis do
that.
But but they're not enough ismuscle.
Keep the muscle high to burnthe carbs and age it.
And this is why thefasting-inducing diet is hidden
all through your conscience.
Rejuvenate the age of the cells.
You're biologically younger.
You're not 27 chronologically,but you're close to it
biologically.
Your cells can burn, yourmuscle is active and muscle
(10:16):
protection, your muscle protectswith the fasting.
Ellen Brown (10:18):
Yeah, absolutely.
So that's the big.
So now Justin's question abouthow this is different than just
doing intermittent fasting.
Joseph Antoun (10:25):
So, justin, when you do intermittent fasting, say
you're skipping breakfast anddelaying a little bit too much.
I don't know if you do the16-hour or the 18-hour 24-hour.
It has to be 23 and a half,because you're eating.
Ellen Brown (10:36):
That's a true fast 24, yep what?
Justin Politti (10:38):
you're doing is called OMAD.
Joseph Antoun (10:41):
Omad, the one meal a day, yep, what you're
doing, yep, which is very badfor longevity.
There you go and I'll tell youwhy.
And I'll tell you why.
We studied the first 13 yearsbefore we developed the fasting.
We were a water fasting, so westudied the entire fasting
science.
It's coming from Walter Longo.
It is.
(11:06):
We started as Waterfast, so wewere a proponent and then, when
it failed at some certain point,we developed the nutrition.
It's actually the NationalInstitute of Health that gave us
funds to develop a fastingcommunity.
It wasn't either a businessproject or anything.
We were studying fasting.
So I'll tell you a little bitabout the trick.
So when you wake up in themorning is when you're thinking.
Your brain needs the mostcalories because you're thinking
, you're going to work, you'rewalking, you're exercising, if
(11:28):
you go to the gym, etc.
This is the need to havecalories and with intermittent
fasting, you're starving thebody when the need is there.
That's why in the afternoon youstart feeling weak a little bit
or dizzy, but you're starvingthe body when it doesn't eat.
Then you go and you eat.
Evening time when you go backfrom work, right, and evening
time when you eat you're goingafter that to sleep, right, and
(11:48):
when you sleep is is the leastneed for calories.
So what the body says is likeokay, I just got a bunch of
calories, her brain isstruggling, the kidneys are, so
the essential organs have beenstruggling for 14 hours and now
I got a calories.
Let me talk about right, theit's.
It's the concept of bingeeating.
And then I I will start, I'msleeping, I'm not burning that.
So when you eat a lot in theevening time, say at four, five,
(12:10):
six, seven, your insulin spikesand your igf spikes, so these
are anabolic there, and when yousleep you're anabolic, meaning
you retain what you eat soyou're giving the calories when
the body is in storage mode,rather than the body is in the
catabolic and it's spending.
So what happens?
You do it Now.
If you're starting by beingvery obese or carrying
overweight, you have high bloodsugar.
(12:31):
It helps some people becauseit's still starving.
It's starving what you don'twant to starve, which is the
essential organ, and it'sfeeding fat.
But still it's better thaneating bad all day.
Ellen Brown (12:42):
Right or eating too much.
Joseph Antoun (12:43):
Overall, yeah, some people say I do OMAD, I do
16 hours.
It helped me.
Of course it's going to helpyou, because if you're
overweight or if you had a verybad diet, it will help.
But what I'm trying to say isyou got to do it in transition
and then you got to move to abetter state.
Better state is eat in themorning, eat a light dinner,
sleep on a little bit emptystomach At night.
You're not storing the excessfat and when you wake up in the
morning you're catabolic.
(13:04):
You're spending Whatever youeat.
You spend your little.
When you sleep, the hormones ofstorage are up, so you're doing
12 to 14 hours of fasting, butthey actually start.
We call it front-ended.
They start at 7 pm, don't eatafter 7, and then eat the next
day at 9.
You did 14 hours, but you didit exactly when the body doesn't
need the food and is trying tostore.
On an empty stomach doesn'tstore and the next day, whatever
(13:25):
you eat, you spend it.
That's the better way of doingthe intermittent fasting.
Ellen Brown (13:28):
So tell us.
I have two questions.
So one, the fast mimicking diet, the FMD.
I want to talk a little bitmore about the science of that
versus intermittent fastingright, and I know you're hitting
on that.
But this idea, because to me,the reality, so like when you do
Prolon, because I don't thinkyou guys have done it before you
know well you talk about I'mnot going to steal the thunder,
but you'll explain the product,but it's.
It is very much like you'regetting little bursts of food
(13:51):
throughout the day and they'revery specific in their dietary,
you know contents to again putyour body into a certain state
of ketosis, but also to thatcellular, you know, to autophagy
, right.
But what I was going to ask istell us to this new diabetic
intervention that you all havecreated and launching, which is,
I think, l-neutral health right.
Because I think everybody knowsL-neutral for Prolon.
(14:12):
But now you've got L-neutralhealth and I'm also wondering
I'm going to see if I how manyquestions you can remember at
once is does that allow you togo from being just a consumer
product to be a B2C throughmedical prescriptions?
Right now, all of a sudden, youcan help people from an access,
because right now, if you don'thave the cash to pay $175 for
Prolon, you don't get it.
(14:32):
So does this also put you allin a position where now, if
you're getting a prescriptionfor food, you can actually seek
the L-Nutra Health version?
All that and you had a question.
Justin Politti (14:41):
Well, so I did the Peter Atiyah fasting app for
a long time.
I don't do it, yeah, zero.
I don't do it anymore and Ihave a broader eating window now
than I did when I first started.
So I've modified.
But my question was on that app, you can't get into ketosis at
14 hours, like you've got to gomuch longer.
Ellen Brown (14:59):
Right, which is why it's five days.
Justin Politti (15:00):
Yeah, like you've got to go much longer,
right which?
Ellen Brown (15:01):
is why it's five days.
Yeah well, so I guess are you?
Justin Politti (15:02):
how does that work?
Like getting into ketosis inthe eating period of time that
the window that you have andpeter left the app and it
actually changed his mind.
Joseph Antoun (15:09):
I don't know, yeah, that's a whole interesting
story this is where we go,because he read our science
right this is where we go backis is we've had enough of books
and theories, just read thescience, and the science is
clear, and so I'm going to closethe intermittent fasting
question, to close that chatterand go back to diabetes.
So it's not to get to anyketosis, because you both are
hitting on ketosis.
There's a shallow ketosis thatmost people get into when you do
(15:32):
intermittent fasting, when youdo a ketogenic diet right.
But it's a shallow ketosis,right.
Fasting is a deep ketosis andwhat you need you need to go
deep to help the cellsrejuvenate exactly so the
biggest difference between toanswer your questions is, if you
skip a meal, you're not goingto rejuvenate the cells you're
going to just say okay, let's goback to the company example,
(15:53):
like okay, you know I need amillion dollar to operate my
company.
I need 2,000 calories to operatein my body.
You give me the check, fourhours late I have some checking
as I come.
So you're saying, okay, I have alittle bit of fat, you can have
a lot of it, but you lose alittle bit of glycogen, you're
done, you don't need to go, youdon't get into crisis.
So the big difference between afive-day prolonged fasting
(16:15):
versus the intermittent fastingis the crisis Got you.
Prolongon induces a deep fastand a crisis so that the cells
rejuvenate and heal andhopefully give you a very good
path to longevity.
Intermittent fasting helps you,on a shorter, on a shorter, to
lose some weight, balance yourmetabolism.
But then you got to do it right.
(16:36):
You got to do the front endstop dinner early and still have
your breakfast.
Breakfast is, I mean, there's abig battle, oh, but breakfast
and and and.
Again it's marketing dominatingthe breakfast and there's many
articles showing not the mostimportant meal of the day it is,
it is it is you should do.
You should eat breakfast, butyou should still do fasting.
(16:56):
Like, how am I going to dofasting?
It's because it's dinner.
Get your dinner early, seveno'clock, even if you eat your
breakfast at eight, nine or ten.
You already did 14 hours offasting.
That's already incredible.
This is the best.
I always tell people that ifyou want to do something right
for longevity, sleep a littlebit hungry or sleep a little bit
of it, which is the mostdifficult things to do in our
(17:17):
life.
Most people are obese, have 60diets and counseling and, if you
go deep, deep, they're stressedeating at night because they're
finishing their late their workbecause they're stressed, and
they're at work because they'resitting in front of a movie with
their significant other andthey're snacking.
Ellen Brown (17:32):
It goes back to the whole concept of satiety.
I think we just have completelylost touch with even talking
about it.
And when you introduce thatconcept it's like, oh yeah, if I
eat to feel satisfied, changeis the game.
Joseph Antoun (17:43):
Yeah, and when you eat late at night, because
it matches our lifestyle and ourstress and our staying late now
with the movies and the work,they say oh, it's easy for me to
intermittent fast because I'mnot hungry in the morning.
Of course you're not hungry.
You ate late at night.
You had reflux, so your throatis a little bit burning.
You don't have appetite in themorning, so intermittent fasting
took off by skipping breakfastbecause it was the easy thing to
(18:04):
do, but it's the wrong thing todo from a longevity perspective
.
Justin Politti (18:06):
Yeah, so you're saying go to bed a little bit
hungry too.
You said that a couple of times.
Is there anything related tolike portion control and what
you're consuming, likethroughout the window Of?
Joseph Antoun (18:16):
course.
So in the past we used to sayone calorie in, one calorie out.
Sorry, it's not perfectly right, but it matters.
Obviously, if you eat a lot ofcalories, you're going to have
to play with timing and exerciseto burn it, but it's not always
.
Actually, what we're saying isto prove that one calorie in at
night is going to be stored.
One calorie when you're workingthroughout the day is going to
go to the path of utility, right, yeah, yeah, because hormonally
(18:38):
, when you sleep, your growthhormone is up, insulin and
morning are up, so you want tostore.
During the day you want tospend, so there's differential
use of calories.
It's not equal.
But of course you don't want toeat a lot and you can assume
you're going to lose weightregardless if you do.
Ellen Brown (18:53):
In terms of this, so wait, before you jump into
the other day thoughts comments,because I know this is like
we're getting into the territorythat you guys rib me on all the
time.
Rib you.
Yeah, you guys rib me.
It's cool.
It's cool about the wearables.
I'm the weird sister, no no.
I'm going to go look it up,ProLon, because I'm interested.
I should have brought the box Iactually have a ProLon at home
(19:14):
that I haven't put at home.
Joseph Antoun (19:15):
Something I'd like to try.
Yeah, to conclude and simplify,because we're getting to some.
For some people it sometimesgets confusing.
Remember, fasting is good whendone right, which is an early
dinner, and still have yourbreakfast.
So you're doing that 12 to 14hours.
We call it circadian fast andthere's a lot more to it,
meaning the sun is down, you'restopping to eat.
You're sleeping well at night,because when you eat late and
(19:36):
you sleep, you don't sleep well.
Right, you have your nightmarebecause your body is working
while your brain is trying tosleep.
We don't realize that your bodyis working right.
There's digestion.
You don't feel it because youdon't have a sensory or nervous
system, but it's working.
So the brain cannot sleep, soit actually impacts your sleep.
It impacts your energy.
The next day you spend lesstime, calories, you exercise
(19:57):
less, you pick up more weight.
And this is where a lot ofintermittent fasters.
They end up saying it helped mea little bit, because the first
5% is easy to use, and then Igot stuck and then I stopped
that's the story of 90% of itand do it right.
It just keeps helping you.
So circadian fasting when thesun is down, have your last meal
, get your breakfast.
You wake up.
Believe me, hungry.
Everyone tells me and I used tobe that I wake up.
(20:17):
I'm not hungry.
This is why I do You'll behungry if you don't eat, you'll
wake up hungry and you want toeat.
And you'll see your body goingperfect.
It's not just eating, it'ssleeping at night.
It's like the biology ofrejuvenating the organs Instead
of having them work at night,they'll sleep at night, they'll
(20:39):
rejuvenate.
So it's five days, the maingoal why to go fight?
It's food, but preciselyformulated to keep you in a
fasting state, in a true fast,not a ketosis, a true fast, and
the goal is to rejuvenateyourself so that you live a
healthier and better life.
We just published in Nature,six months ago Nature is the
number one science journal ofthe world.
We just published an articleshowing if you do three
prologues, you're reversing yourbio-age score by 2.5 years.
(21:02):
If you do it three times peryear, every year between age 50
and 70, it's 11 years of bio-age.
This is big.
We're not promising people theycan live 11 years, but we're
saying we're the age of thecells.
You might die from an accident,you might still develop a
cancer, but we're saying from anage correlated health
conditions, the four big killers.
Justin Politti (21:20):
We're giving you a better chance to keep them so
you use the term true fastingversus fasting, which my night,
well, I always thought fastingwas just water or maybe some
coffee without anything else init.
So you know, for a little bitof caffeine, but what?
What is a true fast versus whatI'm doing?
What I did, yeah, so what?
Joseph Antoun (21:39):
you what?
What you do, which isnon-ingestion of food, is a true
fast, versus what I'm doing orwhat I did.
Yeah, so what you do, which isnon-ingestion of food, is a true
fast.
What we do is fasting with food, is what we call a
physiological fast.
So we developed a nutritionformulation that we looked at
the cells, at the radars, theradars of the cell, how the cell
detects food.
There are three radars sittingon the cell that detects food.
We call them nutrient sensingpathways.
(22:00):
So we studied them the PKA, theTOR and the RAS pathway and we
figured out a formulation thatdoesn't over-trigger the pathway
.
So the cell is getting fedwithout recognizing that it's
getting fed.
This is why it's called afasting-mimicking diet,
physiological fast not a truefast, but it's a big discovery.
So we have now 134 patents onit and 40 clinical trials.
(22:21):
It's a physiological trial,gotcha, but it makes fasting
healthy, because you don't wantto go on a water fast.
Why we developed it?
Because when we learned that torejuvenate the cells you need
at least three days, nobodywants to water fast for three
days.
Actually, you can faint, youcan feel weak.
(22:47):
So it came out of necessity.
You can't work out very well.
At the end of the day, youcannot go to work, yeah.
So this is why it's the US,it's the taxpayers, that
actually came to us to developus and USC to develop the
fasting.
It was out of necessity to havepeople cross a long fast to
benefit themselves withoutfeeling so hungry or so weak.
Ellen Brown (22:55):
And, by the way, you're not supposed to work out
hard when you do ProLine, so itis.
Justin Politti (22:59):
That I don't like.
Ellen Brown (22:59):
That has supposed to work out hard when you do pro
line, so it is that has been abarrier that has been a barrier
for me in the past of doing it,because it's like, no, I'm
somewhere and I want to be ableto go ride my bike or run or
whatever, and I don't want totake five days to not you know,
but you take a week off ofexercise while you're doing this
is that the suggestion no, youcan.
Joseph Antoun (23:14):
You can do your weight lifting, you do your
pilates, your yoga, but don'trun like a marathon.
Justin Politti (23:20):
All right, so I could do my HIIT classes or
whatever.
Ellen Brown (23:24):
That might be kind of like running a marathon.
Joseph Antoun (23:25):
It's a little different, just think that
you're getting half of thecalories that you would
typically get, so you've got toadjust to that.
Justin Politti (23:31):
I'm not sure if you're doing damage or basically
undoing what you're trying todo while you're working out too
hard.
Joseph Antoun (23:36):
You're not undoing but you're getting
yourself.
If you spend a lot of calories,you're taking the risk of
hyperglycemia, because if youwant, you don't want to
overspend Diabetes.
Ellen Brown (23:47):
Alnutra.
Joseph Antoun (23:47):
Health no passing out.
You said something you said forthose who cannot pay the $175,
maybe the medical program gets.
Ellen Brown (23:58):
I was just curious, it's my hypothesis, hypothesis.
Joseph Antoun (24:00):
It's one of my biggest fights today.
The 175 dollars right, becausewe priced it to be neutral.
That people always think oh,they go to the website, they go
to prolo and my first they say,okay, should I pay 175 or not?
The studies show that theaverage us citizen spends on
food, so beverage and supplementlet me be clear.
Ellen Brown (24:20):
I'm talking about the med five days.
I'm talking about the Medicaidpopulation.
So I'm talking about those thatare below the federal poverty
level, that maybe they're onSNAP, maybe they're on.
So there is.
I don't want to say they'renecessarily food insecure, but
they're in that.
Justin Politti (24:35):
Does HSA cover this right?
Prolon HSA FSA yes, okay.
Joseph Antoun (24:42):
Sorry, I just wanted to clarify that because
that's also the perception.
When people come and buy foodfrom from us, prolon or the
others, they're thinkingsometimes they think it's a cost
.
We actually price them to swapthe cost of whatever they would
buy.
Yeah, so in the us, when youknow we're in la la, is even
more expensive.
The average person spends 200on food and beverage and we per
week.
Ellen Brown (25:01):
And what's the new store?
Air One, the new fancy store inLA, air One.
Joseph Antoun (25:07):
Yeah, At Air One you spend $1,000.
Ellen Brown (25:09):
Exactly.
Joseph Antoun (25:10):
I'm just trying to say that when somebody goes
to buy Prolon, keep in mind thatyou don't need to buy other
foods for the five days.
It's just, instead of going toWhole Foods, paying Whole Foods
whatever, you pay for five days,you just buy it's your meal for
the week.
Justin Politti (25:23):
It's a swap of the cost.
Joseph Antoun (25:25):
Now I'm very passionate to help the Medicaid
patients and the poor patients.
By the way, even today, if theycontact us and they want a
heavy discount, we do that.
Okay, we're very passionate.
Our founder, professor WalterLongo, that you mentioned he
actually donates 100% of hisshares to the CreateCruiseFund
mission.
We're a company with a mission.
We're not here to just generateprofits.
(25:46):
No, we're a company driven byMD, phds, doctors and PhDs and a
big mission goal of changingpeople's lives.
So we will not say no, even ifI have to give it for free for a
patient, I will do that for apatient.
As a CEO, I'm 100% behind that.
What we did with doctors.
So we have over 12,000 doctorsin the US registered with us.
(26:08):
So when a doctor because mostlyMedicaid patients or,
unfortunately, the lower theincome, the higher correlation
of having a health condition.
Ellen Brown (26:15):
Oh, absolutely.
Joseph Antoun (26:21):
So through doctors, we actually, if you go
to a doctor and you get a codewith ProLon, you're getting the
box for $130 to $150, dependingon how many good, which is
cheaper.
If you divide that by 15 meals,five days, three meals a day,
it's $5 to $7 a day, which iswhat even a Medicaid patient
would spend on a burger and oron whatever food they give them.
Even for that, but our goalultimately is reimbursement.
So we just launched you talkedabout diabetes we just launched
(26:43):
a big program called L-NeutralHealth.
L-l is longevity dash, neutrallongevity through nutrition
L-NeutralHealthcom.
And the program is calledDiabetes Regression and
Remission.
So it's the five days.
Like Polon, it's the five-dayfasting and vegan diet, but we
have a dietician supervision anda doctor supervision, so it's a
full program.
And what we help people withpatients with diabetes or
(27:06):
pre-diabetes or blood pressure,any metabolic condition, we help
them do five days a month oversix months and then to maintain
the benefits, it's a quarterafter that.
Okay, what we're showing andthis is the first time in
history of medicine two-thirdsof the patients within six
months, two-thirds will drop thedose of their medication or
(27:28):
will drop a full meditation,two-thirds.
And then we're showing that ifon average, it seems every six
months, when we say six months,it's just five days a month.
We're not talking about changeyour lifestyle.
Eat healthy.
There's no eat healthy orexercise in between, nothing,
just five days a month.
And we have two trials.
Now we did another trial for 12months and it's showing similar
(27:48):
results.
You're decreasing insulin,you're decreasing blood sugar,
you're decreasing Hb1c and youdecrease the need of diabetes.
So ACLM, the Association ofLifestyle Medicine, the American
College of Lifestyle Medicine,the Endocrine Society and the
American Dietetic Association,they got together and they
created a claim for us calleddiabetes regression going
(28:12):
backwards, and diabetesremission meaning you read no
more medication because diabetestreatment and cure is an FDA
approved pharma claim.
Diabetes regression andremission is for programs like
ourselves, because diabetestreatment and cure is an
FDA-approved pharmacling.
Diabetes regression andremission is for programs like
ourselves, where we applynutritional intervention to
regress the patient or to takethem off medication.
We call it regression andremission and the program is
just $250 a month.
(28:33):
Again, $250 is not an extracost.
We're swapping your food andwe're giving you a dietician and
a physician for only $250.
Is taking patients offmedication we just published
last week in Value in Health Foreveryone listening to us today
who works at a hospital orhealth system or insurance we
just published an article inValue in Health, which is a top
(28:55):
health economic journal it's theofficial journal of Hisport
showing that if a payer pays$250 to $350, even per month, on
the diabetes program, they willbreak even on month 10.
So within the first year, if ahospital, if a health system, if
an insurer pays $4,000 and evenmore than $250 for our program,
(29:15):
they will break even on month10 because their savings on
their medication and theirsaving on complication there's
no programs that you can savecosts on the chronic disease.
Ellen Brown (29:28):
So, based on all the work that we do in
value-based care on a medicareadvantage population, I would
argue that if you are, if youare regressing and remitting
diabetes, from the research wewe have in the data we have, you
would be looking at somebodywho's costing about their about,
let's say it's about 25 000 ayear in costs.
When that gets remitted youdrop in half, so that's a 4x
(29:51):
return.
So if somebody's spending, youknow, three thousand dollars a
year on your program but they'resaying twelve thousand dollars
a year in cost, that's a 4xreturn for that payer that's
investing in your program withinthe same year.
Joseph Antoun (30:03):
You cannot reverse all the side effects no,
no it's a tema, but after westudied, that's what I'm talking
about we.
We showed 44 000 ultimateinvestment easy 44 000 on a
payer that a lot of players say,hey, I had no patients for two
and a half to four years.
I could, so it was so importantto show savings in year one.
Absolutely Every insurance,every pay one day on year one.
(30:24):
And this is the first time yourpatient is going backwards
rather than forwards.
So you're hitting that yourdoctor is so happy their patient
is getting year limit andreverse and the period is happy.
It's the first time we alignedall three in America and we're
doing the right thing.
It's a metabolic disease.
You treat it with the true, Imean think about it.
Justin Politti (30:44):
It's a real cause.
Joseph Antoun (30:45):
It takes me 30 minutes to explain it all the
time, and then one sentencesummarizes it right you overeat,
you age, you become diabetic.
How you can reverse the fastestand overeating status?
That's why we're making fastingis the fastest way.
Ellen Brown (30:59):
It is.
It is, it is, and it's a lotless expensive than glyphs.
So anyways, well, yeah you guyshave any questions?
Justin Politti (31:07):
no, I don't try that.
So how do I?
Ellen Brown (31:08):
get my hands on some prolon, yeah, yeah I think,
I think you can be helped overhere how you can get your hands
on some prolon.
Joseph Antoun (31:15):
So for everyone who wants to just do it, for
weight and longevity andcellular rejuvenation, do it
three times per year.
Prolonlifecom For those thatare interested in pre-diabetes,
diabetes or other metabolicconditions.
Healthutrahealthcom is the wayyou can find the support there
Outstanding Well.
Justin Politti (31:30):
Thanks for joining us.
It was super fun.
Thank you Appreciate it.
Ellen Brown (31:33):
All right, take care.
Thank you very much.
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