The Y in Psychiatry

The Y in Psychiatry

"The Y in Psychiatry" – a pragmatically endearing podcast talking to the med students, residents, fellows, and attendings of the medicine world about the nuances of psychiatry. Each episode features focused discussions that explore the intersection of the mental health, medicine, and the human experience. Together, we'll uncover the hidden "Y" – the compelling reasons, profound insights, and groundbreaking discoveries shaping the psychiatric landscape. So grab a seat, warm beverage, tune in, and let's embark on this journey to unlock the mysteries of the human psyche, only on "The Y in Psychiatry."

Episodes

December 1, 2025 16 mins

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In this episode of The Y in Psychiatry, Dr. Amayo, Dr. V (Handratta), and Dr. Nguyen go full-neuroscience mode to unpack the neurochemistry and brain circuitry behind bipolar disorder — from dopamine/serotonin tug-of-wars to the roles of the prefrontal cortex, amygdala, and motor pathways in mania vs depression. Expect plenty of brain maps, metaphorical circuit diagram...

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We hop aboard the Bipolar Express to unpack one of the messiest puzzles in psych: why diagnosing Bipolar Disorder sometimes feels like trying to solve a Rubik’s cube — when there could also be ADHD, anxiety, personality disorders, substance use, sleep-issues, or even childhood trauma riding shotgun. We'll walk you through the common—and often overlapping—comorbidi...

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Our crew reunites to unpack one of the most enigmatic diagnoses in mental health: Bipolar Disorder.

Join Dr. Amayo, Dr.  Nguyen, Dr. Handratta, and freshly minted PGY-1 Edmund as they peel back the layers on:

  • What bipolar disorder really is (spoiler: it’s not just mood swings)
  • Why bipolar looks different in kids—and how we often get it wrong
  • The fine line between ADHD ...
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We close with a deep dive into late-life depression, where we explore why growing older can sometimes mean growing sadder. Dr. Handratta and Dr. Amayo uncover the four key culprits: executive dysfunction (DED, not a good acronym!), vascular woes, inflammatory fires, and amyloid beta blues. We’ll discuss why SSRIs might not be the golden ticket and what alternatives, li...

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In this enlightening episode, the squad unravels the intricate tango between the liver and psychiatric medications, focusing on patients with cirrhosis. Discussing 1st-pass metabolism, phase 1 and 2 metabolisms, plasma protein binding, fluid overload, and the implications of these processes on medication efficacy and toxicity. We know you liver this stuff.

Our...

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In this episode, Dr. Handratta and Dr. Amayo explore the importance of the kidney in psychiatry and discuss the impact of renal disease on medication management. They provide insights on dosing adjustments for various medications and highlight the role of the kidney in drug excretion. Tune in to unlock the mysteries of the human psyche on The Y in Psychiatry.

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Explore the intersection of depression and neurocognitive disorders in elderly patients. The discussion highlights the challenges in differentiating between depression and apathy, the importance of accurate diagnosis, and the appropriate pharmacological considerations for treatment. Join us as we delve into the complexities of mental health in the aging population.

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Join Dr. Amayo and Dr. Handratta as they dive into the dark yet enlightening side effects of conventional antidepressants. From weight gain to sexual side effects and hyponatremia, this lively conversation unpacks the mechanisms, challenges, and potential solutions. Get ready for a dose of medical insight with a dash of humor in this must-listen episode.

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In this episode of The Y in Psychiatry, Dr. Amayo and Dr. Handratta explore the potentially potent side effects of SSRIs (selective serotonin reuptake inhibitors). They discuss the risks of switching to mania, the role of mood stabilizers, the increased risk of suicidality in younger patients, and the common side effects of nausea and vomiting. Tune in as they delve in...

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September 30, 2023 16 mins

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When the algorithm for treating depression begin to have more branch point than words hinting at what to do next, we'll come to your aid with this podcast. Tune in as we briefly review the treatments reserved for the refractive cases.

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Join us this evening for a soiree that will give Bridgerton a run for its money. But not really cause it'll be jiving to the conversation of fluoxetine and fluvoxamine: the twins of SSRIs that never were. Got that warm beverage ready yet for this episode?

Good.

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Join us on a journey of hope and healing as we delve into the world of nonpharmacologic treatment options for depression. In this insightful podcast, we explore holistic approaches, therapies, and lifestyle changes that offer powerful tools for managing and overcoming depression.

Our Guru’s  share their experiences, knowledge, and practical advice. Discov...

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Review with us the first line agents when considering psychopharmacology for your patients. The granular details can be daunting sometimes, but at the very least they'll help you be aware of some cautionary contexts, build your psychopharm database for that next test, or just flex when at noon conference ;).

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Come learn about the do’s and don’ts of depression. In this episode, Dr. Miracle and Dr. Hendratta deep dive into depression. They discuss everything from why we need to treat it, how to diagnose it, and its different treatment modalities. Whether you are a seasoned psychiatrist who treats depression on a daily basis and are looking for a chance to refresh your knowled...

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July 20, 2023 14 mins

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Join our journey through a landscape of vortioxetine via neurotransmitters, GABA interneurons, and serotonin receptors, all with the audacious goal of making this complex antidepressant understandable. The hosts' heavy accents might challenge your ears, but their insights will stimulate your brain. This episode is chock-full of wit, laughs, and unexpected revelati...

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On this episode, we will continue our antidepressant journey and find out what the buzz around ketamine is all about. Hear Dr. Miracle and Dr. Hendratta discuss the use of ketamine in the treatment of depression. Explore everything from its receptors in the brain, why it works so fast, and why psychiatrists may be turning to this in their everyday practice. Tune in to ...

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This episode embarks on an intriguing journey into the mysterious world of antidepressants. In this episode, we unravel the mysteries surrounding these medications, delving into how they work in the brain and why they can take time to have an effect. Discover the hidden mechanisms and uncover the secrets behind these transformative treatments. Get ready to embark on a ...

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July 3, 2023 2 mins

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We heard your feedback and decided to introduce another trailer with a little bit more background on the hosts behind the podcast. Be sure to check it out and give us some kudos, or hopefully some constructive feedback.

https://www.nguyenindoubt.com/theyinpsych
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Hold tight as we take a whirlwind tour into the moody labyrinth of depression on "The Y in Psychiatry" express, with Dr. H and Miracle in the driver's seat. This is not your typical clinical field trip - it's a rollercoaster ride through brain inheritance battles, childhood monsters, medical conundrums, and psychosocial puppetry. We shine the neuro-...

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A sneak peek into our podcast on neuropsychopharm, coming to headphones near you in summer of 2023.

https://www.nguyenindoubt.com/theyinpsych
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