The Trip Lab

Psychedelic medicine is moving fast. Faster than regulation. Faster than standardization. And in many ways, faster than the data itself.

In this episode, we explore what psychedelics are teaching us about practicing medicine under uncertainty. From the rapid rise of training programs and self-identified experts, to the tension between lived experience, emerging science, and clinical responsibility, this conversation looks beyond hyp...

Our understanding of how psychedelics work has evolved in meaningful ways over the past several years. While earlier neuroscience frameworks helped move the field forward, newer research has added important nuance and depth to how we interpret brain imaging, network behavior, and subjective experience.

In this episode of The Trip Lab, I offer a refresh on psychedelic neuroscience, focusing on key updates from the past four years and...

Microdosing has gone mainstream and is often described as a tool for creativity, mood, productivity, and emotional healing. But what does the science actually say?

In this episode of The Trip Lab, I take an evidence-based look at microdosing psychedelics. We explore what microdosing is, how it differs from full-dose psychedelic therapy, and the proposed neurobiological mechanisms that have been suggested in the literature. I review ...

Functional medicine testing is everywhere. It is often marketed as “test, don’t guess,” and just as often dismissed as invalidated or unscientific. So what is the truth?

In this episode of The Trip Lab, we take a deep dive into what functional medicine testing actually is, how it differs from traditional laboratory testing, and what clinicians really mean when they say these tests are not “validated.” We explore why some advanced te...

Is modern medicine still evidence-based, or have we quietly mistaken rigor for certainty?

Evidence-based medicine is essential. It’s why we save lives, advance care, and trust modern healthcare. But as medicine has become more specialized and disease more complex, something subtle has happened. Rigor has increasingly turned into reductionism, and evidence is often applied in ways that don’t fully match the realities of clinical prac...

Why do psychedelic experiences so often feel spiritual, sacred, or life-changing? Why are mystical-type experiences so closely linked to lasting therapeutic benefit? And why does medicine struggle to talk about them at all?

In this episode, we explore the neuroscience and psychology behind mystical experiences in psychedelics. We examine how shifts in brain networks involved in meaning, identity, and self-referential thinking can gi...

NAD has become one of the most talked-about molecules in longevity medicine—showing up in supplements, IV clinics, lab testing, and bold claims about aging and healthspan. But what does the science actually show?

In this episode of The Trip Lab, we take a clear, evidence-based look at NAD and use it as a lens to explore the broader field of longevity medicine. We break down what NAD does in the human body, why it’s linked to the hal...

In this Deep Dive episode of The Trip Lab, we unpack hyperlipidemia (high cholesterol) beyond the oversimplified “LDL bad, HDL good” narrative. We also take a clear-eyed look at the most common concerns people have about statins, what the evidence actually shows, and where these medications fit—and don’t fit—within a thoughtful, individualized approach to cardiovascular risk.

From there, we explore integrative strategies for managin...

In this season 2 opening episode of The Trip Lab, I return from maternity leave with a deeply personal exploration of how psychedelic experiences mirror one of the most profound transitions in a woman’s life: motherhood.

From the sudden crash of postpartum hormones to the full dissolution of identity and the slow reconstruction of self, I reflect on how becoming a mother felt strikingly similar to a psychedelic journey — raw, disori...

Osteopathic manipulative treatment (OMT) is a hands on diagnostic and treatment modality that DOs learn in medical school. You may have seen the DO (rather than MD) after your doctor's name and never really understood what that meant. We dive into the difference between MDs and DOs and talk all about what osteopathic medicine is in this episode.

Many OMT treatments actually mirror what a yoga practice can do for you ...

In this episode we will take a deep dive into one of the leading causes of the global burden of disease-- hypertension, or high blood pressure. We will go over the pathophysiology, learn how hypertension develops and why it is so bad for the body. 

After understanding the root causes, we can then better understand how our traditional pharmaceuticals, lifestyle interventions, and holistic integrative therapies work to treat...

Today I will be introducing a new 'deep dive series' on The Trip Lab. We are going to be looking into the most common medical conditions to really understand what is happening in the body and how they develop. With that understanding, we can better understand how our treatments work-- including pharmaceuticals and surgery as well as integrative therapies like herbal medicine and mind-body medicine. 

To start this...

This episode is going to be a high level overview over all of the primary causes of anxiety and depression, and integrative approaches to treat them.

Anxiety and depression is a lot more complicated than just writing a script for sertraline or recommending therapy. These disorders definitely have a psychological component that can stem from chemical imbalances in the brain... but other causes include nutritional deficienc...

Today we interview UCSF psychiatrist Emily Willow, MD. She has a robust career in psychedelic medicine and has worked on clinical trials using MDMA, psilocybin and ketamine. Currently, she has a private practice where she does ketamine assisted psychotherapy and psychedelic integration therapy.

We chat all about her experience using these different psychedelic compounds, and the benefits and cautions of each depending on ...

A Trip Lab Thought Experiment: We will dive into an alternate reality where psychedelics can be used by anyone to explore their consciousness and place in the world (without having a mental health disorder like depression to make it legal).

Find out how psychedelics can help you understand the complex topics of quantum physics, string theory, the illusion of time and parallel universes.

We will also discuss exci...

We chat with Dr. Mark Braunstein about how he pioneered a new path in psychiatric care using cannabis, ketamine and psilocybin... in addition to integrating wilderness programming, exercise, diet and spirituality to treat depression, addiction, anxiety and trauma. He dives deeper into how cannabis works in the mind and the different ways he prescribes this to his patients. We also chat about the future of cannabis and psychedelic m...

Chronic low levels of inflammation is linked to at 8 out of the 10 leading causes of death in the United States. This, along with chronic stress, causes premature aging, cardiovascular disease, neurodegenerative disease, cancer and a lot more.  This episode dives deeper into how this process happens... and what you can change in your diet to combat it. 

This episode rounds out our discussion on inflammation and stress, fol...

Mia Cara Cosco is the Creative Director of Psychedelic Salons. She has 10 years of experience in psychedelic medicine advocacy and has a really beautiful take on these plants and fungi as medicine.

We chat all about the work that she does holding space for people to experience psychedelics, as well as creating spaces to merge social venture capital with artists, business people, leaders and visionaries.  Mia is passionate...

Max C Wood is a graduate student studying developmental neuroscience and psychopathology at the Anna Freud Center in London. He is finishing his studies at Yale, studying the impact that attachment styles have on a psychedelic treatment design, using ketamine.  

We talk all about how developmental neuroscience came to be, and why this goes hand in hand with understanding the brain using psychedelics... in addition to using...