Episode: 34 - Ringing in 2025 With Validating Novel Digital Clinical Measures, Decentralized Trials, and More

In this episode of the Scope of Things, host Deborah Borfitz delivers the news on an investigation into data reporting problems in major Ticagrelor clinical trial PLATO, the need for more sex-aware cancer research, Alzheimer’s studies looking at brain shrinkage associated with immunotherapies (and repurposing drugs as potential new treatments), and a large, decentralized trial that successfully uncovered disease-causing genetic variants in hundreds of participants. Benjamin Vandendriessche, chief delivery officer of Digital Medicine Society, also joins in to talk about a newly completed project with the FDA that is providing guidance and resources on how to validate novel digital clinical measures.  

News Roundup 

PLATO trial investigation 

• Findings published in The BMJ 

“OncoSexome” project 

• Paper in Nucleic Acids Research 

Brain shrinkage with Alzheimer’s treatment 

• Research in The Lancet Neurology  

Repurposing drugs for Alzheimer’s 

• Study in Alzheimer’s & Dementia  

Mayo Clinic Tapestry study 

• Article in Mayo Clinic Proceedings 

Guest  

Benjamin Vandendriessche, chief delivery officer, Digital Medicine Society 

The Scope of Things podcast explores clinical research and its possibilities, promise, and pitfalls. Clinical Research News senior writer, Deborah Borfitz, welcomes guests who are visionaries closest to the topics, but who can still see past their piece of the puzzle. Focusing on game-changing trends and out-of-the-box operational approaches in the clinical research field, the Scope of Things podcast is your no-nonsense, insider’s look at clinical research today.